JP2017529837A5 - - Google Patents
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- JP2017529837A5 JP2017529837A5 JP2017512760A JP2017512760A JP2017529837A5 JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5 JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- independently
- carbon atoms
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C Chemical compound Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C 0.000 description 17
- DEDHGJRRQDQDKF-UHFFFAOYSA-N CC(C)CC(NC(CSC(C)C)C(O)=O)=O Chemical compound CC(C)CC(NC(CSC(C)C)C(O)=O)=O DEDHGJRRQDQDKF-UHFFFAOYSA-N 0.000 description 1
- VRZKVSKELFLXON-UHFFFAOYSA-N CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O Chemical compound CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O VRZKVSKELFLXON-UHFFFAOYSA-N 0.000 description 1
- XOVULDKOTPBNEY-UHFFFAOYSA-N CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O Chemical compound CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O XOVULDKOTPBNEY-UHFFFAOYSA-N 0.000 description 1
- OKBSQXZHPMPSFN-UHFFFAOYSA-N CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O Chemical compound CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O OKBSQXZHPMPSFN-UHFFFAOYSA-N 0.000 description 1
- CKXHHQSSQIMGIF-YYULCGAYSA-N C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O Chemical compound C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O CKXHHQSSQIMGIF-YYULCGAYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045264P | 2014-09-03 | 2014-09-03 | |
| US62/045,264 | 2014-09-03 | ||
| US201462086986P | 2014-12-03 | 2014-12-03 | |
| US62/086,986 | 2014-12-03 | ||
| US201562149379P | 2015-04-17 | 2015-04-17 | |
| US62/149,379 | 2015-04-17 | ||
| US201562186235P | 2015-06-29 | 2015-06-29 | |
| US62/186,235 | 2015-06-29 | ||
| PCT/US2015/048044 WO2016036794A1 (en) | 2014-09-03 | 2015-09-02 | Conjugates comprising cell-binding agents and cytotoxic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529837A JP2017529837A (ja) | 2017-10-12 |
| JP2017529837A5 true JP2017529837A5 (https=) | 2018-10-11 |
Family
ID=54147280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512760A Pending JP2017529837A (ja) | 2014-09-03 | 2015-09-02 | 細胞結合剤及び細胞毒性剤を含む複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10988531B2 (https=) |
| EP (1) | EP3188733B1 (https=) |
| JP (1) | JP2017529837A (https=) |
| KR (3) | KR102638901B1 (https=) |
| CN (1) | CN107580604A (https=) |
| AU (1) | AU2015312075A1 (https=) |
| CA (1) | CA2957964A1 (https=) |
| IL (1) | IL250711A0 (https=) |
| MA (1) | MA40415A (https=) |
| RU (1) | RU2017110068A (https=) |
| SG (2) | SG11201701565PA (https=) |
| TW (1) | TW201609152A (https=) |
| WO (1) | WO2016036794A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999604B (zh) * | 2014-09-02 | 2021-08-03 | 伊缪诺金公司 | 用于配制抗体药物缀合物组合物的方法 |
| TW201609152A (zh) | 2014-09-03 | 2016-03-16 | 免疫原公司 | 包含細胞結合劑及細胞毒性劑之偶聯物 |
| ES2815353T3 (es) * | 2014-09-03 | 2021-03-29 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| JP7297408B2 (ja) | 2015-02-06 | 2023-06-26 | セル アイディーエックス， インコーポレイテッド | 抗原をカップリングさせた免疫試薬 |
| ES2887273T3 (es) * | 2015-06-29 | 2021-12-22 | Immunogen Inc | Anticuerpos anti-CD123 y conjugados y derivados de los mismos |
| SG10202106529XA (en) * | 2015-07-21 | 2021-07-29 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
| MX2018009487A (es) * | 2016-02-05 | 2019-01-31 | Millennium Pharm Inc | Conjugados de anticuerpo y fármaco dirigidos contra gcc. |
| TWI750194B (zh) * | 2016-07-05 | 2021-12-21 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｅｇｆｒ抗體-藥物偶聯物及其在醫藥上的應用 |
| JP7618383B2 (ja) * | 2016-07-22 | 2025-01-21 | ネクター セラピューティクス | オキシム含有リンケージを有する第ｖｉｉｉ因子部分のコンジュゲート |
| AU2017355402A1 (en) * | 2016-11-02 | 2019-05-30 | Health Research, Inc. | Combination treatment with antibody-drug conjugates and PARP inhibitors |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| SI3558391T1 (sl) * | 2016-12-23 | 2022-06-30 | Immunogen, Inc. | Imunokonjugati, ciljno usmerjeni na ADAM9, in načini njihove uporabe |
