JP2017524339A5 - - Google Patents

Download PDF

Info

Publication number
JP2017524339A5
JP2017524339A5 JP2016567890A JP2016567890A JP2017524339A5 JP 2017524339 A5 JP2017524339 A5 JP 2017524339A5 JP 2016567890 A JP2016567890 A JP 2016567890A JP 2016567890 A JP2016567890 A JP 2016567890A JP 2017524339 A5 JP2017524339 A5 JP 2017524339A5
Authority
JP
Japan
Prior art keywords
mers
antibody
cov
antibodies
doi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016567890A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017524339A (ja
JP6934722B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/031800 external-priority patent/WO2015179535A1/en
Publication of JP2017524339A publication Critical patent/JP2017524339A/ja
Publication of JP2017524339A5 publication Critical patent/JP2017524339A5/ja
Priority to JP2021092024A priority Critical patent/JP7297814B2/ja
Application granted granted Critical
Publication of JP6934722B2 publication Critical patent/JP6934722B2/ja
Priority to JP2023060532A priority patent/JP7500812B2/ja
Priority to JP2024090439A priority patent/JP2024123027A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016567890A 2014-05-23 2015-05-20 中東呼吸器症候群−コロナウイルススパイクタンパク質に対するヒト抗体 Active JP6934722B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021092024A JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体
JP2023060532A JP7500812B2 (ja) 2014-05-23 2023-04-04 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体
JP2024090439A JP2024123027A (ja) 2014-05-23 2024-06-04 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462002233P 2014-05-23 2014-05-23
US62/002,233 2014-05-23
US201462004971P 2014-05-30 2014-05-30
US62/004,971 2014-05-30
US201462051717P 2014-09-17 2014-09-17
US62/051,717 2014-09-17
US201462072716P 2014-10-30 2014-10-30
US62/072,716 2014-10-30
PCT/US2015/031800 WO2015179535A1 (en) 2014-05-23 2015-05-20 Human antibodies to middle east respiratory syndrome -coronavirus spike protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021092024A Division JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体

Publications (3)

Publication Number Publication Date
JP2017524339A JP2017524339A (ja) 2017-08-31
JP2017524339A5 true JP2017524339A5 (enExample) 2018-08-16
JP6934722B2 JP6934722B2 (ja) 2021-09-15

Family

ID=53276323

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016567890A Active JP6934722B2 (ja) 2014-05-23 2015-05-20 中東呼吸器症候群−コロナウイルススパイクタンパク質に対するヒト抗体
JP2021092024A Active JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体
JP2023060532A Active JP7500812B2 (ja) 2014-05-23 2023-04-04 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体
JP2024090439A Pending JP2024123027A (ja) 2014-05-23 2024-06-04 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021092024A Active JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体
JP2023060532A Active JP7500812B2 (ja) 2014-05-23 2023-04-04 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体
JP2024090439A Pending JP2024123027A (ja) 2014-05-23 2024-06-04 中東呼吸器症候群-コロナウイルススパイクタンパク質に対するヒト抗体

