JP2017527579A - メラニン合成を阻害するための美容組成物及び方法 - Google Patents
メラニン合成を阻害するための美容組成物及び方法 Download PDFInfo
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- JP2017527579A JP2017527579A JP2017513453A JP2017513453A JP2017527579A JP 2017527579 A JP2017527579 A JP 2017527579A JP 2017513453 A JP2017513453 A JP 2017513453A JP 2017513453 A JP2017513453 A JP 2017513453A JP 2017527579 A JP2017527579 A JP 2017527579A
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- cosmetic composition
- bis
- ethylhexyl
- weight
- bisabolol
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 20
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- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 59
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- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
美容組成物は、哺乳類のケラチン組織、特にヒトの皮膚に適用されることができる。美容組成物は、様々な形態をとってもよい。例えば、形態のいくつかの非限定例としては、溶液、懸濁液、ローション、クリーム、ゲル、化粧水、スティック、ペンシル、スプレー、エアゾール、軟膏、クレンジング洗剤液及びクレンジング棒状固形物、シャンプー及びヘアコンディショナー、ペースト、フォーム、パウダー、ムース、髭剃りクリーム、ワイプ、ストリップ、パッチ、電動パッチ、創傷被覆材及び粘着性包帯、ヒドロゲル、フィルム形成製品、顔及び皮膚マスク、化粧品(例えば、ファンデーション、アイライナー、アイシャドウ)などが挙げられる。
前述の成分に加えて、本明細書に記載の美容組成物は、1種類以上の他の成分も含み得る。美容組成物に通常使用される他の成分(例えば、スキンケア活性物質)、スキンケア活性物質の識別方法、及び/又は美容組成物の配合方法の非限定例は、米国特許出願公開第2002/0022040号、同第2003/0049212号、同第2007/0196344号、同第2008/0181956号、同第2010/00092408号、同第2008/0206373号、同第2010/0239510号、同第2010/0189669号、同第2011/0262025号、同第2011/0097286号、同第2012/0197016号、同第2012/0128683号、同第2012/0148515号、同第2012/0156146号、及び同第2013/0022557号、並びに米国特許第5,939,082号、同第5,872,112号、同第6,492,326号、同第6,696,049号、同第6,524,598号、同第5,972,359号、及び同第6,174,533号に記載されている。
R3SiO[R2SiO]xSiR3
式中、Rは、水素又はC1〜30直鎖又は分岐鎖、飽和又は不飽和アルキル、フェニル若しくはアリール、トリアルキルシロキシから独立して選択され、xは、所望の分子量を得るために選択される、0〜約10,000の整数である。]Rの非限定例としては、水素、メチル、及びエチルが挙げられる。市販のポリシロキサンとしては、ジメチコンとしても知られるポリジメチルシロキサンが挙げられ、その例としては、信越化学工業株式会社製のDM−Fluidシリーズ、Momentive Performance Materials Inc.より販売されるVicasil(登録商標)シリーズ、及びDow Corning Corporationより販売されるDow Corning(登録商標)200シリーズが挙げられる。好適なポリジメチルシロキサンの具体例としては、0.65、1.5、50、100、350、10,000、12,500、100,000、及び300,000mm2/s(0.65、1.5、50、100、350、10,000、12,500、100,000、及び300,000センチストークス)の粘度を有するDow Corning(登録商標)200流体(Xiameter(登録商標)PMX−200 Silicone Fluidsとしても販売されている)が挙げられる。
R3SiO[R2SiO]x[RR’SiO]ySiR3
