JP2017526753A5 - - Google Patents
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- Publication number
- JP2017526753A5 JP2017526753A5 JP2016571093A JP2016571093A JP2017526753A5 JP 2017526753 A5 JP2017526753 A5 JP 2017526753A5 JP 2016571093 A JP2016571093 A JP 2016571093A JP 2016571093 A JP2016571093 A JP 2016571093A JP 2017526753 A5 JP2017526753 A5 JP 2017526753A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- peo
- alkyl
- icg
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 239000007850 fluorescent dye Substances 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 239000000693 micelle Substances 0.000 claims 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical group [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 claims 3
- 229960004657 indocyanine green Drugs 0.000 claims 3
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000000975 dye Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000000295 emission spectrum Methods 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 210000005167 vascular cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009019P | 2014-06-06 | 2014-06-06 | |
| US62/009,019 | 2014-06-06 | ||
| PCT/US2015/034575 WO2015188157A1 (en) | 2014-06-06 | 2015-06-05 | Library of ph responsive polymers and nanoprobes thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526753A JP2017526753A (ja) | 2017-09-14 |
| JP2017526753A5 true JP2017526753A5 (enExample) | 2018-07-19 |
| JP6598161B2 JP6598161B2 (ja) | 2019-10-30 |
Family
ID=54767484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571093A Expired - Fee Related JP6598161B2 (ja) | 2014-06-06 | 2015-06-05 | ｐＨ応答性ポリマーのライブラリー及びそのナノプローブ |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10098971B2 (enExample) |
| EP (1) | EP3151867A4 (enExample) |
| JP (1) | JP6598161B2 (enExample) |
| KR (1) | KR20170029430A (enExample) |
| CN (1) | CN106573076A (enExample) |
| AU (1) | AU2015269068A1 (enExample) |
| CA (1) | CA2951180A1 (enExample) |
| IL (1) | IL249363A0 (enExample) |
| MX (1) | MX2016016135A (enExample) |
| SG (1) | SG11201610180YA (enExample) |
| WO (1) | WO2015188157A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015269068A1 (en) * | 2014-06-06 | 2016-12-22 | The Board Of Regents Of The University Of Texas System | Library of pH responsive polymers and nanoprobes thereof |
| AU2017225769B2 (en) * | 2016-03-02 | 2023-01-05 | The Board Of Regents Of The University Of Texas System | Sting activating nanovaccine for immunotherapy |
| CN107389636B (zh) * | 2017-07-13 | 2019-09-10 | 湖南科技大学 | 一种可检测内源性谷胱甘肽的荧光传感器的制备及应用 |
| US20200333357A1 (en) * | 2017-11-13 | 2020-10-22 | The Board Of Regents Of The University Of Texas System | Novel tfeb pathway agonists for metabolic diseases and ageing |
| WO2019126144A1 (en) * | 2017-12-22 | 2019-06-27 | North Carolina State University | Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same |
| BR102018007667A2 (pt) * | 2018-04-16 | 2019-10-29 | Mendes Alves Pereira Ricardo | dispositivo, sistema e processo de armazenamento de dados clínicos-cirúrgicos |
| CN110856750B (zh) * | 2018-08-16 | 2024-01-19 | 北京大学 | pH敏感缀合物、胶束及其制备方法和用途 |
| AU2019339428A1 (en) * | 2018-09-15 | 2021-04-08 | The Board Of Regents Of The University Of Texas System | Dual modality ups nanoprobes for tumor acidosis imaging |
| CN114144399A (zh) * | 2019-05-28 | 2022-03-04 | 德克萨斯大学系统董事会 | pH响应性组合物及其用途 |
| CN110201189B (zh) * | 2019-06-03 | 2021-12-07 | 沈阳药科大学 | 白蛋白结合型近红外荧光染料-马来酰亚胺共轭物 |
| JP7676331B2 (ja) * | 2019-06-22 | 2025-05-14 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 生分解性超ｐＨ感受性ポリマー |
| CN110272539B (zh) * | 2019-07-04 | 2021-09-17 | 广东工业大学 | 一种用于结合pmsa的配体缀合物、探针及其制备方法和应用 |
