|
US3740385A
(en)
|
1970-05-07 |
1973-06-19 |
M Ondetti |
N-terminal derivatives of secretin
|
|
US4275152A
(en)
|
1977-02-03 |
1981-06-23 |
Eastman Kodak Company |
Hydrolysis of protein-bound cholesterol esters
|
|
DK119785D0
(da)
|
1985-03-15 |
1985-03-15 |
Nordisk Gentofte |
Insulinpraeparat
|
|
PT83613B
(en)
|
1985-10-28 |
1988-11-21 |
Lilly Co Eli |
Process for the selective chemical removal of a protein amino-terminal residue
|
|
US4741897A
(en)
|
1986-07-08 |
1988-05-03 |
Baxter Travenol |
Thyroxine analogs and reagents for thyroid hormone assays
|
|
US4876242A
(en)
|
1987-09-21 |
1989-10-24 |
Merck & Co., Inc. |
Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast
|
|
GB8728561D0
(en)
|
1987-12-07 |
1988-01-13 |
Glaxo Group Ltd |
Chemical compounds
|
|
US5514646A
(en)
|
1989-02-09 |
1996-05-07 |
Chance; Ronald E. |
Insulin analogs modified at position 29 of the B chain
|
|
US6225449B1
(en)
|
1991-10-04 |
2001-05-01 |
Washington University |
Hormone analogs with multiple CTP extensions
|
|
AU631868B2
(en)
|
1989-04-20 |
1992-12-10 |
Mount Sinai School Of Medicine Of The City University Of New York, The |
Hepatospecific insulin analogues
|
|
US5268453A
(en)
|
1991-08-08 |
1993-12-07 |
Scios Inc. |
Tissue-selective insulin analogs
|
|
EP0688364A4
(en)
|
1993-03-09 |
1997-10-15 |
Abbott Lab |
ENZYMES PRODUCED BY GENETIC ENGINEERING AND CONJUGATES OF SAID ENZYMES FOR DIAGNOSTIC ANALYSIS
|
|
US5359030A
(en)
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
US6476290B1
(en)
|
1995-04-19 |
2002-11-05 |
Dalhousie University |
Transgenic tilapia comprising a humanized insulin gene
|
|
AU5724996A
(en)
|
1995-05-05 |
1996-11-21 |
Eli Lilly And Company |
Single chain insulin with high bioactivity
|
|
US6180767B1
(en)
|
1996-01-11 |
2001-01-30 |
Thomas Jefferson University |
Peptide nucleic acid conjugates
|
|
EP0932614A1
(en)
|
1996-09-09 |
1999-08-04 |
Zealand Pharmaceuticals A/S |
Peptide prodrugs containing an alpha-hydroxyacid linker
|
|
UA65549C2
(uk)
|
1996-11-05 |
2004-04-15 |
Елі Ліллі Енд Компані |
Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
|
|
IL137904A0
(en)
|
1998-02-23 |
2001-10-31 |
Neurocrine Biosciences Inc |
Peptide analogues of insulin and pharmaceutical compositions containing the same
|
|
AU757658B2
(en)
|
1998-03-09 |
2003-02-27 |
Zealand Pharma A/S |
Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
|
|
US20030236190A1
(en)
|
1998-09-02 |
2003-12-25 |
Renuka Pillutla |
Isulin and IGF-1 receptor agonists and antagonists
|
|
US6875741B2
(en)
|
1998-09-02 |
2005-04-05 |
Renuka Pillutla |
Insulin and IGF-1 receptor agonists and antagonists
|
|
DE19908041A1
(de)
|
1999-02-24 |
2000-08-31 |
Hoecker Hartwig |
Kovalent verbrückte Insulindimere
|
|
DE60012721T4
(de)
|
1999-03-29 |
2010-09-09 |
Uutech Ltd., Coleraine |
Analoge des magensaft inhibierenden peptides und ihre verwendung für die behandlung von diabetes
|
|
US6746853B1
(en)
|
1999-05-19 |
2004-06-08 |
Xencor, Inc. |
Proteins with insulin-like activity useful in the treatment of diabetes
