JP2017525393A5 - - Google Patents
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- JP2017525393A5 JP2017525393A5 JP2017529972A JP2017529972A JP2017525393A5 JP 2017525393 A5 JP2017525393 A5 JP 2017525393A5 JP 2017529972 A JP2017529972 A JP 2017529972A JP 2017529972 A JP2017529972 A JP 2017529972A JP 2017525393 A5 JP2017525393 A5 JP 2017525393A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- reactive
- human
- progenitor
- human ventricular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 claims description 79
- 210000004027 cell Anatomy 0.000 claims description 77
- 230000002861 ventricular Effects 0.000 claims description 57
- 102000001003 Frizzled-4 Human genes 0.000 claims description 41
- 108050007986 Frizzled-4 Proteins 0.000 claims description 41
- 210000000130 stem cell Anatomy 0.000 claims description 40
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 239000002243 precursor Substances 0.000 claims description 23
- 101000994439 Danio rerio Protein jagged-1a Proteins 0.000 claims description 22
- 230000000747 cardiac effect Effects 0.000 claims description 19
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims description 18
- 108010090448 insulin gene enhancer binding protein Isl-1 Proteins 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 10
- 239000003550 marker Substances 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 238000012258 culturing Methods 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 8
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 8
- 210000005260 human cell Anatomy 0.000 claims description 7
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 6
- 108020001507 fusion proteins Proteins 0.000 claims description 6
- 102000037865 fusion proteins Human genes 0.000 claims description 6
- 210000003716 mesoderm Anatomy 0.000 claims description 6
- 206010048610 Cardiotoxicity Diseases 0.000 claims description 4
- 231100000259 cardiotoxicity Toxicity 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 231100000419 toxicity Toxicity 0.000 claims description 4
- 230000001988 toxicity Effects 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 3
- KHZOJCQBHJUJFY-UHFFFAOYSA-N 2-[4-(2-methylpyridin-4-yl)phenyl]-n-(4-pyridin-3-ylphenyl)acetamide Chemical compound C1=NC(C)=CC(C=2C=CC(CC(=O)NC=3C=CC(=CC=3)C=3C=NC=CC=3)=CC=2)=C1 KHZOJCQBHJUJFY-UHFFFAOYSA-N 0.000 claims description 2
- MDZCSIDIPDZWKL-UHFFFAOYSA-N CHIR-98014 Chemical compound C1=C([N+]([O-])=O)C(N)=NC(NCCNC=2N=C(C(=CN=2)N2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1 MDZCSIDIPDZWKL-UHFFFAOYSA-N 0.000 claims description 2
- 208000020446 Cardiac disease Diseases 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
- 108010068426 Contractile Proteins Proteins 0.000 claims description 2
- 101100540419 Danio rerio kdrl gene Proteins 0.000 claims description 2
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 claims description 2
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 claims description 2
- 101710107751 Myelin expression factor 2 Proteins 0.000 claims description 2
- 101150114527 Nkx2-5 gene Proteins 0.000 claims description 2
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims description 2
- 101100460507 Xenopus laevis nkx-2.5 gene Proteins 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000002771 cell marker Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 230000004217 heart function Effects 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 5
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 5
- 101001042362 Homo sapiens Leukemia inhibitory factor receptor Proteins 0.000 claims 5
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 5
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims 5
- 102000049556 Jagged-1 Human genes 0.000 claims 5
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 claims 5
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 5
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 5
- 238000012136 culture method Methods 0.000 claims 1
- 102100032702 Protein jagged-1 Human genes 0.000 description 38
- 108700003486 Jagged-1 Proteins 0.000 description 21
- 108700037966 Protein jagged-1 Proteins 0.000 description 21
- 238000004113 cell culture Methods 0.000 description 4
- 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 description 2
- 108700037638 Neurogenic locus notch homolog protein 1 Proteins 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462040892P | 2014-08-22 | 2014-08-22 | |
| US62/040,892 | 2014-08-22 | ||
| US201562194016P | 2015-07-17 | 2015-07-17 | |
| US62/194,016 | 2015-07-17 | ||
| PCT/US2015/046309 WO2016029122A1 (en) | 2014-08-22 | 2015-08-21 | Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076020A Division JP2020120677A (ja) | 2014-08-22 | 2020-04-22 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525393A JP2017525393A (ja) | 2017-09-07 |
| JP2017525393A5 true JP2017525393A5 (enExample) | 2018-08-02 |
| JP6738808B2 JP6738808B2 (ja) | 2020-08-12 |
Family
ID=54062813
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529972A Active JP6738808B2 (ja) | 2014-08-22 | 2015-08-21 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
| JP2020076020A Pending JP2020120677A (ja) | 2014-08-22 | 2020-04-22 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076020A Pending JP2020120677A (ja) | 2014-08-22 | 2020-04-22 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10597637B2 (enExample) |