| CN110551263B (zh) * | 2019-09-05 | 2021-09-24 | 华南师范大学 | 一种多嵌段聚合物及其合成方法和肿瘤检测用荧光探针 |
| CA3159915A1 (en) * | 2019-11-04 | 2021-05-14 | Onconano Medicine, Inc. | Ph responsive block copolymer compositions, micelles, and methods of use |
| AU2020387279A1 (en) * | 2019-11-18 | 2022-06-02 | Onconano Medicine, Inc. | pH responsive compositions, formulations, and methods of imaging a tumor |
| US11928193B2 (en) | 2019-12-10 | 2024-03-12 | Winkk, Inc. | Multi-factor authentication using behavior and machine learning |
| CN111159932B (zh) * | 2019-12-10 | 2022-09-27 | 中国船舶重工集团公司第七一九研究所 | 一种针对Mullins效应参数的优化反演方法 |
| CN111154118B (zh) * | 2020-01-19 | 2022-12-16 | 浙江理工大学 | 一种具有不同长径比的单晶聚合物胶束及其制备方法 |
| EP4162445A4 (en) * | 2020-06-09 | 2024-07-10 | Temasek Life Sciences Laboratory Limited | AUTOMATED DISEASE DETECTION SYSTEM |
| CN113916844A (zh) * | 2020-07-08 | 2022-01-11 | 长春工业大学 | 一种蓝红光双发射纳米杂化探针的制备方法及其在离子检测中的应用 |
| US20250127921A1 (en) * | 2021-08-10 | 2025-04-24 | Wisconsin Alumni Research Foundation | Ph-responsive nano particle for delivery of ribonucleoproteins |
| CN115785346B (zh) * | 2022-01-20 | 2025-07-18 | 北京大学 | 含非pH敏感型单体的pH敏感聚合物的合成及应用 |
| CN115337398B (zh) * | 2022-09-07 | 2023-09-12 | 大连理工大学 | 一种atp响应的用于肿瘤化疗与光动力联合治疗的纳米药物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020028474A1 (en) * | 1996-09-19 | 2002-03-07 | Daiichi Pure Chemical Co., Ltd. | Composition for immunohistochemical staining |
| CA2459724C (en) * | 2001-09-04 | 2011-02-15 | Texas Tech University System | Multi-use multimodal imaging chelates |
| WO2007141050A2 (de) * | 2006-06-08 | 2007-12-13 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste polymernanopartikel für diagnostische und therapeutische anwendungen |
| WO2010029760A1 (en) * | 2008-09-12 | 2010-03-18 | Nitto Denko Corporation | Imaging agents of fibrotic diseases |
| EP2522366B1 (en) * | 2010-01-08 | 2018-10-31 | FUJIFILM Corporation | Targeting agent for tumor site |
| WO2012040513A1 (en) | 2010-09-22 | 2012-03-29 | The Board Of Regents Of The University Of Texas System | Compositions and methods for the delivery of beta lapachone |
| WO2012039855A1 (en) * | 2010-09-22 | 2012-03-29 | The Board Of Regents Of The University Of Texas System | Ph-sensitive compositions for delivery of beta lapachone and methods of use |
| US9511152B2 (en) * | 2012-04-05 | 2016-12-06 | The Board Of Regents Of The University Of Texas System | Multicolored pH-activatable fluorescence nanoplatform |
| AU2015269068A1 (en) * | 2014-06-06 | 2016-12-22 | The Board Of Regents Of The University Of Texas System | Library of pH responsive polymers and nanoprobes thereof |
-
2015
- 2015-06-05 AU AU2015269068A patent/AU2015269068A1/en not_active Abandoned
- 2015-06-05 CA CA2951180A patent/CA2951180A1/en not_active Abandoned
- 2015-06-05 SG SG11201610180YA patent/SG11201610180YA/en unknown
- 2015-06-05 CN CN201580042073.XA patent/CN106573076A/zh active Pending
- 2015-06-05 WO PCT/US2015/034575 patent/WO2015188157A1/en not_active Ceased
- 2015-06-05 KR KR1020167035901A patent/KR20170029430A/ko not_active Withdrawn
- 2015-06-05 MX MX2016016135A patent/MX2016016135A/es unknown
- 2015-06-05 JP JP2016571093A patent/JP6598161B2/ja not_active Expired - Fee Related
- 2015-06-05 EP EP15803416.5A patent/EP3151867A4/en not_active Withdrawn
-
2016
- 2016-12-04 IL IL249363A patent/IL249363A0/en unknown
- 2016-12-05 US US15/369,701 patent/US10098971B2/en active Active
-
2018
- 2018-08-27 US US16/114,187 patent/US11013818B2/en active Active
-
2021
- 2021-04-15 US US17/231,922 patent/US11723990B2/en active Active
-
2023
- 2023-08-14 US US18/449,675 patent/US20240115741A1/en active Pending
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