JP2017523197A - ２−ピリドン部分を含む選択的抗菌剤としてのアリールヒドラジド - Google Patents
２−ピリドン部分を含む選択的抗菌剤としてのアリールヒドラジド Download PDFInfo
- Publication number
- JP2017523197A JP2017523197A JP2017505253A JP2017505253A JP2017523197A JP 2017523197 A JP2017523197 A JP 2017523197A JP 2017505253 A JP2017505253 A JP 2017505253A JP 2017505253 A JP2017505253 A JP 2017505253A JP 2017523197 A JP2017523197 A JP 2017523197A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- oxo
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(C1*)C(*)=C(*)C(*)=C1N(*)N(*)COC=* Chemical compound *C(C1*)C(*)=C(*)C(*)=C1N(*)N(*)COC=* 0.000 description 10
- ZUHAJBXAXKAMMT-UHFFFAOYSA-N C#CCN1C(C(NNc(cc2)ccc2F)=O)=CC=CC1=O Chemical compound C#CCN1C(C(NNc(cc2)ccc2F)=O)=CC=CC1=O ZUHAJBXAXKAMMT-UHFFFAOYSA-N 0.000 description 1
- FBJGDKDUIFLGNT-UHFFFAOYSA-N C#CCN1C(C(O)=O)=CC=CC1=O Chemical compound C#CCN1C(C(O)=O)=CC=CC1=O FBJGDKDUIFLGNT-UHFFFAOYSA-N 0.000 description 1
- RGZCKPXTNJAWMR-UHFFFAOYSA-N CN(C=C(C=C1)C(O)=O)C1=O Chemical compound CN(C=C(C=C1)C(O)=O)C1=O RGZCKPXTNJAWMR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
- C07D213/87—Hydrazides; Thio or imino analogues thereof in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179089.9 | 2014-07-30 | ||
| EP14179089 | 2014-07-30 | ||
| PCT/EP2015/067345 WO2016016291A1 (en) | 2014-07-30 | 2015-07-29 | Arylhydrazides containing a 2-pyridone moiety as selective antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017523197A true JP2017523197A (ja) | 2017-08-17 |
| JP2017523197A5 JP2017523197A5 (enExample) | 2018-08-30 |
Family
ID=51260651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505253A Pending JP2017523197A (ja) | 2014-07-30 | 2015-07-29 | ２−ピリドン部分を含む選択的抗菌剤としてのアリールヒドラジド |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9840467B2 (enExample) |
| EP (1) | EP3174852B1 (enExample) |
| JP (1) | JP2017523197A (enExample) |
| KR (1) | KR20170038822A (enExample) |
| CN (1) | CN106660962A (enExample) |
| AU (1) | AU2015295380A1 (enExample) |
| BR (1) | BR112017001803A2 (enExample) |
| CA (1) | CA2955559A1 (enExample) |
| CL (1) | CL2017000231A1 (enExample) |
| DK (1) | DK3174852T3 (enExample) |
| ES (1) | ES2687826T3 (enExample) |
| MX (1) | MX2017001280A (enExample) |
| PE (1) | PE20170430A1 (enExample) |
| PH (1) | PH12017500057A1 (enExample) |
| PL (1) | PL3174852T3 (enExample) |
| PT (1) | PT3174852T (enExample) |
| RU (1) | RU2017101154A (enExample) |
| WO (1) | WO2016016291A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180232A (es) | 2015-10-27 | 2018-05-31 | Hoffmann La Roche | Macrociclos peptídicos contra acinetobacter baumannii |
| ES2651943B2 (es) | 2016-07-29 | 2018-08-14 | ABAC Therapeutics, S.L. | Agentes antibacterianos de 2-pirrolidin fenilihidrazidas |
| US11505573B2 (en) | 2018-03-28 | 2022-11-22 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| US11819532B2 (en) | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| WO2020169683A1 (en) * | 2019-02-19 | 2020-08-27 | Yncrea Hauts De France | Hydrazonopyrrolidine derivatives for use in preventing and/or treating disorders associated to acinetobacter baumannii |
| WO2020169682A1 (en) * | 2019-02-19 | 2020-08-27 | Yncrea Hauts De France | Hydrazide derivatives and their specific use as antibacterial agents by controlling acinetobacter baumannii bacterium |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0399058A (ja) * | 1989-09-09 | 1991-04-24 | Kaken Pharmaceut Co Ltd | 複素５員環化合物 |
| WO2004043924A1 (en) * | 2002-11-12 | 2004-05-27 | Astrazeneca Ab | 2-pyridone derivatives as inhibitors of neutrophile elastase |
| JP2005531501A (ja) * | 2002-02-14 | 2005-10-20 | ファルマシア・コーポレーション | Ｐ３８ｍａｐキナーゼのモジュレータとしての置換されたピリジノン |
