CN106459994A - 用于治疗花生过敏的核酸 - Google Patents

用于治疗花生过敏的核酸 Download PDF

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Publication number
CN106459994A
CN106459994A CN201580034361.0A CN201580034361A CN106459994A CN 106459994 A CN106459994 A CN 106459994A CN 201580034361 A CN201580034361 A CN 201580034361A CN 106459994 A CN106459994 A CN 106459994A
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CN
China
Prior art keywords
nucleic acid
seq
acid molecule
identity
lamp
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Pending
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CN201580034361.0A
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English (en)
Chinese (zh)
Inventor
威廉·赫尔
特瑞·海兰
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Immunomic Therapeutics Inc
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Immunomic Therapeutics Inc
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Publication of CN106459994A publication Critical patent/CN106459994A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201580034361.0A 2014-06-23 2015-06-23 用于治疗花生过敏的核酸 Pending CN106459994A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462015981P 2014-06-23 2014-06-23
US62/015,981 2014-06-23
PCT/US2015/037240 WO2015200357A2 (en) 2014-06-23 2015-06-23 Nucleic acids for treatment of peanut allergies

Publications (1)

Publication Number Publication Date
CN106459994A true CN106459994A (zh) 2017-02-22

Family

ID=53546722

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580034361.0A Pending CN106459994A (zh) 2014-06-23 2015-06-23 用于治疗花生过敏的核酸

Country Status (9)

Country Link
US (2) US20170304432A1 (enExample)
EP (1) EP3157558A2 (enExample)
JP (1) JP2017521064A (enExample)
KR (1) KR20170019457A (enExample)
CN (1) CN106459994A (enExample)
AU (2) AU2015280143A1 (enExample)
BR (1) BR112016030439A2 (enExample)
CA (1) CA2952726A1 (enExample)
WO (1) WO2015200357A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109115737A (zh) * 2018-07-27 2019-01-01 青岛大学 一种三螺旋pH生物传感器及其应用
CN112225815A (zh) * 2020-09-30 2021-01-15 四川携光生物技术有限公司 一种牛奶、小麦、花生及大豆过敏原融合蛋白及其构建方法、应用
CN113631231A (zh) * 2019-03-13 2021-11-09 普梭梅根公司 用于过敏治疗的基于表位的方法和克罗恩病的抑制剂
WO2022099695A1 (en) * 2020-11-16 2022-05-19 Jiangsu Cell Tech Medical Research Institute Co., Ltd. Cd164 fusion and uses thereof

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10143742B2 (en) 2015-02-20 2018-12-04 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US10166286B2 (en) 2015-02-20 2019-01-01 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US10149904B2 (en) 2015-02-20 2018-12-11 The Board Of Trusteees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US11452774B2 (en) 2015-02-20 2022-09-27 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
WO2017186808A1 (en) * 2016-04-27 2017-11-02 Allergy Therapeutics (Uk) Limited Treatment of peanut allergy
US11826423B2 (en) 2016-11-16 2023-11-28 Immunomic Therapeutics, Inc. Nucleic acids for treatment of allergies
WO2018195527A1 (en) * 2017-04-22 2018-10-25 Immunomic Therapeutics, Inc. Improved lamp constructs
KR20200016224A (ko) 2017-05-02 2020-02-14 이뮤노믹 쎄라퓨틱스, 인크. 암 항원을 포함하는 lamp (리소솜 연관 막 단백질) 구축물
US11382934B2 (en) 2017-07-18 2022-07-12 Before Brands, Inc. Methods for making mixed allergen compositions
CA3099495A1 (en) 2018-05-11 2019-11-14 Astellas Pharma Inc. Nucleic acid for treating mite allergy
WO2019216396A1 (ja) 2018-05-11 2019-11-14 アステラス製薬株式会社 甲殻類アレルギー治療のための核酸
US12398195B2 (en) 2018-05-15 2025-08-26 Immunomic Therapeutics, Inc. Lamp constructs comprising allergens
CA3127337A1 (en) 2019-01-23 2020-07-30 Before Brands, Inc. Methods for making mixed allergen compositions
CN114438088B (zh) * 2020-11-03 2025-05-23 韩达 一种溶酶体靶向的核酸嵌合体的制备及应用
KR102527331B1 (ko) * 2020-11-10 2023-05-02 (주)프로테옴텍 밀가루 유래의 오메가-5-글리아딘의 신규 에피토프 중합체 및 이의 용도
CN115057927B (zh) * 2022-05-30 2024-02-20 南开大学 一种花生过敏原Ara h1特异性纳米抗体及其应用
WO2025199077A1 (en) * 2024-03-19 2025-09-25 Modernatx, Inc. Tolerizing antigen specific immunotherapies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018185A1 (en) * 1992-03-03 1993-09-16 The Salk Institute For Biological Studies Receptor internalization signals
WO2013187906A1 (en) * 2012-06-15 2013-12-19 Immunomic Therapeutics, Inc. Nucleic acids for treatment of allergies

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US20060251667A1 (en) * 2002-08-29 2006-11-09 Chua Kaw Y Recombinant nucleic acid useful for inducing protective immune response against allergens
US9774230B2 (en) * 2015-11-25 2017-09-26 Caterpillar Inc. Generator set having coupling member between flywheel and generator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018185A1 (en) * 1992-03-03 1993-09-16 The Salk Institute For Biological Studies Receptor internalization signals
WO2013187906A1 (en) * 2012-06-15 2013-12-19 Immunomic Therapeutics, Inc. Nucleic acids for treatment of allergies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARLINGTON HEIGHTS 等: "T-cell biology in immunotherapy", 《ANNALS OF ALLERGY,ASTHMA AND IMMUNOLOGY》 *
H.WU: "YXXM motifs in the PDGF-Receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosinre-based endocytic sorting signals", 《JOURNAL OD BIOLOGICAL CHEMISTRY》 *
第4期: "Relevance of Ara h1,Ara h2 and Ara h3 in peanut-allergic patients,as determined by immunoglobulin E Western blotting,basophil-histamine release and intracutaneous testing:Ara h2 is the most important allergen", 《CLINICAL AND EXPERIMENTAL ALLERGY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109115737A (zh) * 2018-07-27 2019-01-01 青岛大学 一种三螺旋pH生物传感器及其应用
CN113631231A (zh) * 2019-03-13 2021-11-09 普梭梅根公司 用于过敏治疗的基于表位的方法和克罗恩病的抑制剂
CN112225815A (zh) * 2020-09-30 2021-01-15 四川携光生物技术有限公司 一种牛奶、小麦、花生及大豆过敏原融合蛋白及其构建方法、应用
WO2022099695A1 (en) * 2020-11-16 2022-05-19 Jiangsu Cell Tech Medical Research Institute Co., Ltd. Cd164 fusion and uses thereof

Also Published As

Publication number Publication date
JP2017521064A (ja) 2017-08-03
EP3157558A2 (en) 2017-04-26
AU2020204277A1 (en) 2020-07-16
BR112016030439A2 (pt) 2018-07-17
US20190298821A1 (en) 2019-10-03
AU2015280143A1 (en) 2017-01-05
WO2015200357A3 (en) 2016-04-21
KR20170019457A (ko) 2017-02-21
US20170304432A1 (en) 2017-10-26
CA2952726A1 (en) 2015-12-30
WO2015200357A2 (en) 2015-12-30

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Application publication date: 20170222