JP2017524029A5 - - Google Patents
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- JP2017524029A5 JP2017524029A5 JP2017510528A JP2017510528A JP2017524029A5 JP 2017524029 A5 JP2017524029 A5 JP 2017524029A5 JP 2017510528 A JP2017510528 A JP 2017510528A JP 2017510528 A JP2017510528 A JP 2017510528A JP 2017524029 A5 JP2017524029 A5 JP 2017524029A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- methyl
- amino
- dione
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 13
- PZFAZQUREQIODZ-LJQANCHMSA-N dvf0pr037d Chemical compound C1CCOC(C=N2)=C1C=C2CNC(CC1)CCN1C[C@H]1N2C(=O)C=NC(C=CC3=O)=C2N3C1 PZFAZQUREQIODZ-LJQANCHMSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 10
- -1 pyrrolidin-4-ylmethyl Chemical group 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- OPQFKYZLJABARW-UHFFFAOYSA-N 1,4,7-triazatricyclo[6.3.1.04,12]dodeca-2,6,8(12),9-tetraene-5,11-dione Chemical compound N1=CC(=O)N2C=CN3C(=O)C=CC1=C32 OPQFKYZLJABARW-UHFFFAOYSA-N 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 206010018612 Gonorrhoea Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- RAMYROWBFPNRRN-OAQYLSRUSA-N (1r)-1-[(4-{[(2-oxo-2h-chromen-7-yl)methyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4h,9h-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione Chemical compound N12C(=O)C=CC(C=CC3=O)=C1N3C[C@H]2CN(CC1)CCC1NCC1=CC=C2C=CC(=O)OC2=C1 RAMYROWBFPNRRN-OAQYLSRUSA-N 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- MMUYWCUHCPWDAH-UHFFFAOYSA-N 1,4-diazatricyclo[6.3.1.04,12]dodeca-2,6,8(12),9-tetraene-5,11-dione Chemical compound C1=CC(=O)N2C=CN3C(=O)C=CC1=C32 MMUYWCUHCPWDAH-UHFFFAOYSA-N 0.000 claims 2
- KLADTWZAHGRNKH-UHFFFAOYSA-N 2-[[4-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound O1CCOC(C=N2)=C1C=C2CNC(CC1)CCN1CC1N2C(=O)C=CC(C=CC3=O)=C2N3C1 KLADTWZAHGRNKH-UHFFFAOYSA-N 0.000 claims 2
- HIGACJLWDPTSID-UHFFFAOYSA-N 2-[[4-[(3-oxo-4H-1,4-benzothiazin-6-yl)methylamino]piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound N12C(=O)C=CC(C=CC3=O)=C1N3CC2CN(CC1)CCC1NCC1=CC=C2SCC(=O)NC2=C1 HIGACJLWDPTSID-UHFFFAOYSA-N 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- UTOPGSISJNOHQK-OAHLLOKOSA-N (1r)-1-[(4-{[(4-chloro-7-oxo-6,7-dihydro-1h-pyrimido[5,4-b][1,4]oxazin-2-yl)methyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4h,9h-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione Chemical compound N12C(=O)C=CC(C=CC3=O)=C1N3C[C@H]2CN(CC1)CCC1NCC(N1)=NC(Cl)=C2C1=NC(=O)CO2 UTOPGSISJNOHQK-OAHLLOKOSA-N 0.000 claims 1
- RHGRMWGOKQLRGE-MSOLQXFVSA-N (2R)-2-[[(2S)-2-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)methyl]morpholin-4-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@@H]1OCCN(C1)C[C@H]1N2C(=O)C=CC=3C=CC(N(C1)C=32)=O)NCC(N=C1)=CC2=C1OCS2 RHGRMWGOKQLRGE-MSOLQXFVSA-N 0.000 claims 1
