EA035335B1 - Способы лечения офтальмологических расстройств с применением варениклина - Google Patents

Способы лечения офтальмологических расстройств с применением варениклина Download PDF

Info

Publication number
EA035335B1
EA035335B1 EA201790893A EA201790893A EA035335B1 EA 035335 B1 EA035335 B1 EA 035335B1 EA 201790893 A EA201790893 A EA 201790893A EA 201790893 A EA201790893 A EA 201790893A EA 035335 B1 EA035335 B1 EA 035335B1
Authority
EA
Eurasian Patent Office
Prior art keywords
nicotinic acetylcholine
acetylcholine receptor
receptor agonist
another embodiment
administered
Prior art date
Application number
EA201790893A
Other languages
English (en)
Russian (ru)
Other versions
EA201790893A1 (ru
Inventor
Дуглас Майкл Джр. Акерманн
Джеймс Лудин
Кеннет Дж. Манделл
Original Assignee
Ойстер Поинт Фарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55748136&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA035335(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ойстер Поинт Фарма, Инк. filed Critical Ойстер Поинт Фарма, Инк.
Publication of EA201790893A1 publication Critical patent/EA201790893A1/ru
Publication of EA035335B1 publication Critical patent/EA035335B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emergency Medicine (AREA)
EA201790893A 2014-10-20 2015-10-19 Способы лечения офтальмологических расстройств с применением варениклина EA035335B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462066280P 2014-10-20 2014-10-20
US201562100844P 2015-01-07 2015-01-07
PCT/US2015/056273 WO2016064759A1 (en) 2014-10-20 2015-10-19 Methods of treating ocular conditions

Publications (2)

Publication Number Publication Date
EA201790893A1 EA201790893A1 (ru) 2018-01-31
EA035335B1 true EA035335B1 (ru) 2020-05-28

Family

ID=55748136

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790893A EA035335B1 (ru) 2014-10-20 2015-10-19 Способы лечения офтальмологических расстройств с применением варениклина

Country Status (21)

Country Link
US (14) US9532944B2 (enExample)
EP (3) EP4413974A3 (enExample)
JP (3) JP6873906B2 (enExample)
KR (2) KR102511955B1 (enExample)
CN (3) CN107106542B (enExample)
AU (2) AU2015336216B2 (enExample)
BR (2) BR112017008097B1 (enExample)
CA (1) CA2965129C (enExample)
DK (2) DK3848028T5 (enExample)
EA (1) EA035335B1 (enExample)
ES (2) ES2848977T5 (enExample)
FI (1) FI3848028T3 (enExample)
IL (3) IL318427A (enExample)
MX (2) MX392383B (enExample)
MY (1) MY186870A (enExample)
PH (1) PH12017500602A1 (enExample)
PL (1) PL3848028T3 (enExample)
PT (2) PT3209295T (enExample)
SG (2) SG10202011669PA (enExample)
WO (1) WO2016064759A1 (enExample)
ZA (1) ZA201703467B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4413974A3 (en) 2014-10-20 2024-10-09 Oyster Point Pharma, Inc. Methods of treating ocular conditions
KR102512777B1 (ko) * 2016-04-07 2023-03-23 오이스터 포인트 파마 인코포레이티드 안구 장애의 치료 방법
TW202019424A (zh) * 2018-07-10 2020-06-01 美商奧伊斯特普安生物製藥公司 治療眼部症狀之方法
CN112638364A (zh) 2018-07-10 2021-04-09 奥伊斯特普安生物制药公司 用于治疗眼部病症的正向别构调节剂和烟碱型乙酰胆碱受体激动剂的组合
TW202206078A (zh) 2020-04-28 2022-02-16 美商奧伊斯特普安生物製藥公司 局部投與菸鹼乙醯膽鹼受體促效劑用以抑制冠狀病毒感染
WO2025037323A1 (en) * 2023-08-12 2025-02-20 Pavan Kumar Kothapuvari Pharmaceutical compositions for treatment of dry eye disease and associated disorders
DE102023208057A1 (de) * 2023-08-23 2025-02-27 Ursapharm Arzneimittel Gmbh Ophthalmologische zusammensetzung enthaltend mindestens einen nikotinischen acetylcholinrezeptor-agonist zur topischen applikation am auge bei der prävention oder behandlung von entzündungen am auge

