JP5702366B2 - 蛍光リン脂質エーテル化合物、組成物、及びその使用 - Google Patents

蛍光リン脂質エーテル化合物、組成物、及びその使用 Download PDF

Info

Publication number
JP5702366B2
JP5702366B2 JP2012510929A JP2012510929A JP5702366B2 JP 5702366 B2 JP5702366 B2 JP 5702366B2 JP 2012510929 A JP2012510929 A JP 2012510929A JP 2012510929 A JP2012510929 A JP 2012510929A JP 5702366 B2 JP5702366 B2 JP 5702366B2
Authority
JP
Japan
Prior art keywords
fluorescent phospholipid
ether compound
phospholipid ether
tissue
fluorescent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012510929A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012526822A (ja
JP2012526822A5 (enExample
Inventor
ピンチュク アナトリー
ピンチュク アナトリー
ピー．ウェイチャート ジェイミー
ピー．ウェイチャート ジェイミー
ロンギーノ マルク
ロンギーノ マルク
カンデラ イラワティ
カンデラ イラワティ
アール．クラーク ウィリアム
アール．クラーク ウィリアム
Original Assignee
セレクター，インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/463,983 external-priority patent/US20100286510A1/en
Priority claimed from US12/463,970 external-priority patent/US7811548B1/en
Priority claimed from US12/463,990 external-priority patent/US20100284930A1/en
Priority claimed from US12/463,978 external-priority patent/US20100284929A1/en
Priority claimed from US12/463,998 external-priority patent/US20100284931A1/en
Application filed by セレクター，インコーポレイティド filed Critical セレクター，インコーポレイティド
Publication of JP2012526822A publication Critical patent/JP2012526822A/ja
Publication of JP2012526822A5 publication Critical patent/JP2012526822A5/ja
Application granted granted Critical
Publication of JP5702366B2 publication Critical patent/JP5702366B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Endoscopes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012510929A 2009-05-11 2010-05-11 蛍光リン脂質エーテル化合物、組成物、及びその使用 Active JP5702366B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US12/463,983 US20100286510A1 (en) 2009-05-11 2009-05-11 Use of fluorescent phospholipid ether compounds in biopsies
US12/463,970 US7811548B1 (en) 2009-05-11 2009-05-11 Fluorescent phospholipid ether compounds and compositions
US12/463,990 2009-05-11
US12/463,998 2009-05-11
US12/463,978 2009-05-11
US12/463,990 US20100284930A1 (en) 2009-05-11 2009-05-11 Fluorescent imaging of skin cancers using phospholipid ether compounds
US12/463,970 2009-05-11
US12/463,983 2009-05-11
US12/463,978 US20100284929A1 (en) 2009-05-11 2009-05-11 Fluorescent imaging of tumors using phospholipid ether compounds
US12/463,998 US20100284931A1 (en) 2009-05-11 2009-05-11 Fluorescent phospholipid ether compounds, compositions, and methods of use
PCT/US2010/034361 WO2010132428A1 (en) 2009-05-11 2010-05-11 Fluorescent phospholipid ether compounds, compositions, and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014183841A Division JP6006271B2 (ja) 2009-05-11 2014-09-10 蛍光リン脂質エーテル化合物、組成物、及びその使用

Publications (3)

Publication Number Publication Date
JP2012526822A JP2012526822A (ja) 2012-11-01
JP2012526822A5 JP2012526822A5 (enExample) 2013-06-27
JP5702366B2 true JP5702366B2 (ja) 2015-04-15

Family

ID=43085298

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012510929A Active JP5702366B2 (ja) 2009-05-11 2010-05-11 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2014183841A Active JP6006271B2 (ja) 2009-05-11 2014-09-10 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2015098391A Active JP6073961B2 (ja) 2009-05-11 2015-05-13 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2016089336A Pending JP2016193907A (ja) 2009-05-11 2016-04-27 蛍光リン脂質エーテル化合物、組成物、及びその使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2014183841A Active JP6006271B2 (ja) 2009-05-11 2014-09-10 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2015098391A Active JP6073961B2 (ja) 2009-05-11 2015-05-13 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2016089336A Pending JP2016193907A (ja) 2009-05-11 2016-04-27 蛍光リン脂質エーテル化合物、組成物、及びその使用

Country Status (5)

