JP2017523783A5 - - Google Patents
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- Publication number
- JP2017523783A5 JP2017523783A5 JP2017505569A JP2017505569A JP2017523783A5 JP 2017523783 A5 JP2017523783 A5 JP 2017523783A5 JP 2017505569 A JP2017505569 A JP 2017505569A JP 2017505569 A JP2017505569 A JP 2017505569A JP 2017523783 A5 JP2017523783 A5 JP 2017523783A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- aptamer
- acid aptamer
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091008104 nucleic acid aptamers Proteins 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 108091023037 Aptamer Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462031406P | 2014-07-31 | 2014-07-31 | |
| US62/031,406 | 2014-07-31 | ||
| PCT/US2015/043133 WO2016019255A1 (en) | 2014-07-31 | 2015-07-31 | Antagonistic ctla-4 aptamers and applications thereof in enhancing immune activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523783A JP2017523783A (ja) | 2017-08-24 |
| JP2017523783A5 true JP2017523783A5 (enExample) | 2018-09-13 |
| JP6702938B2 JP6702938B2 (ja) | 2020-06-03 |
Family
ID=55218357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505569A Expired - Fee Related JP6702938B2 (ja) | 2014-07-31 | 2015-07-31 | アンタゴニストｉｃ ｃｔｌａ−４アプタマー及びその免疫活性増強への応用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10533179B2 (enExample) |
| EP (1) | EP3174984B1 (enExample) |
| JP (1) | JP6702938B2 (enExample) |
| KR (1) | KR20170055473A (enExample) |
| CN (1) | CN107075517A (enExample) |
| CA (1) | CA2956808A1 (enExample) |
| TW (1) | TWI604846B (enExample) |
| WO (1) | WO2016019255A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018207024A1 (en) * | 2017-05-08 | 2018-11-15 | Augmanity Nano Ltd | Treatment of rapidly evolving biological entities |
| CN111500572B (zh) * | 2020-04-22 | 2022-04-22 | 南京大学 | 一种基于毛细管电泳筛选非天然核酸适体的方法 |
| CN116270702B (zh) * | 2022-10-25 | 2025-02-14 | 中南大学 | 一种双特异性探针-连接体复合物及其制备方法和用途 |
| CN117731684A (zh) * | 2023-12-20 | 2024-03-22 | 天津大学浙江研究院 | Dna水凝胶双靶点免疫抑制剂及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060246123A1 (en) * | 2003-03-12 | 2006-11-02 | Eli Gilboa | Oligonucleotide mimetics |
| EP2623601B1 (en) * | 2003-04-21 | 2015-02-18 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US8088976B2 (en) * | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
| US20130209514A1 (en) * | 2009-06-09 | 2013-08-15 | Eli Gilboa | Aptamer-targeted costimulatory ligand aptamer |
| EP2655621B1 (en) * | 2010-12-20 | 2018-05-23 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| CA2742342A1 (en) * | 2011-02-12 | 2012-08-12 | Baylor Research Institute | Msh3 expression status determines the responsiveness of cancer cells to the chemotherapeutic treatment with parp inhibitors and platinum drugs |
| US9549981B2 (en) * | 2011-07-19 | 2017-01-24 | Philogen S.P.A. | Sequential antibody therapy |
| RU2633510C2 (ru) * | 2011-09-28 | 2017-10-12 | Рибомик Инк. | Аптамер против ngf и его применение |
| US20150240253A1 (en) * | 2012-08-30 | 2015-08-27 | E. I. Du Pont De Nemours And Company | Long intergenic non-coding rnas in maize |
-
2015
- 2015-07-31 CN CN201580041383.XA patent/CN107075517A/zh active Pending
- 2015-07-31 KR KR1020177005532A patent/KR20170055473A/ko not_active Withdrawn
- 2015-07-31 US US15/500,345 patent/US10533179B2/en active Active
- 2015-07-31 WO PCT/US2015/043133 patent/WO2016019255A1/en not_active Ceased
- 2015-07-31 JP JP2017505569A patent/JP6702938B2/ja not_active Expired - Fee Related
- 2015-07-31 EP EP15827848.1A patent/EP3174984B1/en active Active
- 2015-07-31 CA CA2956808A patent/CA2956808A1/en not_active Abandoned
- 2015-07-31 TW TW104124952A patent/TWI604846B/zh not_active IP Right Cessation