|
|
AUPQ661800A0
(en)
|
2000-03-31 |
2000-05-04 |
Metabolic Pharmaceuticals Limited |
Insulin-potentiating compounds
|
|
EP1305338A2
(en)
|
2000-08-02 |
2003-05-02 |
Theratechnologies Inc. |
Modified peptides with increased potency
|
|
AU2001284697A1
(en)
|
2000-08-04 |
2002-02-18 |
Dmi Biosciences, Inc. |
Method of synthesizing diketopiperazines
|
|
ATE516820T1
(de)
|
2000-09-29 |
2011-08-15 |
Schering Corp |
Pegyliertes interleukin 10
|
|
KR100449454B1
(ko)
|
2000-10-02 |
2004-09-21 |
이현철 |
단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
|
|
KR101229995B1
(ko)
|
2000-12-11 |
2013-02-06 |
씨제이 주식회사 |
생체내 에리스로포이에틴 활성이 증진된 융합단백질
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
IL158418A0
(en)
|
2001-04-19 |
2004-05-12 |
Scripps Research Inst |
In vivo incorporation of unnatural amino acids
|
|
CZ2004710A3
(cs)
|
2001-12-20 |
2005-02-16 |
Eli Lilly And Company |
Inzulínová sloučenina s protrahovaným účinkem
|
|
IL163666A0
(en)
*
|
2002-02-22 |
2005-12-18 |
New River Pharmaceuticals Inc |
Active agent delivery systems and methods for protecting and administering active agents
|
|
FR2842209B1
(fr)
|
2002-07-09 |
2007-11-23 |
|
Nouvelle protease aspartique dite saspase et son utilisation dans le domaine cosmetique et therapeutique
|
|
US20050059605A1
(en)
|
2003-01-31 |
2005-03-17 |
Krishna Peri |
Chemically modified metabolites of regulatory peptides and methods of producing and using same
|
|
WO2004078777A2
(en)
|
2003-03-04 |
2004-09-16 |
Biorexis Pharmaceutical Corporation |
Dipeptidyl-peptidase protected proteins
|
|
AU2004231461B2
(en)
|
2003-03-19 |
2009-11-12 |
Eli Lilly And Company |
Polyethelene glycol linked GLP-1 compounds
|
|
CA2521784C
(en)
|
2003-04-08 |
2012-03-27 |
Yeda Research And Development Co. Ltd. |
Reversible pegylated drugs
|
|
GB0310593D0
(en)
*
|
2003-05-08 |
2003-06-11 |
Leuven K U Res & Dev |
Peptidic prodrugs
|
|
KR101241862B1
(ko)
|
2003-09-19 |
2013-03-13 |
노보 노르디스크 에이/에스 |
신규 ｇｌｐ-1 유도체
|
|
WO2005035003A2
(en)
|
2003-09-22 |
2005-04-21 |
Dihedron Corporation |
Compositions and methods for increasing drug efficiency
|
|
WO2005044839A2
(en)
|
2003-11-05 |
2005-05-19 |
Dana-Farber Cancer Institute, Inc. |
Stabilized alpha helical peptides and uses thereof
|
|
JP5697831B2
(ja)
|
2003-12-03 |
2015-04-08 |
ノヴォ ノルディスク アー／エス |
単鎖インシュリン
|
|
CA2582552A1
(en)
|
2004-10-21 |
2006-05-04 |
Igf Oncology, Llc |
Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer
|
|
JP2008533100A
(ja)
|
2005-03-18 |
2008-08-21 |
ノボ ノルディスク アクティーゼルスカブ |
Ｐｅｇ化された単鎖インスリン
|
|
US7521211B2
(en)
|
2005-04-05 |
2009-04-21 |
Regeneron Pharmaceuticals, Inc |
IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof
|
|
US20090209453A1
(en)
|
2005-04-13 |
2009-08-20 |
University Of Medicine And Dentistry Of New Jersey |
Glycoprotein Hormone Analogs
|
|
US8304386B2
(en)
|
2006-02-03 |
2012-11-06 |
Prolor Biotech, Inc. |
Long-acting growth hormone and methods of producing same
|
|
EP1991575A1
(en)
|
2006-02-21 |
2008-11-19 |
Novo Nordisk A/S |
