JP2017526614A5 - - Google Patents
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- Publication number
- JP2017526614A5 JP2017526614A5 JP2016563838A JP2016563838A JP2017526614A5 JP 2017526614 A5 JP2017526614 A5 JP 2017526614A5 JP 2016563838 A JP2016563838 A JP 2016563838A JP 2016563838 A JP2016563838 A JP 2016563838A JP 2017526614 A5 JP2017526614 A5 JP 2017526614A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- cycloalkyl
- aryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(CC(*)(*)C(C)*C1)*(C)N1C([C@](*)NC(C1=CC=CC(C)(*)C=C1)=O)=O Chemical compound CC(CC(*)(*)C(C)*C1)*(C)N1C([C@](*)NC(C1=CC=CC(C)(*)C=C1)=O)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983146P | 2014-04-23 | 2014-04-23 | |
| US61/983,146 | 2014-04-23 | ||
| PCT/US2015/026811 WO2015175171A1 (en) | 2014-04-23 | 2015-04-21 | Substituted n-(2-(amino)-2-oxoethyl)benzamide inhibitors of autotaxin and their preparation and use in the treatment of lpa-dependent or lpa-mediated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019170253A Division JP2020007360A (ja) | 2014-04-23 | 2019-09-19 | オートタキシンの置換ｎ−（２−アミノ）−２−オキソエチルベンズアミド阻害剤およびそれらの調製、ならびにｌｐａ依存性またはｌｐａ媒介性疾患の処置における使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526614A JP2017526614A (ja) | 2017-09-14 |
| JP2017526614A5 true JP2017526614A5 (enExample) | 2018-05-24 |
| JP6592008B2 JP6592008B2 (ja) | 2019-10-16 |
Family
ID=54480420
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563838A Expired - Fee Related JP6592008B2 (ja) | 2014-04-23 | 2015-04-21 | オートタキシンの置換ｎ−（２−アミノ）−２−オキソエチルベンズアミド阻害剤およびそれらの調製、ならびにｌｐａ依存性またはｌｐａ媒介性疾患の処置における使用 |
| JP2019170253A Pending JP2020007360A (ja) | 2014-04-23 | 2019-09-19 | オートタキシンの置換ｎ−（２−アミノ）−２−オキソエチルベンズアミド阻害剤およびそれらの調製、ならびにｌｐａ依存性またはｌｐａ媒介性疾患の処置における使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019170253A Pending JP2020007360A (ja) | 2014-04-23 | 2019-09-19 | オートタキシンの置換ｎ−（２−アミノ）−２−オキソエチルベンズアミド阻害剤およびそれらの調製、ならびにｌｐａ依存性またはｌｐａ媒介性疾患の処置における使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20170037007A1 (enExample) |
| EP (1) | EP3134079A4 (enExample) |
| JP (2) | JP6592008B2 (enExample) |
| CN (1) | CN107205972A (enExample) |
| BR (1) | BR112016024473A2 (enExample) |
| WO (1) | WO2015175171A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015154023A1 (en) | 2014-04-04 | 2015-10-08 | X-Rx Discovery, Inc. | Substituted spirocydic inhibitors of autotaxin |
| JP6860551B2 (ja) | 2016-03-11 | 2021-04-14 | 武田薬品工業株式会社 | 芳香環化合物 |
| TWI885539B (zh) | 2017-09-29 | 2025-06-01 | 日商第一三共股份有限公司 | 抗體－吡咯并苯二氮呯衍生物複合體 |
| CN108753699B (zh) * | 2018-06-19 | 2021-04-30 | 青岛农业大学 | 一种玉米赤霉烯酮对猪卵母细胞体外发育危害的挽救方法 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| AU2020246448A1 (en) * | 2019-03-25 | 2021-10-14 | Daiichi Sankyo Company, Limited | Anti-HER2 antibody-pyrrolobenzodiazepine derivative conjugate |
| WO2021122645A1 (en) | 2019-12-20 | 2021-06-24 | Syngenta Crop Protection Ag | Pesticidally active azole-amide compounds |
| US12383547B2 (en) | 2020-07-01 | 2025-08-12 | Vanderbilt University | Methods of treatment for a kidney disease |
| CN113943274B (zh) * | 2020-07-16 | 2025-07-15 | 武汉人福创新药物研发中心有限公司 | 酰胺类化合物及其制备方法 |
| CN112675308B (zh) * | 2020-12-09 | 2023-05-05 | 中国人民解放军军事科学院军事医学研究院 | 抑制enpp2基因和/或蛋白表达的物质在制备治疗多发性骨髓瘤的药物中的应用 |
| EP4599849A3 (en) | 2021-01-05 | 2025-10-22 | Zydus Lifesciences Limited | Novel inhibitors of autotaxin |