Country Status (19)

Country Link
US (3) US9718872B2 (enExample)
EP (1) EP3145539A1 (enExample)
JP (4) JP6934722B2 (enExample)
KR (1) KR102371300B1 (enExample)
CN (2) CN114057869B (enExample)
AU (1) AU2015264189B2 (enExample)
BR (1) BR112016025009B1 (enExample)
CA (1) CA2949438A1 (enExample)
CL (1) CL2016002934A1 (enExample)
EA (1) EA036023B1 (enExample)
IL (1) IL248392B2 (enExample)
JO (1) JO3701B1 (enExample)
MA (1) MA40688A (enExample)
MX (1) MX373581B (enExample)
MY (1) MY180741A (enExample)
PH (1) PH12016502064A1 (enExample)
SG (1) SG11201608567YA (enExample)
WO (1) WO2015179535A1 (enExample)
ZA (1) ZA201607047B (enExample)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
JO3701B1 (ar) 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
TW201628649A (zh) 2014-10-09 2016-08-16 再生元醫藥公司 減少醫藥調配物中微可見顆粒之方法
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
CN106928326B (zh) * 2015-12-31 2019-12-24 中国科学院微生物研究所 一种基于二聚化的受体结合区亚单位的冠状病毒疫苗
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
CN107298712B (zh) * 2016-04-14 2020-04-07 中国疾病预防控制中心病毒病预防控制所 全人源化抗中东呼吸综合征冠状病毒中和抗体
TW201815821A (zh) * 2016-07-18 2018-05-01 美商再生元醫藥公司 抗茲卡病毒抗體及使用方法
KR20230041834A (ko) * 2016-08-16 2023-03-24 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
EP3504328A1 (en) 2016-08-24 2019-07-03 Regeneron Pharmaceuticals, Inc. Host cell protein modification
CN119492842A (zh) 2016-10-25 2025-02-21 里珍纳龙药品有限公司 用于色谱数据分析的方法和系统
WO2018097603A2 (ko) * 2016-11-23 2018-05-31 에스케이케미칼 주식회사 중동호흡기증후군 코로나바이러스 s 단백질 면역원 조성물 및 이의 제작 방법
US12016313B2 (en) * 2017-01-19 2024-06-25 Omniab Operations, Inc. Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
WO2018215389A1 (en) 2017-05-22 2018-11-29 F. Hoffmann-La Roche Ag Therapeutic compounds and compositions, and methods of use thereof
BR112020000127A2 (pt) 2017-07-06 2020-07-07 Regeneron Pharmaceuticals, Inc. método para selecionar um hidrolisado de soja, e, glicoproteína
KR101895228B1 (ko) 2017-08-23 2018-10-30 대한민국 중동호흡기증후군 코로나바이러스의 스파이크 단백질에 대한 단일클론항체 및 이의 용도
CN118416215A (zh) 2017-09-19 2024-08-02 里珍纳龙药品有限公司 减少粒子形成的方法以及由其形成的组合物
WO2019067671A1 (en) * 2017-09-27 2019-04-04 David Weiner DNA ANTIBODY CONSTRUCTS FOR USE IN CORONAVIRUS RESPIRATORY SYNDROME OF THE MIDDLE EAST
KR102017217B1 (ko) * 2017-10-19 2019-09-02 주식회사 엔케이맥스 중동호흡기증후군 코로나바이러스에 대한 항체 및 이를 이용한 항체역가 측정방법
BR112020010615A2 (pt) 2017-12-22 2020-10-27 Regeneron Pharmaceuticals, Inc. produto farmacêutico proteico, método e sistema para caracterizar impurezas de produto farmacêutico proteico e de fármaco de baixo peso molecular, método para produzir um anticorpo, anticorpo, e, usos do método e do sistema
WO2019151632A1 (ko) * 2018-01-31 2019-08-08 (주)셀트리온 중동호흡기증후군 코로나바이러스에 중화활성을 갖는 결합 분자
KR20190093107A (ko) * 2018-01-31 2019-08-08 (주)셀트리온 중동호흡기증후군 코로나바이러스에 중화활성을 갖는 결합 분자
MX2020008095A (es) 2018-01-31 2020-09-24 Regeneron Pharma Sistemas y métodos para caracterizar variantes de tamaño y carga de impurezas de productos farmacológicos.