- GLTMIYGEUVNRHF-MOPGFXCFSA-N (2R)-2-[[(2S)-2-[[(6-fluoro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]methyl]morpholin-4-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound N12C(=O)C=CC(C=CC3=O)=C1N3C[C@H]2CN(CCO1)C[C@@H]1CNCC1=CC(OCCO2)=C2C=C1F GLTMIYGEUVNRHF-MOPGFXCFSA-N 0.000 claims 1
- QFFDFDRUCUXPOF-MAUKXSAKSA-N (2R)-2-[[(3S)-3-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)methyl]pyrrolidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@@H]1CCN(C1)C[C@H]1N2C(=O)C=CC=3C=CC(N(C1)C=32)=O)NCC(N=C1)=CC2=C1OCS2 QFFDFDRUCUXPOF-MAUKXSAKSA-N 0.000 claims 1
- QGEMCDCWUJVVCP-GOSISDBHSA-N (2R)-2-[[4-(1,2,3-benzothiadiazol-5-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1=C2SN=NC2=CC(CNC2CCN(CC2)C[C@H]2N3C(=O)C=CC=4C=CC(N(C2)C=43)=O)=C1 QGEMCDCWUJVVCP-GOSISDBHSA-N 0.000 claims 1
- WYDAGHFQMHHLEY-OAQYLSRUSA-N (2R)-2-[[4-(1,3-dihydrofuro[3,4-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@H]1N2C(=O)C=CC=3C=CC(N(C1)C=32)=O)N(CC1)CCC1NCC(N=C1)=CC2=C1COC2 WYDAGHFQMHHLEY-OAQYLSRUSA-N 0.000 claims 1
- QWTKTRPTFIUKDC-GOSISDBHSA-N (2R)-2-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound O1CCOC2=CC(CNC3CCN(CC3)C[C@H]3N4C(=O)C=CC=5N=CC(N(C3)C=54)=O)=CC=C21 QWTKTRPTFIUKDC-GOSISDBHSA-N 0.000 claims 1
- CBWKIERCSVTDRI-HXUWFJFHSA-N (2R)-2-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound O1CCOC2=CC(CNC3CCN(CC3)C[C@H]3N4C(=O)C=CC=5C=CC(N(C3)C=54)=O)=CC=C21 CBWKIERCSVTDRI-HXUWFJFHSA-N 0.000 claims 1
- WZZJTAPTHCMUTL-OAQYLSRUSA-N (2R)-2-[[4-(2,3-dihydro-1-benzofuran-5-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1=C2OCCC2=CC(CNC2CCN(CC2)C[C@H]2N3C(=O)C=CC=4C=CC(N(C2)C=43)=O)=C1 WZZJTAPTHCMUTL-OAQYLSRUSA-N 0.000 claims 1
- JVGKMLISRBCZAV-OAQYLSRUSA-N (2R)-2-[[4-(2,3-dihydro-1-benzofuran-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1=C2CCOC2=CC(CNC2CCN(CC2)C[C@H]2N3C(=O)C=CC=4C=CC(N(C2)C=43)=O)=C1 JVGKMLISRBCZAV-OAQYLSRUSA-N 0.000 claims 1
- BMVZYCHVFNYXJZ-GOSISDBHSA-N (2R)-2-[[4-(2,3-dihydrofuro[2,3-c]pyridin-5-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@H]1N2C(=O)C=CC=3N=CC(N(C1)C=32)=O)N(CC1)CCC1NCC(N=C1)=CC2=C1OCC2 BMVZYCHVFNYXJZ-GOSISDBHSA-N 0.000 claims 1
- DUXFDBOJWHARNV-JOCHJYFZSA-N (2R)-2-[[4-(3,4-dihydro-2H-chromen-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound O1CCCC2=CC(CNC3CCN(CC3)C[C@H]3N4C(=O)C=CC=5C=CC(N(C3)C=54)=O)=CC=C21 DUXFDBOJWHARNV-JOCHJYFZSA-N 0.000 claims 1
- PEVLAFPJSPRSFM-JOCHJYFZSA-N (2R)-2-[[4-(3,4-dihydro-2H-chromen-7-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1CCOC2=CC(CNC3CCN(CC3)C[C@H]3N4C(=O)C=CC=5C=CC(N(C3)C=54)=O)=CC=C21 PEVLAFPJSPRSFM-JOCHJYFZSA-N 0.000 claims 1
