|
US3740385A
(en)
|
1970-05-07 |
1973-06-19 |
M Ondetti |
N-terminal derivatives of secretin
|
|
US4275152A
(en)
|
1977-02-03 |
1981-06-23 |
Eastman Kodak Company |
Hydrolysis of protein-bound cholesterol esters
|
|
DK119785D0
(da)
|
1985-03-15 |
1985-03-15 |
Nordisk Gentofte |
Insulinpraeparat
|
|
PT83613B
(en)
|
1985-10-28 |
1988-11-21 |
Lilly Co Eli |
Process for the selective chemical removal of a protein amino-terminal residue
|
|
US4741897A
(en)
|
1986-07-08 |
1988-05-03 |
Baxter Travenol |
Thyroxine analogs and reagents for thyroid hormone assays
|
|
US4876242A
(en)
|
1987-09-21 |
1989-10-24 |
Merck & Co., Inc. |
Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast
|
|
GB8728561D0
(en)
|
1987-12-07 |
1988-01-13 |
Glaxo Group Ltd |
Chemical compounds
|
|
US5514646A
(en)
|
1989-02-09 |
1996-05-07 |
Chance; Ronald E. |
Insulin analogs modified at position 29 of the B chain
|
|
US6225449B1
(en)
|
1991-10-04 |
2001-05-01 |
Washington University |
Hormone analogs with multiple CTP extensions
|
|
AU631868B2
(en)
|
1989-04-20 |
1992-12-10 |
Mount Sinai School Of Medicine Of The City University Of New York, The |
Hepatospecific insulin analogues
|
|
US5268453A
(en)
|
1991-08-08 |
1993-12-07 |
Scios Inc. |
Tissue-selective insulin analogs
|
|
AU6550294A
(en)
|
1993-03-09 |
1994-09-26 |
Abbott Laboratories |
Genetically engineered enzymes and their conjugates for diagnostic assays
|
|
US5359030A
(en)
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
US6476290B1
(en)
|
1995-04-19 |
2002-11-05 |
Dalhousie University |
Transgenic tilapia comprising a humanized insulin gene
|
|
IL118127A0
(en)
|
1995-05-05 |
1996-09-12 |
Lilly Co Eli |
Single chain insulin with high bioactivity
|
|
US6180767B1
(en)
|
1996-01-11 |
2001-01-30 |
Thomas Jefferson University |
Peptide nucleic acid conjugates
|
|
NZ334595A
(en)
|
1996-09-09 |
2000-08-25 |
Zealand Pharmaceuticals As |
Peptide prodrugs containing an alpha-hydroxyacid linker that have increased stability against enzymatic cleavage
|
|
UA65549C2
(uk)
|
1996-11-05 |
2004-04-15 |
Елі Ліллі Енд Компані |
Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
|
|
NZ506447A
(en)
|
1998-02-23 |
2002-11-26 |
Neurocrine Biosciences Inc |
Peptide analogues of insulin with alanine substitutions and pharmaceutical use
|
|
JP4394279B2
(ja)
|
1998-03-09 |
2010-01-06 |
ジーランド ファーマ アクティーゼルスカブ |
酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体
|
|
US20030236190A1
(en)
|
1998-09-02 |
2003-12-25 |
Renuka Pillutla |
Isulin and IGF-1 receptor agonists and antagonists
|
|
US6875741B2
(en)
|
1998-09-02 |
2005-04-05 |
Renuka Pillutla |
Insulin and IGF-1 receptor agonists and antagonists
|
|
DE19908041A1
(de)
|
1999-02-24 |
2000-08-31 |
Hoecker Hartwig |
Kovalent verbrückte Insulindimere
|
|
US6921748B1
(en)
|
1999-03-29 |
2005-07-26 |
Uutech Limited |
Analogs of gastric inhibitory polypeptide and their use for treatment of diabetes
|
|
US6746853B1
(en)
|
1999-05-19 |
2004-06-08 |
Xencor, Inc. |
Proteins with insulin-like activity useful in the treatment of diabetes
|
|
AUPQ661800A0
(en)
|
