CA2966332C - Methods and compositions for safe and effective thrombolysis - Google Patents
Methods and compositions for safe and effective thrombolysis Download PDFInfo
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- CA2966332C CA2966332C CA2966332A CA2966332A CA2966332C CA 2966332 C CA2966332 C CA 2966332C CA 2966332 A CA2966332 A CA 2966332A CA 2966332 A CA2966332 A CA 2966332A CA 2966332 C CA2966332 C CA 2966332C
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- C—CHEMISTRY; METALLURGY
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- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Landscapes
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- Biotechnology (AREA)
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- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
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| US201462074374P | 2014-11-03 | 2014-11-03 | |
| US62/074,374 | 2014-11-03 | ||
| PCT/US2015/058878 WO2016073514A2 (en) | 2014-11-03 | 2015-11-03 | Methods and compositions for safe and effective thrombolysis |
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| CA2966332A1 CA2966332A1 (en) | 2016-05-12 |
| CA2966332C true CA2966332C (en) | 2024-04-16 |
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| US (2) | US11213574B2 (enExample) |
| EP (2) | EP3215221B1 (enExample) |
| JP (1) | JP6826040B2 (enExample) |
| CN (1) | CN107073292B (enExample) |
| CA (1) | CA2966332C (enExample) |
| DK (1) | DK3215221T3 (enExample) |
| EA (1) | EA035358B1 (enExample) |
| ES (1) | ES2788697T3 (enExample) |
| MX (1) | MX383561B (enExample) |
| WO (1) | WO2016073514A2 (enExample) |
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| EP3215221B1 (en) | 2014-11-03 | 2020-02-26 | Thrombolytic Science, LLC | Methods and compositions for safe and effective thrombolysis |
| WO2018232305A1 (en) * | 2017-06-16 | 2018-12-20 | Thrombolytic Science, Llc | Methods and compositions for thrombolysis |
| CN107516010B (zh) * | 2017-08-19 | 2021-02-09 | 上海矩点医疗科技有限公司 | 溶栓剂量模型的构建方法 |
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| US4381346A (en) | 1979-11-13 | 1983-04-26 | Huasin Syed S | Isolation of plasminogen activators useful as therapeutic and diagnostic agents |
| GB2197195B (en) | 1986-10-03 | 1991-01-23 | Sandoz Ltd | Improvments in or relating to organic compounds |
| GB8623823D0 (en) | 1986-10-03 | 1986-11-05 | Sandoz Ltd | Therapeutic lysis of fibrin blood clots |
| US5108901A (en) | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| GB8823833D0 (en) | 1988-10-11 | 1988-11-16 | Erba Carlo Spa | Production of human prourokinase |
| US5843089A (en) | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
| US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| EP0786257B1 (en) * | 1992-06-03 | 2003-07-30 | Genentech, Inc. | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
| WO1994018315A1 (en) | 1993-02-05 | 1994-08-18 | Vascular Laboratories, Inc. | Use of intra-platelet urokinase-type plasminogen activators for long-term inhibition of thrombosis |
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- 2015-11-03 EA EA201790969A patent/EA035358B1/ru unknown
- 2015-11-03 EP EP20158876.1A patent/EP3708226A1/en not_active Withdrawn
- 2015-11-03 WO PCT/US2015/058878 patent/WO2016073514A2/en not_active Ceased
- 2015-11-03 CN CN201580058489.0A patent/CN107073292B/zh active Active
- 2015-11-03 JP JP2017543288A patent/JP6826040B2/ja active Active
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- 2015-11-03 US US15/523,900 patent/US11213574B2/en active Active
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| EP3708226A1 (en) | 2020-09-16 |
| DK3215221T3 (da) | 2020-05-11 |
| JP6826040B2 (ja) | 2021-02-03 |
| ES2788697T3 (es) | 2020-10-22 |
| WO2016073514A2 (en) | 2016-05-12 |
| US20220184189A1 (en) | 2022-06-16 |
| CA2966332A1 (en) | 2016-05-12 |
| EP3215221A4 (en) | 2018-08-08 |
| EA201790969A1 (ru) | 2017-11-30 |
| WO2016073514A3 (en) | 2016-08-11 |
| JP2017533961A (ja) | 2017-11-16 |
| BR112017008749A2 (pt) | 2017-12-19 |
| EP3215221B1 (en) | 2020-02-26 |
| US11213574B2 (en) | 2022-01-04 |
| EA035358B1 (ru) | 2020-06-01 |
| EP3215221A2 (en) | 2017-09-13 |
| CN107073292A (zh) | 2017-08-18 |
| HK1243666A1 (en) | 2018-07-20 |
| CN107073292B (zh) | 2021-07-02 |
| MX2017005793A (es) | 2017-10-23 |
| MX383561B (es) | 2025-03-14 |
| US20180311322A1 (en) | 2018-11-01 |
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