- OFNLAVFKMSMGDS-LJQANCHMSA-N (2R)-2-[[4-(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1CCOC(C=N2)=C1C=C2CNC(CC1)CCN1C[C@@H]1CN2C(=O)C=NC3=C2N1C(=O)C=C3 OFNLAVFKMSMGDS-LJQANCHMSA-N 0.000 claims 1
- ICEFMYXDABSJEB-OAQYLSRUSA-N (2R)-2-[[4-(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1CCOC(C=N2)=C1C=C2CNC(CC1)CCN1C[C@H]1N2C(=O)C=CC(C=CC3=O)=C2N3C1 ICEFMYXDABSJEB-OAQYLSRUSA-N 0.000 claims 1
- QVFCTNFLPSJPQN-LJQANCHMSA-N (2R)-2-[[4-(3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound S1CCNC2=NC(CNC3CCN(CC3)C[C@H]3N4C(=O)C=CC=5C=CC(N(C3)C=54)=O)=CC=C21 QVFCTNFLPSJPQN-LJQANCHMSA-N 0.000 claims 1
- CLYVNLVGBVTDSA-HSZRJFAPSA-N (2R)-2-[[4-(5,6,7,8-tetrahydroisoquinolin-3-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1CCCC(C=N2)=C1C=C2CNC(CC1)CCN1C[C@H]1N2C(=O)C=CC(C=CC3=O)=C2N3C1 CLYVNLVGBVTDSA-HSZRJFAPSA-N 0.000 claims 1
- ZOXCLKYRAFCQRK-JOCHJYFZSA-N (2R)-2-[[4-(6,7-dihydro-5H-cyclopenta[c]pyridin-3-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@H]1N2C(=O)C=CC=3C=CC(N(C1)C=32)=O)N(CC1)CCC1NCC(N=C1)=CC2=C1CCC2 ZOXCLKYRAFCQRK-JOCHJYFZSA-N 0.000 claims 1
- KIWAKXFQIRVLDG-MRXNPFEDSA-N (2R)-2-[[4-([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@@H]1CN2C(=O)C=NC=3C=CC(N1C=32)=O)N(CC1)CCC1NCC(N=C1)=CC2=C1OCS2 KIWAKXFQIRVLDG-MRXNPFEDSA-N 0.000 claims 1
- MMKKZZRTGQEWMB-GOSISDBHSA-N (2R)-2-[[4-([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@H]1N2C(=O)C=CC=3C=CC(N(C1)C=32)=O)N(CC1)CCC1NCC(N=C1)=CC2=C1OCS2 MMKKZZRTGQEWMB-GOSISDBHSA-N 0.000 claims 1
- FZNZGXHLNWWFRD-QGZVFWFLSA-N (2R)-2-[[4-[(4-fluoro-1H-benzimidazol-2-yl)methylamino]piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound N12C(=O)C=CC(C=CC3=O)=C1N3C[C@H]2CN(CC1)CCC1NCC(N1)=NC2=C1C=CC=C2F FZNZGXHLNWWFRD-QGZVFWFLSA-N 0.000 claims 1
- VTAVAXMXOYKAEA-QGZVFWFLSA-N (2R)-2-[[4-[(5-fluoro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound O1CCOC2=C1C=C(CNC1CCN(C[C@H]3N4C=5N(C(C=NC=5C=CC4=O)=O)C3)CC1)C=C2F VTAVAXMXOYKAEA-QGZVFWFLSA-N 0.000 claims 1
- UKPSUEHNNCZJMF-LJQANCHMSA-N (2R)-2-[[4-[(5-fluoro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound O1CCOC2=C1C=C(CNC1CCN(C[C@H]3N4C=5N(C(C=CC=5C=CC4=O)=O)C3)CC1)C=C2F UKPSUEHNNCZJMF-LJQANCHMSA-N 0.000 claims 1
- SOYYVDIBAUMRSG-QGZVFWFLSA-N (2R)-2-[[4-[(6-fluoro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound N12C(=O)C=CC(N=CC3=O)=C1N3C[C@H]2CN(CC1)CCC1NCC1=CC(OCCO2)=C2C=C1F SOYYVDIBAUMRSG-QGZVFWFLSA-N 0.000 claims 1
- XRKPIHKEOCFNBS-MRXNPFEDSA-N (2R)-2-[[4-[(7-chloro-3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound N12C(=O)C=CC(C=CC3=O)=C1N3C[C@H]2CN(CC1)CCC1NCC1=NC(NC(=O)CO2)=C2C=C1Cl XRKPIHKEOCFNBS-MRXNPFEDSA-N 0.000 claims 1