TWI786265B (zh) 2018-02-02 2022-12-11 美商再生元醫藥公司 用於表徵蛋白質二聚合之系統及方法
KR20200127979A (ko) 2018-02-28 2020-11-11 리제너론 파마슈티칼스 인코포레이티드 바이러스 오염물질을 확인하기 위한 시스템 및 방법
US12259355B2 (en) 2018-03-19 2025-03-25 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
CA3246952A1 (en) 2018-03-19 2025-10-31 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
US12253490B2 (en) 2018-03-19 2025-03-18 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
TW202016125A (zh) 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
US11690907B2 (en) 2018-06-12 2023-07-04 Kbio Holdings Limited Vaccines formed by virus and antigen conjugation
US11696948B2 (en) 2018-06-12 2023-07-11 Kbio Holdings Limited Vaccines formed by virus and antigen conjugation
CN110616198B (zh) * 2018-06-19 2021-02-19 清华大学 一种基于黑猩猩腺病毒68型和MERS-CoV全长膜蛋白的新型冠状病毒疫苗
TWI853823B (zh) 2018-07-02 2024-09-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
KR102682192B1 (ko) * 2018-08-17 2024-07-04 한림대학교 산학협력단 메르스 코로나바이러스 s 단백질에 대한 단클론 항체 및 그 용도
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
US11754569B2 (en) 2018-08-30 2023-09-12 Regeneron Pharmaceuticals, Inc. Methods for characterizing protein complexes
RU2709659C1 (ru) * 2018-09-06 2019-12-19 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Иммунобиологическое средство и способ его использования для индукции специфического иммунитета к вирусу ближневосточного респираторного синдрома (варианты)
KR102007161B1 (ko) * 2018-11-07 2019-08-07 대한민국 메르스 코로나 바이러스 스파이크 s1 단백질에 특이적으로 결합하는 단클론 항체
PL3857237T3 (pl) 2019-01-16 2023-07-10 Regeneron Pharmaceuticals, Inc. Sposoby charakteryzowania mostka disiarczkowego
WO2020169755A2 (en) 2019-02-20 2020-08-27 Harbour Antibodies Bv Antibodies
EP3934620A1 (en) 2019-03-05 2022-01-12 Regeneron Pharmaceuticals, Inc. Human serum albumin in formulations
US11364276B2 (en) 2019-03-26 2022-06-21 National Guard Health Affairs Antiviral peptides for treatment of the middle east respiratory syndrome
JP7524214B2 (ja) * 2019-04-03 2024-07-29 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗体コード配列をセーフハーバー遺伝子座に挿入するための方法および組成物
KR102213745B1 (ko) * 2019-04-16 2021-02-09 주식회사 바이오앱 돼지 유행성 설사병 바이러스 백신 조성물 및 이의 제조 방법
AU2020275406A1 (en) 2019-05-13 2021-11-18 Regeneron Pharmaceuticals, Inc. Improved competitive ligand binding assays
KR20220070262A (ko) * 2019-09-23 2022-05-30 서울대학교산학협력단 항-mers-cov 항체 및 이의 용도
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
MY207613A (en) 2019-11-25 2025-03-06 Regeneron Pharma Sustained release formulations using non-aqueous emulsions
US11835527B2 (en) 2020-01-21 2023-12-05 Regeneron Pharmaceuticals, Inc. Deglycosylation methods for electrophoresis of glycosylated proteins
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
EP4050035A4 (en) * 2020-02-10 2022-12-28 Institute of Microbiology of Chinese Academy of Science Beta-coronavirus antigen, preparation method therefor and use thereof
EP4103619A1 (en) 2020-02-10 2022-12-21 Regeneron Pharmaceuticals, Inc. Anti-tmprss2 antibodies and antigen-binding fragments
WO2021173753A1 (en) 2020-02-26 2021-09-02 Vir Biotechnology, Inc. Antibodies against sars-cov-2 and methods of using the same
CN113321713B (zh) * 2020-02-28 2022-11-01 深圳市亚辉龙生物科技股份有限公司 SARS-CoV-2的重组RBD蛋白及其制备方法
MX2022011142A (es) * 2020-03-09 2022-12-13 Abcellera Biologics Inc Anticuerpos anti-coronavirus y metodos de uso.