| KR102524669B1 (ko) * | 2021-10-01 | 2023-04-21 | 주식회사 넥스트젠바이오사이언스 | 신규한 피페리딘 유도체 및 이를 포함하는 오토탁신 저해용 약학 조성물 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000056729A1 (en) * | 1999-03-24 | 2000-09-28 | Anormed Inc. | Chemokine recpetor binding heterocyclic compounds |
| GB0030303D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| JP2004529184A (ja) * | 2001-05-10 | 2004-09-24 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規１−アミドメチルカルボニル−ピペリジン誘導体、該誘導体を製造するための方法及び中間体並びにこれらの化合物を含有している医薬 |
| EP1597256A1 (en) * | 2003-02-21 | 2005-11-23 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
| EP1599447A1 (en) * | 2003-02-28 | 2005-11-30 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
| JP4761756B2 (ja) * | 2003-10-31 | 2011-08-31 | 大塚製薬株式会社 | ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物 |
| US7601844B2 (en) * | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| AR060404A1 (es) * | 2006-04-11 | 2008-06-11 | Novartis Ag | Compuestos organicos utiles como inhibidores de dipeptidil-peptidasa iv |
| HUP0600808A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them |
| US20100298299A1 (en) * | 2007-10-27 | 2010-11-25 | Istvan Vago | non-peptide derivatives as bradykinin b1 antagonists |
| AU2009225441B2 (en) * | 2008-03-20 | 2012-12-13 | Forest Laboratories Holdings Limited | Novel piperidine derivatives as inhibitors of stearoyl-CoA desaturase |
| WO2010065799A2 (en) * | 2008-12-04 | 2010-06-10 | Palatin Technologies, Inc. | Amine substituted piperidine melanocortin receptor-specific compounds |
| WO2010091164A1 (en) * | 2009-02-06 | 2010-08-12 | Exelixis, Inc. | Inhibitors of glucosylceramide synthase |
| DE102009033392A1 (de) * | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
| CN102574822A (zh) * | 2009-08-04 | 2012-07-11 | 阿米拉制药公司 | 作为溶血磷脂酸受体拮抗剂的化合物 |
| US8497371B2 (en) * | 2009-10-26 | 2013-07-30 | University Of Memphis Research Foundation | Pipemidic acid derivative autotaxin inhibitors |
| US8518945B2 (en) * | 2010-03-22 | 2013-08-27 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| JP2011219368A (ja) * | 2010-04-02 | 2011-11-04 | Daiichi Sankyo Co Ltd | Ｎ−サリチルアミノ酸誘導体 |
| WO2012024620A2 (en) * | 2010-08-20 | 2012-02-23 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| EP2714680B1 (en) * | 2011-05-27 | 2015-11-25 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| WO2013061297A1 (en) * | 2011-10-28 | 2013-05-02 | Pfizer Limited | Pyridazine Derivatives Useful in Therapy |
| ES2623528T3 (es) * | 2012-09-21 | 2017-07-11 | Sanofi | Derivados de amida de ácido benzoimidazolcarboxílico para tratar enfermedades metabólicas o cardiovasculares |
-
2015
- 2015-04-21 WO PCT/US2015/026811 patent/WO2015175171A1/en not_active Ceased
- 2015-04-21 US US15/303,848 patent/US20170037007A1/en not_active Abandoned
- 2015-04-21 BR BR112016024473A patent/BR112016024473A2/pt not_active Application Discontinuation
- 2015-04-21 EP EP15792570.2A patent/EP3134079A4/en not_active Withdrawn
- 2015-04-21 CN CN201580031612.XA patent/CN107205972A/zh active Pending
- 2015-04-21 JP JP2016563838A patent/JP6592008B2/ja not_active Expired - Fee Related
-
2019
- 2019-09-19 JP JP2019170253A patent/JP2020007360A/ja active Pending
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