[式中、R及びR’は、それぞれ独立して、水素、又はC1〜30の直鎖若しくは分枝鎖の、飽和若しくは不飽和のアルキル、アリール、若しくはトリアルキルシロキシであり、x及びyはそれぞれ、所望の分子量が得られるように選択される1〜1,000,000の整数である。]ジメチコンの非限定例としては、フェニルジメチコン(Botanigenics,Inc.のBotansil(商標)PD−151)、ジフェニルジメチコン(Shin−EtsuのKF−53及びKF−54)、フェニルトリメチコン(Dow Corningの556 Cosmetic Grade Fluid)、又はトリメチルシロキシフェニルジメチコン(Wacker−BelsilのPDM−20、PDM−200、又はPDM−1000)が挙げられる。他の非限定例としては、少なくともR’が脂肪族アルキル(例えば、C12〜22)であるアルキルジメチコンが挙げられる。好適なアルキルジメチコンは、R’がC16直鎖であり、Rがメチルである、セチルジメチコンである。セチルジメチコンは、2502 Cosmetic FluidとしてDow Corningから、あるいはAbil Wax 9801又は9814としてEvonik Goldschmidt GmbHから入手可能である。
メラニン合成を測定するためのアッセイとして、B16−F1マウスメラノーマ細胞株を使用することができる。B16−F1細胞は、American Tissue culture Collection,Virginia,USAから得られる。アッセイに使用できる細胞培養液は、500mLのDulbecco改変イーグル培地(DMEM)、50mLのウシ胎児血清(FBS)、及び5mLのペニシリン−ストレプトマイシン液を含み得る。この培地で培養し、集密度90%超まで増殖させたB16−F1細胞は、メラニンを合成する。任意の理論により束縛されるものではないが、メラニン合成は、培養液により及び/又は高培養密度まで増殖させることより誘導されるストレスにより刺激されるものと仮定される。DMEM及びFBSはAmerican Tissue culture Collectionから入手でき、ペニシリン−ストレプトマイシン液はInvitrogen,Inc.,California,USAから入手できる。アッセイに使用する機器としては、Therma Scientific,Massachusets,USAのForma Series Model 3110などのCO2インキュベータ;Hauser Scientific,Pennsylvania,USAのBright Lineモデルなどの血球計数器;及びMolecular Devices,California,USAのSpectraMax250などのUV−可視スペクトルプレートリーダーが挙げられる。アッセイは、次の工程を包含し得る。
0日目−細胞増殖。細胞培養液を37℃に加温し、29mLをT−150フラスコに入れる。継代数1のB16−F1のマウス細胞約1×106個をT−150フラスコに加え、37℃で3日間、5% CO2、90%相対湿度で、集密度が約80%になるまで培養する。
3日目−96ウェルプレートでの培養の開始。3日目にT−150フラスコの細胞をトリプシン処理し、血球計数器を使用して細胞密度を測定する。96ウェルプレートを細胞培養液100μL中2,500細胞/ウェルで培養を開始する。集密度が少なくとも20%〜40%になるまで、37℃、5% CO2、90%相対湿度で約2日間、プレートをインキュベートする。
5日目−プレートから細胞培養液をデカントし、新鮮な培養液(100μL/ウェル)で置き換える。[水又はDSMO]溶媒で希釈した[試験化合物]1μLを添加する。複数の希釈比を試験して用量応答曲線を生成してもよく、好ましくは3つのウェルを各希釈比で処理する。対照は、細胞培養液、B16−F1細胞、及び溶媒を有するウェル(対照#1);細胞培養液及び溶媒を含むウェル(対照#2);並びに[試験化合物]の背景色を管理する必要がある場合、任意追加的に細胞培養液、溶媒、及び[試験化合物]を含むウェル(対照#3)を含む。
7日目−メラニン生成の測定。細胞は約90%超の集密度を有するべきである。そうでない場合、このデータ点は使用しない。各ウェルに100μLの0.75%水酸化ナトリウム溶液を加える。UV−Visプレートリーダーを使用して、96ウェルプレートを410nmにて読み取り、[試験化合物]で処理されたウェルと、試験化合物で処理されなかった対照ウェルとの間で、生成されたメラニンの量を光学的に測定する。メラニンが生成されたウェルは、一般的に茶色がかって見える。メラニンが殆ど生成されなかったウェルは、一般的に透明から薄紫色に見える。メラニン合成阻害率(%)は、次式により計算する。
本明細書に開示される美容組成物は、使用者の日課又は処方計画の1つとして1箇所以上の皮膚表面及び/又は1箇所以上の哺乳類のケラチン組織表面に塗布することができる。これに加えるか又はこれに代えて、本明細書の美容組成物は、「必要に応じて」使用することもできる。いくつかの例では、美容組成物の有効量をケラチン組織又は皮膚の標的部分に塗布してもよい。いくつかの例では、美容組成物は、適用処方計画を詳細に記載する説明書と共にパッケージで提供されてもよい。
Claims (9)
