JP2017527563A5 - - Google Patents
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- JP2017527563A5 JP2017527563A5 JP2017512775A JP2017512775A JP2017527563A5 JP 2017527563 A5 JP2017527563 A5 JP 2017527563A5 JP 2017512775 A JP2017512775 A JP 2017512775A JP 2017512775 A JP2017512775 A JP 2017512775A JP 2017527563 A5 JP2017527563 A5 JP 2017527563A5
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- JP
- Japan
- Prior art keywords
- ala
- carbon atoms
- optionally substituted
- val
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045248P | 2014-09-03 | 2014-09-03 | |
| US62/045,248 | 2014-09-03 | ||
| US201462087040P | 2014-12-03 | 2014-12-03 | |
| US62/087,040 | 2014-12-03 | ||
| US201562149370P | 2015-04-17 | 2015-04-17 | |
| US62/149,370 | 2015-04-17 | ||
| US201562164305P | 2015-05-20 | 2015-05-20 | |
| US62/164,305 | 2015-05-20 | ||
| PCT/US2015/048059 WO2016036801A1 (en) | 2014-09-03 | 2015-09-02 | Cytotoxic benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192174A Division JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527563A JP2017527563A (ja) | 2017-09-21 |
| JP2017527563A5 true JP2017527563A5 (https=) | 2019-10-03 |
| JP6606545B2 JP6606545B2 (ja) | 2019-11-13 |
Family
ID=54140691
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512775A Expired - Fee Related JP6606545B2 (ja) | 2014-09-03 | 2015-09-02 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2019192174A Expired - Fee Related JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2020195666A Active JP7132311B2 (ja) | 2014-09-03 | 2020-11-26 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2022133442A Ceased JP2022166293A (ja) | 2014-09-03 | 2022-08-24 | 細胞障害性ベンゾジアゼピン誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192174A Expired - Fee Related JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2020195666A Active JP7132311B2 (ja) | 2014-09-03 | 2020-11-26 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2022133442A Ceased JP2022166293A (ja) | 2014-09-03 | 2022-08-24 | 細胞障害性ベンゾジアゼピン誘導体 |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US9669102B2 (https=) |
| EP (2) | EP3778601A1 (https=) |
| JP (4) | JP6606545B2 (https=) |
| KR (2) | KR20240023671A (https=) |
| CN (2) | CN116514903A (https=) |
| AU (3) | AU2015311987B2 (https=) |
| BR (1) | BR112017002963A2 (https=) |
| CA (1) | CA2959630A1 (https=) |
| CL (1) | CL2017000507A1 (https=) |
| CO (1) | CO2017003011A2 (https=) |
| CR (1) | CR20170111A (https=) |
| CY (1) | CY1123325T1 (https=) |
| DK (1) | DK3189056T3 (https=) |
| DO (1) | DOP2017000053A (https=) |
| EA (1) | EA034138B1 (https=) |
| EC (1) | ECSP17020133A (https=) |
| ES (1) | ES2815353T3 (https=) |
| HU (1) | HUE051002T2 (https=) |
| IL (4) | IL250712B (https=) |
| LT (1) | LT3189056T (https=) |
| MA (1) | MA54254A (https=) |
| MX (1) | MX2017002758A (https=) |
| PE (1) | PE20170775A1 (https=) |
| PH (1) | PH12017500358A1 (https=) |
| PL (1) | PL3189056T3 (https=) |
| PT (1) | PT3189056T (https=) |
| RS (1) | RS60751B1 (https=) |
| SG (2) | SG11201701455SA (https=) |
| SI (1) | SI3189056T1 (https=) |
| SM (1) | SMT202000449T1 (https=) |
| TN (1) | TN2017000070A1 (https=) |
| TW (4) | TWI697493B (https=) |
| WO (1) | WO2016036801A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999604B (zh) * | 2014-09-02 | 2021-08-03 | 伊缪诺金公司 | 用于配制抗体药物缀合物组合物的方法 |
| ES2815353T3 (es) | 2014-09-03 | 2021-03-29 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| ES2887273T3 (es) * | 2015-06-29 | 2021-12-22 | Immunogen Inc | Anticuerpos anti-CD123 y conjugados y derivados de los mismos |
| SG10202106529XA (en) * | 2015-07-21 | 2021-07-29 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
| PT3380525T (pt) | 2015-11-25 | 2024-02-05 | Immunogen Inc | Formulações farmacêuticas e métodos que as utilizam |
| MX2018009487A (es) * | 2016-02-05 | 2019-01-31 | Millennium Pharm Inc | Conjugados de anticuerpo y fármaco dirigidos contra gcc. |
| TWI845890B (zh) | 2016-11-23 | 2024-06-21 | 美商伊繆諾金公司 | 苯二氮平衍生物之選擇性磺化 |
| SI3558391T1 (sl) | 2016-12-23 | 2022-06-30 | Immunogen, Inc. | Imunokonjugati, ciljno usmerjeni na ADAM9, in načini njihove uporabe |
| WO2018129029A1 (en) | 2017-01-04 | 2018-07-12 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| WO2018183494A1 (en) | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| EP3612533A1 (en) | 2017-04-20 | 2020-02-26 | Immunogen, Inc. | Methods of preparing indolinobenzodiazepine derivatives |
