JP6657192B2 - メラニン合成を阻害するための美容組成物 - Google Patents
メラニン合成を阻害するための美容組成物 Download PDFInfo
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- JP6657192B2 JP6657192B2 JP2017513453A JP2017513453A JP6657192B2 JP 6657192 B2 JP6657192 B2 JP 6657192B2 JP 2017513453 A JP2017513453 A JP 2017513453A JP 2017513453 A JP2017513453 A JP 2017513453A JP 6657192 B2 JP6657192 B2 JP 6657192B2
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- cosmetic composition
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- ethylhexyl
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- bis
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- 150000001924 cycloalkanes Chemical class 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- KBODESQIOVVMAI-UHFFFAOYSA-N decyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCC KBODESQIOVVMAI-UHFFFAOYSA-N 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- NZZIMKJIVMHWJC-UHFFFAOYSA-N dibenzoylmethane Chemical class C=1C=CC=CC=1C(=O)CC(=O)C1=CC=CC=C1 NZZIMKJIVMHWJC-UHFFFAOYSA-N 0.000 description 1
- 229940100539 dibutyl adipate Drugs 0.000 description 1
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 description 1
- 229960001673 diethyltoluamide Drugs 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940090934 diphenylsiloxy phenyl trimethicone Drugs 0.000 description 1
- GLCJMPWWQKKJQZ-UHFFFAOYSA-L disodium;2-[4-(4,6-disulfonato-1h-benzimidazol-2-yl)phenyl]-1h-benzimidazole-4,6-disulfonate;hydron Chemical compound [Na+].[Na+].C1=C(S(O)(=O)=O)C=C2NC(C3=CC=C(C=C3)C3=NC4=C(C=C(C=C4N3)S(=O)(=O)O)S([O-])(=O)=O)=NC2=C1S([O-])(=O)=O GLCJMPWWQKKJQZ-UHFFFAOYSA-L 0.000 description 1
- QDCHWIWENYCPIL-UHFFFAOYSA-L disodium;4-hydroxy-5-(2-hydroxy-4-methoxy-5-sulfonatobenzoyl)-2-methoxybenzenesulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC(S([O-])(=O)=O)=C(OC)C=C1O QDCHWIWENYCPIL-UHFFFAOYSA-L 0.000 description 1
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- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229960004697 enzacamene Drugs 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 150000002194 fatty esters Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
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- 210000001061 forehead Anatomy 0.000 description 1
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- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036252 glycation Effects 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 210000004919 hair shaft Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- RSRQBSGZMPVCOI-UHFFFAOYSA-N hexadecyl propanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CC RSRQBSGZMPVCOI-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 230000004132 lipogenesis Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940102398 methyl anthranilate Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960004738 nicotinyl alcohol Drugs 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- YAGMLECKUBJRNO-UHFFFAOYSA-N octyl 4-(dimethylamino)benzoate Chemical compound CCCCCCCCOC(=O)C1=CC=C(N(C)C)C=C1 YAGMLECKUBJRNO-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 125000001232 pantothenyl group Chemical group C(CCNC([C@H](O)C(C)(C)CO)=O)(=O)* 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000013500 performance material Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 229940057874 phenyl trimethicone Drugs 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
