CN106660962A - 用作选择性抗菌剂的含2‑吡啶酮部分的芳基酰肼 - Google Patents

用作选择性抗菌剂的含2‑吡啶酮部分的芳基酰肼 Download PDF

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Publication number
CN106660962A
CN106660962A CN201580041697.XA CN201580041697A CN106660962A CN 106660962 A CN106660962 A CN 106660962A CN 201580041697 A CN201580041697 A CN 201580041697A CN 106660962 A CN106660962 A CN 106660962A
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CN
China
Prior art keywords
alkyl
alkoxy
hydrogen
oxo
carboxylic acid
Prior art date
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Pending
Application number
CN201580041697.XA
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English (en)
Chinese (zh)
Inventor
D·加尔加洛维奥拉
A·帕劳密贝尼特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
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Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Publication of CN106660962A publication Critical patent/CN106660962A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C07D213/87—Hydrazides; Thio or imino analogues thereof in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
CN201580041697.XA 2014-07-30 2015-07-29 用作选择性抗菌剂的含2‑吡啶酮部分的芳基酰肼 Pending CN106660962A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14179089.9 2014-07-30
EP14179089 2014-07-30
PCT/EP2015/067345 WO2016016291A1 (en) 2014-07-30 2015-07-29 Arylhydrazides containing a 2-pyridone moiety as selective antibacterial agents

Publications (1)

Publication Number Publication Date
CN106660962A true CN106660962A (zh) 2017-05-10

Family

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CN201580041697.XA Pending CN106660962A (zh) 2014-07-30 2015-07-29 用作选择性抗菌剂的含2‑吡啶酮部分的芳基酰肼

Country Status (18)

Country Link
US (1) US9840467B2 (enExample)
EP (1) EP3174852B1 (enExample)
JP (1) JP2017523197A (enExample)
KR (1) KR20170038822A (enExample)
CN (1) CN106660962A (enExample)
AU (1) AU2015295380A1 (enExample)
BR (1) BR112017001803A2 (enExample)
CA (1) CA2955559A1 (enExample)
CL (1) CL2017000231A1 (enExample)
DK (1) DK3174852T3 (enExample)
ES (1) ES2687826T3 (enExample)
MX (1) MX2017001280A (enExample)
PE (1) PE20170430A1 (enExample)
PH (1) PH12017500057A1 (enExample)
PL (1) PL3174852T3 (enExample)
PT (1) PT3174852T (enExample)
RU (1) RU2017101154A (enExample)
WO (1) WO2016016291A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20180232A (es) 2015-10-27 2018-05-31 Hoffmann La Roche Macrociclos peptídicos contra acinetobacter baumannii
ES2651943B2 (es) 2016-07-29 2018-08-14 ABAC Therapeutics, S.L. Agentes antibacterianos de 2-pirrolidin fenilihidrazidas
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
WO2020169683A1 (en) * 2019-02-19 2020-08-27 Yncrea Hauts De France Hydrazonopyrrolidine derivatives for use in preventing and/or treating disorders associated to acinetobacter baumannii
WO2020169682A1 (en) * 2019-02-19 2020-08-27 Yncrea Hauts De France Hydrazide derivatives and their specific use as antibacterial agents by controlling acinetobacter baumannii bacterium

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1711243A (zh) * 2002-11-12 2005-12-21 阿斯利康(瑞典)有限公司 用作嗜中性白细胞弹性蛋白酶抑制剂的2－吡啶酮衍生物
WO2012051708A1 (en) * 2010-10-21 2012-04-26 The University Of British Columbia Anti-bacterial pyruvate kinase modulator compounds, compositions, uses, and methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0399058A (ja) * 1989-09-09 1991-04-24 Kaken Pharmaceut Co Ltd 複素５員環化合物
DE60330126D1 (de) * 2002-02-14 2009-12-31 Pharmacia Corp Substituierte pyridinone als modulatoren für p38 map kinase
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
JP2007519735A (ja) * 2004-01-30 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害剤として有用であるｎ−ベンジル−３，４−ジヒドロキシピリジン−２−カルボキサミド及びｎ−ベンジル−２，３−ジヒドロキシピリジン−４−カルボキサミド化合物
EP2859007B1 (en) * 2013-07-14 2019-04-17 Olle Svenssons Partiaffär AB Alkaloid compositions from ribes species to treat conditions associated with mitochondrial function or inhibition of pde4, pde5 and ikk-beta
KR102076820B1 (ko) * 2013-10-21 2020-02-13 주식회사 대웅테라퓨틱스 신규한 항진균성 옥소다이하이드로피리딘카보하이드라자이드 유도체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1711243A (zh) * 2002-11-12 2005-12-21 阿斯利康(瑞典)有限公司 用作嗜中性白细胞弹性蛋白酶抑制剂的2－吡啶酮衍生物
WO2012051708A1 (en) * 2010-10-21 2012-04-26 The University Of British Columbia Anti-bacterial pyruvate kinase modulator compounds, compositions, uses, and methods

Non-Patent Citations (5)

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-: "1317306-41-4", 《STN REGISTRY》 *
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-: "356583-19-2", 《STN REGISTRY》 *
WEBER H: "DECKER-OXIDATION 2-SUBSTITUIERTER N-ALKYLPYRIDINIUMUERBINDUNGEN，5 MITT.DIE DECKER-OXIDATION UON HOMARIN", 《ARCHIU DER PHARMAZIE》 *

Also Published As

Publication number Publication date
BR112017001803A2 (pt) 2018-02-14
CA2955559A1 (en) 2016-02-04
MX2017001280A (es) 2017-06-20
JP2017523197A (ja) 2017-08-17
ES2687826T3 (es) 2018-10-29
US9840467B2 (en) 2017-12-12
US20170217887A1 (en) 2017-08-03
WO2016016291A1 (en) 2016-02-04
EP3174852B1 (en) 2018-07-18
PL3174852T3 (pl) 2018-11-30
KR20170038822A (ko) 2017-04-07
PE20170430A1 (es) 2017-04-13
RU2017101154A3 (enExample) 2019-01-30
DK3174852T3 (en) 2018-09-10
PT3174852T (pt) 2018-10-23
CL2017000231A1 (es) 2017-07-28
EP3174852A1 (en) 2017-06-07
AU2015295380A1 (en) 2017-02-02
RU2017101154A (ru) 2018-08-30
PH12017500057A1 (en) 2017-05-15

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