ES2549459T3 - Compuestos de éter de fosfolípido fluorescentes, composiciones y procedimientos de uso - Google Patents
Compuestos de éter de fosfolípido fluorescentes, composiciones y procedimientos de uso Download PDFInfo
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- ES2549459T3 ES2549459T3 ES10775385.7T ES10775385T ES2549459T3 ES 2549459 T3 ES2549459 T3 ES 2549459T3 ES 10775385 T ES10775385 T ES 10775385T ES 2549459 T3 ES2549459 T3 ES 2549459T3
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- fluorescent phospholipid
- compound
- malignant
- fluorescent
- tissue
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Endoscopes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (11)
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| US12/463,983 US20100286510A1 (en) | 2009-05-11 | 2009-05-11 | Use of fluorescent phospholipid ether compounds in biopsies |
| US12/463,970 US7811548B1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds and compositions |
| US12/463,990 US20100284930A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of skin cancers using phospholipid ether compounds |
| US463970 | 2009-05-11 | ||
| US463998 | 2009-05-11 | ||
| US12/463,978 US20100284929A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of tumors using phospholipid ether compounds |
| US463990 | 2009-05-11 | ||
| US463983 | 2009-05-11 | ||
| US463978 | 2009-05-11 | ||
| US12/463,998 US20100284931A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| PCT/US2010/034361 WO2010132428A1 (en) | 2009-05-11 | 2010-05-11 | Fluorescent phospholipid ether compounds, compositions, and methods of use |
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| WO2010132428A1 (en) * | 2009-05-11 | 2010-11-18 | Cellectar, Inc. | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| DK3708192T3 (da) * | 2009-06-12 | 2023-11-06 | Cellectar Inc | Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller |
| JP2013032297A (ja) * | 2011-08-01 | 2013-02-14 | Univ Of Tsukuba | バイオイメージングのための近赤外発光物質及びその合成方法 |
| JP6260259B2 (ja) * | 2013-12-24 | 2018-01-17 | 日油株式会社 | ボロン酸含有ホスホリルコリン化合物及びその製造方法、並びにヨード基含有化合物修飾剤 |
| EP3750545B1 (en) * | 2014-11-17 | 2024-03-27 | Cellectar Biosciences, Inc. | Phospholipid ether analogs as cancer-targeting drug vehicles |
| US10265398B2 (en) * | 2015-11-06 | 2019-04-23 | Wisconsin Alumni Research Foundation | Long-lived gadolinium based tumor targeted imaging and therapy agents |
| AU2017286604B2 (en) * | 2016-06-14 | 2023-05-18 | Cellectar Biosciences, Inc. | Phospholipid ether analogs for the identification and isolation of circulating tumor cells |
| KR102148067B1 (ko) * | 2016-09-02 | 2020-08-26 | 주식회사 엘지화학 | 화합물 및 이를 포함하는 색변환필름 |
| JP2020066637A (ja) * | 2017-02-27 | 2020-04-30 | 富士フイルム株式会社 | 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素 |
| JP6495989B1 (ja) | 2017-10-02 | 2019-04-03 | 株式会社アマダホールディングス | プログラム作成装置、溶接システム、及びプログラム作成方法 |
| CN112272556B (zh) | 2018-04-10 | 2023-12-19 | 塞勒科塔生物科学公司 | 磷脂-flavagline缀合物及将其用于靶向癌症治疗的方法 |
| CN112204039A (zh) | 2018-06-01 | 2021-01-08 | 富士胶片株式会社 | 荧光性化合物及使用了该荧光性化合物的荧光标记生物物质 |
| JP7631329B2 (ja) | 2019-10-10 | 2025-02-18 | セレクター・バイオサイエンシズ・インコーポレイテッド | リン脂質－フラバグリン抱合体及び標的化されたがん治療のためのリン脂質－フラバグリン抱合体の使用方法 |
| KR102400464B1 (ko) * | 2020-07-28 | 2022-05-19 | 부산대학교 산학협력단 | 암 줄기세포 검출용 바이오 마커 조성물 |
| EP4168501B1 (en) * | 2020-09-05 | 2025-12-17 | Council Of Scientific & Industrial Research | A thermoresponsive self-assembled organic material as photonic ink and a process of making thereof |
| CN114957330A (zh) * | 2022-07-06 | 2022-08-30 | 南京师范大学 | 一种新型花菁染料中间体及其制备方法 |
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| US4925649A (en) | 1987-06-12 | 1990-05-15 | The University Of Michigan | Radioiodinated diacylglycerol analogues and methods of use |
| US5087721A (en) | 1987-10-23 | 1992-02-11 | The University Of Michigan | Radioiodinated phosphate esters |
| US4965391A (en) | 1987-10-23 | 1990-10-23 | The University Of Michigan | Radioiodinated phospholipid ether analogues |
| US5347030A (en) | 1987-10-23 | 1994-09-13 | The Board Of Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogues and methods of using same |
| US5369097A (en) | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| US5728529A (en) * | 1995-06-23 | 1998-03-17 | Baylor College Of Medicine | Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis |
| US5626654A (en) | 1995-12-05 | 1997-05-06 | Xerox Corporation | Ink compositions containing liposomes |
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2010
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- 2010-05-11 ES ES10775385.7T patent/ES2549459T3/es active Active
- 2010-05-11 EP EP10775385.7A patent/EP2429591B1/en active Active
- 2010-05-11 JP JP2012510929A patent/JP5702366B2/ja active Active
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2015
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| US20150044142A1 (en) | 2015-02-12 |
| JP5702366B2 (ja) | 2015-04-15 |
| EP2429591A1 (en) | 2012-03-21 |
| JP2015166372A (ja) | 2015-09-24 |
| EP2429591A4 (en) | 2013-02-20 |
| WO2010132428A1 (en) | 2010-11-18 |
| JP2012526822A (ja) | 2012-11-01 |
| JP2016193907A (ja) | 2016-11-17 |
| JP6073961B2 (ja) | 2017-02-01 |
| JP6006271B2 (ja) | 2016-10-12 |
| JP2015007118A (ja) | 2015-01-15 |
| US9616140B2 (en) | 2017-04-11 |
| EP2429591B1 (en) | 2015-08-26 |
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