Single-chain insulin analogues and pharmaceutical formulations thereof
|
|
US20090054305A1
(en)
|
2006-03-15 |
2009-02-26 |
Novo Nordisk A/S |
Mixtures of Amylin and Insulin
|
|
US9505823B2
(en)
|
2006-08-07 |
2016-11-29 |
TEV A Biopharmaceuticals USA, Inc. |
Albumin-insulin fusion proteins
|
|
WO2008021560A2
(en)
|
2006-08-17 |
2008-02-21 |
Amylin Pharmaceuticals, Inc. |
Dpp-iv resistant gip hybrid polypeptides with selectable properties
|
|
CL2007002502A1
(es)
|
2006-08-31 |
2008-05-30 |
Hoffmann La Roche |
Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
|
|
WO2008030558A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
|
US20090098130A1
(en)
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
|
EP2036539A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Stable formulations of amylin and its analogues
|
|
EP2036923A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Improved derivates of amylin
|
|
US8261025B2
(en)
|
2007-11-12 |
2012-09-04 |
International Business Machines Corporation |
Software pipelining on a network on chip
|
|
ES2632504T3
(es)
|
2007-11-20 |
2017-09-13 |
Ambrx, Inc. |
Polipéptidos de insulina modificados y sus usos
|
|
WO2009099763A1
(en)
|
2008-01-30 |
2009-08-13 |
Indiana University Research And Technology Corporation |
Ester-based peptide prodrugs
|
|
CA2712224C
(en)
|
2008-02-01 |
2016-03-08 |
Ascendis Pharma As |
Prodrug comprising a drug linker conjugate
|
|
US20110144306A1
(en)
|
2008-07-23 |
2011-06-16 |
President And Fellows Of Harvard College |
Ligation of stapled polypeptides
|
|
KR20110114568A
(ko)
|
2008-12-19 |
2011-10-19 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
디펩티드 링크된 약효 물질
|
|
CN102245624B
(zh)
|
2008-12-19 |
2016-08-10 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰岛素前药
|
|
RU2550696C2
(ru)
|
2008-12-19 |
2015-05-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Основанные на амидах пролекарства пептидов глюкагонового надсемейства
|
|
JP5789515B2
(ja)
|
2008-12-19 |
2015-10-07 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ |
インスリン類似体
|
|
EP2408470A4
(en)
|
2009-03-20 |
2012-08-29 |
Smartcells Inc |
SOLUBLE NONDEPOT INSULIN CONJUGATE AND ITS USE
|
|
EP2292306B1
(en)
|
2009-09-02 |
2013-05-01 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Method for separation of racemic compound-forming chiral substances by a cyclic crystallization process and a crystallization device
|
|
EP2582719B1
(en)
|
2010-06-16 |
2016-08-10 |
Indiana University Research and Technology Corporation |
Single chain insulin agonists exhibiting high activity at the insulin receptor
|
|
MX2012014576A
(es)
|
2010-06-24 |
2013-02-21 |
Univ Indiana Res & Tech Corp |
Profarmacos de peptido de la superfamilia de glucagon basado en amida.
|
|
WO2011163460A1
(en)
|
2010-06-24 |
2011-12-29 |
Indiana University Research And Technology Corporation |
Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor
|
|
CA2803164C
(en)
|
2010-06-24 |
2018-08-21 |
Indiana University Research And Technology Corporation |
Amide-based insulin prodrugs
|