JP2017520583A5 - - Google Patents
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- JP2017520583A5 JP2017520583A5 JP2016575950A JP2016575950A JP2017520583A5 JP 2017520583 A5 JP2017520583 A5 JP 2017520583A5 JP 2016575950 A JP2016575950 A JP 2016575950A JP 2016575950 A JP2016575950 A JP 2016575950A JP 2017520583 A5 JP2017520583 A5 JP 2017520583A5
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- JP
- Japan
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- sepsis
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002536 stromal cell Anatomy 0.000 claims description 16
- 206010040047 Sepsis Diseases 0.000 claims description 13
- 210000000577 adipose tissue Anatomy 0.000 claims description 7
- -1 CD49A Proteins 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 5
- 230000002757 inflammatory effect Effects 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 4
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 206010035664 Pneumonia Diseases 0.000 claims description 3
- 102000007469 Actins Human genes 0.000 claims description 2
- 108010085238 Actins Proteins 0.000 claims description 2
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 2
- 102100032912 CD44 antigen Human genes 0.000 claims description 2
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 2
- 102100037904 CD9 antigen Human genes 0.000 claims description 2
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims description 2
- 102100036912 Desmin Human genes 0.000 claims description 2
- 108010044052 Desmin Proteins 0.000 claims description 2
- 102100037241 Endoglin Human genes 0.000 claims description 2
- 102000001690 Factor VIII Human genes 0.000 claims description 2
- 108010054218 Factor VIII Proteins 0.000 claims description 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 2
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims description 2
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims description 2
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims description 2
- 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 claims description 2
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 2
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims description 2
- 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 claims description 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 2
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 2
- 102100022338 Integrin alpha-M Human genes 0.000 claims description 2
- 102100022337 Integrin alpha-V Human genes 0.000 claims description 2
- 102100022297 Integrin alpha-X Human genes 0.000 claims description 2
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 2
- 102000011782 Keratins Human genes 0.000 claims description 2
- 108010076876 Keratins Proteins 0.000 claims description 2
- 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 claims description 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 2
- 102000003729 Neprilysin Human genes 0.000 claims description 2
- 108090000028 Neprilysin Proteins 0.000 claims description 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims description 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 2
- 230000000735 allogeneic effect Effects 0.000 claims description 2
- 210000005045 desmin Anatomy 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229960000301 factor viii Drugs 0.000 claims description 2
- 238000007917 intracranial administration Methods 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007919 intrasynovial administration Methods 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 102100038021 Steryl-sulfatase Human genes 0.000 claims 8
- 241000894006 Bacteria Species 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 7
- 210000000130 stem cell Anatomy 0.000 description 2
- GNENVASJJIUNER-UHFFFAOYSA-N 2,4,6-tricyclohexyloxy-1,3,5,2,4,6-trioxatriborinane Chemical compound C1CCCCC1OB1OB(OC2CCCCC2)OB(OC2CCCCC2)O1 GNENVASJJIUNER-UHFFFAOYSA-N 0.000 description 1
- 208000022120 Jeavons syndrome Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14175095.0 | 2014-06-30 | ||
| EP14175095 | 2014-06-30 | ||
| PCT/IB2015/054923 WO2016001846A1 (en) | 2014-06-30 | 2015-06-30 | Mesenchymal stromal cells for treating sepsis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520583A JP2017520583A (ja) | 2017-07-27 |
