CA2956808A1 - Antagonistic ctla-4 aptamers and applications thereof in enhancing immune activity - Google Patents
Antagonistic ctla-4 aptamers and applications thereof in enhancing immune activity Download PDFInfo
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- CA2956808A1 CA2956808A1 CA2956808A CA2956808A CA2956808A1 CA 2956808 A1 CA2956808 A1 CA 2956808A1 CA 2956808 A CA2956808 A CA 2956808A CA 2956808 A CA2956808 A CA 2956808A CA 2956808 A1 CA2956808 A1 CA 2956808A1
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- Prior art keywords
- aptamer
- seq
- ctla
- nucleic acid
- cancer
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201462031406P | 2014-07-31 | 2014-07-31 | |
| US62/031,406 | 2014-07-31 | ||
| PCT/US2015/043133 WO2016019255A1 (en) | 2014-07-31 | 2015-07-31 | Antagonistic ctla-4 aptamers and applications thereof in enhancing immune activity |
Publications (1)
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| CA2956808A1 true CA2956808A1 (en) | 2016-02-04 |
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| WO2018207024A1 (en) * | 2017-05-08 | 2018-11-15 | Augmanity Nano Ltd | Treatment of rapidly evolving biological entities |
| CN111500572B (zh) * | 2020-04-22 | 2022-04-22 | 南京大学 | 一种基于毛细管电泳筛选非天然核酸适体的方法 |
| CN116270702B (zh) * | 2022-10-25 | 2025-02-14 | 中南大学 | 一种双特异性探针-连接体复合物及其制备方法和用途 |
| CN117731684A (zh) * | 2023-12-20 | 2024-03-22 | 天津大学浙江研究院 | Dna水凝胶双靶点免疫抑制剂及其制备方法和应用 |
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| US20060246123A1 (en) * | 2003-03-12 | 2006-11-02 | Eli Gilboa | Oligonucleotide mimetics |
| EP2623601B1 (en) * | 2003-04-21 | 2015-02-18 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US8088976B2 (en) * | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
| US20130209514A1 (en) * | 2009-06-09 | 2013-08-15 | Eli Gilboa | Aptamer-targeted costimulatory ligand aptamer |
| EP2655621B1 (en) * | 2010-12-20 | 2018-05-23 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| CA2742342A1 (en) * | 2011-02-12 | 2012-08-12 | Baylor Research Institute | Msh3 expression status determines the responsiveness of cancer cells to the chemotherapeutic treatment with parp inhibitors and platinum drugs |
| US9549981B2 (en) * | 2011-07-19 | 2017-01-24 | Philogen S.P.A. | Sequential antibody therapy |
| RU2633510C2 (ru) * | 2011-09-28 | 2017-10-12 | Рибомик Инк. | Аптамер против ngf и его применение |
| US20150240253A1 (en) * | 2012-08-30 | 2015-08-27 | E. I. Du Pont De Nemours And Company | Long intergenic non-coding rnas in maize |
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| US10533179B2 (en) | 2020-01-14 |
| CN107075517A (zh) | 2017-08-18 |
| TWI604846B (zh) | 2017-11-11 |
| EP3174984A4 (en) | 2018-02-21 |
| JP2017523783A (ja) | 2017-08-24 |
| JP6702938B2 (ja) | 2020-06-03 |
| EP3174984B1 (en) | 2020-05-06 |
| US20170211067A1 (en) | 2017-07-27 |
| KR20170055473A (ko) | 2017-05-19 |
| TW201620527A (zh) | 2016-06-16 |
| WO2016019255A1 (en) | 2016-02-04 |
| EP3174984A1 (en) | 2017-06-07 |
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