US20210283243A1 (en) * 2020-03-11 2021-09-16 Ibio, Inc. Lichenase-covid-19 based vaccine
CA3171235A1 (en) * 2020-03-12 2021-09-16 Sydney David Cullis-Hill Treatment for coronavirus infection and associated cytokine toxicity
US11365239B2 (en) * 2020-03-20 2022-06-21 Tsb Therapeutics (Beijing) Co., Ltd. Anti-SARS-COV-2 antibodies and uses thereof
WO2021207948A1 (en) * 2020-04-14 2021-10-21 Tsb Therapeutics (Beijing) Co., Ltd. Anti-sars-cov-2 antibodies and uses thereof
MX2022011892A (es) 2020-03-26 2022-10-18 Univ Vanderbilt Anticuerpos monoclonales humanos dirigidos contra el coronavirus 2 del sindrome respiratorio agudo grave (sars-cov-2).
JP2023521618A (ja) * 2020-04-01 2023-05-25 チオジェネシス セラピューティクス, インコーポレイテッド ベータコロナウイルス感染症の治療のためのシステアミン前駆体化合物
WO2021201679A1 (en) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions and methods targeting coronaviruses
CR20220552A (es) 2020-04-02 2023-01-17 Regeneron Pharma Anticuerpos contra glicoproteína de espícula anti-sars-cov-2 y fragmentos de unión al antígeno
WO2021216876A2 (en) * 2020-04-24 2021-10-28 The Board Of Regents Of The University Of Texas System Antibodies to coronavirus spike protein and methods of use thereof
EP4144353A4 (en) * 2020-04-30 2024-08-28 FUJIFILM Toyama Chemical Co., Ltd. THERAPEUTIC AGENT AGAINST CORONAVIRUS INFECTION FORMED BY COMBINATION OF A PYRAZINE DERIVATIVE AND ANOTHER THERAPEUTIC DRUG AGAINST CORONAVIRUS INFECTION
GB202007532D0 (en) * 2020-05-20 2020-07-01 Alchemab Therapeutics Ltd Polypeptides
CN116829177A (zh) * 2020-05-20 2023-09-29 纽约市哥伦比亚大学理事会 抗SARS-CoV-2的有效中和抗体及其生成和用途
WO2021238910A1 (en) * 2020-05-25 2021-12-02 Guo Bingshi Anti-coronavirus spike protein antibodies and uses thereof
AU2021282179A1 (en) 2020-05-26 2023-01-19 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
CN111606981B (zh) * 2020-05-27 2022-02-08 中国医学科学院基础医学研究所 Sars-cov冠状病毒s1蛋白多肽及其应用
MX2022014852A (es) 2020-06-03 2023-02-01 Regeneron Pharma Métodos para tratar o prevenir infecciones por sars-cov-2 y covid-19 con anticuerpos de glicoproteína espícular anti-sars-cov-2.
WO2021257695A2 (en) * 2020-06-16 2021-12-23 Hifibio (Hk) Limited Methods and compositions related to neutralizing antibodies against human coronavirus
WO2021260052A1 (en) * 2020-06-23 2021-12-30 Navigo Proteins Gmbh Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (sars-cov-2)
US20250263468A1 (en) * 2020-07-24 2025-08-21 Celltrion Inc. Binding molecule having neutralizing activity against coronavirus superfamily
WO2022026807A2 (en) * 2020-07-30 2022-02-03 Albert Einstein College Of Medicine Antibodies targeting sars-cov-2 and uses thereof
WO2022031576A1 (en) * 2020-08-03 2022-02-10 Janssen Biotech, Inc. Materials and methods for multidirectional biotransportation in virotherapeutics
WO2022031137A1 (ko) * 2020-08-07 2022-02-10 주식회사 노블젠 코로나바이러스에 대한 항바이러스용 조성물
IL300828A (en) 2020-08-31 2023-04-01 Regeneron Pharma Asparagine feeding strategies to improve cell culture performance and reduce asparagine sequence variants
WO2022054068A1 (en) * 2020-09-14 2022-03-17 Ramot At Tel-Aviv University Ltd. Antibodies for the prevention, treatment and detection of coronavirus infection
US20250188154A1 (en) * 2020-09-15 2025-06-12 Duke University Coronavirus antibodies and uses thereof
CN116390945A (zh) * 2020-09-24 2023-07-04 博德研究所 无细胞抗体工程化平台和针对SARS-CoV-2的中和抗体
CN112379087B (zh) * 2020-10-21 2022-02-11 中国医学科学院医学生物学研究所 一种应用于新型冠状病毒灭活疫苗的裂解液及抗原解离的方法
MX2023006077A (es) 2020-11-25 2023-06-06 Regeneron Pharma Formulaciones de liberacion sostenida mediante emulsificacion por membrana no acuosa.