2000-03-31 |
2000-05-04 |
Metabolic Pharmaceuticals Limited |
Insulin-potentiating compounds
|
|
CN1454214A
(zh)
|
2000-08-02 |
2003-11-05 |
赛莱技术公司 |
具有增高功效的修饰生物肽
|
|
AU2001284697A1
(en)
|
2000-08-04 |
2002-02-18 |
Dmi Biosciences, Inc. |
Method of synthesizing diketopiperazines
|
|
WO2002026265A2
(en)
|
2000-09-29 |
2002-04-04 |
Schering Corporation |
Pegylated interleukin-10
|
|
KR100449454B1
(ko)
|
2000-10-02 |
2004-09-21 |
이현철 |
단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
|
|
KR101229995B1
(ko)
|
2000-12-11 |
2013-02-06 |
씨제이 주식회사 |
생체내 에리스로포이에틴 활성이 증진된 융합단백질
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
DK2322631T3
(en)
|
2001-04-19 |
2015-01-12 |
Scripps Research Inst |
Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar
|
|
BR0215029A
(pt)
|
2001-12-20 |
2005-12-20 |
Lilly Co Eli |
Molécula de insulina, uso da mesma, composição, uso desta, microcristal, processo para prepará-lo, uso deste, e, métodos para preparar uma molécula de insulina, para tratar hiperglicemia, e para tratar diabetes mellitus
|
|
IL163666A0
(en)
*
|
2002-02-22 |
2005-12-18 |
New River Pharmaceuticals Inc |
Active agent delivery systems and methods for protecting and administering active agents
|
|
FR2842209B1
(fr)
|
2002-07-09 |
2007-11-23 |
|
Nouvelle protease aspartique dite saspase et son utilisation dans le domaine cosmetique et therapeutique
|
|
WO2004067548A2
(en)
|
2003-01-31 |
2004-08-12 |
Theratechnologies Inc. |
Chemically modified metabolites of regulatory peptides and methods of producing and using same
|
|
WO2004078777A2
(en)
|
2003-03-04 |
2004-09-16 |
Biorexis Pharmaceutical Corporation |
Dipeptidyl-peptidase protected proteins
|
|
EA009366B1
(ru)
|
2003-03-19 |
2007-12-28 |
Эли Лилли Энд Компани |
Связанные с полиэтиленгликолем соединения гпп-1
|
|
CA2843439A1
(en)
|
2003-04-08 |
2004-10-21 |
Yeda Research And Development Co. Ltd |
Reversible pegylated drugs
|
|
GB0310593D0
(en)
*
|
2003-05-08 |
2003-06-11 |
Leuven K U Res & Dev |
Peptidic prodrugs
|
|
CA2539253A1
(en)
|
2003-09-19 |
2005-03-31 |
Novo Nordisk A/S |
Albumin-binding derivatives of therapeutic peptides
|
|
US20050187147A1
(en)
|
2003-09-22 |
2005-08-25 |
Newman Michael J. |
Compositions and methods for increasing drug efficiency
|
|
PL1680443T3
(pl)
|
2003-11-05 |
2014-02-28 |
Dana Farber Cancer Inst Inc |
Stabilizowane alfa-helikalne peptydy i ich zastosowanie
|
|
JP5697831B2
(ja)
|
2003-12-03 |
2015-04-08 |
ノヴォ ノルディスク アー／エス |
単鎖インシュリン
|
|
JP2008517917A
(ja)
|
2004-10-21 |
2008-05-29 |
アイジーエフ オンコロジー エルエルシー |
癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド
|
|
WO2006097521A1
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Pegylated single-chain insulin
|
|
US7521211B2
(en)
|
2005-04-05 |
2009-04-21 |
Regeneron Pharmaceuticals, Inc |
IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof
|
|
US20090209453A1
(en)
|
2005-04-13 |
2009-08-20 |
University Of Medicine And Dentistry Of New Jersey |
Glycoprotein Hormone Analogs
|
|
US8304386B2
(en)
|
2006-02-03 |
2012-11-06 |
Prolor Biotech, Inc. |
Long-acting growth hormone and methods of producing same