- a)ビサボロールと、
b)N−ウンデシレノイル−L−フェニルアラニン、ヘキシルデカノール、及びそれらの混合物からなる群から選択される第1原料と、
c)パルミチン酸エチル、ステアリルアルコール、アジピン酸ビス(2−エチルヘキシル)、マレイン酸ビス(2−エチルヘキシル)、5−ペンタデカノール、1−ステアロイル−rac−グリセロール、セバシン酸ビス(2−エチルヘキシル)、及びそれらの混合物からなる群から選択される第2原料と、を含む、美容組成物。 - 前記ヘキシルデカノールが、前記美容組成物の0.01重量%〜8重量%、好ましくは前記美容組成物の0.05重量%〜5重量%の濃度を有する、請求項1に記載の美容組成物。
- 前記ビサボロールが、前記美容組成物の0.003重量%〜2重量%の濃度を有する、請求項1に記載の美容組成物。
- 前記N−ウンデシレノイル−L−フェニルアラニンが、前記美容組成物の0.01重量%〜約2重量%の濃度を有する、請求項1に記載の美容組成物。
- 前記美容組成物が、ヒドロキシ桂皮酸、イノシトール、甘草抽出物、グリシルレチン酸、グラブリジン、ビタミンEコハク酸エステル、サリチル酸、カラフトコンブ抽出物、ベンガルボダイジュ抽出物、N−アセチルグルコサミン、紫外線有効成分、及びそれらの組み合わせからなる群から選択される原料を更に含む、請求項1に記載の美容組成物。
- 前記美容組成物が、油中水型エマルション、水中油型エマルション、又はシリコーン中水型エマルションの形態で提供される、請求項1に記載の美容組成物。
- メラニン合成を低下させる方法であって、
a)メラニンの減少が必要なケラチン組織の標的部分を識別することと、
b)前記ケラチン組織の前記標的部分に美容組成物の有効量を局所適用することと、を含み、前記美容組成物が、
i)好ましくは前記美容組成物の0.003重量%〜2重量%の濃度を有する、ビサボロールと、
ii)N−ウンデシレノイル−L−フェニルアラニン、ヘキシルデカノール、及びそれらの混合物からなる群から選択される第1原料、と、
iii)パルミチン酸エチル、ステアリルアルコール、アジピン酸ビス(2−エチルヘキシル)、マレイン酸ビス(2−エチルヘキシル)、5−ペンタデカノール、1−ステアロイル−rac−グリセロール、セバシン酸ビス(2−エチルヘキシル)、及びそれらの混合物からなる群から選択される第2原料と、を含む、方法。 - 前記組成物がビタミンB化合物を更に含み、好ましくは前記ビタミンB化合物がナイアシンアミドを含み、好ましくは前記美容組成物の11重量%以下の濃度を有する、請求項1〜7のいずれか一項に記載の美容組成物又は方法。
- 前記美容組成物が、バチルアルコールを更に含み、好ましくはバチルアルコールが前記美容組成物の0.03重量%〜5重量%の濃度を有する、請求項1〜8のいずれか一項に記載の美容組成物又は方法。
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JP2013523721A (ja) * | 2010-03-31 | 2013-06-17 | 株式會社アモーレパシフィック | メラニン色素生成抑制剤及びこれを含有する化粧料組成物 |
JP2012520349A (ja) * | 2010-07-22 | 2012-09-06 | ザ プロクター アンド ギャンブル カンパニー | フトコンブの抽出物を用いた色素過剰スポットの外観を改善するための方法 |
JP2013543001A (ja) * | 2010-11-19 | 2013-11-28 | ザ プロクター アンド ギャンブル カンパニー | 顔の毛穴の外観を改善するための組成物及び方法 |
JP2014506596A (ja) * | 2011-02-22 | 2014-03-17 | アクゾ ノーベル ケミカルズ インターナショナル ベスローテン フエンノートシャップ | ベンガルボダイジュ、ハス及びクローバーのセラム画分を含む組成物(色素沈着過剰) |
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CN106687100B (zh) | 2020-09-04 |
KR102008587B1 (ko) | 2019-08-07 |
JP6657192B2 (ja) | 2020-03-04 |
EP3191074B1 (en) | 2020-02-12 |
US20160074293A1 (en) | 2016-03-17 |
KR20170032475A (ko) | 2017-03-22 |
US9757317B2 (en) | 2017-09-12 |
EP3191074A1 (en) | 2017-07-19 |
CA2958428A1 (en) | 2016-03-17 |
CN106687100A (zh) | 2017-05-17 |
WO2016040757A1 (en) | 2016-03-17 |
CA2958428C (en) | 2020-08-18 |
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