JP2017524127A5 - - Google Patents

Info

Publication number

JP2017524127A5

JP2017524127A5 JP2017502806A JP2017502806A JP2017524127A5 JP 2017524127 A5 JP2017524127 A5 JP 2017524127A5 JP 2017502806 A JP2017502806 A JP 2017502806A JP 2017502806 A JP2017502806 A JP 2017502806A JP 2017524127 A5 JP2017524127 A5 JP 2017524127A5

Authority

JP

Japan

Prior art keywords

aflibercept

treatment

level

interleukin

colorectal cancer

Prior art date

2015-07-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 102000004890 Interleukin-8 Human genes 0.000 claims description 37
• 108090001007 Interleukin-8 Proteins 0.000 claims description 37
• 229940096397 interleukin-8 Drugs 0.000 claims description 37
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims description 37
• 108010081667 aflibercept Proteins 0.000 claims description 31
• 206010009944 Colon cancer Diseases 0.000 claims description 22
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 19
• 229960002833 aflibercept Drugs 0.000 claims description 15
• 229960002760 ziv-aflibercept Drugs 0.000 claims description 14
• 238000000034 method Methods 0.000 claims description 13
• 239000008194 pharmaceutical composition Substances 0.000 claims description 4
• 208000029742 colonic neoplasm Diseases 0.000 claims description 3
• 239000000090 biomarker Substances 0.000 claims description 2
• 230000001225 therapeutic effect Effects 0.000 claims description 2
• 239000012472 biological sample Substances 0.000 claims 6
• 239000000523 sample Substances 0.000 claims 5
• 238000003556 assay Methods 0.000 claims 2
• 230000004071 biological effect Effects 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000005022 packaging material Substances 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 3
• 206010028980 Neoplasm Diseases 0.000 description 3
• 201000011510 cancer Diseases 0.000 description 3
• 229960002949 fluorouracil Drugs 0.000 description 3
• 229960000397 bevacizumab Drugs 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 229940036061 zaltrap Drugs 0.000 description 2
• VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
• 206010052358 Colorectal cancer metastatic Diseases 0.000 description 1
• MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 230000002491 angiogenic effect Effects 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
• 235000008191 folinic acid Nutrition 0.000 description 1
• 239000011672 folinic acid Substances 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
• 229960004768 irinotecan Drugs 0.000 description 1
• 229960001691 leucovorin Drugs 0.000 description 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
• 229960001756 oxaliplatin Drugs 0.000 description 1
• 206010038038 rectal cancer Diseases 0.000 description 1
• 201000001275 rectum cancer Diseases 0.000 description 1