JP2015007118A5 - - Google Patents
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- Publication number
- JP2015007118A5 JP2015007118A5 JP2014183841A JP2014183841A JP2015007118A5 JP 2015007118 A5 JP2015007118 A5 JP 2015007118A5 JP 2014183841 A JP2014183841 A JP 2014183841A JP 2014183841 A JP2014183841 A JP 2014183841A JP 2015007118 A5 JP2015007118 A5 JP 2015007118A5
- Authority
- JP
- Japan
- Prior art keywords
- ether compound
- phospholipid ether
- diagnostic composition
- fluorescent phospholipid
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 28
- -1 phospholipid ether compound Chemical class 0.000 claims 28
- 238000000034 method Methods 0.000 claims 21
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 17
- 230000003211 malignant effect Effects 0.000 claims 10
- 210000001519 tissue Anatomy 0.000 claims 10
- 210000000130 stem cell Anatomy 0.000 claims 8
- 238000009825 accumulation Methods 0.000 claims 7
- 230000001575 pathological effect Effects 0.000 claims 7
- 238000003384 imaging method Methods 0.000 claims 3
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 210000000683 abdominal cavity Anatomy 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 210000001953 common bile duct Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001198 duodenum Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000000115 thoracic cavity Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 0 C=NNc(cc1)ccc1C(C1=CC=C*1*1(N)N)=C2*1=CC=C2 Chemical compound C=NNc(cc1)ccc1C(C1=CC=C*1*1(N)N)=C2*1=CC=C2 0.000 description 1
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/463,990 | 2009-05-11 | ||
| US12/463,983 | 2009-05-11 | ||
| US12/463,978 | 2009-05-11 | ||
| US12/463,990 US20100284930A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of skin cancers using phospholipid ether compounds |
| US12/463,970 | 2009-05-11 | ||
| US12/463,970 US7811548B1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds and compositions |
| US12/463,978 US20100284929A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of tumors using phospholipid ether compounds |
| US12/463,998 US20100284931A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US12/463,998 | 2009-05-11 | ||
| US12/463,983 US20100286510A1 (en) | 2009-05-11 | 2009-05-11 | Use of fluorescent phospholipid ether compounds in biopsies |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510929A Division JP5702366B2 (ja) | 2009-05-11 | 2010-05-11 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098391A Division JP6073961B2 (ja) | 2009-05-11 | 2015-05-13 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2016089336A Division JP2016193907A (ja) | 2009-05-11 | 2016-04-27 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015007118A JP2015007118A (ja) | 2015-01-15 |
| JP2015007118A5 true JP2015007118A5 (enExample) | 2015-07-02 |
| JP6006271B2 JP6006271B2 (ja) | 2016-10-12 |
Family
ID=43085298
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510929A Active JP5702366B2 (ja) | 2009-05-11 | 2010-05-11 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2014183841A Active JP6006271B2 (ja) | 2009-05-11 | 2014-09-10 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2015098391A Active JP6073961B2 (ja) | 2009-05-11 | 2015-05-13 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2016089336A Pending JP2016193907A (ja) | 2009-05-11 | 2016-04-27 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510929A Active JP5702366B2 (ja) | 2009-05-11 | 2010-05-11 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098391A Active JP6073961B2 (ja) | 2009-05-11 | 2015-05-13 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2016089336A Pending JP2016193907A (ja) | 2009-05-11 | 2016-04-27 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9616140B2 (enExample) |
| EP (1) | EP2429591B1 (enExample) |
| JP (4) | JP5702366B2 (enExample) |
| ES (1) | ES2549459T3 (enExample) |
| WO (1) | WO2010132428A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2429591B1 (en) * | 2009-05-11 | 2015-08-26 | Cellectar, Inc. | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| JP6092624B2 (ja) | 2009-06-12 | 2017-03-08 | セレクター，インコーポレイティド | 癌の治療並びに癌幹細胞の造影および検出のためのエーテルおよびアルキルリン脂質化合物 |
| JP2013032297A (ja) * | 2011-08-01 | 2013-02-14 | Univ Of Tsukuba | バイオイメージングのための近赤外発光物質及びその合成方法 |
| JP6260259B2 (ja) * | 2013-12-24 | 2018-01-17 | 日油株式会社 | ボロン酸含有ホスホリルコリン化合物及びその製造方法、並びにヨード基含有化合物修飾剤 |
| WO2016081203A2 (en) * | 2014-11-17 | 2016-05-26 | Cellectar Biosciences, Inc. | Phospholipid ether analogs as cancer-targeting drug vehicles |
| CN108430520B (zh) | 2015-11-06 | 2021-08-13 | 威斯康星校友研究基金会 | 长效钆基肿瘤靶向成像与治疗剂 |
| ES2952867T3 (es) * | 2016-06-14 | 2023-11-06 | Cellectar Biosciences Inc | Análogos de éteres de fosfolípidos para la identificación y aislamiento de células tumorales circulantes |
| KR102148067B1 (ko) * | 2016-09-02 | 2020-08-26 | 주식회사 엘지화학 | 화합물 및 이를 포함하는 색변환필름 |
| JP2020066637A (ja) * | 2017-02-27 | 2020-04-30 | 富士フイルム株式会社 | 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素 |
