JP2017521064A5 - - Google Patents
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- Publication number
- JP2017521064A5 JP2017521064A5 JP2016575347A JP2016575347A JP2017521064A5 JP 2017521064 A5 JP2017521064 A5 JP 2017521064A5 JP 2016575347 A JP2016575347 A JP 2016575347A JP 2016575347 A JP2016575347 A JP 2016575347A JP 2017521064 A5 JP2017521064 A5 JP 2017521064A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid sequence
- acid molecule
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 51
- 108020004707 nucleic acids Proteins 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 36
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 15
- 239000013566 allergen Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 235000017060 Arachis glabrata Nutrition 0.000 claims 12
- 241001553178 Arachis glabrata Species 0.000 claims 12
- 235000010777 Arachis hypogaea Nutrition 0.000 claims 12
- 235000018262 Arachis monticola Nutrition 0.000 claims 12
- 235000020232 peanut Nutrition 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 5
- 108010064171 Lysosome-Associated Membrane Glycoproteins Proteins 0.000 claims 4
- 102000014944 Lysosome-Associated Membrane Glycoproteins Human genes 0.000 claims 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000025864 peanut allergic reaction Diseases 0.000 claims 3
- 201000010853 peanut allergy Diseases 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000004044 response Effects 0.000 claims 3
- 230000006641 stabilisation Effects 0.000 claims 3
- 238000011105 stabilization Methods 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 108010009489 Lysosomal-Associated Membrane Protein 3 Proteins 0.000 claims 2
- 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 2
- 210000001163 endosome Anatomy 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 210000003712 lysosome Anatomy 0.000 claims 2
- 230000001868 lysosomic effect Effects 0.000 claims 2
- 210000003463 organelle Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010029862 Endolyn Proteins 0.000 claims 1
- 102000049978 Endolyn Human genes 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102100020983 Lysosome membrane protein 2 Human genes 0.000 claims 1
- 101710165448 Lysosome membrane protein 2 Proteins 0.000 claims 1
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 1
- 101710116782 Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 1
- 102100038225 Lysosome-associated membrane glycoprotein 2 Human genes 0.000 claims 1
- 101710116771 Lysosome-associated membrane glycoprotein 2 Proteins 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000017307 interleukin-4 production Effects 0.000 claims 1
- 210000005061 intracellular organelle Anatomy 0.000 claims 1
- 230000002132 lysosomal effect Effects 0.000 claims 1
- 235000014571 nuts Nutrition 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462015981P | 2014-06-23 | 2014-06-23 | |
| US62/015,981 | 2014-06-23 | ||
| PCT/US2015/037240 WO2015200357A2 (en) | 2014-06-23 | 2015-06-23 | Nucleic acids for treatment of peanut allergies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017521064A JP2017521064A (ja) | 2017-08-03 |
| JP2017521064A5 true JP2017521064A5 (enExample) | 2018-07-26 |
Family
ID=53546722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575347A Pending JP2017521064A (ja) | 2014-06-23 | 2015-06-23 | ピーナッツアレルギーの治療のための核酸 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20170304432A1 (enExample) |
| EP (1) | EP3157558A2 (enExample) |
| JP (1) | JP2017521064A (enExample) |
| KR (1) | KR20170019457A (enExample) |
| CN (1) | CN106459994A (enExample) |
| AU (2) | AU2015280143A1 (enExample) |
| BR (1) | BR112016030439A2 (enExample) |
| CA (1) | CA2952726A1 (enExample) |