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- 229920002282 polysilicones-15 Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229940078491 ppg-15 stearyl ether Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- XLCIFRJORZNGEV-UHFFFAOYSA-N propan-2-yl 2-[dodecanoyl(methyl)amino]acetate Chemical compound CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C XLCIFRJORZNGEV-UHFFFAOYSA-N 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229960003581 pyridoxal Drugs 0.000 description 1
- 235000008164 pyridoxal Nutrition 0.000 description 1
- 239000011674 pyridoxal Substances 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 229940116351 sebacate Drugs 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
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- 239000000344 soap Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
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- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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Description
美容組成物は、哺乳類のケラチン組織、特にヒトの皮膚に適用されることができる。美容組成物は、様々な形態をとってもよい。例えば、形態のいくつかの非限定例としては、溶液、懸濁液、ローション、クリーム、ゲル、化粧水、スティック、ペンシル、スプレー、エアゾール、軟膏、クレンジング洗剤液及びクレンジング棒状固形物、シャンプー及びヘアコンディショナー、ペースト、フォーム、パウダー、ムース、髭剃りクリーム、ワイプ、ストリップ、パッチ、電動パッチ、創傷被覆材及び粘着性包帯、ヒドロゲル、フィルム形成製品、顔及び皮膚マスク、化粧品(例えば、ファンデーション、アイライナー、アイシャドウ)などが挙げられる。
前述の成分に加えて、本明細書に記載の美容組成物は、1種類以上の他の成分も含み得る。美容組成物に通常使用される他の成分(例えば、スキンケア活性物質)、スキンケア活性物質の識別方法、及び/又は美容組成物の配合方法の非限定例は、米国特許出願公開第2002/0022040号、同第2003/0049212号、同第2007/0196344号、同第2008/0181956号、同第2010/00092408号、同第2008/0206373号、同第2010/0239510号、同第2010/0189669号、同第2011/0262025号、同第2011/0097286号、同第2012/0197016号、同第2012/0128683号、同第2012/0148515号、同第2012/0156146号、及び同第2013/0022557号、並びに米国特許第5,939,082号、同第5,872,112号、同第6,492,326号、同第6,696,049号、同第6,524,598号、同第5,972,359号、及び同第6,174,533号に記載されている。
R3SiO[R2SiO]xSiR3
式中、Rは、水素又はC1〜30直鎖又は分岐鎖、飽和又は不飽和アルキル、フェニル若しくはアリール、トリアルキルシロキシから独立して選択され、xは、所望の分子量を得るために選択される、0〜約10,000の整数である。]Rの非限定例としては、水素、メチル、及びエチルが挙げられる。市販のポリシロキサンとしては、ジメチコンとしても知られるポリジメチルシロキサンが挙げられ、その例としては、信越化学工業株式会社製のDM−Fluidシリーズ、Momentive Performance Materials Inc.より販売されるVicasil(登録商標)シリーズ、及びDow Corning Corporationより販売されるDow Corning(登録商標)200シリーズが挙げられる。好適なポリジメチルシロキサンの具体例としては、0.65、1.5、50、100、350、10,000、12,500、100,000、及び300,000mm2/s(0.65、1.5、50、100、350、10,000、12,500、100,000、及び300,000センチストークス)の粘度を有するDow Corning(登録商標)200流体(Xiameter(登録商標)PMX−200 Silicone Fluidsとしても販売されている)が挙げられる。
R3SiO[R2SiO]x[RR’SiO]ySiR3
[式中、R及びR’は、それぞれ独立して、水素、又はC1〜30の直鎖若しくは分枝鎖の、飽和若しくは不飽和のアルキル、アリール、若しくはトリアルキルシロキシであり、x及びyはそれぞれ、所望の分子量が得られるように選択される1〜1,000,000の整数である。]ジメチコンの非限定例としては、フェニルジメチコン(Botanigenics,Inc.のBotansil(商標)PD−151)、ジフェニルジメチコン(Shin−EtsuのKF−53及びKF−54)、フェニルトリメチコン(Dow Corningの556 Cosmetic Grade Fluid)、又はトリメチルシロキシフェニルジメチコン(Wacker−BelsilのPDM−20、PDM−200、又はPDM−1000)が挙げられる。他の非限定例としては、少なくともR’が脂肪族アルキル(例えば、C12〜22)であるアルキルジメチコンが挙げられる。好適なアルキルジメチコンは、R’がC16直鎖であり、Rがメチルである、セチルジメチコンである。セチルジメチコンは、2502 Cosmetic FluidとしてDow Corningから、あるいはAbil Wax 9801又は9814としてEvonik Goldschmidt GmbHから入手可能である。
