JP2017531044A5 - - Google Patents
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- Publication number
- JP2017531044A5 JP2017531044A5 JP2017539528A JP2017539528A JP2017531044A5 JP 2017531044 A5 JP2017531044 A5 JP 2017531044A5 JP 2017539528 A JP2017539528 A JP 2017539528A JP 2017539528 A JP2017539528 A JP 2017539528A JP 2017531044 A5 JP2017531044 A5 JP 2017531044A5
- Authority
- JP
- Japan
- Prior art keywords
- varenicline
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical formulation
- micrograms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims description 54
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims description 54
- 239000008194 pharmaceutical composition Substances 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 26
- JQSHBVHOMNKWFT-DTORHVGOSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 JQSHBVHOMNKWFT-DTORHVGOSA-N 0.000 claims description 24
- 229960004751 varenicline Drugs 0.000 claims description 24
- 210000003928 nasal cavity Anatomy 0.000 claims description 21
- 102000003923 Protein Kinase C Human genes 0.000 claims description 15
- 108090000315 Protein Kinase C Proteins 0.000 claims description 15
- 238000011200 topical administration Methods 0.000 claims description 12
- 102000001253 Protein Kinase Human genes 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 108060006633 protein kinase Proteins 0.000 claims description 10
- 230000002093 peripheral effect Effects 0.000 claims description 9
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims description 8
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims description 8
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 claims description 5
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 claims description 5
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 5
- 108010036949 Cyclosporine Proteins 0.000 claims description 5
- 241000021559 Dicerandra Species 0.000 claims description 5
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 5
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 5
- 239000000443 aerosol Substances 0.000 claims description 5
- 229960001265 ciclosporin Drugs 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- 229930182912 cyclosporin Natural products 0.000 claims description 5
- 238000000586 desensitisation Methods 0.000 claims description 5
- 239000000499 gel Substances 0.000 claims description 5
- 239000000865 liniment Substances 0.000 claims description 5
- 239000006210 lotion Substances 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 5
- 239000006072 paste Substances 0.000 claims description 5
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims description 5
- 229960005330 pimecrolimus Drugs 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 229940098458 powder spray Drugs 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 230000009885 systemic effect Effects 0.000 claims description 5
- 229960001967 tacrolimus Drugs 0.000 claims description 5
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 5
- 239000006200 vaporizer Substances 0.000 claims description 5
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 4
- 206010013774 Dry eye Diseases 0.000 claims description 4
- 230000004489 tear production Effects 0.000 claims description 4
- 206010052143 Ocular discomfort Diseases 0.000 claims description 3
- 230000008499 blood brain barrier function Effects 0.000 claims description 2
- 210000001218 blood-brain barrier Anatomy 0.000 claims description 2
- 210000004907 gland Anatomy 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 230000011514 reflex Effects 0.000 claims description 2
- 230000007704 transition Effects 0.000 claims description 2
- 210000003901 trigeminal nerve Anatomy 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 21
- 239000003814 drug Substances 0.000 claims 17
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229940046731 calcineurin inhibitors Drugs 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940122578 Acetylcholine receptor agonist Drugs 0.000 description 38