- IFLSEVONAYZDGL-MRXNPFEDSA-N (2R)-2-[[4-[(7-oxo-8H-pyrimido[5,4-b][1,4]thiazin-2-yl)methylamino]piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound N12C(=O)C=CC(C=CC3=O)=C1N3C[C@H]2CN(CC1)CCC1NCC1=NC=C2SCC(=O)N=C2N1 IFLSEVONAYZDGL-MRXNPFEDSA-N 0.000 claims 1
- GLPRDZSYLBBDLT-GOSISDBHSA-N (2R)-2-[[4-methyl-4-([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4-diazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1CN(C[C@H]2N3C=4N(C(C=CC=4C=CC3=O)=O)C2)CCC1(C)NCC(N=C1)=CC2=C1OCS2 GLPRDZSYLBBDLT-GOSISDBHSA-N 0.000 claims 1
- GXAMZVLKELUPES-MRXNPFEDSA-N (3R)-3-[[4-(2,1,3-benzothiadiazol-5-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1=CC2=NSN=C2C=C1CNC(CC1)CCN1C[C@H]1N2C(=O)C=NC(C=CC3=O)=C2N3C1 GXAMZVLKELUPES-MRXNPFEDSA-N 0.000 claims 1
- LKTSUDBZUBEDTQ-GOSISDBHSA-N (3R)-3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound O1CCOC2=CC(CNC3CCN(CC3)C[C@H]3N4C(=O)C=NC=5C=CC(N(C3)C=54)=O)=CC=C21 LKTSUDBZUBEDTQ-GOSISDBHSA-N 0.000 claims 1
- GTOBAXKBBVOAQH-GOSISDBHSA-N (3R)-3-[[4-(3,4-dihydro-2H-[1,4]oxathiepino[2,3-c]pyridin-8-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound S1CCCOC(C=N2)=C1C=C2CNC(CC1)CCN1C[C@H]1N2C(=O)C=NC(C=CC3=O)=C2N3C1 GTOBAXKBBVOAQH-GOSISDBHSA-N 0.000 claims 1
- TUHWOZWYEBHVFD-OAHLLOKOSA-N (3R)-3-[[4-([1,2,5]thiadiazolo[3,4-b]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C1=NC2=NSN=C2C=C1CNC(CC1)CCN1C[C@H]1N2C(=O)C=NC(C=CC3=O)=C2N3C1 TUHWOZWYEBHVFD-OAHLLOKOSA-N 0.000 claims 1
- OKUFHCDPAKULIQ-MRXNPFEDSA-N (3R)-3-[[4-([1,3]oxathiolo[4,5-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@H]1N2C(=O)C=NC=3C=CC(N(C1)C=32)=O)N(CC1)CCC1NCC(N=C1)=CC2=C1SCO2 OKUFHCDPAKULIQ-MRXNPFEDSA-N 0.000 claims 1
- CCNWBTVQMPIXKO-MRXNPFEDSA-N (3R)-3-[[4-([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione Chemical compound C([C@H]1N2C(=O)C=NC=3C=CC(N(C1)C=32)=O)N(CC1)CCC1NCC(N=C1)=CC2=C1OCS2 CCNWBTVQMPIXKO-MRXNPFEDSA-N 0.000 claims 1
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| AR053602A1 (es) | 2005-05-03 | 2007-05-09 | Smithkline Beecham Corp | Compuesto de 2- arilamino -4-oxo-1,3-tiazol-5(4h)- substituido, composicion farmaceutica que lo comprende, proceso para prepararla y uso del compuesto para preparar un medicamento |
| JP2008542249A (ja) | 2005-05-24 | 2008-11-27 | アストラゼネカ アクチボラグ | 抗細菌活性を持つアミノピペリジンキノリン及びそのアザ等立体類似体 |
| CN101180298B (zh) | 2005-05-25 | 2011-04-27 | 埃科特莱茵药品有限公司 | 抗生素衍生物 |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| EP1900732A4 (en) | 2005-06-24 | 2009-11-18 | Toyama Chemical Co Ltd | NEW NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF |
| WO2007016610A2 (en) | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | Antibacterial agents |
