JP2017530125A5 - - Google Patents
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- Publication number
- JP2017530125A5 JP2017530125A5 JP2017516101A JP2017516101A JP2017530125A5 JP 2017530125 A5 JP2017530125 A5 JP 2017530125A5 JP 2017516101 A JP2017516101 A JP 2017516101A JP 2017516101 A JP2017516101 A JP 2017516101A JP 2017530125 A5 JP2017530125 A5 JP 2017530125A5
- Authority
- JP
- Japan
- Prior art keywords
- reactor
- carboy
- lai
- coiled
- inch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055286P | 2014-09-25 | 2014-09-25 | |
| US62/055,286 | 2014-09-25 | ||
| PCT/US2015/052320 WO2016049509A1 (en) | 2014-09-25 | 2015-09-25 | Continuous flow carboxylation reaction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019189312A Division JP2020045341A (ja) | 2014-09-25 | 2019-10-16 | 連続流のカルボキシル化反応 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530125A JP2017530125A (ja) | 2017-10-12 |
| JP6754356B2 JP6754356B2 (ja) | 2020-09-09 |
| JP2017530125A5 true JP2017530125A5 (enExample) | 2020-09-17 |
Family
ID=55582084
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516101A Active JP6754356B2 (ja) | 2014-09-25 | 2015-09-25 | 連続流のカルボキシル化反応 |
| JP2019189312A Withdrawn JP2020045341A (ja) | 2014-09-25 | 2019-10-16 | 連続流のカルボキシル化反応 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019189312A Withdrawn JP2020045341A (ja) | 2014-09-25 | 2019-10-16 | 連続流のカルボキシル化反応 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9725413B2 (enExample) |
| EP (1) | EP3197454B1 (enExample) |
| JP (2) | JP6754356B2 (enExample) |
| CN (1) | CN106714801B (enExample) |
| AU (1) | AU2015320349B2 (enExample) |
| BR (1) | BR112017005856A2 (enExample) |
| CA (1) | CA2960392A1 (enExample) |
| ES (1) | ES2857730T3 (enExample) |
| HU (1) | HUE053118T2 (enExample) |
| IL (2) | IL250958B (enExample) |
| MX (1) | MX365010B (enExample) |
| PL (1) | PL3197454T3 (enExample) |
| PT (1) | PT3197454T (enExample) |
| SA (1) | SA517381158B1 (enExample) |
| WO (1) | WO2016049509A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015320349B2 (en) | 2014-09-25 | 2020-03-12 | Bausch + Lomb Ireland Limited | Continuous flow carboxylation reaction |
| CA3068522A1 (en) * | 2017-06-30 | 2019-01-03 | Scinopharm Taiwan, Ltd. | Process for preparing lifitegrast and intermediates thereof |
| EP3662994A4 (en) * | 2017-07-31 | 2021-03-17 | Kaneka Corporation | FLOW REACTOR |
| KR102650254B1 (ko) * | 2017-11-14 | 2024-03-21 | 알베마를 저머니 게엠베하 | 연속 유동 조건 하에 유기리튬 공정 |
| CN109384717A (zh) * | 2018-10-29 | 2019-02-26 | 广安凯特制药有限公司 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酸盐酸盐水合物及其制备方法和用途 |
| CN110724098A (zh) * | 2019-11-13 | 2020-01-24 | 成都福柯斯医药技术有限公司 | 一种5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸盐酸盐的合成方法 |
| CN113845478B (zh) * | 2020-12-18 | 2023-11-21 | 四川大学 | 一种中间体及其制备方法和应用 |
| CN113277942B (zh) * | 2021-05-25 | 2024-05-03 | 都创(上海)医药开发有限公司 | 一种基于微通道反应技术快速制备5-氯-2-氟-4-(三氟甲基)苯甲酸的方法 |
| CN116239532B (zh) * | 2022-12-19 | 2023-11-07 | 浙江博崤生物制药有限公司 | 一种二氯四氢异喹啉羧酸的中间体及其制备方法和应用 |
| CN115872929B (zh) * | 2022-12-27 | 2024-12-03 | 山东金城柯瑞化学有限公司 | 芳基类化合物连续羧基化反应制备立他司特中间体的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767856B2 (en) * | 2007-01-25 | 2010-08-03 | Xerox Corporation | System and method for producing arylamine compounds |
| CN101450300A (zh) * | 2007-12-05 | 2009-06-10 | 海南大学 | 连续流微反应器及其制备和应用 |
| US8378105B2 (en) * | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| CN104105718B (zh) * | 2011-12-14 | 2017-05-10 | 联邦科学和工业研究组织 | Raft聚合物 |
| SI3715345T1 (sl) | 2012-07-25 | 2024-07-31 | Bausch + Lomb Ireland Limited | Priprava zaviralca lfa-1 |
| AU2015320349B2 (en) * | 2014-09-25 | 2020-03-12 | Bausch + Lomb Ireland Limited | Continuous flow carboxylation reaction |
-
2015
- 2015-09-25 AU AU2015320349A patent/AU2015320349B2/en active Active
- 2015-09-25 JP JP2017516101A patent/JP6754356B2/ja active Active
- 2015-09-25 PT PT158448464T patent/PT3197454T/pt unknown
- 2015-09-25 ES ES15844846T patent/ES2857730T3/es active Active
- 2015-09-25 PL PL15844846T patent/PL3197454T3/pl unknown
- 2015-09-25 HU HUE15844846A patent/HUE053118T2/hu unknown
- 2015-09-25 US US14/866,085 patent/US9725413B2/en active Active
- 2015-09-25 BR BR112017005856A patent/BR112017005856A2/pt not_active Application Discontinuation
- 2015-09-25 CN CN201580050837.XA patent/CN106714801B/zh active Active
- 2015-09-25 WO PCT/US2015/052320 patent/WO2016049509A1/en not_active Ceased
- 2015-09-25 MX MX2017003505A patent/MX365010B/es active IP Right Grant
- 2015-09-25 EP EP15844846.4A patent/EP3197454B1/en active Active
- 2015-09-25 CA CA2960392A patent/CA2960392A1/en not_active Abandoned
-
2017
- 2017-03-06 IL IL250958A patent/IL250958B/en active IP Right Grant
- 2017-03-22 SA SA517381158A patent/SA517381158B1/ar unknown
- 2017-06-28 US US15/635,632 patent/US10273212B2/en active Active
-
2019
- 2019-04-09 US US16/378,868 patent/US10899715B2/en active Active
- 2019-08-01 IL IL268432A patent/IL268432B/en active IP Right Grant
- 2019-10-16 JP JP2019189312A patent/JP2020045341A/ja not_active Withdrawn
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