| EP (2) | EP3524673A1 (enExample) |
| JP (2) | JP6738808B2 (enExample) |
| DK (1) | DK3183337T3 (enExample) |
| MA (1) | MA40589A (enExample) |
| WO (1) | WO2016029122A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016029122A1 (en) | 2014-08-22 | 2016-02-25 | Chien Kenneth R | Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| DK3417073T3 (da) * | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| WO2017192606A1 (en) * | 2016-05-02 | 2017-11-09 | Emory University | Methods of producing specialized cardio-like cells from stem cell |
| EP3519559A1 (en) * | 2016-09-30 | 2019-08-07 | Wisconsin Alumini Research Foundation | Primed cardiac progenitors and methods for making and using same |
| US10508263B2 (en) * | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| JP7275109B2 (ja) * | 2017-08-23 | 2023-05-17 | プロセラ セラピューティクス アーベー | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
| CN109189051A (zh) * | 2018-10-29 | 2019-01-11 | 江苏罗思韦尔电气有限公司 | 一种基于T-Box的故障存储及处理方法 |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| EP4402249A1 (en) * | 2021-09-13 | 2024-07-24 | Fujifilm Cellular Dynamics, Inc. | Methods for the production of committed cardiac progenitor cells |
| US20230330264A1 (en) | 2022-04-15 | 2023-10-19 | Smartcella Solutions Ab | COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS |
| GB202314218D0 (en) | 2023-09-18 | 2023-11-01 | Astrazeneca Ab | Cell therapy |
| CN118897089B (zh) * | 2024-08-09 | 2026-02-17 | 山西医科大学 | Sarcolipin在早期无创诊断I型射血分数保留性心衰中的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5561384A (en) | 1995-11-08 | 1996-10-01 | Advanced Micro Devices, Inc. | Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| WO2003024462A1 (en) | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
| US7745113B2 (en) | 2003-01-31 | 2010-06-29 | The Regents Of The University Of California | Use of islet 1 as a marker for isolating or generating stem cells |
| US20080038229A1 (en) | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
| US20100166714A1 (en) | 2006-11-02 | 2010-07-01 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| EP2518140A1 (en) | 2006-11-09 | 2012-10-31 | The Johns Hopkins University | Dedifferentation of adult mammalian cardiomyocytes into cardiac stem cells |
| US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
| EP2222837A2 (en) | 2007-02-09 | 2010-09-01 | The General Hospital Corporation | Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof |
| GB2465502B (en) | 2007-07-31 | 2013-06-26 | Es Cell Int Pte Ltd | Method for identifying and selecting cardiomyocytes |
| AU2008333972A1 (en) * | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising HDAC inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| US20120027807A1 (en) | 2008-10-09 | 2012-02-02 | The General Hospital Corporation | Tissue engineered myocardium and methods of production and uses thereof |
| WO2011091944A1 (en) * | 2010-01-26 | 2011-08-04 | Université Libre de Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| US20130209415A1 (en) * | 2010-06-03 | 2013-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Purified compositions of cardiovascular progenitor cells |
| US20120009158A1 (en) | 2010-06-18 | 2012-01-12 | The General Hospital Corporation | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF |
| WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
| WO2012162741A1 (en) * | 2011-06-01 | 2012-12-06 | Monash University | Enrichment of cardiomyocytes |
| US8951798B2 (en) | 2011-10-13 | 2015-02-10 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
| EP2826855B1 (en) | 2012-03-15 | 2018-08-29 | iHeart Japan Corporation | Myocardial sheet |
| WO2014078414A1 (en) | 2012-11-13 | 2014-05-22 | Joseph Wu | Chemically defined production of cardiomyocytes from pluripotent stem cells |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| WO2015058117A1 (en) | 2013-10-18 | 2015-04-23 | Icahn School Of Medicine At Mount Sinai | Directed cardiomyocyte differentiation and ventricular specification of stem cells |
| ES2689804T3 (es) | 2013-11-20 | 2018-11-15 | Miltenyi Biotec Gmbh | Composiciones de subpoblaciones de cardiomiocitos |
| SI3105253T1 (sl) * | 2014-02-12 | 2018-10-30 | F. Hoffmann-La Roche Ag | Protitelesa anti-Jagged1 in načini njihove uporabe |
| US10208287B2 (en) * | 2014-05-01 | 2019-02-19 | Iheart Japan Corporation | CD82-positive cardiac progenitor cells |
| WO2016029122A1 (en) | 2014-08-22 | 2016-02-25 | Chien Kenneth R | Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| JP2018510649A (ja) | 2015-02-17 | 2018-04-19 | ユニバーシティー ヘルス ネットワーク | 洞房結節様ペースメーカー心筋細胞および心室様心筋細胞を作製および使用するための方法 |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
-
2015
- 2015-08-21 WO PCT/US2015/046309 patent/WO2016029122A1/en not_active Ceased
- 2015-08-21 DK DK15759585.1T patent/DK3183337T3/en active
- 2015-08-21 EP EP18211720.0A patent/EP3524673A1/en not_active Ceased
- 2015-08-21 MA MA040589A patent/MA40589A/fr unknown
- 2015-08-21 JP JP2017529972A patent/JP6738808B2/ja active Active
- 2015-08-21 US US14/832,324 patent/US10597637B2/en active Active
- 2015-08-21 EP EP15759585.1A patent/EP3183337B1/en active Active
-
2020
- 2020-04-22 JP JP2020076020A patent/JP2020120677A/ja active Pending
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