|
|
US20090069216A1
(en)
|
2006-02-21 |
2009-03-12 |
Novo Nordisk A/S |
Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
|
|
ES2397659T3
(es)
|
2006-03-15 |
2013-03-08 |
Novo Nordisk A/S |
Mezclas de amilina e insulina
|
|
EP2054437A2
(en)
|
2006-08-07 |
2009-05-06 |
Teva Biopharmaceuticals USA, Inc. |
Albumin-insulin fusion proteins
|
|
WO2008021560A2
(en)
|
2006-08-17 |
2008-02-21 |
Amylin Pharmaceuticals, Inc. |
Dpp-iv resistant gip hybrid polypeptides with selectable properties
|
|
CL2007002502A1
(es)
|
2006-08-31 |
2008-05-30 |
Hoffmann La Roche |
Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
|
|
DK2615108T3
(en)
|
2006-09-08 |
2017-01-30 |
Ambrx Inc |
Modified human plasma polypeptide or fc scaffolds and their applications
|
|
US20090098130A1
(en)
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
|
EP2036923A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Improved derivates of amylin
|
|
EP2036539A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Stable formulations of amylin and its analogues
|
|
US8261025B2
(en)
|
2007-11-12 |
2012-09-04 |
International Business Machines Corporation |
Software pipelining on a network on chip
|
|
US8946148B2
(en)
|
2007-11-20 |
2015-02-03 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
EP2249853A4
(en)
|
2008-01-30 |
2012-12-26 |
Univ Indiana Res & Tech Corp |
ESTER BASED PEPTIDE PRODRUGS
|
|
CN101980725B
(zh)
|
2008-02-01 |
2013-06-12 |
阿森迪斯药物股份有限公司 |
包含可自裂解的连接体的前药
|
|
EP2356139A4
(en)
|
2008-07-23 |
2013-01-09 |
Harvard College |
LIGURE COMBINED POLYPEPTIDES
|
|
AU2009327418A1
(en)
|
2008-12-19 |
2010-06-24 |
Indiana University Research And Technology Corporation |
Amide based glucagon superfamily peptide prodrugs
|
|
WO2010080606A1
(en)
|
2008-12-19 |
2010-07-15 |
Indiana University Research And Technology Corporation |
Insulin analogs
|
|
CN102245624B
(zh)
|
2008-12-19 |
2016-08-10 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰岛素前药
|
|
KR20110114568A
(ko)
|
2008-12-19 |
2011-10-19 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
디펩티드 링크된 약효 물질
|
|
EP2408470A4
(en)
|
2009-03-20 |
2012-08-29 |
Smartcells Inc |
SOLUBLE NONDEPOT INSULIN CONJUGATE AND ITS USE
|
|
EP2292306B1
(en)
|
2009-09-02 |
2013-05-01 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Method for separation of racemic compound-forming chiral substances by a cyclic crystallization process and a crystallization device
|
|
WO2011159895A2
(en)
|
2010-06-16 |
2011-12-22 |
Indiana University Research And Technology Corporation |
Single chain insulin agonists exhibiting high activity at the insulin receptor
|
|
WO2011163460A1
(en)
|
2010-06-24 |
2011-12-29 |
Indiana University Research And Technology Corporation |
Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor
|
|
US8946147B2
(en)
*
|
2010-06-24 |
2015-02-03 |
Indiana University Research And Technology Corporation |
Amide-based insulin prodrugs
|
|
EP2588126A4
(en)
|
2010-06-24 |
2015-07-08 |
Univ Indiana Res & Tech Corp |
AMID-BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS
|