| JP6495989B1 (ja) | 2017-10-02 | 2019-04-03 | 株式会社アマダホールディングス | プログラム作成装置、溶接システム、及びプログラム作成方法 |
| WO2019230963A1 (ja) | 2018-06-01 | 2019-12-05 | 富士フイルム株式会社 | 蛍光性化合物及びこれを用いた蛍光標識生体物質 |
| CA3154192A1 (en) | 2019-10-10 | 2021-04-15 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| KR102400464B1 (ko) * | 2020-07-28 | 2022-05-19 | 부산대학교 산학협력단 | 암 줄기세포 검출용 바이오 마커 조성물 |
| JP7423855B2 (ja) * | 2020-09-05 | 2024-01-29 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | フォトニックインクとしての熱応答性自己組織化有機材料及びその製造方法 |
| CN114957330A (zh) * | 2022-07-06 | 2022-08-30 | 南京师范大学 | 一种新型花菁染料中间体及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925649A (en) | 1987-06-12 | 1990-05-15 | The University Of Michigan | Radioiodinated diacylglycerol analogues and methods of use |
| US4965391A (en) | 1987-10-23 | 1990-10-23 | The University Of Michigan | Radioiodinated phospholipid ether analogues |
| US5087721A (en) | 1987-10-23 | 1992-02-11 | The University Of Michigan | Radioiodinated phosphate esters |
| US5347030A (en) | 1987-10-23 | 1994-09-13 | The Board Of Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogues and methods of using same |
| US5369097A (en) | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| US5728529A (en) * | 1995-06-23 | 1998-03-17 | Baylor College Of Medicine | Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis |
| US5626654A (en) | 1995-12-05 | 1997-05-06 | Xerox Corporation | Ink compositions containing liposomes |
| CA2276284C (en) | 1996-12-04 | 2006-10-10 | The Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US6255519B1 (en) | 1996-12-04 | 2001-07-03 | Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US5830701A (en) * | 1997-03-28 | 1998-11-03 | Tao Medical Electronics Co., Ltd. | Method of detecting hematopoietic progenitor cells |
| US6939985B1 (en) | 1997-04-09 | 2005-09-06 | Commonwealth Scientific And Industrial Research Organisation | Aryl borates |
| US7385038B2 (en) * | 2002-07-18 | 2008-06-10 | Protein Express Co., Ltd. | Non-natural labeled amino acid and method of constructing amino acid/tRNA complex |
| JP4004385B2 (ja) * | 2002-11-07 | 2007-11-07 | 独立行政法人科学技術振興機構 | 二重染色法によるガン検出方法 |
| US7829742B2 (en) | 2003-12-22 | 2010-11-09 | Johns Hopkins University | Boronic acid aryl analogs |
| WO2006014589A2 (en) | 2004-07-08 | 2006-02-09 | Cellectar, Llc | Virtual colonoscopy with radiolabeled phospholipid ether analogs |
| US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| AU2005219412A1 (en) | 2004-03-02 | 2005-09-15 | Cellectar, Inc. | Phospholipid analogs for diagnosis and treatment of cancer |
| US7041859B1 (en) | 2004-09-09 | 2006-05-09 | University Of Tennessee Research Foundation | Method for halogenating or radiohalogenating a chemical compound |
| EP1833514A2 (en) * | 2004-12-20 | 2007-09-19 | Cellectar, Llc | Phospholipid ether analogs for detecting and treating cancer |
| JP2007143624A (ja) * | 2005-11-24 | 2007-06-14 | Hamamatsu Photonics Kk | 蛍光観察装置 |
| US20070297988A1 (en) * | 2006-06-21 | 2007-12-27 | Bin Wu | Optical probes for in vivo imaging |
| CA2660778A1 (en) * | 2006-08-15 | 2009-01-08 | Cellectar, Inc. | Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications |
| WO2008150439A1 (en) | 2007-06-01 | 2008-12-11 | Cellectar, Inc. | Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use |
| ES2326458B1 (es) * | 2008-04-04 | 2010-07-26 | Consejo Superior De Investigaciones Cientificas (Csic) (85%) | Compuestos fluorescentes para diagnostico de infecciones, procedimiento de obtencion y sus aplicaciones. |
| US20100286510A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Use of fluorescent phospholipid ether compounds in biopsies |
| US20100284931A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US20100284929A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent imaging of tumors using phospholipid ether compounds |
| US8871181B2 (en) | 2009-05-11 | 2014-10-28 | Cellectar, Inc. | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| EP2429591B1 (en) * | 2009-05-11 | 2015-08-26 | Cellectar, Inc. | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US20100284930A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent imaging of skin cancers using phospholipid ether compounds |
| US7811548B1 (en) | 2009-05-11 | 2010-10-12 | Cellectar, Inc. | Fluorescent phospholipid ether compounds and compositions |
| JP6092624B2 (ja) | 2009-06-12 | 2017-03-08 | セレクター，インコーポレイティド | 癌の治療並びに癌幹細胞の造影および検出のためのエーテルおよびアルキルリン脂質化合物 |
-
2010
- 2010-05-11 EP EP10775385.7A patent/EP2429591B1/en active Active
- 2010-05-11 WO PCT/US2010/034361 patent/WO2010132428A1/en not_active Ceased
- 2010-05-11 JP JP2012510929A patent/JP5702366B2/ja active Active
- 2010-05-11 ES ES10775385.7T patent/ES2549459T3/es active Active
-
2014
- 2014-09-10 JP JP2014183841A patent/JP6006271B2/ja active Active
- 2014-09-23 US US14/493,489 patent/US9616140B2/en active Active
-
2015
- 2015-05-13 JP JP2015098391A patent/JP6073961B2/ja active Active
-
2016
- 2016-04-27 JP JP2016089336A patent/JP2016193907A/ja active Pending
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