JP2017529837A - 細胞結合剤及び細胞毒性剤を含む複合体 - Google Patents

細胞結合剤及び細胞毒性剤を含む複合体 Download PDF

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JP2017529837A
JP2017529837A JP2017512760A JP2017512760A JP2017529837A JP 2017529837 A JP2017529837 A JP 2017529837A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017529837 A JP2017529837 A JP 2017529837A
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ala
antibody
complex
optionally substituted
antigen
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JP2017529837A5 (https=
Inventor
ハリス，ルーク・ビー
タバーレス，ダニエル
ルイ，リンギュン
フィシュキン，ネイサン・エリオット
シズカ，マナミ
ミラー，マイケル・ルイス
チャリ，ラビ・ヴイ・ジェイ
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イミュノジェン・インコーポレーテッド
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Neurology (AREA)
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  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
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JP2017512760A 2014-09-03 2015-09-02 細胞結合剤及び細胞毒性剤を含む複合体 Pending JP2017529837A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462045264P 2014-09-03 2014-09-03
US62/045,264 2014-09-03
US201462086986P 2014-12-03 2014-12-03
US62/086,986 2014-12-03
US201562149379P 2015-04-17 2015-04-17
US62/149,379 2015-04-17
US201562186235P 2015-06-29 2015-06-29
US62/186,235 2015-06-29
PCT/US2015/048044 WO2016036794A1 (en) 2014-09-03 2015-09-02 Conjugates comprising cell-binding agents and cytotoxic agents

Publications (2)

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JP2017529837A true JP2017529837A (ja) 2017-10-12
JP2017529837A5 JP2017529837A5 (https=) 2018-10-11

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US (3) US10988531B2 (https=)
EP (1) EP3188733B1 (https=)
JP (1) JP2017529837A (https=)
KR (3) KR102638901B1 (https=)
CN (1) CN107580604A (https=)
AU (1) AU2015312075A1 (https=)
CA (1) CA2957964A1 (https=)
IL (1) IL250711A0 (https=)
MA (1) MA40415A (https=)
RU (1) RU2017110068A (https=)
SG (2) SG11201701565PA (https=)
TW (1) TW201609152A (https=)
WO (1) WO2016036794A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2017527563A (ja) * 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞障害性ベンゾジアゼピン誘導体
JP2019511462A (ja) * 2016-02-05 2019-04-25 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｇｃｃ標的化抗体−薬物コンジュゲート
JP2021510694A (ja) * 2018-01-12 2021-04-30 イミュノジェン， インコーポレイテッド 抗体薬物のコンジュゲーション、精製、及び製剤のための方法

