MX2021006065A - Procesos para la preparacion de propanedioles nitrosilados, composiciones que los comprenden y usos medicos de estos. - Google Patents

Procesos para la preparacion de propanedioles nitrosilados, composiciones que los comprenden y usos medicos de estos.

Info

Publication number
MX2021006065A
MX2021006065A MX2021006065A MX2021006065A MX2021006065A MX 2021006065 A MX2021006065 A MX 2021006065A MX 2021006065 A MX2021006065 A MX 2021006065A MX 2021006065 A MX2021006065 A MX 2021006065A MX 2021006065 A MX2021006065 A MX 2021006065A
Authority
MX
Mexico
Prior art keywords
nitrite
nitrosylated
compositions
propanediols
source
Prior art date
Application number
MX2021006065A
Other languages
English (en)
Inventor
Johan Salman Malmberg
Agvald Per Håkan
Leif Christofer Adding
Kristofer Bo Ingemar Nilsson
Anna Lena Elisabeth Minidis
Alexander Bogdan Emil Minidis
Original Assignee
Attgeno Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Attgeno Ab filed Critical Attgeno Ab
Publication of MX2021006065A publication Critical patent/MX2021006065A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/02—Formation or introduction of functional groups containing nitrogen of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/04—Preparation of esters of nitrous acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

La presente invención se refiere a un nuevo proceso para la síntesis de propanodioles mono y bis-nitrosilados, así como nuevas composiciones y formulaciones farmacéuticas que comprenden dichos compuestos. El proceso avanza al hacer reaccionar un propanodiol correspondiente que no está nitrosilado con una fuente de nitrito, opcionalmente en presencia de un ácido adecuado. En donde, cuando la fuente de nitrito es un nitrito orgánico, la etapa de reacción se realiza en un solvente orgánico adecuado, y cuando la fuente de nitrito es un nitrito inorgánico, la etapa de reacción se realiza en una mezcla de solventes bifásica que comprende una fase acuosa y una fase no acuosa La invención también se refiere a métodos para tratar una afección en donde la administración de óxido nítrico (NO) tiene un efecto beneficioso al administrar dichos compuestos, composiciones o formulaciones.
MX2021006065A 2018-11-27 2019-11-27 Procesos para la preparacion de propanedioles nitrosilados, composiciones que los comprenden y usos medicos de estos. MX2021006065A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1819298.9A GB2579240B (en) 2018-11-27 2018-11-27 New processes, compositions and medical uses
PCT/EP2019/082800 WO2020109420A1 (en) 2018-11-27 2019-11-27 Processes for preparing nitrosylated propanediols, compositions comprising the same, and medical uses thereof

Publications (1)

Publication Number Publication Date
MX2021006065A true MX2021006065A (es) 2021-08-11

Family

ID=65024345

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021006065A MX2021006065A (es) 2018-11-27 2019-11-27 Procesos para la preparacion de propanedioles nitrosilados, composiciones que los comprenden y usos medicos de estos.

Country Status (12)

Country Link
US (1) US20220002223A1 (es)
EP (1) EP3886834A1 (es)
JP (1) JP2022513153A (es)
KR (1) KR20210116450A (es)
CN (1) CN113164427A (es)
AU (1) AU2019390693A1 (es)
BR (1) BR112021010119A2 (es)
CA (1) CA3121045A1 (es)
GB (1) GB2579240B (es)
IL (1) IL283318A (es)
MX (1) MX2021006065A (es)
WO (1) WO2020109420A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202007929D0 (en) * 2020-05-27 2020-07-08 Attgeno Ab New medical uses

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468416B (sv) 1991-09-27 1993-01-18 Lars Erik Gustafsson Saett att faststaella aktuell lungfunktion samt anordning foer att indikera naemnda lungfunktion
US5646181A (en) 1992-07-02 1997-07-08 Research Foundation Of State University Of New York Method and compositions for treating impotence
US5278192A (en) * 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
WO1994016740A1 (en) 1993-01-29 1994-08-04 Brigham And Women's Hospital The use of nitric oxide-delivering compounds for the treatment or prevention of alcoholic liver injury
AU7197594A (en) 1993-07-06 1995-02-06 Kjell Alving A system to be used for the determination of no levels in exhaled air and diagnostic methods for disorders related to abnormal no levels
EP0855912B1 (fr) 1995-10-20 2001-12-05 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Composition a base de monoxyde d'azote en tant que medicament
DE19654895C2 (de) 1996-02-07 2000-07-27 Sanol Arznei Schwarz Gmbh Detektionsverfahren
GB0022084D0 (en) * 2000-09-08 2000-10-25 Univ Aberdeen Treatment of multiply antibiotic-resistant organisms
JP4426840B2 (ja) * 2001-08-03 2010-03-03 ビーエーエスエフ ソシエタス・ヨーロピア 亜硝酸アルキル及び二亜硝酸アルキルの製造方法
SE0402221D0 (sv) 2004-09-14 2004-09-14 Aerocrine Ab Treatment of insufficient perfusion
US8030511B2 (en) * 2006-03-14 2011-10-04 Gustafsson Lars E Method for the manufacture of therapeutic compounds and compositions, compounds and compositions produced therewith, and their use

Also Published As

Publication number Publication date
JP2022513153A (ja) 2022-02-07
IL283318A (en) 2021-07-29
AU2019390693A1 (en) 2021-06-03
KR20210116450A (ko) 2021-09-27
GB2579240B (en) 2020-12-16
CA3121045A1 (en) 2020-06-04
WO2020109420A1 (en) 2020-06-04
GB201819298D0 (en) 2019-01-09
GB2579240A (en) 2020-06-17
EP3886834A1 (en) 2021-10-06
US20220002223A1 (en) 2022-01-06
BR112021010119A2 (pt) 2021-09-28
CN113164427A (zh) 2021-07-23

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