US12350374B2 (en) 2020-12-17 2025-07-08 Regeneron Pharmaceuticals, Inc. Fabrication of protein-encapsulating microgels
CN114716541B (zh) * 2021-01-05 2023-07-21 中国科学院分子细胞科学卓越创新中心 抗冠状病毒的全人广谱中和抗体76e1及其应用
EP4274608A4 (en) * 2021-01-05 2025-07-09 Immunome Inc ANTIBODY COCKTAIL AGAINST SARS-CoV-2 SPIKE PROTEIN
TW202233827A (zh) 2021-01-20 2022-09-01 美商再生元醫藥公司 改良細胞培養中蛋白質效價的方法
AU2022210469A1 (en) * 2021-01-22 2023-07-13 The Government Of The United States, As Represented By The Secretary Of The Army Monoclonal antibodies against corovaviruses and uses thereof
WO2022170126A2 (en) * 2021-02-05 2022-08-11 Adagio Therapeutics, Inc. Compounds specific to coronavirus s protein and uses thereof
WO2022182662A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Compositions and methods for mapping antigen-binding molecule affinity to antigen regions of interest
EP4301784A4 (en) * 2021-03-02 2025-01-01 NovaRock Biotherapeutics, Ltd. Antibodies against claudin-6 and uses thereof
AR125585A1 (es) 2021-03-03 2023-08-02 Regeneron Pharma Sistemas y métodos para cuantificar y modificar la viscosidad de proteínas
WO2022187626A1 (en) 2021-03-05 2022-09-09 Regeneron Pharmaceuticals, Inc. Anti-sars-cov-2-variant-spike glycoprotein antibodies and antigen-binding fragments
US20240158478A1 (en) * 2021-03-15 2024-05-16 Emory University SARS-CoV-2 Antibodies and Fragments, Therapeutic Uses, Diagnostic Uses, and Compositions Related Thereto
WO2022212654A2 (en) * 2021-04-02 2022-10-06 The Scripps Research Institute Cross-reactive monoclonal antibodies against coronaviruses
WO2022241200A1 (en) * 2021-05-14 2022-11-17 Vanderbilt University Cross-reactive coronavirus antibodies
BR112023024984A2 (pt) 2021-06-01 2024-02-20 Regeneron Pharma Tampão de amostra de eletroforese aquosa, método para identificar contaminantes ou impurezas em uma amostra de droga proteica, e, kit
EP4370210A1 (en) 2021-07-14 2024-05-22 Regeneron Pharmaceuticals, Inc. Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments
JP2024528710A (ja) * 2021-07-23 2024-07-30 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Sars-cov-2、その変異株、及び関連コロナウイルスに対する強力かつ広域の中和モノクローナル抗体の特性評価ならびに使用方法
TW202326138A (zh) 2021-09-08 2023-07-01 美商再生元醫藥公司 用於定量抗體及其他含Fc蛋白之高通量及基於質譜之方法
CA3232463A1 (en) 2021-09-20 2023-03-23 Philip Mellors Methods of controlling antibody heterogeneity
CN116178530A (zh) * 2021-09-26 2023-05-30 上海君实生物医药科技股份有限公司 抗体在治疗SARS-CoV-2感染的用途
KR20240090312A (ko) 2021-10-07 2024-06-21 리제너론 파아마슈티컬스, 인크. Ph 미터 보정 및 교정
JP2024538673A (ja) 2021-10-07 2024-10-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッド pHモデリング及び制御のシステム及び方法
WO2023244276A2 (en) * 2021-10-13 2023-12-21 The Wistar Institute Of Anatomy And Biology DNA ENCODED ANTIBODIES WITH Fc MODIFICATIONS
MX2024005090A (es) 2021-10-26 2024-07-19 Regeneron Pharma Sistemas y metodos para generar agua de laboratorio y distribuir agua de laboratorio a diferentes temperaturas.