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CN106999604B (zh) * 2014-09-02 2021-08-03 伊缪诺金公司 用于配制抗体药物缀合物组合物的方法
TW201609152A (zh) 2014-09-03 2016-03-16 免疫原公司 包含細胞結合劑及細胞毒性劑之偶聯物
JP7297408B2 (ja) 2015-02-06 2023-06-26 セル アイディーエックス， インコーポレイテッド 抗原をカップリングさせた免疫試薬
ES2887273T3 (es) * 2015-06-29 2021-12-22 Immunogen Inc Anticuerpos anti-CD123 y conjugados y derivados de los mismos
SG10202106529XA (en) * 2015-07-21 2021-07-29 Immunogen Inc Methods of preparing cytotoxic benzodiazepine derivatives
TWI750194B (zh) * 2016-07-05 2021-12-21 大陸商江蘇恆瑞醫藥股份有限公司 Ｅｇｆｒ抗體-藥物偶聯物及其在醫藥上的應用
JP7618383B2 (ja) * 2016-07-22 2025-01-21 ネクター セラピューティクス オキシム含有リンケージを有する第ｖｉｉｉ因子部分のコンジュゲート
AU2017355402A1 (en) * 2016-11-02 2019-05-30 Health Research, Inc. Combination treatment with antibody-drug conjugates and PARP inhibitors
EP3554544A4 (en) 2016-12-16 2020-07-29 Bluefin Biomedicine, Inc. ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
SI3558391T1 (sl) * 2016-12-23 2022-06-30 Immunogen, Inc. Imunokonjugati, ciljno usmerjeni na ADAM9, in načini njihove uporabe
KR20250171447A (ko) * 2017-02-28 2025-12-08 이뮤노젠 아이엔씨 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체
WO2018183494A1 (en) * 2017-03-31 2018-10-04 Immunogen, Inc. Cd19-targeting antibody-drug conjugates
EP3658568A4 (en) * 2017-07-26 2021-04-28 The University of Queensland Disulfide bond containing compounds and uses thereof
IL301637B2 (en) 2017-09-29 2024-10-01 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
EP3713962A4 (en) * 2017-11-21 2021-08-25 Novartis AG TRISPECIFIC BINDING MOLECULES AGAINST TUMOR-ASSOCIATED ANTIGENS AND THEIR USE
CN115925952A (zh) 2018-03-13 2023-04-07 东莞凡恩世生物医药有限公司 抗叶酸受体1抗体及其用途
KR102821508B1 (ko) 2018-04-10 2025-06-16 셀렉타 바이오사이언시스, 인코퍼레이티드 인지질-플라베글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법
CN112955548B (zh) 2018-07-09 2023-11-24 普众发现医药科技(上海)有限公司 叶酸受体α特异性抗体
JP2022500454A (ja) * 2018-09-17 2022-01-04 ストロ バイオファーマ インコーポレーテッド 抗葉酸受容体抗体コンジュゲートによる併用療法
TWI897855B (zh) * 2018-10-26 2025-09-21 美商免疫遺傳股份有限公司 Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途
WO2020092631A1 (en) * 2018-10-31 2020-05-07 Fred Hutchinson Cancer Research Center Compositions and methods for detecting and treating cancers characterized by expression of mesothelin
US20210032285A1 (en) * 2019-03-11 2021-02-04 Cell Idx, Inc. Methods, compositions, and kits for trapping modified biomolecules
CN120131907A (zh) 2019-03-19 2025-06-13 瓦尔希伯伦私人肿瘤研究基金会 采用Omomyc和结合PD-1或CTLA-4的抗体治疗癌症的联合疗法
US11833214B2 (en) * 2019-03-21 2023-12-05 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
PE20220568A1 (es) 2019-05-21 2022-04-20 Novartis Ag Moleculas de union a cd19 y usos de las mismas
EP3972993A1 (en) 2019-05-21 2022-03-30 Novartis AG Variant cd58 domains and uses thereof
CA3154192A1 (en) 2019-10-10 2021-04-15 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy
CN110922482B (zh) * 2019-12-25 2021-08-31 源道隆（苏州）医学科技有限公司 可结合cd19的多肽及其应用
CN112794911B (zh) * 2021-04-14 2021-08-03 上海偌妥生物科技有限公司 人源化抗叶酸受体1抗体及其应用
CN113908589B (zh) * 2021-10-08 2022-09-27 天津工业大学 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法
AU2023370106A1 (en) 2022-10-25 2025-05-08 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy for the treatment of cancer
EP4473974A1 (en) 2023-06-07 2024-12-11 Peptomyc, S.L. Omomyc and kras inhibitors combination therapy for the treatment of cancer
TW202513088A (zh) 2023-06-07 2025-04-01 瓦爾希伯倫私人腫瘤研究基金會 用於治療癌症的與ｍｅｋ抑制劑的組合療法
KR20260020418A (ko) 2023-06-07 2026-02-11 펀다시오 프리바다 인스티튜트 드인베스티가시오 온콜로지카 데 발 헤브론 Braf 저해제를 이용한 암 치료용 조합 요법
CN117659041A (zh) * 2023-12-08 2024-03-08 联宁（苏州）生物制药有限公司 用于抗体偶联药物的氘代蒽环类毒素连接子及其合成方法和应用
KR20250146159A (ko) * 2024-03-29 2025-10-13 진메디신 주식회사 약물 및 항체를 연결하는 링커 화합물 및 이를 이용한 항체-약물 복합체

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508638A (ja) * 1991-09-27 1994-09-29 ファイザー　インク． 変性ペプチド誘導体
US20100129314A1 (en) * 2008-04-30 2010-05-27 Immunogen Inc. Potent conjugates and hydrophilic linkers
JP2011503000A (ja) * 2007-11-02 2011-01-27 セントコア・オーソ・バイオテツク・インコーポレーテツド 半合成ＧＬＰ−１ペプチド−Ｆｃ融合コンストラクト、その方法及び使用
JP2014506892A (ja) * 2011-02-15 2014-03-20 イミュノジェン・インコーポレーテッド 複合体の調製方法
JP2015523961A (ja) * 2012-05-01 2015-08-20 ジェネンテック， インコーポレイテッド 抗ｐｍｅｌ１７抗体および免疫複合体

