JP2019508455A5 - - Google Patents

Download PDF

Info

Publication number
JP2019508455A5
JP2019508455A5 JP2018548356A JP2018548356A JP2019508455A5 JP 2019508455 A5 JP2019508455 A5 JP 2019508455A5 JP 2018548356 A JP2018548356 A JP 2018548356A JP 2018548356 A JP2018548356 A JP 2018548356A JP 2019508455 A5 JP2019508455 A5 JP 2019508455A5
Authority
JP
Japan
Prior art keywords
fistula
agent according
weeks
patient
remission
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018548356A
Other languages
English (en)
Japanese (ja)
Other versions
JP6931656B2 (ja
JP2019508455A (ja
Filing date
Publication date
Priority claimed from GBGB1604304.4A external-priority patent/GB201604304D0/en
Application filed filed Critical
Publication of JP2019508455A publication Critical patent/JP2019508455A/ja
Publication of JP2019508455A5 publication Critical patent/JP2019508455A5/ja
Priority to JP2021083406A priority Critical patent/JP2021119789A/ja
Application granted granted Critical
Publication of JP6931656B2 publication Critical patent/JP6931656B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018548356A 2016-03-14 2017-03-14 クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 Active JP6931656B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021083406A JP2021119789A (ja) 2016-03-14 2021-05-17 クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
GB1604304.4 2016-03-14
PCT/IB2017/051468 WO2017158509A1 (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021083406A Division JP2021119789A (ja) 2016-03-14 2021-05-17 クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞

Publications (3)

Publication Number Publication Date
JP2019508455A JP2019508455A (ja) 2019-03-28
JP2019508455A5 true JP2019508455A5 (https=) 2020-04-23
JP6931656B2 JP6931656B2 (ja) 2021-09-08

Family

ID=55952284

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018548356A Active JP6931656B2 (ja) 2016-03-14 2017-03-14 クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞
JP2021083406A Pending JP2021119789A (ja) 2016-03-14 2021-05-17 クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021083406A Pending JP2021119789A (ja) 2016-03-14 2021-05-17 クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞

Country Status (27)

Country Link
US (3) US10357518B2 (https=)
EP (2) EP3219321B1 (https=)
JP (2) JP6931656B2 (https=)
KR (1) KR102277789B1 (https=)
CN (2) CN108883135B (https=)
AU (1) AU2017232718B2 (https=)
BE (1) BE1024781B1 (https=)
CA (1) CA3017694C (https=)
CY (1) CY1125513T1 (https=)
DE (1) DE102017002458B4 (https=)
DK (1) DK3219321T3 (https=)
ES (2) ES2681774B1 (https=)
FR (1) FR3048614B1 (https=)
GB (2) GB201604304D0 (https=)
HR (1) HRP20220539T1 (https=)
HU (1) HUE058739T2 (https=)
IL (2) IL261730B2 (https=)
LT (1) LT3219321T (https=)
MX (1) MX2018010699A (https=)
NL (1) NL2018512B1 (https=)
NO (1) NO345415B1 (https=)
PL (1) PL3219321T3 (https=)
RS (1) RS63163B1 (https=)
RU (1) RU2742308C2 (https=)
SG (2) SG11201807404XA (https=)
SI (1) SI3219321T1 (https=)
WO (1) WO2017158509A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
AU2018244922A1 (en) 2017-03-30 2019-09-12 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
SG11202108114YA (en) * 2019-02-27 2021-08-30 Tigenix S A U Improved stem cell populations for allogeneic therapy
BR112022018022A2 (pt) * 2020-03-11 2022-10-18 Mesoblast Int Sarl Método para tratar doença inflamatória intestinal ii
EP4117691A1 (en) * 2020-03-11 2023-01-18 Mesoblast International Sàrl Method for treating inflammatory bowel disease i
CN111481573A (zh) * 2020-03-26 2020-08-04 卡替（上海）生物技术股份有限公司 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途
CA3200227A1 (en) * 2020-11-25 2022-06-02 Alexandra Sophie DE BOER Adipogenic cell compositions and methods
WO2023230524A1 (en) * 2022-05-25 2023-11-30 Flagship Pioneering Innovations Vi, Llc Compositions of secretory and/or catalytic cells and methods using the same