- 239000000556 agonist Substances 0.000 description 9
- ANJTVLIZGCUXLD-BDAKNGLRSA-N (-)-Cytisine Natural products C1NC[C@@H]2CN3C(=O)C=CC=C3[C@H]1C2 ANJTVLIZGCUXLD-BDAKNGLRSA-N 0.000 description 3
- MBQYQLWSBRANKQ-IMTBSYHQSA-N (1s,5s)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane Chemical compound N1=C(Cl)C(Cl)=CC(N2C[C@H]3NC[C@H]3C2)=C1 MBQYQLWSBRANKQ-IMTBSYHQSA-N 0.000 description 3
- LVGMMVAWLISWJD-MRVPVSSYSA-N (3r)-1-pyridin-3-ylpyrrolidin-3-amine Chemical compound C1[C@H](N)CCN1C1=CC=CN=C1 LVGMMVAWLISWJD-MRVPVSSYSA-N 0.000 description 3
- USXYDBGSWSSTGE-UHFFFAOYSA-N 3-(6-chloropyridazin-3-yl)-3,8-diazabicyclo[3.2.1]octane Chemical compound N1=NC(Cl)=CC=C1N1CC(N2)CCC2C1 USXYDBGSWSSTGE-UHFFFAOYSA-N 0.000 description 3
- XKFMBGWHHBCWCD-QMMMGPOBSA-N 3-[[(2s)-azetidin-2-yl]methoxy]pyridine Chemical compound C([C@H]1NCC1)OC1=CC=CN=C1 XKFMBGWHHBCWCD-QMMMGPOBSA-N 0.000 description 3
- GPXAWLDGWSBLKM-MWLCHTKSSA-N 5-[(1r,5s)-3,6-diazabicyclo[3.2.0]heptan-6-yl]pyridine-3-carbonitrile Chemical compound N#CC1=CN=CC(N2[C@@H]3CNC[C@@H]3C2)=C1 GPXAWLDGWSBLKM-MWLCHTKSSA-N 0.000 description 3
- RPYWXZCFYPVCNQ-RVDMUPIBSA-N DMXB-A Chemical compound COC1=CC(OC)=CC=C1\C=C/1C(C=2C=NC=CC=2)=NCCC\1 RPYWXZCFYPVCNQ-RVDMUPIBSA-N 0.000 description 3
- NLPRAJRHRHZCQQ-UHFFFAOYSA-N Epibatidine Natural products C1=NC(Cl)=CC=C1C1C(N2)CCC2C1 NLPRAJRHRHZCQQ-UHFFFAOYSA-N 0.000 description 3
- WECKJONDRAUFDD-ZDUSSCGKSA-N N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide Chemical compound C1=CC(Cl)=CC=C1C(=O)N[C@@H]1C(CC2)CCN2C1 WECKJONDRAUFDD-ZDUSSCGKSA-N 0.000 description 3
- IPKZCLGGYKRDES-ZDUSSCGKSA-N Pha-543613 Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(N=C1)=CC2=C1OC=C2 IPKZCLGGYKRDES-ZDUSSCGKSA-N 0.000 description 3
- PEAMDZVDNYENPN-UHFFFAOYSA-N [2-(4-fluoroanilino)-4-methyl-1,3-thiazol-5-yl]-thiophen-3-ylmethanone Chemical compound S1C(C(=O)C2=CSC=C2)=C(C)N=C1NC1=CC=C(F)C=C1 PEAMDZVDNYENPN-UHFFFAOYSA-N 0.000 description 3
- ILLGYRJAYAAAEW-QMMMGPOBSA-N abt-418 Chemical compound CN1CCC[C@H]1C1=CC(C)=NO1 ILLGYRJAYAAAEW-QMMMGPOBSA-N 0.000 description 3
- ANJTVLIZGCUXLD-DTWKUNHWSA-N cytisine Chemical compound C1NC[C@H]2CN3C(=O)C=CC=C3[C@@H]1C2 ANJTVLIZGCUXLD-DTWKUNHWSA-N 0.000 description 3
- 229940027564 cytisine Drugs 0.000 description 3
- 229930017327 cytisine Natural products 0.000 description 3
- ANJTVLIZGCUXLD-UHFFFAOYSA-N ent-cytisine Natural products C1NCC2CN3C(=O)C=CC=C3C1C2 ANJTVLIZGCUXLD-UHFFFAOYSA-N 0.000 description 3
- NLPRAJRHRHZCQQ-IVZWLZJFSA-N epibatidine Chemical compound C1=NC(Cl)=CC=C1[C@@H]1[C@H](N2)CC[C@H]2C1 NLPRAJRHRHZCQQ-IVZWLZJFSA-N 0.000 description 3
- LEXDAVFCJPDCNA-VNTMZGSJSA-N molport-035-765-978 Chemical compound C1([C@@H](C2)C3)=CC=CC(=O)N1C[C@@H]3CN2CCN(C1)C[C@@H]2C[C@H]1C1=CC=CC(=O)N1C2 LEXDAVFCJPDCNA-VNTMZGSJSA-N 0.000 description 3
- -1 tevanicline Chemical compound 0.000 description 3
- 229940044601 receptor agonist Drugs 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 102000004631 Calcineurin Human genes 0.000 description 1
- 108010042955 Calcineurin Proteins 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066280P | 2014-10-20 | 2014-10-20 | |
| US62/066,280 | 2014-10-20 | ||
| US201562100844P | 2015-01-07 | 2015-01-07 | |
| US62/100,844 | 2015-01-07 | ||
| PCT/US2015/056273 WO2016064759A1 (en) | 2014-10-20 | 2015-10-19 | Methods of treating ocular conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020193269A Division JP7257371B2 (ja) | 2014-10-20 | 2020-11-20 | 眼の病状の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531044A JP2017531044A (ja) | 2017-10-19 |
| JP2017531044A5 true JP2017531044A5 (enExample) | 2018-11-29 |
| JP6873906B2 JP6873906B2 (ja) | 2021-05-19 |
Family
ID=55748136
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539528A Active JP6873906B2 (ja) | 2014-10-20 | 2015-10-19 | 眼の病状の治療方法 |
| JP2020193269A Active JP7257371B2 (ja) | 2014-10-20 | 2020-11-20 | 眼の病状の治療方法 |