Country Link
US (1) US9616140B2 (enExample)
EP (1) EP2429591B1 (enExample)
JP (4) JP5702366B2 (enExample)
ES (1) ES2549459T3 (enExample)
WO (1) WO2010132428A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015166372A (ja) * 2009-05-11 2015-09-24 セレクター，インコーポレイティド 蛍光リン脂質エーテル化合物、組成物、及びその使用
WO2022025625A1 (ko) * 2020-07-28 2022-02-03 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3708192T3 (da) * 2009-06-12 2023-11-06 Cellectar Inc Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller
JP2013032297A (ja) * 2011-08-01 2013-02-14 Univ Of Tsukuba バイオイメージングのための近赤外発光物質及びその合成方法
JP6260259B2 (ja) * 2013-12-24 2018-01-17 日油株式会社 ボロン酸含有ホスホリルコリン化合物及びその製造方法、並びにヨード基含有化合物修飾剤
EP3750545B1 (en) * 2014-11-17 2024-03-27 Cellectar Biosciences, Inc. Phospholipid ether analogs as cancer-targeting drug vehicles
US10265398B2 (en) * 2015-11-06 2019-04-23 Wisconsin Alumni Research Foundation Long-lived gadolinium based tumor targeted imaging and therapy agents
AU2017286604B2 (en) * 2016-06-14 2023-05-18 Cellectar Biosciences, Inc. Phospholipid ether analogs for the identification and isolation of circulating tumor cells
KR102148067B1 (ko) * 2016-09-02 2020-08-26 주식회사 엘지화학 화합물 및 이를 포함하는 색변환필름
JP2020066637A (ja) * 2017-02-27 2020-04-30 富士フイルム株式会社 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素
JP6495989B1 (ja) 2017-10-02 2019-04-03 株式会社アマダホールディングス プログラム作成装置、溶接システム、及びプログラム作成方法
CN112272556B (zh) 2018-04-10 2023-12-19 塞勒科塔生物科学公司 磷脂-flavagline缀合物及将其用于靶向癌症治疗的方法
CN112204039A (zh) 2018-06-01 2021-01-08 富士胶片株式会社 荧光性化合物及使用了该荧光性化合物的荧光标记生物物质
JP7631329B2 (ja) 2019-10-10 2025-02-18 セレクター・バイオサイエンシズ・インコーポレイテッド リン脂質－フラバグリン抱合体及び標的化されたがん治療のためのリン脂質－フラバグリン抱合体の使用方法
EP4168501B1 (en) * 2020-09-05 2025-12-17 Council Of Scientific & Industrial Research A thermoresponsive self-assembled organic material as photonic ink and a process of making thereof
CN114957330A (zh) * 2022-07-06 2022-08-30 南京师范大学 一种新型花菁染料中间体及其制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925649A (en) 1987-06-12 1990-05-15 The University Of Michigan Radioiodinated diacylglycerol analogues and methods of use
US5087721A (en) 1987-10-23 1992-02-11 The University Of Michigan Radioiodinated phosphate esters
US4965391A (en) 1987-10-23 1990-10-23 The University Of Michigan Radioiodinated phospholipid ether analogues
US5347030A (en) 1987-10-23 1994-09-13 The Board Of Regents Of The University Of Michigan Radioiodinated phospholipid ether analogues and methods of using same
US5369097A (en) 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
US5728529A (en) * 1995-06-23 1998-03-17 Baylor College Of Medicine Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis
US5626654A (en) 1995-12-05 1997-05-06 Xerox Corporation Ink compositions containing liposomes
WO1998024480A1 (en) 1996-12-04 1998-06-11 The Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US6255519B1 (en) 1996-12-04 2001-07-03 Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US5830701A (en) * 1997-03-28 1998-11-03 Tao Medical Electronics Co., Ltd. Method of detecting hematopoietic progenitor cells
US6939985B1 (en) 1997-04-09 2005-09-06 Commonwealth Scientific And Industrial Research Organisation Aryl borates
US7385038B2 (en) * 2002-07-18 2008-06-10 Protein Express Co., Ltd. Non-natural labeled amino acid and method of constructing amino acid/tRNA complex
JP4004385B2 (ja) * 2002-11-07 2007-11-07 独立行政法人科学技術振興機構 二重染色法によるガン検出方法
WO2005063774A1 (en) 2003-12-22 2005-07-14 Johns Hopkins University Boronic acid aryl analogs
EP2044960B1 (en) 2004-03-02 2013-11-20 Cellectar, Inc. Phospholipid analogue for the in vivo diagnosis of cancers
US8540968B2 (en) * 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
EP1773408A2 (en) 2004-07-08 2007-04-18 Cellectar, Llc Virtual colonoscopy with radiolabeled phospholipid ether analogs
US7041859B1 (en) 2004-09-09 2006-05-09 University Of Tennessee Research Foundation Method for halogenating or radiohalogenating a chemical compound
MX2007007497A (es) * 2004-12-20 2008-01-11 Cellectar Llc Analogos de fosfolipido eter para la deteccion y tratamiento del cancer.
JP2007143624A (ja) * 2005-11-24 2007-06-14 Hamamatsu Photonics Kk 蛍光観察装置
US20070297988A1 (en) * 2006-06-21 2007-12-27 Bin Wu Optical probes for in vivo imaging
CA2660778A1 (en) * 2006-08-15 2009-01-08 Cellectar, Inc. Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications
WO2008150439A1 (en) 2007-06-01 2008-12-11 Cellectar, Inc. Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use
ES2326458B1 (es) * 2008-04-04 2010-07-26 Consejo Superior De Investigaciones Cientificas (Csic) (85%) Compuestos fluorescentes para diagnostico de infecciones, procedimiento de obtencion y sus aplicaciones.
US20100284929A1 (en) 2009-05-11 2010-11-11 Pinchuk Anatoly Fluorescent imaging of tumors using phospholipid ether compounds
US7811548B1 (en) 2009-05-11 2010-10-12 Cellectar, Inc. Fluorescent phospholipid ether compounds and compositions
US20100286510A1 (en) 2009-05-11 2010-11-11 Pinchuk Anatoly Use of fluorescent phospholipid ether compounds in biopsies
US20100284931A1 (en) 2009-05-11 2010-11-11 Pinchuk Anatoly Fluorescent phospholipid ether compounds, compositions, and methods of use
US20100284930A1 (en) 2009-05-11 2010-11-11 Pinchuk Anatoly Fluorescent imaging of skin cancers using phospholipid ether compounds
WO2010132428A1 (en) * 2009-05-11 2010-11-18 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
US8871181B2 (en) 2009-05-11 2014-10-28 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
DK3708192T3 (da) 2009-06-12 2023-11-06 Cellectar Inc Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015166372A (ja) * 2009-05-11 2015-09-24 セレクター，インコーポレイティド 蛍光リン脂質エーテル化合物、組成物、及びその使用
WO2022025625A1 (ko) * 2020-07-28 2022-02-03 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물
KR20220014003A (ko) * 2020-07-28 2022-02-04 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물