| SI1954697T1 (sl) | 2005-10-21 | 2010-05-31 | Glaxo Group Ltd | Peri kondenzirane triciklične spojine uporabne kot antibakterijska sredstva |
| WO2007067511A2 (en) | 2005-12-06 | 2007-06-14 | Merck & Co., Inc. | Morpholine carboxamide prokineticin receptor antagonists |
| US20070185153A1 (en) | 2005-12-22 | 2007-08-09 | Nathalie Cailleau | Compounds |
| JP2009532504A (ja) | 2006-04-06 | 2009-09-10 | グラクソ グループ リミテッド | 抗菌薬 |
| ATE481406T1 (de) | 2006-04-06 | 2010-10-15 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| GB0608263D0 (en) | 2006-04-26 | 2006-06-07 | Glaxo Group Ltd | Compounds |
| US20100256124A1 (en) | 2006-06-09 | 2010-10-07 | David Thomas Davies | Substituted 1-Methyl-1H-Quinolin-2-Ones And 1-Methyl-1H-1,5-Naphthyridin-2-Ones As Antibacterials |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| KR101567096B1 (ko) * | 2007-04-20 | 2015-11-06 | 글락소 그룹 리미티드 | 항균제로서의 트리시클릭 질소 함유 화합물 |
| JP5474941B2 (ja) * | 2008-05-23 | 2014-04-16 | グラクソ グループ リミテッド | 窒素含有三環式化合物およびその抗菌剤としての使用 |
| JP2012505866A (ja) * | 2008-10-17 | 2012-03-08 | グラクソ グループ リミテッド | 抗菌剤として使用される三環式窒素化合物 |
| BR112017003705B1 (pt) * | 2014-08-22 | 2022-07-12 | Glaxosmithkline Intellectual Property Development Limited | Compostos contendo nitrogênio tricíclicos para o tratamento de infecção por neisseria gonorrhoea |
-
2015
- 2015-08-20 BR BR112017003705-0A patent/BR112017003705B1/pt active IP Right Grant
- 2015-08-20 EP EP19197439.3A patent/EP3639824A1/en not_active Withdrawn
- 2015-08-20 EA EA201790442A patent/EA031589B1/ru not_active IP Right Cessation
- 2015-08-20 ES ES15762763T patent/ES2759303T3/es active Active
- 2015-08-20 JP JP2017510528A patent/JP6546654B2/ja active Active
- 2015-08-20 US US15/505,715 patent/US10702521B2/en active Active
- 2015-08-20 KR KR1020177007353A patent/KR20170043603A/ko not_active Withdrawn
- 2015-08-20 SG SG11201700566SA patent/SG11201700566SA/en unknown
- 2015-08-20 EP EP15762763.9A patent/EP3182973B1/en active Active
- 2015-08-20 WO PCT/IB2015/056325 patent/WO2016027249A1/en not_active Ceased
- 2015-08-20 AR ARP150102680A patent/AR101674A1/es unknown
- 2015-08-20 CN CN201580045166.8A patent/CN106659717B/zh active Active
- 2015-08-20 PE PE2017000215A patent/PE20170501A1/es not_active Application Discontinuation
- 2015-08-20 TW TW104127098A patent/TW201618779A/zh unknown
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- 2015-08-20 CA CA2958800A patent/CA2958800C/en active Active
- 2015-08-20 CN CN201910738641.XA patent/CN110403939A/zh active Pending
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2019
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2020
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