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US6010696A (en) 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
FR2680931B1 (fr) 1991-08-27 1997-08-14 Thomson Csf Procede de detection et de suivi d'objets en mouvement par analyse de sequences d'images.
US5627175A (en) 1992-12-02 1997-05-06 Shellinternationale Research Maatschappij B.V. Azoxycyanobenzene compounds
WO1995002698A1 (en) 1993-07-12 1995-01-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US5472183A (en) 1994-03-17 1995-12-05 Nisca Corporation Sheet feeding device with multiple sheet stackers
US6174333B1 (en) 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
CA2192103C (en) 1994-06-06 2002-02-05 Arnold I. Caplan Biomatrix for tissue regeneration
ATE285477T1 (de) 1995-06-07 2005-01-15 Inex Pharmaceutical Corp Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US6546106B2 (en) 1996-09-03 2003-04-08 New Transducers Limited Acoustic device
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
CA2312847C (en) 1997-12-02 2014-09-30 Zen Bio, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US9585916B2 (en) 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
AU2999199A (en) 1998-04-03 1999-10-25 Osiris Therapeutics, Inc. Mesenchymal stem cells as immunosuppressants
US6546105B1 (en) 1998-10-30 2003-04-08 Matsushita Electric Industrial Co., Ltd. Sound image localization device and sound image localization method
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
BR0008552A (pt) 1999-03-10 2002-05-07 Univ Pittsburgh Células tronco e redes derivadas de tecido adiposo
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
CN1201268C (zh) 1999-06-30 2005-05-11 国际商业机器公司 实现运动模糊化的图像处理
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
JP4680483B2 (ja) 2001-02-23 2011-05-11 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 組織および臓器の治療および修復に用いるための幹細胞マトリックスの迅速な調製方法
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
KR20050044393A (ko) * 2001-11-09 2005-05-12 아르테셀 사이언스, 인크. 지방 조직 유래된 스트로마 세포의 내분비 췌장 분화 및이의 용도
JP2005508393A (ja) 2001-11-09 2005-03-31 アーテセル・サイエンシズ・インコーポレーテツド 胚および成人幹細胞をサポートするための間質細胞の使用の方法および組成物
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
IL164079A0 (en) 2002-03-15 2005-12-18 Us Dept Veterans Affairs Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
ES2306876T3 (es) 2002-06-14 2008-11-16 Cartela Ab Marcador para celulas madre y su uso.
US20040101959A1 (en) 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
ATE482725T1 (de) 2003-04-01 2010-10-15 Us Dept Of Veteran S Affaires Auf stammzellen, vorläuferzellen oder targetzellen basierende behandlung von multiorganversagen.
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
EP2399990B1 (en) 2003-06-27 2015-07-22 DePuy Synthes Products, Inc. Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system
US7645229B2 (en) 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
US9074190B2 (en) 2003-10-07 2015-07-07 Biomaster, Inc. Cell differentiation of adipose-derived precursor cells
KR100821128B1 (ko) 2003-11-04 2008-04-14 가부시키가이샤 바이오마스타 지방 조직으로부터 줄기세포를 생성하는 방법 및 시스템
EP2298864B1 (en) 2004-03-22 2017-10-11 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
US7732126B2 (en) 2004-09-03 2010-06-08 University Of Maryland, Baltimore Integrin CD18 is a novel stromal stem cell marker and functions to promote osteogenesis
WO2006110582A1 (en) 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
EP3184630B1 (en) 2005-09-23 2019-07-17 TiGenix, S.A.U. Cell populations having immunoregulatory activity, method for isolation and uses
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
WO2008036374A2 (en) 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
US20110262402A1 (en) 2007-09-07 2011-10-27 Masahiko Kuroda Therapeutic and prophylactic agents for arthritis
KR20140107677A (ko) 2007-09-19 2014-09-04 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
US20100247577A1 (en) 2007-10-17 2010-09-30 Txcell Tr1 cells, mesenchymal stem cells and uses thereof
GB0814249D0 (en) 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
ES2345867B1 (es) * 2009-04-03 2011-07-28 Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) Celulas madre multipotentes derivadas de estroma de mesenterio.
JP5647230B2 (ja) * 2009-04-28 2014-12-24 アントロジェン カンパニー リミテッドＡｎｔｅｒｏｇｅｎ Ｃｏ．， Ｌｔｄ． 瘻孔治療のための自家及び同種異系の脂肪由来間質幹細胞組成物
CA2767300C (en) 2009-07-09 2020-01-07 Cellerix Sa Methods and compositions for use in cellular therapies
AU2011338682B2 (en) * 2010-12-06 2017-04-27 Quark Pharmaceuticals, Inc. Double stranded oligonucleotide compounds comprising threose modifications
EP2663316A2 (en) 2011-01-12 2013-11-20 TiGenix, S.A.U. Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases
ES2479565T1 (es) 2011-03-11 2014-08-20 Tigenix, S.A.U. Poblaciones celulares que tienen actividad immunoreguladora, método para el aislamiento y usos
US20140134140A1 (en) 2012-11-09 2014-05-15 Case Western Reserve University Mesenchymal stem cell compositions for the treatment of microbial infections
EP2972368B1 (en) * 2013-03-15 2019-07-24 TiGenix, S.A.U. Lymphocyte biomarkers for determining the clinical response to cell therapy
WO2014207679A1 (en) 2013-06-25 2014-12-31 Tigenix S.A.U. Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
WO2016001846A1 (en) * 2014-06-30 2016-01-07 Tigenix S.A.U. Mesenchymal stromal cells for treating sepsis
EP3353286A1 (en) * 2015-09-24 2018-08-01 Cellect Biotherapeutics Ltd. Methods for propagating mesenchymal stem cells (msc) for use in transplantation
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
US10152822B2 (en) 2017-04-01 2018-12-11 Intel Corporation Motion biased foveated renderer
US10890966B2 (en) 2017-07-27 2021-01-12 Arm Limited Graphics processing systems
US10818080B2 (en) 2018-07-25 2020-10-27 Disney Enterprises, Inc. Piecewise-polynomial coupling layers for warp-predicting neural networks
US11109065B2 (en) 2018-09-26 2021-08-31 Google Llc Video encoding by providing geometric proxies

