JP2017533961A5 - - Google Patents
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- Publication number
- JP2017533961A5 JP2017533961A5 JP2017543288A JP2017543288A JP2017533961A5 JP 2017533961 A5 JP2017533961 A5 JP 2017533961A5 JP 2017543288 A JP2017543288 A JP 2017543288A JP 2017543288 A JP2017543288 A JP 2017543288A JP 2017533961 A5 JP2017533961 A5 JP 2017533961A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- administration
- bolus
- subject
- tpa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 33
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 8
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 8
- 229960000187 tissue plasminogen activator Drugs 0.000 claims 8
- 108010073863 saruplase Proteins 0.000 claims 6
- 208000006011 Stroke Diseases 0.000 claims 5
- 102000055157 Complement C1 Inhibitor Human genes 0.000 claims 4
- 108700040183 Complement C1 Inhibitor Proteins 0.000 claims 4
- 206010000891 acute myocardial infarction Diseases 0.000 claims 4
- 238000001802 infusion Methods 0.000 claims 4
- 238000001990 intravenous administration Methods 0.000 claims 4
- 230000002537 thrombolytic effect Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 229920000742 Cotton Polymers 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000000740 bleeding effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 125000003588 lysine group Chemical class [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462074374P | 2014-11-03 | 2014-11-03 | |
| US62/074,374 | 2014-11-03 | ||
| PCT/US2015/058878 WO2016073514A2 (en) | 2014-11-03 | 2015-11-03 | Methods and compositions for safe and effective thrombolysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533961A JP2017533961A (ja) | 2017-11-16 |
| JP2017533961A5 true JP2017533961A5 (enExample) | 2018-12-06 |
| JP6826040B2 JP6826040B2 (ja) | 2021-02-03 |
Family
ID=55910021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017543288A Active JP6826040B2 (ja) | 2014-11-03 | 2015-11-03 | 安全かつ効果的な血栓溶解（Ｔｈｒｏｍｂｏｌｙｓｉｓ）のための方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11213574B2 (enExample) |
| EP (2) | EP3215221B1 (enExample) |
| JP (1) | JP6826040B2 (enExample) |
| CN (1) | CN107073292B (enExample) |
| CA (1) | CA2966332C (enExample) |
| DK (1) | DK3215221T3 (enExample) |
| EA (1) | EA035358B1 (enExample) |
| ES (1) | ES2788697T3 (enExample) |
| MX (1) | MX383561B (enExample) |
| WO (1) | WO2016073514A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3215221B1 (en) | 2014-11-03 | 2020-02-26 | Thrombolytic Science, LLC | Methods and compositions for safe and effective thrombolysis |
| WO2018232305A1 (en) * | 2017-06-16 | 2018-12-20 | Thrombolytic Science, Llc | Methods and compositions for thrombolysis |
| CN107516010B (zh) * | 2017-08-19 | 2021-02-09 | 上海矩点医疗科技有限公司 | 溶栓剂量模型的构建方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4381346A (en) | 1979-11-13 | 1983-04-26 | Huasin Syed S | Isolation of plasminogen activators useful as therapeutic and diagnostic agents |
| GB2197195B (en) | 1986-10-03 | 1991-01-23 | Sandoz Ltd | Improvments in or relating to organic compounds |
| GB8623823D0 (en) | 1986-10-03 | 1986-11-05 | Sandoz Ltd | Therapeutic lysis of fibrin blood clots |
| US5108901A (en) | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| GB8823833D0 (en) | 1988-10-11 | 1988-11-16 | Erba Carlo Spa | Production of human prourokinase |
| US5843089A (en) | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
| US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| EP0786257B1 (en) * | 1992-06-03 | 2003-07-30 | Genentech, Inc. | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