| EP3717021A1 (en) | 2017-11-27 | 2020-10-07 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| EP3727463A1 (en) | 2017-12-21 | 2020-10-28 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| TWI897855B (zh) | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| US11833214B2 (en) * | 2019-03-21 | 2023-12-05 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| TWI841715B (zh) * | 2019-03-27 | 2024-05-11 | 日商第一三共股份有限公司 | 抗體-吡咯并苯二氮呯衍生物結合物及ｐａｒｐ抑制劑之組合及其用途 |
| US20220306751A1 (en) | 2019-09-13 | 2022-09-29 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| KR20250031149A (ko) | 2022-06-30 | 2025-03-06 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
| CN119212735A (zh) * | 2023-04-27 | 2024-12-27 | 石药集团巨石生物制药有限公司 | 一种抗体药物偶联物 |
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2015
- 2015-09-02 ES ES15763739T patent/ES2815353T3/es active Active
- 2015-09-02 TN TN2017000070A patent/TN2017000070A1/en unknown
- 2015-09-02 MX MX2017002758A patent/MX2017002758A/es unknown
- 2015-09-02 CA CA2959630A patent/CA2959630A1/en active Pending
- 2015-09-02 AU AU2015311987A patent/AU2015311987B2/en not_active Ceased
- 2015-09-02 KR KR1020247003505A patent/KR20240023671A/ko not_active Abandoned
- 2015-09-02 CN CN202210858832.1A patent/CN116514903A/zh active Pending
- 2015-09-02 CR CR20170111A patent/CR20170111A/es unknown
- 2015-09-02 LT LTEP15763739.8T patent/LT3189056T/lt unknown
- 2015-09-02 SG SG11201701455SA patent/SG11201701455SA/en unknown
- 2015-09-02 CN CN201580047847.8A patent/CN106604927B/zh not_active Expired - Fee Related
- 2015-09-02 BR BR112017002963A patent/BR112017002963A2/pt not_active Application Discontinuation
- 2015-09-02 TW TW104128985A patent/TWI697493B/zh not_active IP Right Cessation
- 2015-09-02 SI SI201531320T patent/SI3189056T1/sl unknown
- 2015-09-02 WO PCT/US2015/048059 patent/WO2016036801A1/en not_active Ceased
- 2015-09-02 PL PL15763739T patent/PL3189056T3/pl unknown
- 2015-09-02 EP EP20178715.7A patent/EP3778601A1/en not_active Withdrawn
- 2015-09-02 HU HUE15763739A patent/HUE051002T2/hu unknown
- 2015-09-02 RS RS20201000A patent/RS60751B1/sr unknown
- 2015-09-02 PT PT157637398T patent/PT3189056T/pt unknown
- 2015-09-02 TW TW112135631A patent/TW202417447A/zh unknown
- 2015-09-02 KR KR1020177009021A patent/KR102632830B1/ko active Active
- 2015-09-02 TW TW111102997A patent/TWI819474B/zh not_active IP Right Cessation
- 2015-09-02 SG SG10201901824UA patent/SG10201901824UA/en unknown
- 2015-09-02 EP EP15763739.8A patent/EP3189056B1/en active Active
- 2015-09-02 PE PE2017000378A patent/PE20170775A1/es unknown
- 2015-09-02 JP JP2017512775A patent/JP6606545B2/ja not_active Expired - Fee Related
- 2015-09-02 SM SM20200449T patent/SMT202000449T1/it unknown
- 2015-09-02 EA EA201790446A patent/EA034138B1/ru unknown
- 2015-09-02 MA MA054254A patent/MA54254A/fr unknown
- 2015-09-02 US US14/843,520 patent/US9669102B2/en not_active Expired - Fee Related
- 2015-09-02 DK DK15763739.8T patent/DK3189056T3/da active
- 2015-09-02 TW TW109118465A patent/TWI757759B/zh not_active IP Right Cessation
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2017
- 2017-02-22 IL IL250712A patent/IL250712B/en active IP Right Grant
- 2017-02-28 PH PH12017500358A patent/PH12017500358A1/en unknown
- 2017-03-02 DO DO2017000053A patent/DOP2017000053A/es unknown
- 2017-03-03 CL CL2017000507A patent/CL2017000507A1/es unknown
- 2017-03-28 CO CONC2017/0003011A patent/CO2017003011A2/es unknown
- 2017-04-03 EC ECIEPI201720133A patent/ECSP17020133A/es unknown
- 2017-04-28 US US15/581,749 patent/US10238751B2/en active Active
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2019
- 2019-02-13 US US16/274,665 patent/US10722588B2/en active Active
- 2019-10-21 JP JP2019192174A patent/JP6802340B2/ja not_active Expired - Fee Related
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2020
- 2020-04-21 IL IL281317A patent/IL281317B/en unknown
- 2020-04-21 IL IL274114A patent/IL274114A/en unknown
- 2020-06-15 US US16/901,754 patent/US11116845B2/en not_active Expired - Fee Related
- 2020-08-31 AU AU2020227006A patent/AU2020227006B2/en not_active Ceased
- 2020-09-04 CY CY20201100835T patent/CY1123325T1/el unknown
- 2020-11-26 JP JP2020195666A patent/JP7132311B2/ja active Active
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2022
- 2022-03-22 IL IL291598A patent/IL291598A/en unknown
- 2022-04-12 AU AU2022202418A patent/AU2022202418B2/en not_active Expired - Fee Related
- 2022-08-24 JP JP2022133442A patent/JP2022166293A/ja not_active Ceased
- 2022-10-25 US US17/973,209 patent/US20230233697A1/en not_active Abandoned
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