| JP2007519735A (ja) * | 2004-01-30 | 2007-07-19 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害剤として有用であるｎ−ベンジル−３，４−ジヒドロキシピリジン−２−カルボキサミド及びｎ−ベンジル−２，３−ジヒドロキシピリジン−４−カルボキサミド化合物 |
| WO2012051708A1 (en) * | 2010-10-21 | 2012-04-26 | The University Of British Columbia | Anti-bacterial pyruvate kinase modulator compounds, compositions, uses, and methods |
| WO2015060613A1 (en) * | 2013-10-21 | 2015-04-30 | Daewoong Pharmaceutical Co., Ltd. | Novel antifungal oxodihydropyridinecarbohydrazide derivative |
| JP2016525103A (ja) * | 2013-07-14 | 2016-08-22 | アシロス・エ／エス | リベス種から誘導可能な新たな生物活性アルカロイドおよびアルカロイド画分 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0203348D0 (sv) * | 2002-11-12 | 2002-11-12 | Astrazeneca Ab | Novel compounds |
-
2015
- 2015-07-29 CA CA2955559A patent/CA2955559A1/en not_active Abandoned
- 2015-07-29 KR KR1020177003051A patent/KR20170038822A/ko not_active Withdrawn
- 2015-07-29 PE PE2017000133A patent/PE20170430A1/es not_active Application Discontinuation
- 2015-07-29 PL PL15750274T patent/PL3174852T3/pl unknown
- 2015-07-29 RU RU2017101154A patent/RU2017101154A/ru not_active Application Discontinuation
- 2015-07-29 JP JP2017505253A patent/JP2017523197A/ja active Pending
- 2015-07-29 AU AU2015295380A patent/AU2015295380A1/en not_active Abandoned
- 2015-07-29 BR BR112017001803A patent/BR112017001803A2/pt not_active Application Discontinuation
- 2015-07-29 CN CN201580041697.XA patent/CN106660962A/zh active Pending
- 2015-07-29 DK DK15750274.1T patent/DK3174852T3/en active
- 2015-07-29 MX MX2017001280A patent/MX2017001280A/es unknown
- 2015-07-29 US US15/500,333 patent/US9840467B2/en active Active
- 2015-07-29 WO PCT/EP2015/067345 patent/WO2016016291A1/en not_active Ceased
- 2015-07-29 PT PT15750274T patent/PT3174852T/pt unknown
- 2015-07-29 EP EP15750274.1A patent/EP3174852B1/en active Active
- 2015-07-29 ES ES15750274.1T patent/ES2687826T3/es active Active
-
2017
- 2017-01-09 PH PH12017500057A patent/PH12017500057A1/en unknown
- 2017-01-27 CL CL2017000231A patent/CL2017000231A1/es unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0399058A (ja) * | 1989-09-09 | 1991-04-24 | Kaken Pharmaceut Co Ltd | 複素５員環化合物 |
| JP2005531501A (ja) * | 2002-02-14 | 2005-10-20 | ファルマシア・コーポレーション | Ｐ３８ｍａｐキナーゼのモジュレータとしての置換されたピリジノン |
| WO2004043924A1 (en) * | 2002-11-12 | 2004-05-27 | Astrazeneca Ab | 2-pyridone derivatives as inhibitors of neutrophile elastase |
| JP2007519735A (ja) * | 2004-01-30 | 2007-07-19 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害剤として有用であるｎ−ベンジル−３，４−ジヒドロキシピリジン−２−カルボキサミド及びｎ−ベンジル−２，３−ジヒドロキシピリジン−４−カルボキサミド化合物 |
| WO2012051708A1 (en) * | 2010-10-21 | 2012-04-26 | The University Of British Columbia | Anti-bacterial pyruvate kinase modulator compounds, compositions, uses, and methods |
| JP2016525103A (ja) * | 2013-07-14 | 2016-08-22 | アシロス・エ／エス | リベス種から誘導可能な新たな生物活性アルカロイドおよびアルカロイド画分 |
| WO2015060613A1 (en) * | 2013-10-21 | 2015-04-30 | Daewoong Pharmaceutical Co., Ltd. | Novel antifungal oxodihydropyridinecarbohydrazide derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112017001803A2 (pt) | 2018-02-14 |
| CA2955559A1 (en) | 2016-02-04 |
| MX2017001280A (es) | 2017-06-20 |
| ES2687826T3 (es) | 2018-10-29 |
| US9840467B2 (en) | 2017-12-12 |
| US20170217887A1 (en) | 2017-08-03 |
| WO2016016291A1 (en) | 2016-02-04 |
| EP3174852B1 (en) | 2018-07-18 |
| PL3174852T3 (pl) | 2018-11-30 |
| KR20170038822A (ko) | 2017-04-07 |
| PE20170430A1 (es) | 2017-04-13 |
| RU2017101154A3 (enExample) | 2019-01-30 |
| DK3174852T3 (en) | 2018-09-10 |
| PT3174852T (pt) | 2018-10-23 |
| CL2017000231A1 (es) | 2017-07-28 |
| EP3174852A1 (en) | 2017-06-07 |
| AU2015295380A1 (en) | 2017-02-02 |
| RU2017101154A (ru) | 2018-08-30 |
| PH12017500057A1 (en) | 2017-05-15 |
| CN106660962A (zh) | 2017-05-10 |
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