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2801904B1 (fr) 1999-12-07 2002-02-08 Pasteur Institut Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn
CA2499496C (fr) 2002-09-19 2012-04-24 Centre National De La Recherche Scientifique - Cnrs Synthese et caracterisation de nouveaux systemes de guidage et de vectorisation de molecules d'interet therapeutique vers des cellules cibles
EA008866B1 (ru) 2002-12-26 2007-08-31 Маунтин Вью Фамэсьютикэлс, Инк. ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ
GB0305704D0 (en) 2003-03-13 2003-04-16 Amersham Plc Radiofluorination methods
KR20120064120A (ko) 2004-06-01 2012-06-18 제넨테크, 인크. 항체 약물 접합체 및 방법
WO2006042848A2 (en) 2004-10-18 2006-04-27 Novo Nordisk A/S Growth hormone conjugates
CA2600749C (en) 2005-03-10 2014-04-15 Nascacell Ip Gmbh Dimeric or multimeric microproteins
EP1877100A2 (en) 2005-04-25 2008-01-16 GE Healthcare AS Liposomes
JP4938263B2 (ja) * 2005-08-19 2012-05-23 独立行政法人農業生物資源研究所 一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用
WO2007048127A2 (en) 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
FR2897616B1 (fr) 2006-02-20 2008-05-30 Univ Grenoble 1 Presentation de motifs de reconnaissance par une matrice multivalente greffee sur un support solide
US7985783B2 (en) * 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
DK2474557T3 (da) 2007-07-16 2014-11-10 Genentech Inc Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
RU2476441C2 (ru) 2007-10-19 2013-02-27 Сиэтл Дженетикс, Инк. Cd19-связывающие средства и их применение
CN103037900B (zh) * 2010-02-24 2016-04-06 伊缪诺金公司 叶酸受体1抗体与免疫缀合物以及其用途
US9381058B2 (en) * 2010-11-05 2016-07-05 Ethicon Endo-Surgery, Llc Recharge system for medical devices
EP2855521A4 (en) * 2012-05-24 2016-03-02 Mountgate Group Ltd COMPOSITIONS AND METHODS RELATED TO PREVENTING AND TREATING TOLL WUTINFECTION
JP6310909B2 (ja) 2012-06-06 2018-04-11 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ 免疫原及び投薬反応物として使用するためのウイルスタンパク質に由来するペプチド
US9834597B2 (en) 2012-09-21 2017-12-05 The Regents Of The University Of California Modified FC polypeptides, FC conjugates, and methods of use thereof
EP3300108B1 (en) * 2013-03-28 2019-07-24 Toshiba Hokuto Electronics Corporation Light emitting device and method for manufacturing the same
EP3001813B1 (en) 2013-05-13 2019-03-27 Vision Global Holdings Ltd. Pharmaceutical composition comprising modified hemoglobin- based therapeutic agent for cancer targeting treatment and diagnostic imaging
AU2014312086B2 (en) * 2013-08-30 2020-03-12 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
WO2015079376A1 (en) 2013-11-26 2015-06-04 Novartis Ag Methods for oxime conjugation to ketone-modified polypeptides
TW201609152A (zh) 2014-09-03 2016-03-16 免疫原公司 包含細胞結合劑及細胞毒性劑之偶聯物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508638A (ja) * 1991-09-27 1994-09-29 ファイザー　インク． 変性ペプチド誘導体
JP2011503000A (ja) * 2007-11-02 2011-01-27 セントコア・オーソ・バイオテツク・インコーポレーテツド 半合成ＧＬＰ−１ペプチド−Ｆｃ融合コンストラクト、その方法及び使用
US20100129314A1 (en) * 2008-04-30 2010-05-27 Immunogen Inc. Potent conjugates and hydrophilic linkers
JP2014506892A (ja) * 2011-02-15 2014-03-20 イミュノジェン・インコーポレーテッド 複合体の調製方法
JP2015523961A (ja) * 2012-05-01 2015-08-20 ジェネンテック， インコーポレイテッド 抗ｐｍｅｌ１７抗体および免疫複合体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017527563A (ja) * 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞障害性ベンゾジアゼピン誘導体
JP2019511462A (ja) * 2016-02-05 2019-04-25 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｇｃｃ標的化抗体−薬物コンジュゲート
JP2021510694A (ja) * 2018-01-12 2021-04-30 イミュノジェン， インコーポレイテッド 抗体薬物のコンジュゲーション、精製、及び製剤のための方法
JP7474195B2 (ja) 2018-01-12 2024-04-24 イミュノジェン， インコーポレイテッド 抗体薬物のコンジュゲーション、精製、及び製剤のための方法

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