メラニン合成を測定するためのアッセイとして、B16−F1マウスメラノーマ細胞株を使用することができる。B16−F1細胞は、American Tissue culture Collection,Virginia,USAから得られる。アッセイに使用できる細胞培養液は、500mLのDulbecco改変イーグル培地(DMEM)、50mLのウシ胎児血清(FBS)、及び5mLのペニシリン−ストレプトマイシン液を含み得る。この培地で培養し、集密度90%超まで増殖させたB16−F1細胞は、メラニンを合成する。任意の理論により束縛されるものではないが、メラニン合成は、培養液により及び/又は高培養密度まで増殖させることより誘導されるストレスにより刺激されるものと仮定される。DMEM及びFBSはAmerican Tissue culture Collectionから入手でき、ペニシリン−ストレプトマイシン液はInvitrogen,Inc.,California,USAから入手できる。アッセイに使用する機器としては、Therma Scientific,Massachusets,USAのForma Series Model 3110などのCO2インキュベータ;Hauser Scientific,Pennsylvania,USAのBright Lineモデルなどの血球計数器;及びMolecular Devices,California,USAのSpectraMax250などのUV−可視スペクトルプレートリーダーが挙げられる。アッセイは、次の工程を包含し得る。
0日目−細胞増殖。細胞培養液を37℃に加温し、29mLをT−150フラスコに入れる。継代数1のB16−F1のマウス細胞約1×106個をT−150フラスコに加え、37℃で3日間、5% CO2、90%相対湿度で、集密度が約80%になるまで培養する。
3日目−96ウェルプレートでの培養の開始。3日目にT−150フラスコの細胞をトリプシン処理し、血球計数器を使用して細胞密度を測定する。96ウェルプレートを細胞培養液100μL中2,500細胞/ウェルで培養を開始する。集密度が少なくとも20%〜40%になるまで、37℃、5% CO2、90%相対湿度で約2日間、プレートをインキュベートする。
5日目−プレートから細胞培養液をデカントし、新鮮な培養液(100μL/ウェル)で置き換える。[水又はDSMO]溶媒で希釈した[試験化合物]1μLを添加する。複数の希釈比を試験して用量応答曲線を生成してもよく、好ましくは3つのウェルを各希釈比で処理する。対照は、細胞培養液、B16−F1細胞、及び溶媒を有するウェル(対照#1);細胞培養液及び溶媒を含むウェル(対照#2);並びに[試験化合物]の背景色を管理する必要がある場合、任意追加的に細胞培養液、溶媒、及び[試験化合物]を含むウェル(対照#3)を含む。
7日目−メラニン生成の測定。細胞は約90%超の集密度を有するべきである。そうでない場合、このデータ点は使用しない。各ウェルに100μLの0.75%水酸化ナトリウム溶液を加える。UV−Visプレートリーダーを使用して、96ウェルプレートを410nmにて読み取り、[試験化合物]で処理されたウェルと、試験化合物で処理されなかった対照ウェルとの間で、生成されたメラニンの量を光学的に測定する。メラニンが生成されたウェルは、一般的に茶色がかって見える。メラニンが殆ど生成されなかったウェルは、一般的に透明から薄紫色に見える。メラニン合成阻害率(%)は、次式により計算する。
本明細書に開示される美容組成物は、使用者の日課又は処方計画の1つとして1箇所以上の皮膚表面及び/又は1箇所以上の哺乳類のケラチン組織表面に塗布することができる。これに加えるか又はこれに代えて、本明細書の美容組成物は、「必要に応じて」使用することもできる。いくつかの例では、美容組成物の有効量をケラチン組織又は皮膚の標的部分に塗布してもよい。いくつかの例では、美容組成物は、適用処方計画を詳細に記載する説明書と共にパッケージで提供されてもよい。
Claims (6)
- a)美容組成物の0.003重量%〜2重量%の濃度を有する、ビサボロールと、
b)美容組成物の0.01重量%〜2重量%の濃度を有する、N−ウンデシレノイル−L−フェニルアラニンからなる第1原料と、
c)美容組成物の0.03重量%〜1重量%の濃度を有する、パルミチン酸エチル、アジピン酸ビス(2−エチルヘキシル)、マレイン酸ビス(2−エチルヘキシル)、セバシン酸ビス(2−エチルヘキシル)、及びそれらの混合物からなる群から選択される第2原料と、
美容組成物の0.0005重量%〜11重量%の濃度を有する、ナイアシンアミドと、を含む、美容組成物。 - a)美容組成物の0.003重量%〜2重量%の濃度を有する、ビサボロールと、
b)美容組成物の0.01重量%〜8重量%の濃度を有する、ヘキシルデカノールからなる第1原料と、
c)美容組成物の0.03重量%〜1重量%の濃度を有するパルミチン酸エチル、マレイン酸ビス(2−エチルヘキシル)、5−ペンタデカノール、セバシン酸ビス(2−エチルヘキシル)、及びそれらの混合物からなる群から選択される第2原料と、
美容組成物の0.0005重量%〜11重量%の濃度を有する、ナイアシンアミドと、を含む、美容組成物。 - a)美容組成物の0.003重量%〜2重量%の濃度を有する、ビサボロールと、
b)美容組成物の0.01重量%〜2重量%の濃度を有する、N−ウンデシレノイル−L−フェニルアラニンと、美容組成物の0.01重量%〜8重量%の濃度を有する、ヘキシルデカノールとの混合物からなる第1原料と、
c)美容組成物の0.03重量%〜1重量%の濃度を有する、1−ステアロイル−rac−グリセロールからなる第2原料と、
美容組成物の0.0005重量%〜11重量%の濃度を有する、ナイアシンアミドと、を含む、美容組成物。 - 前記美容組成物が、ヒドロキシ桂皮酸、イノシトール、甘草抽出物、グリシルレチン酸、グラブリジン、ビタミンEコハク酸エステル、サリチル酸、カラフトコンブ抽出物、ベンガルボダイジュ抽出物、N−アセチルグルコサミン、紫外線有効成分、及びそれらの組み合わせからなる群から選択される原料を更に含む、請求項1〜3のいずれか一項に記載の美容組成物。
- 前記美容組成物が、油中水型エマルション、水中油型エマルション、又はシリコーン中水型エマルションの形態で提供される、請求項1〜4のいずれか一項に記載の美容組成物。
- 前記美容組成物が、バチルアルコールを更に含み、バチルアルコールが前記美容組成物の0.03重量%〜5重量%の濃度を有する、請求項1〜5のいずれか一項に記載の美容組成物。
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