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1214062B1 (en) * 2000-04-21 2003-11-12 Inspire Pharmaceuticals Use of nicotinic acetylcholine receptor agonists for the preparation of a medicament for the treatment of dry eye disease
WO2004039366A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
US20110263629A1 (en) * 2008-09-05 2011-10-27 Targacept, Inc. Amides of diazabicyclooctanes and uses thereof
US20120095062A1 (en) * 2007-02-02 2012-04-19 Pfizer Inc. Tricyclic compounds, compositions, and methods
US20120289572A1 (en) * 2006-11-02 2012-11-15 Targacept, Inc. Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes
WO2013057687A2 (en) * 2011-10-20 2013-04-25 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008892A1 (en) 2001-07-09 2003-01-09 Pfizer Inc. Pharmaceutical composition and method of modulating cholinergic function in a mammal
DE60209929T2 (de) 2001-11-29 2006-11-16 Pfizer Products Inc., Groton Succinatsalze von 58;8;14-triatetracyclo[10.3.1.0 2,11 .0 4,9]-hexadeca-2,11,3,5,7,9,-pentaen und pharmazeutische zusammensetzungen
US20060270592A1 (en) * 2004-03-19 2006-11-30 Ophthalmic Research Associates, Inc. Use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions
WO2006040680A1 (en) * 2004-10-15 2006-04-20 Pfizer Products Inc. Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline
DK1809238T3 (da) * 2004-11-09 2010-01-25 Novagali Pharma Sa Ophthalmiske emulsioner indeholdende et immunosuppressivt middel
WO2006100075A2 (en) * 2005-03-22 2006-09-28 Niconovum Ab Use of an artificial sweetener to enhance absorption of nicotine
US20110086086A1 (en) 2005-07-26 2011-04-14 Pfizer Inc Transdermal system for varenicline
US20070054843A1 (en) 2005-08-26 2007-03-08 Yeomans David C Methods for treatment of headaches by administration of oxytocin
CA2949643C (en) 2005-09-27 2018-05-15 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and methods of use
US20080132475A1 (en) * 2006-12-05 2008-06-05 Charles Gerald Connor Treatment for dry eye
EP1977746B8 (en) * 2007-04-02 2014-09-24 Parkinson's Institute Methods and compositions for reduction of side effects of therapeutic treatments
US20090093446A1 (en) 2007-10-05 2009-04-09 Winston Laboratories, Inc. Method for alleviating keratoconjunctivitis sicca
CL2008003507A1 (es) * 2007-11-26 2009-11-27 Neuroderm Ltd Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico.
US20090215787A1 (en) 2008-02-22 2009-08-27 Mai De Ltd. Preparations of new polymorphic forms of varenicline tartrate
MX2010009727A (es) 2008-03-05 2010-09-28 Targacept Inc Amidas selectivas del subtipo del receptor nicotinico de acetilcolina de diazabicicloalcanos.
WO2010028011A1 (en) 2008-09-05 2010-03-11 Targacept, Inc. Amides of diazabicyclononanes and uses thereof
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
MX2011005611A (es) 2008-12-01 2011-09-15 Targacept Inc Sintesis y formas de sales novedosas de (r)-5-((e)-2-(pirrolidin-3 -il-vinil)pirimidina.
US20110274628A1 (en) 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
US8821457B2 (en) * 2010-09-08 2014-09-02 Johnson & Johnson Vision Care, Inc. Punctal plug containing drug formulation
CA2841416A1 (en) * 2011-06-15 2012-12-20 Glaxosmithkline Intellectual Property (No.2) Limited Method of selecting therapeutic indications
BR112013032044A2 (pt) * 2011-06-30 2016-12-13 Toray Industries antiprurítico
WO2013080196A1 (en) * 2011-11-30 2013-06-06 D.E.S. Diagnostics Ltd. Dry eye diagnostic
ES2426517B1 (es) * 2012-04-20 2014-05-14 Genetracer Biotech S.L Método para predecir la seguridad de un tratamiento farmacológico
PT2968368T (pt) 2013-03-15 2017-11-15 Glia Llc Administração craniana de substâncias farmacêuticas
EP2986339A4 (en) 2013-04-19 2016-12-21 Oculeve Inc Nasal stimulation devices and methods
EP4413974A3 (en) 2014-10-20 2024-10-09 Oyster Point Pharma, Inc. Methods of treating ocular conditions
KR102512777B1 (ko) 2016-04-07 2023-03-23 오이스터 포인트 파마 인코포레이티드 안구 장애의 치료 방법
TW202019424A (zh) 2018-07-10 2020-06-01 美商奧伊斯特普安生物製藥公司 治療眼部症狀之方法
CN112638364A (zh) 2018-07-10 2021-04-09 奥伊斯特普安生物制药公司 用于治疗眼部病症的正向别构调节剂和烟碱型乙酰胆碱受体激动剂的组合

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1214062B1 (en) * 2000-04-21 2003-11-12 Inspire Pharmaceuticals Use of nicotinic acetylcholine receptor agonists for the preparation of a medicament for the treatment of dry eye disease
WO2004039366A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
US20120289572A1 (en) * 2006-11-02 2012-11-15 Targacept, Inc. Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes
US20120095062A1 (en) * 2007-02-02 2012-04-19 Pfizer Inc. Tricyclic compounds, compositions, and methods
US20110263629A1 (en) * 2008-09-05 2011-10-27 Targacept, Inc. Amides of diazabicyclooctanes and uses thereof
WO2013057687A2 (en) * 2011-10-20 2013-04-25 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment

Also Published As

Publication number Publication date
DK3209295T3 (da) 2021-03-01
US11224598B2 (en) 2022-01-18
US20170239244A1 (en) 2017-08-24
US20160106744A1 (en) 2016-04-21
EP3209295A1 (en) 2017-08-30
EP3209295B1 (en) 2020-12-09
JP2021038250A (ja) 2021-03-11
US20200246336A1 (en) 2020-08-06
US20250275963A1 (en) 2025-09-04
CA2965129A1 (en) 2016-04-28
US20250255865A1 (en) 2025-08-14
CN111956650A (zh) 2020-11-20
US20230226052A1 (en) 2023-07-20
EP3209295B2 (en) 2023-12-06
EP3848028A1 (en) 2021-07-14
MY186870A (en) 2021-08-26
WO2016064759A1 (en) 2016-04-28
IL251769A0 (en) 2017-06-29
DK3848028T3 (da) 2024-08-26
US20160106745A1 (en) 2016-04-21
KR102511955B1 (ko) 2023-03-22
US11903942B2 (en) 2024-02-20
CN111956803B (zh) 2025-10-31
AU2015336216B2 (en) 2020-05-21
BR122022025737B1 (pt) 2023-12-26
AU2020213351B2 (en) 2023-04-06
PT3209295T (pt) 2021-02-05
ZA201703467B (en) 2023-12-20
JP2023024574A (ja) 2023-02-16
US9504644B2 (en) 2016-11-29
CN107106542A (zh) 2017-08-29
SG10202011669PA (en) 2020-12-30
KR20170086040A (ko) 2017-07-25
KR20230042144A (ko) 2023-03-27
US10456396B2 (en) 2019-10-29
MX2017005064A (es) 2018-02-23
MX2022005888A (es) 2022-06-14
IL293188A (en) 2022-07-01
US9597284B2 (en) 2017-03-21
IL293188B2 (en) 2025-06-01
JP6873906B2 (ja) 2021-05-19
KR102601505B1 (ko) 2023-11-14
JP7257371B2 (ja) 2023-04-13
EA201790893A1 (ru) 2018-01-31
AU2020213351A1 (en) 2020-08-27
JP7502404B2 (ja) 2024-06-18
US11903941B2 (en) 2024-02-20
EP3848028B9 (en) 2024-10-16
JP2017531044A (ja) 2017-10-19
BR112017008097B1 (pt) 2023-03-28
SG11201703135XA (en) 2017-05-30
BR112017008097A2 (pt) 2018-02-20
US9532944B2 (en) 2017-01-03
US20230226054A1 (en) 2023-07-20
PT3848028T (pt) 2024-09-20
FI3848028T3 (fi) 2024-08-21
US20250235449A1 (en) 2025-07-24
IL251769B (en) 2022-06-01
US11911380B2 (en) 2024-02-27
CA2965129C (en) 2024-03-12
IL293188B1 (en) 2025-02-01
MX392383B (es) 2025-03-24
US11903943B2 (en) 2024-02-20
PL3848028T3 (pl) 2024-11-18
CN111956650B (zh) 2024-06-04
AU2015336216A1 (en) 2017-06-08
EP3209295A4 (en) 2018-05-23
US20230226053A1 (en) 2023-07-20
US20160106665A1 (en) 2016-04-21
ES2848977T5 (es) 2024-06-06
EP3848028B1 (en) 2024-05-29
IL318427A (en) 2025-03-01
EP4413974A3 (en) 2024-10-09
ES2986830T3 (es) 2024-11-12
DK3848028T5 (da) 2025-01-20
CN111956803A (zh) 2020-11-20
US20160106746A1 (en) 2016-04-21
US20220233528A1 (en) 2022-07-28
DK3209295T4 (da) 2024-02-26
CN107106542B (zh) 2020-05-08
US9504645B2 (en) 2016-11-29
PH12017500602A1 (en) 2017-09-04
EP4413974A2 (en) 2024-08-14
ES2848977T3 (es) 2021-08-13
US20240173318A1 (en) 2024-05-30

Similar Documents

Publication Publication Date Title
US11911380B2 (en) Compositions and use of varenicline for treating dry eye
HK40049315A (en) Methods of treating ocular conditions
HK40035962A (en) Methods of treating ocular conditions
HK40035961A (en) Methods for treating eye disease
HK40049315B (en) Methods of treating ocular conditions
HK1242208A1 (en) Methods of treating ocular conditions
HK1242208B (en) Methods of treating ocular conditions