Also Published As

Publication number Publication date
US20150044142A1 (en) 2015-02-12
EP2429591A1 (en) 2012-03-21
JP2015166372A (ja) 2015-09-24
EP2429591A4 (en) 2013-02-20
WO2010132428A1 (en) 2010-11-18
JP2012526822A (ja) 2012-11-01
JP2016193907A (ja) 2016-11-17
JP6073961B2 (ja) 2017-02-01
JP6006271B2 (ja) 2016-10-12
JP2015007118A (ja) 2015-01-15
US9616140B2 (en) 2017-04-11
EP2429591B1 (en) 2015-08-26
ES2549459T3 (es) 2015-10-28

Similar Documents

Publication Publication Date Title
JP6073961B2 (ja) 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2022078023A (ja) 近赤外蛍光造影バイオイメージング剤及びその使用方法
JP3955093B2 (ja) 光化学治療における光増感剤としての５−アミノレブリン酸のエステル
CN111362971B (zh) 靶向psma的双苯并噻二唑类化合物及其制备方法与应用
CN107057398B (zh) 一种七甲川菁荧光染料及其肿瘤精准诊断和治疗的应用
US20100284929A1 (en) Fluorescent imaging of tumors using phospholipid ether compounds
US20100286510A1 (en) Use of fluorescent phospholipid ether compounds in biopsies
US7811548B1 (en) Fluorescent phospholipid ether compounds and compositions
US8871181B2 (en) Fluorescent phospholipid ether compounds, compositions, and methods of use
US20100284931A1 (en) Fluorescent phospholipid ether compounds, compositions, and methods of use
US20200390909A1 (en) Drug fragment imaging agent conjugates
JP5070549B2 (ja) 腫瘍選択的蛍光染色剤
JP2023525601A (ja) 腫瘍組織を標識するための新規蛍光化合物
US20170072072A1 (en) Ph sensitive fluorescent compounds and methods for tumor detection
US20100284930A1 (en) Fluorescent imaging of skin cancers using phospholipid ether compounds
CN116917419B (zh) 用于肿瘤检测和外科手术指导的化合物和组合物
CN115785437B (zh) 一种花菁素类探针化合物、其制备方法及应用
US20240181087A1 (en) Composition for contrast imaging of cancer
TW202330498A (zh) 用於腫瘤偵測及手術指引之化合物及組合物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130513

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130513

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20140424

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140513

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140813

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140820

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140910

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150120

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150219

R150 Certificate of patent or registration of utility model

Ref document number: 5702366

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250