TW202342510A (zh) 2022-02-18 2023-11-01 英商Rq生物科技有限公司 抗體
WO2023178182A1 (en) 2022-03-16 2023-09-21 10X Genomics, Inc. Compositions and methods for detection and treatment of coronavirus infection
CN115850461A (zh) * 2022-12-06 2023-03-28 中国科学院微生物研究所 沙贝病毒广谱中和抗体及其应用
US20240245779A1 (en) 2023-01-25 2024-07-25 Regeneron Pharmaceuticals, Inc. Methods of modeling liquid protein composition stability
WO2024158961A1 (en) 2023-01-25 2024-08-02 Regeneron Pharmaceuticals, Inc. Mass spectrometry-based characterization of antibodies co-expressed in vivo
WO2024163708A1 (en) 2023-02-01 2024-08-08 Regeneron Pharmaceuticals, Inc. Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis
US20240280551A1 (en) 2023-02-22 2024-08-22 Regeneron Pharmaceuticals, Inc. System suitability parameters and column aging
TW202508625A (zh) 2023-05-01 2025-03-01 美商再生元醫藥公司 使用苯酚或苯甲醇之多劑量抗體藥物產品
CN121925272A (zh) 2023-09-29 2026-04-24 瑞泽恩制药公司 利用受控成核进行冻干
WO2025085594A1 (en) 2023-10-18 2025-04-24 Regeneron Pharmaceuticals, Inc. Rapid purification of monoclonal antibody from in-process upstream cell culture material
AU2024373307A1 (en) 2023-11-02 2026-05-14 Regeneron Pharmaceuticals, Inc. Methods for reducing lipase activity using stress
WO2025166281A1 (en) 2024-02-01 2025-08-07 Regeneron Pharmaceuticals, Inc. Platform for charge-detection mass spectrometry analysis of aavs
WO2025175164A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods
WO2025194043A1 (en) 2024-03-15 2025-09-18 Regeneron Pharmaceuticals, Inc. Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations
WO2026025028A1 (en) 2024-07-26 2026-01-29 Regeneron Pharmaceuticals, Inc. Methods of making ultra-high concentrated protein formulations using lyophilization
WO2026060350A1 (en) 2024-09-13 2026-03-19 Regeneron Pharmaceuticals, Inc. Methods of improving photo stability and controlling formation of hmw species in biologic formulations, and biologic formulations produced by the methods
CN119264262B (zh) * 2024-09-19 2025-09-02 中山大学 一种双特异性抗体及其应用
WO2026076201A2 (en) 2024-10-03 2026-04-09 Regeneron Pharmaceuticals, Inc. Systems and methods for producing therapeutic proteins using single pass tangential flow filtration for in-line concentration and volume reduction of production pools
WO2026080597A1 (en) 2024-10-08 2026-04-16 Regeneron Pharmaceuticals, Inc. Sustained delivery of biologics and non-aqueous manufacture of same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
NZ543467A (en) * 2003-04-10 2008-07-31 Novartis Vaccines & Diagnostic The severe acute respiratory syndrome coronavirus
CN1914226B (zh) * 2003-11-25 2012-02-01 达纳-法伯癌症研究院有限公司 SARS-CoV抗体及其使用方法
WO2005103081A2 (en) 2004-04-20 2005-11-03 Genmab A/S Human monoclonal antibodies against cd20
US8257740B1 (en) 2011-08-15 2012-09-04 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
US8246995B2 (en) 2005-05-10 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
NZ587107A (en) 2006-06-02 2012-05-25 Regeneron Pharma High affinity antibodies to human il-6 receptor
LT2975051T (lt) 2009-06-26 2021-07-12 Regeneron Pharmaceuticals, Inc. Lengvai išskiriami bispecifiniai antikūnai su natyvios formos imunoglobulinu