| WO1994018315A1 (en) | 1993-02-05 | 1994-08-18 | Vascular Laboratories, Inc. | Use of intra-platelet urokinase-type plasminogen activators for long-term inhibition of thrombosis |
| US5472692A (en) | 1993-07-02 | 1995-12-05 | New England Deaconess Hospital Corporation | Pro-urokinase mutants |
| US5510330A (en) | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
| US5810767A (en) | 1994-05-11 | 1998-09-22 | Localmed, Inc. | Method and apparatus for pressurized intraluminal drug delivery |
| US5759542A (en) | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
| US5569197A (en) | 1994-12-21 | 1996-10-29 | Schneider (Usa) Inc | Drug delivery guidewire |
| KR100396411B1 (ko) | 1994-12-29 | 2003-11-28 | 소니 가부시끼 가이샤 | 디스크카트리지 |
| US6759042B2 (en) | 1999-06-04 | 2004-07-06 | Thrombotech Ltd | Use of cross-linked, covalently bound urokinase plasminogen activator (scuPA)-urokinase plasminogen activator receptor (suPAR) complex as a fibrinolytic agent |
| US6867177B2 (en) | 1999-08-13 | 2005-03-15 | The Trustees Of Columbia University In The City Of New York | CD39/ECTO-adpase as a treatment for thrombotic and ischemic disorders |
| US6699230B2 (en) | 2000-05-10 | 2004-03-02 | Minnesota Medical Physics, Llc | Apparatus and method for out-of-hospital thrombolytic therapy |
| GB0025473D0 (en) | 2000-10-17 | 2000-11-29 | Pfizer Ltd | Pharmaceutical combinations |
| CN1142278C (zh) | 2001-04-04 | 2004-03-17 | 刘建宁 | 一类能被尿激酶或自身激活的尿激酶原变体及其编码基因、制备方法和用途 |
| US7084118B2 (en) * | 2002-02-22 | 2006-08-01 | Genentech, Inc. | Combination treatment with t-PA variant and low molecular weight heparin |
| CA2426115A1 (en) | 2003-04-18 | 2004-10-18 | Victor Gurewich | Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots |
| US7070958B2 (en) | 2003-04-18 | 2006-07-04 | Thrombolytic Science, Inc. | Methods of making pro-urokinase mutants |
| JP2006241109A (ja) | 2005-03-04 | 2006-09-14 | Paion Deutschland Gmbh | ヒトＰセレクチンおよびＤＳＰＡα１に対する抗体を含む融合タンパク質 |
| HRP20110622T1 (hr) * | 2005-12-21 | 2011-09-30 | Pharming Intellectual Property B.V. | Upotreba inhibitora c1 u sprječavanju ishemijsko-reperfuzijske ozljede |
| US7837992B2 (en) | 2006-06-22 | 2010-11-23 | Beth Israel Deaconess Medical Center | C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis |
| US20090010916A1 (en) * | 2006-06-22 | 2009-01-08 | Victor Gurewich | C-1 Inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis |
| US20070298024A1 (en) * | 2006-06-22 | 2007-12-27 | Thrombolytic Science, Inc. | C-1 inactivator inhibits two-chain urokinase mutant and limits hemostatic bleeding during thrombolysis |
| CN101015686B (zh) * | 2007-02-06 | 2010-05-19 | 中国人民解放军军事医学科学院基础医学研究所 | 一种溶栓药物增效剂及其制备方法 |
| CN101549150A (zh) * | 2008-03-31 | 2009-10-07 | 刘建宁 | 尿激酶原及尿激酶原变体在急性心肌梗塞易化经皮冠状动脉介入中的应用 |
| EP3215221B1 (en) | 2014-11-03 | 2020-02-26 | Thrombolytic Science, LLC | Methods and compositions for safe and effective thrombolysis |
-
2015
- 2015-11-03 EP EP15856204.1A patent/EP3215221B1/en active Active
- 2015-11-03 EA EA201790969A patent/EA035358B1/ru unknown
- 2015-11-03 EP EP20158876.1A patent/EP3708226A1/en not_active Withdrawn
- 2015-11-03 WO PCT/US2015/058878 patent/WO2016073514A2/en not_active Ceased
- 2015-11-03 CN CN201580058489.0A patent/CN107073292B/zh active Active
- 2015-11-03 JP JP2017543288A patent/JP6826040B2/ja active Active
- 2015-11-03 DK DK15856204.1T patent/DK3215221T3/da active
- 2015-11-03 MX MX2017005793A patent/MX383561B/es unknown
- 2015-11-03 CA CA2966332A patent/CA2966332C/en active Active
- 2015-11-03 ES ES15856204T patent/ES2788697T3/es active Active
- 2015-11-03 US US15/523,900 patent/US11213574B2/en active Active
-
2021
- 2021-12-30 US US17/566,077 patent/US20220184189A1/en active Pending
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