| WO (1) | WO2015200357A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10143742B2 (en) | 2015-02-20 | 2018-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US10166286B2 (en) | 2015-02-20 | 2019-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US10149904B2 (en) | 2015-02-20 | 2018-12-11 | The Board Of Trusteees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US11452774B2 (en) | 2015-02-20 | 2022-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| WO2017186808A1 (en) * | 2016-04-27 | 2017-11-02 | Allergy Therapeutics (Uk) Limited | Treatment of peanut allergy |
| US11826423B2 (en) | 2016-11-16 | 2023-11-28 | Immunomic Therapeutics, Inc. | Nucleic acids for treatment of allergies |
| WO2018195527A1 (en) * | 2017-04-22 | 2018-10-25 | Immunomic Therapeutics, Inc. | Improved lamp constructs |
| KR20200016224A (ko) | 2017-05-02 | 2020-02-14 | 이뮤노믹 쎄라퓨틱스, 인크. | 암 항원을 포함하는 lamp (리소솜 연관 막 단백질) 구축물 |
| US11382934B2 (en) | 2017-07-18 | 2022-07-12 | Before Brands, Inc. | Methods for making mixed allergen compositions |
| CA3099495A1 (en) | 2018-05-11 | 2019-11-14 | Astellas Pharma Inc. | Nucleic acid for treating mite allergy |
| WO2019216396A1 (ja) | 2018-05-11 | 2019-11-14 | アステラス製薬株式会社 | 甲殻類アレルギー治療のための核酸 |
| US12398195B2 (en) | 2018-05-15 | 2025-08-26 | Immunomic Therapeutics, Inc. | Lamp constructs comprising allergens |
| CN109115737B (zh) * | 2018-07-27 | 2021-03-26 | 青岛大学 | 一种三螺旋pH生物传感器及其应用 |
| CA3127337A1 (en) | 2019-01-23 | 2020-07-30 | Before Brands, Inc. | Methods for making mixed allergen compositions |
| JP7266700B2 (ja) * | 2019-03-13 | 2023-04-28 | プソマーゲン， インコーポレイテッド | アレルギー治療のためのエピトープベースアプローチ及びクローン病のための阻害薬 |
| CN112225815A (zh) * | 2020-09-30 | 2021-01-15 | 四川携光生物技术有限公司 | 一种牛奶、小麦、花生及大豆过敏原融合蛋白及其构建方法、应用 |
| CN114438088B (zh) * | 2020-11-03 | 2025-05-23 | 韩达 | 一种溶酶体靶向的核酸嵌合体的制备及应用 |
| KR102527331B1 (ko) * | 2020-11-10 | 2023-05-02 | (주)프로테옴텍 | 밀가루 유래의 오메가-5-글리아딘의 신규 에피토프 중합체 및 이의 용도 |
| WO2022099695A1 (en) * | 2020-11-16 | 2022-05-19 | Jiangsu Cell Tech Medical Research Institute Co., Ltd. | Cd164 fusion and uses thereof |
| CN115057927B (zh) * | 2022-05-30 | 2024-02-20 | 南开大学 | 一种花生过敏原Ara h1特异性纳米抗体及其应用 |
| WO2025199077A1 (en) * | 2024-03-19 | 2025-09-25 | Modernatx, Inc. | Tolerizing antigen specific immunotherapies |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018185A1 (en) * | 1992-03-03 | 1993-09-16 | The Salk Institute For Biological Studies | Receptor internalization signals |
| US20060251667A1 (en) * | 2002-08-29 | 2006-11-09 | Chua Kaw Y | Recombinant nucleic acid useful for inducing protective immune response against allergens |
| HUE052481T2 (hu) * | 2012-06-15 | 2021-04-28 | Immunomic Therapeutics Inc | Nukleinsavak, allergiák kezelésére |
| US9774230B2 (en) * | 2015-11-25 | 2017-09-26 | Caterpillar Inc. | Generator set having coupling member between flywheel and generator |
-
2015
- 2015-06-23 CN CN201580034361.0A patent/CN106459994A/zh active Pending
- 2015-06-23 WO PCT/US2015/037240 patent/WO2015200357A2/en not_active Ceased
- 2015-06-23 KR KR1020177001547A patent/KR20170019457A/ko not_active Withdrawn
- 2015-06-23 US US15/321,366 patent/US20170304432A1/en not_active Abandoned
- 2015-06-23 AU AU2015280143A patent/AU2015280143A1/en not_active Abandoned
- 2015-06-23 JP JP2016575347A patent/JP2017521064A/ja active Pending
- 2015-06-23 CA CA2952726A patent/CA2952726A1/en not_active Abandoned
- 2015-06-23 EP EP15738190.6A patent/EP3157558A2/en not_active Withdrawn
- 2015-06-23 BR BR112016030439A patent/BR112016030439A2/pt not_active Application Discontinuation
-
2019
- 2019-03-17 US US16/355,785 patent/US20190298821A1/en not_active Abandoned
-
2020
- 2020-06-26 AU AU2020204277A patent/AU2020204277A1/en not_active Abandoned
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