| JP2022202809A Active JP7502404B2 (ja) | 2014-10-20 | 2022-12-20 | 眼の病状の治療方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020193269A Active JP7257371B2 (ja) | 2014-10-20 | 2020-11-20 | 眼の病状の治療方法 |
| JP2022202809A Active JP7502404B2 (ja) | 2014-10-20 | 2022-12-20 | 眼の病状の治療方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (14) | US9597284B2 (enExample) |
| EP (3) | EP3848028B9 (enExample) |
| JP (3) | JP6873906B2 (enExample) |
| KR (2) | KR102511955B1 (enExample) |
| CN (3) | CN107106542B (enExample) |
| AU (2) | AU2015336216B2 (enExample) |
| BR (2) | BR112017008097B1 (enExample) |
| CA (1) | CA2965129C (enExample) |
| DK (2) | DK3209295T4 (enExample) |
| EA (1) | EA035335B1 (enExample) |
| ES (2) | ES2986830T3 (enExample) |
| FI (1) | FI3848028T3 (enExample) |
| IL (3) | IL293188B2 (enExample) |
| MX (2) | MX392383B (enExample) |
| MY (1) | MY186870A (enExample) |
| PH (1) | PH12017500602A1 (enExample) |
| PL (1) | PL3848028T3 (enExample) |
| PT (2) | PT3848028T (enExample) |
| SG (2) | SG10202011669PA (enExample) |
| WO (1) | WO2016064759A1 (enExample) |
| ZA (1) | ZA201703467B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3848028B9 (en) | 2014-10-20 | 2024-10-16 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| DK3439661T3 (da) * | 2016-04-07 | 2021-10-18 | Oyster Point Pharma Inc | Fremgangsmåder til behandling af øjenlidelser |
| TW202019424A (zh) * | 2018-07-10 | 2020-06-01 | 美商奧伊斯特普安生物製藥公司 | 治療眼部症狀之方法 |
| EP3820443A1 (en) | 2018-07-10 | 2021-05-19 | Oyster Point Pharma, Inc. | Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions |
| ES3039903T3 (en) | 2020-04-28 | 2025-10-27 | Oyster Point Pharma Inc | Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections |
| WO2025037323A1 (en) * | 2023-08-12 | 2025-02-20 | Pavan Kumar Kothapuvari | Pharmaceutical compositions for treatment of dry eye disease and associated disorders |
| DE102023208057A1 (de) * | 2023-08-23 | 2025-02-27 | Ursapharm Arzneimittel Gmbh | Ophthalmologische zusammensetzung enthaltend mindestens einen nikotinischen acetylcholinrezeptor-agonist zur topischen applikation am auge bei der prävention oder behandlung von entzündungen am auge |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
| US20030008892A1 (en) | 2001-07-09 | 2003-01-09 | Pfizer Inc. | Pharmaceutical composition and method of modulating cholinergic function in a mammal |
| CA2468705A1 (en) | 2001-11-29 | 2003-06-05 | Pfizer Products Inc. | Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof |
| WO2004039366A1 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
| US20060270592A1 (en) * | 2004-03-19 | 2006-11-30 | Ophthalmic Research Associates, Inc. | Use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions |
| WO2006040680A1 (en) * | 2004-10-15 | 2006-04-20 | Pfizer Products Inc. | Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline |
| KR101319772B1 (ko) * | 2004-11-09 | 2013-10-23 | 노바갈리 파르마 에스 에이 | 면역 억제제를 포함하는 안과용 유제 |
| WO2006100075A2 (en) * | 2005-03-22 | 2006-09-28 | Niconovum Ab | Use of an artificial sweetener to enhance absorption of nicotine |
| US20110086086A1 (en) | 2005-07-26 | 2011-04-14 | Pfizer Inc | Transdermal system for varenicline |
| WO2007025286A2 (en) | 2005-08-26 | 2007-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Therapy procedure for drug delivery for trigeminal pain |
| CN101316602B (zh) | 2005-09-27 | 2015-06-03 | 组织技术公司 | 羊膜制品和纯化的组合物及其使用方法 |
| TWI454262B (zh) | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
| US20080132475A1 (en) * | 2006-12-05 | 2008-06-05 | Charles Gerald Connor | Treatment for dry eye |
| WO2008093227A1 (en) * | 2007-02-02 | 2008-08-07 | Pfizer Products Inc. | Tricyclic compounds and their use as glucocorticoid receptor modulators |
| ES2521494T3 (es) * | 2007-04-02 | 2014-11-12 | Parkinson's Institute | Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos |
| US20090093446A1 (en) | 2007-10-05 | 2009-04-09 | Winston Laboratories, Inc. | Method for alleviating keratoconjunctivitis sicca |