| KR20250171447A (ko) * | 2017-02-28 | 2025-12-08 | 이뮤노젠 아이엔씨 | 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체 |
| WO2018183494A1 (en) * | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| EP3658568A4 (en) * | 2017-07-26 | 2021-04-28 | The University of Queensland | Disulfide bond containing compounds and uses thereof |
| IL301637B2 (en) | 2017-09-29 | 2024-10-01 | Daiichi Sankyo Co Ltd | Antibody-pyrrolobenzodiazepine derivative conjugate |
| EP3713962A4 (en) * | 2017-11-21 | 2021-08-25 | Novartis AG | TRISPECIFIC BINDING MOLECULES AGAINST TUMOR-ASSOCIATED ANTIGENS AND THEIR USE |
| MA51629A (fr) * | 2018-01-12 | 2020-11-18 | Immunogen Inc | Procédés de production, purification et formulation de conjugués anticorps-médicaments |
| CN115925952A (zh) | 2018-03-13 | 2023-04-07 | 东莞凡恩世生物医药有限公司 | 抗叶酸受体1抗体及其用途 |
| KR102821508B1 (ko) | 2018-04-10 | 2025-06-16 | 셀렉타 바이오사이언시스, 인코퍼레이티드 | 인지질-플라베글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법 |
| CN112955548B (zh) | 2018-07-09 | 2023-11-24 | 普众发现医药科技(上海)有限公司 | 叶酸受体α特异性抗体 |
| JP2022500454A (ja) * | 2018-09-17 | 2022-01-04 | ストロ バイオファーマ インコーポレーテッド | 抗葉酸受容体抗体コンジュゲートによる併用療法 |
| TWI897855B (zh) * | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| WO2020092631A1 (en) * | 2018-10-31 | 2020-05-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for detecting and treating cancers characterized by expression of mesothelin |
| US20210032285A1 (en) * | 2019-03-11 | 2021-02-04 | Cell Idx, Inc. | Methods, compositions, and kits for trapping modified biomolecules |
| CN120131907A (zh) | 2019-03-19 | 2025-06-13 | 瓦尔希伯伦私人肿瘤研究基金会 | 采用Omomyc和结合PD-1或CTLA-4的抗体治疗癌症的联合疗法 |
| US11833214B2 (en) * | 2019-03-21 | 2023-12-05 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| PE20220568A1 (es) | 2019-05-21 | 2022-04-20 | Novartis Ag | Moleculas de union a cd19 y usos de las mismas |
| EP3972993A1 (en) | 2019-05-21 | 2022-03-30 | Novartis AG | Variant cd58 domains and uses thereof |
| CA3154192A1 (en) | 2019-10-10 | 2021-04-15 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| CN110922482B (zh) * | 2019-12-25 | 2021-08-31 | 源道隆（苏州）医学科技有限公司 | 可结合cd19的多肽及其应用 |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| CN113908589B (zh) * | 2021-10-08 | 2022-09-27 | 天津工业大学 | 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法 |
| AU2023370106A1 (en) | 2022-10-25 | 2025-05-08 | Fundació Privada Institut D'investigació Oncològica De Vall Hebron | Combination therapy for the treatment of cancer |
| EP4473974A1 (en) | 2023-06-07 | 2024-12-11 | Peptomyc, S.L. | Omomyc and kras inhibitors combination therapy for the treatment of cancer |
| TW202513088A (zh) | 2023-06-07 | 2025-04-01 | 瓦爾希伯倫私人腫瘤研究基金會 | 用於治療癌症的與ｍｅｋ抑制劑的組合療法 |
| KR20260020418A (ko) | 2023-06-07 | 2026-02-11 | 펀다시오 프리바다 인스티튜트 드인베스티가시오 온콜로지카 데 발 헤브론 | Braf 저해제를 이용한 암 치료용 조합 요법 |
| CN117659041A (zh) * | 2023-12-08 | 2024-03-08 | 联宁（苏州）生物制药有限公司 | 用于抗体偶联药物的氘代蒽环类毒素连接子及其合成方法和应用 |
| KR20250146159A (ko) * | 2024-03-29 | 2025-10-13 | 진메디신 주식회사 | 약물 및 항체를 연결하는 링커 화합물 및 이를 이용한 항체-약물 복합체 |
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| US5362852A (en) | 1991-09-27 | 1994-11-08 | Pfizer Inc. | Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties |
| FR2801904B1 (fr) | 1999-12-07 | 2002-02-08 | Pasteur Institut | Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn |
| CA2499496C (fr) | 2002-09-19 | 2012-04-24 | Centre National De La Recherche Scientifique - Cnrs | Synthese et caracterisation de nouveaux systemes de guidage et de vectorisation de molecules d'interet therapeutique vers des cellules cibles |
| EA008866B1 (ru) | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| GB0305704D0 (en) | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| KR20120064120A (ko) | 2004-06-01 | 2012-06-18 | 제넨테크, 인크. | 항체 약물 접합체 및 방법 |
| WO2006042848A2 (en) | 2004-10-18 | 2006-04-27 | Novo Nordisk A/S | Growth hormone conjugates |
| CA2600749C (en) | 2005-03-10 | 2014-04-15 | Nascacell Ip Gmbh | Dimeric or multimeric microproteins |