| JP2017520583A5 true JP2017520583A5 (https=) | 2018-08-09 |
| JP6722599B2 JP6722599B2 (ja) | 2020-07-15 |
Family
ID=51033023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575950A Active JP6722599B2 (ja) | 2014-06-30 | 2015-06-30 | 全身性炎症反応症候群の治療のための間葉系間質細胞 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20170151284A1 (https=) |
| EP (1) | EP3160481B1 (https=) |
| JP (1) | JP6722599B2 (https=) |
| KR (1) | KR102213527B1 (https=) |
| CN (1) | CN106573017B (https=) |
| AU (1) | AU2015283662B2 (https=) |
| BR (1) | BR112016030758B8 (https=) |
| CA (1) | CA2953884C (https=) |
| IL (1) | IL249814B (https=) |
| MX (1) | MX381544B (https=) |
| NZ (1) | NZ727950A (https=) |
| RU (1) | RU2715866C2 (https=) |
| SG (1) | SG11201610844PA (https=) |
| WO (1) | WO2016001846A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11518982B2 (en) * | 2015-12-01 | 2022-12-06 | Adiposeeds, Inc. | Method for manufacturing mesenchymal cell line derived from vertebrate animal adipose tissue |
| US11701389B2 (en) * | 2016-03-09 | 2023-07-18 | Emory University | Methods of preserving mesenchymal stem cells |
| GB201604304D0 (en) * | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| JP7248984B2 (ja) | 2017-02-28 | 2023-03-30 | ユニバーシティ デ ロライン | 敗血症の治療のための、ワルトンジェリーから取得された間葉系幹細胞 |
| WO2019084010A1 (en) | 2017-10-26 | 2019-05-02 | Emory University | MCL-1 INHIBITORS, COMPOSITIONS AND USES IN CANCER CARE |
| JP7480454B2 (ja) * | 2018-06-05 | 2024-05-10 | メディポスト・カンパニー・リミテッド | 有効成分として間葉系幹細胞を含む炎症性疾患の予防又は治療のための医薬組成物 |
| KR20210086662A (ko) * | 2018-10-29 | 2021-07-08 | 오타와 하스피털 리서치 인스티튜트 | Aoah를 과발현하는 유전자조작된 중간엽 줄기 세포 및 이의 용도 |
| EP4098267A4 (en) * | 2020-01-30 | 2024-03-06 | JCR Pharmaceuticals Co., Ltd. | MEDICINAL COMPOSITION COMPRISING CELLS DERIVED FROM DENTAL PULP |
| JP2024517954A (ja) * | 2021-05-13 | 2024-04-23 | プライムジェン ユーエス インコーポレイテッド | 肝疾患を治療するための方法および組成物 |
| CN113398150A (zh) * | 2021-06-18 | 2021-09-17 | 卡替(上海)生物技术有限公司 | 牙髓间充质干细胞在脓毒症治疗中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5627175A (en) | 1992-12-02 | 1997-05-06 | Shellinternationale Research Maatschappij B.V. | Azoxycyanobenzene compounds |
| WO1995002698A1 (en) | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| ATE285477T1 (de) | 1995-06-07 | 2005-01-15 | Inex Pharmaceutical Corp | Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| US5705308A (en) | 1996-09-30 | 1998-01-06 | Eastman Kodak Company | Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element |
| US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| EP2298864B1 (en) * | 2004-03-22 | 2017-10-11 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| EP3184630B1 (en) | 2005-09-23 | 2019-07-17 | TiGenix, S.A.U. | Cell populations having immunoregulatory activity, method for isolation and uses |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| CA2829586C (en) * | 2011-03-11 | 2021-03-02 | Children's Medical Center Corporation | Methods and compositions relating to mesenchymal stem cell exosomes |
| JP2014016782A (ja) * | 2012-07-09 | 2014-01-30 | Toshiba Corp | 情報処理装置およびプログラム |
| US20140134140A1 (en) * | 2012-11-09 | 2014-05-15 | Case Western Reserve University | Mesenchymal stem cell compositions for the treatment of microbial infections |
-
2015
- 2015-06-30 WO PCT/IB2015/054923 patent/WO2016001846A1/en not_active Ceased
- 2015-06-30 EP EP15742102.5A patent/EP3160481B1/en active Active
- 2015-06-30 RU RU2016151738A patent/RU2715866C2/ru active
- 2015-06-30 AU AU2015283662A patent/AU2015283662B2/en active Active
- 2015-06-30 JP JP2016575950A patent/JP6722599B2/ja active Active
- 2015-06-30 US US15/323,373 patent/US20170151284A1/en not_active Abandoned
- 2015-06-30 BR BR112016030758A patent/BR112016030758B8/pt active IP Right Grant
- 2015-06-30 KR KR1020177002380A patent/KR102213527B1/ko active Active
- 2015-06-30 MX MX2017000142A patent/MX381544B/es unknown
- 2015-06-30 NZ NZ727950A patent/NZ727950A/en unknown
- 2015-06-30 CN CN201580042833.7A patent/CN106573017B/zh active Active
- 2015-06-30 CA CA2953884A patent/CA2953884C/en active Active
- 2015-06-30 SG SG11201610844PA patent/SG11201610844PA/en unknown
-
2016
- 2016-12-28 IL IL249814A patent/IL249814B/en active IP Right Grant
-
2020
- 2020-08-14 US US16/994,379 patent/US20200376038A1/en not_active Abandoned
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