| CL2008003507A1 (es) * | 2007-11-26 | 2009-11-27 | Neuroderm Ltd | Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico. |
| US20090215787A1 (en) | 2008-02-22 | 2009-08-27 | Mai De Ltd. | Preparations of new polymorphic forms of varenicline tartrate |
| US20110071180A1 (en) | 2008-03-05 | 2011-03-24 | Targacept, Inc. | Sub-type selective amides of diazabicycloalkanes |
| WO2010028011A1 (en) | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides of diazabicyclononanes and uses thereof |
| US20110263629A1 (en) * | 2008-09-05 | 2011-10-27 | Targacept, Inc. | Amides of diazabicyclooctanes and uses thereof |
| US9145396B2 (en) | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
| CN102232070A (zh) | 2008-12-01 | 2011-11-02 | 塔加西普特公司 | (r)-5-((e)-2-(吡咯烷-3-基乙烯基)嘧啶的合成和新的盐形式 |
| GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| US8821457B2 (en) * | 2010-09-08 | 2014-09-02 | Johnson & Johnson Vision Care, Inc. | Punctal plug containing drug formulation |
| WO2012174338A2 (en) * | 2011-06-15 | 2012-12-20 | Glaxosmithkline Llc | Method of selecting therapeutic indications |
| WO2013002365A1 (ja) * | 2011-06-30 | 2013-01-03 | 東レ株式会社 | 止痒剤 |
| KR102043077B1 (ko) * | 2011-10-20 | 2019-11-11 | 노파르티스 아게 | 알파 ７ 니코틴성 아세틸콜린 수용체 활성화제 치료에 대한 반응성을 예측하는 바이오마커 |
| EP2786142A4 (en) * | 2011-11-30 | 2015-07-22 | Diagnostear Ltd | DIAGNOSIS OF THE DRY EYE |
| ES2426517B1 (es) * | 2012-04-20 | 2014-05-14 | Genetracer Biotech S.L | Método para predecir la seguridad de un tratamiento farmacológico |
| CN105188708B (zh) | 2013-03-15 | 2019-06-28 | 格利亚有限责任公司 | 颅部的药物递送 |
| EP2986339A4 (en) | 2013-04-19 | 2016-12-21 | Oculeve Inc | Nasal stimulation devices and methods |
| EP3848028B9 (en) | 2014-10-20 | 2024-10-16 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| DK3439661T3 (da) | 2016-04-07 | 2021-10-18 | Oyster Point Pharma Inc | Fremgangsmåder til behandling af øjenlidelser |
| TW202019424A (zh) | 2018-07-10 | 2020-06-01 | 美商奧伊斯特普安生物製藥公司 | 治療眼部症狀之方法 |
| EP3820443A1 (en) | 2018-07-10 | 2021-05-19 | Oyster Point Pharma, Inc. | Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions |
-
2015
- 2015-10-19 EP EP20212556.3A patent/EP3848028B9/en active Active
- 2015-10-19 FI FIEP20212556.3T patent/FI3848028T3/fi active
- 2015-10-19 CN CN201580067940.5A patent/CN107106542B/zh active Active
- 2015-10-19 US US14/887,248 patent/US9597284B2/en active Active
- 2015-10-19 BR BR112017008097-4A patent/BR112017008097B1/pt active IP Right Grant
- 2015-10-19 KR KR1020177013534A patent/KR102511955B1/ko active Active
- 2015-10-19 CN CN202010304809.9A patent/CN111956650B/zh active Active
- 2015-10-19 KR KR1020237009057A patent/KR102601505B1/ko active Active
- 2015-10-19 JP JP2017539528A patent/JP6873906B2/ja active Active
- 2015-10-19 CN CN202010304375.2A patent/CN111956803B/zh active Active
- 2015-10-19 AU AU2015336216A patent/AU2015336216B2/en active Active
- 2015-10-19 IL IL293188A patent/IL293188B2/en unknown
- 2015-10-19 IL IL251769A patent/IL251769B/en unknown
- 2015-10-19 DK DK15852340.7T patent/DK3209295T4/da active
- 2015-10-19 WO PCT/US2015/056273 patent/WO2016064759A1/en not_active Ceased
- 2015-10-19 US US14/887,253 patent/US9532944B2/en active Active
- 2015-10-19 ES ES20212556T patent/ES2986830T3/es active Active
- 2015-10-19 EA EA201790893A patent/EA035335B1/ru unknown
- 2015-10-19 US US14/887,243 patent/US9504644B2/en active Active
- 2015-10-19 SG SG10202011669PA patent/SG10202011669PA/en unknown
- 2015-10-19 PT PT202125563T patent/PT3848028T/pt unknown
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- 2015-10-19 ES ES15852340T patent/ES2848977T5/es active Active
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2017
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2020
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2021
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2022
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2023
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