| EP1877100A2 (en) | 2005-04-25 | 2008-01-16 | GE Healthcare AS | Liposomes |
| JP4938263B2 (ja) * | 2005-08-19 | 2012-05-23 | 独立行政法人農業生物資源研究所 | 一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用 |
| WO2007048127A2 (en) | 2005-10-20 | 2007-04-26 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
| FR2897616B1 (fr) | 2006-02-20 | 2008-05-30 | Univ Grenoble 1 | Presentation de motifs de reconnaissance par une matrice multivalente greffee sur un support solide |
| US7985783B2 (en) * | 2006-09-21 | 2011-07-26 | The Regents Of The University Of California | Aldehyde tags, uses thereof in site-specific protein modification |
| DK2474557T3 (da) | 2007-07-16 | 2014-11-10 | Genentech Inc | Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse |
| RU2476441C2 (ru) | 2007-10-19 | 2013-02-27 | Сиэтл Дженетикс, Инк. | Cd19-связывающие средства и их применение |
| WO2009059278A1 (en) | 2007-11-02 | 2009-05-07 | Centocor, Inc. | Semi-synthetic glp-1 peptide-fc fusion constructs, methods and uses |
| EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | EFFICIENT CONJUGATES AND HYDROPHILIC BINDER |
| CN103037900B (zh) * | 2010-02-24 | 2016-04-06 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| US9381058B2 (en) * | 2010-11-05 | 2016-07-05 | Ethicon Endo-Surgery, Llc | Recharge system for medical devices |
| JP6049642B2 (ja) * | 2011-02-15 | 2016-12-21 | イミュノジェン・インコーポレーテッド | 複合体の調製方法 |
| AU2013256596A1 (en) | 2012-05-01 | 2014-10-09 | Genentech, Inc. | Anti-PMEL17 antibodies and immunoconjugates |
| EP2855521A4 (en) * | 2012-05-24 | 2016-03-02 | Mountgate Group Ltd | COMPOSITIONS AND METHODS RELATED TO PREVENTING AND TREATING TOLL WUTINFECTION |
| JP6310909B2 (ja) | 2012-06-06 | 2018-04-11 | ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ | 免疫原及び投薬反応物として使用するためのウイルスタンパク質に由来するペプチド |
| US9834597B2 (en) | 2012-09-21 | 2017-12-05 | The Regents Of The University Of California | Modified FC polypeptides, FC conjugates, and methods of use thereof |
| EP3300108B1 (en) * | 2013-03-28 | 2019-07-24 | Toshiba Hokuto Electronics Corporation | Light emitting device and method for manufacturing the same |
| EP3001813B1 (en) | 2013-05-13 | 2019-03-27 | Vision Global Holdings Ltd. | Pharmaceutical composition comprising modified hemoglobin- based therapeutic agent for cancer targeting treatment and diagnostic imaging |
| AU2014312086B2 (en) * | 2013-08-30 | 2020-03-12 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| WO2015079376A1 (en) | 2013-11-26 | 2015-06-04 | Novartis Ag | Methods for oxime conjugation to ketone-modified polypeptides |
| TW201609152A (zh) | 2014-09-03 | 2016-03-16 | 免疫原公司 | 包含細胞結合劑及細胞毒性劑之偶聯物 |
-
2015
- 2015-09-02 TW TW104128984A patent/TW201609152A/zh unknown
- 2015-09-02 KR KR1020237007792A patent/KR102638901B1/ko active Active
- 2015-09-02 RU RU2017110068A patent/RU2017110068A/ru not_active Application Discontinuation
- 2015-09-02 EP EP15766288.3A patent/EP3188733B1/en active Active
- 2015-09-02 CN CN201580059534.4A patent/CN107580604A/zh active Pending
- 2015-09-02 CA CA2957964A patent/CA2957964A1/en not_active Abandoned
- 2015-09-02 WO PCT/US2015/048044 patent/WO2016036794A1/en not_active Ceased
- 2015-09-02 SG SG11201701565PA patent/SG11201701565PA/en unknown
- 2015-09-02 US US14/843,429 patent/US10988531B2/en not_active Expired - Fee Related
- 2015-09-02 AU AU2015312075A patent/AU2015312075A1/en not_active Abandoned
- 2015-09-02 JP JP2017512760A patent/JP2017529837A/ja active Pending
- 2015-09-02 KR KR1020177009020A patent/KR102508023B1/ko active Active
- 2015-09-02 MA MA040415A patent/MA40415A/fr unknown
- 2015-09-02 KR KR1020247005372A patent/KR20240027148A/ko active Pending
- 2015-09-02 SG SG10201901825YA patent/SG10201901825YA/en unknown
-
2017
- 2017-02-22 IL IL250711A patent/IL250711A0/en unknown
-
2021
- 2021-02-12 US US17/174,911 patent/US11732038B2/en active Active
-
2023
- 2023-06-28 US US18/343,455 patent/US20240190956A1/en active Pending
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