SG11201502189UA (en) 2012-09-23 2015-04-29 Univ Erasmus Medical Ct Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor
CN103554244B (zh) * 2013-05-09 2016-09-07 香雪集团(香港)有限公司 具有抑制呼吸道病毒感染的活性的肽及其应用和制备方法
CN103554235B (zh) * 2013-06-17 2015-06-24 清华大学 MERS-CoV病毒膜蛋白中的RBD片段及其编码基因和应用
EP3134111B1 (en) * 2014-04-25 2022-06-08 Dana-Farber Cancer Institute, Inc. Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof
JO3701B1 (ar) 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
AU2015266841C1 (en) * 2014-05-30 2018-06-07 Regeneron Pharmaceuticals, Inc. Humanized dipeptidyl peptidase IV (DPP4) animals

Similar Documents

Publication Publication Date Title
JOP20200091A1 (ar) جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري
EA201890874A1 (ru) Антитела, которые эффективно нейтрализуют вирус гепатита в, и их применение
EA201891435A1 (ru) Гуманизированные моноклональные антитела, моноклональные антитела мыши или химерные моноклональные антитела против cd47
HK1246658A1 (zh) 猪流行性腹泻病毒品种及其免疫原性组合物
MX352338B (es) Anticuerpos neutralizantes del virus de la influenza a y usos de estos.
WO2016154003A8 (en) Neutralizing antibodies to gp120 and their use
JP2010521147A5 (enExample)
HRP20161740T1 (hr) Ljudske molekule za vezanje koje su sposobne neutralizirati viruse influence a filogenetske skupine 1 i filogenetske skupine 2, te viruse influence b
WO2016196975A8 (en) Neutralizing antibodies to hiv-1 env and their use
WO2016100807A3 (en) Human antibodies to influenza hemagglutinin
BR112019005726A8 (pt) Anticorpo ou fragmento de ligação ao antígeno do mesmo que se liga ao cd27 humano, polipeptídeo isolado, ácido nucleico isolado, vetor de expressão, célula hospedeira, composição, métodos de produção de um anticorpo ou de um fragmento de ligação ao antígeno, de tratamento de câncer e de tratamento de uma infecção ou de uma doença infecciosa, e, uso do anticorpo ou do fragmento de ligação ao antígeno
WO2016201124A3 (en) T cell receptor-like antibody agents specific for ebv latent membrane protein 2a peptide presented by human hla
WO2017079479A8 (en) Neutralizing antibodies to hiv-1 gp41 and their use
JP2012254092A5 (enExample)
PE20161221A1 (es) Anticuerpos de il-21
WO2014200898A3 (en) Cmv neutralizing antigen binding proteins
PH12021550521A1 (en) Antibodies that potently neutralize rabies virus and other lyssaviruses and uses thereof
RU2014127287A (ru) Антитела, используемые для пассивной вакцинации против гриппа
Morales et al. HIV-1 envelope proteins and V1/V2 domain scaffolds with mannose-5 to improve the magnitude and quality of protective antibody responses to HIV-1
PH12020551051A1 (en) Human antibodies to influenza hemagglutinin
WO2016054053A3 (en) Hiv-1 antibodies and uses thereof (adcc and bispecific abs)
WO2013033319A3 (en) A cluster of neutralizing antibodies to hepatitis c virus
EA201390735A1 (ru) Композиции вакцин с фрагментами расщепленных иммуноглобулинов
EA201270794A1 (ru) Маркерная вакцина против классической чумы свиней
AR106471A1 (es) Anticuerpo que neutraliza el virus respiratorio sincitial humano