Similar Documents

Publication Publication Date Title
JP2019508455A5 (https=)
JP2021119789A5 (https=)
Hoang et al. Stem cell-based therapy for human diseases
Mei et al. Advances and clinical challenges of mesenchymal stem cell therapy
US20220088084A1 (en) Uses of mesenchymal stem cells
US8562973B2 (en) Treatment of sarcoidosis using placental stem cells
Wu et al. Therapeutic potential of human umbilical cord derived stem cells in a rat myocardial infarction model
RU2018131519A (ru) Стромальные стволовые клетки жировой ткани для использования в лечении рефракторных сложных перианальных фистул при болезни крона
WO2012092458A2 (en) Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof
Alamoudi et al. Treatment of oral ulcers in dogs using adipose tissue-derived mesenchymal stem cells
JP2015521630A5 (https=)
Huang et al. Updates on GMSCs treatment for autoimmune diseases
CN111212654A (zh) 用激活的调节性t细胞治疗肝衰竭
Grabowska et al. Myogenic potential of mesenchymal stem cells-the case of adhesive fraction of human umbilical cord blood cells
Chen et al. Current state of heart failure treatment: are mesenchymal stem cells and their exosomes a future therapy?
JP2017520582A5 (https=)
Ling et al. Pretreatment of rat bone marrow mesenchymal stem cells with a combination of hypergravity and 5‐azacytidine enhances therapeutic efficacy for myocardial infarction
Tufan Mesenchymal stem cells as a treatment strategy for coronavirus disease 2019 (COVID-19): need for authority regulations and clinical guidelines
EP2931876B1 (en) Treatment of diseases of endothelial dysfunction and inflammation
EP3053589B1 (en) Il-17 production inhibitory composition
Ishii Stem Cell Therapy and Regenerative
Carvalho et al. UM171 EXPANDS IMMATURE BONE MARROW CD34+ CELLS FROM PATIENTS WITH TELOMEROPATHIES
Li et al. 253. The Use of Osteoporotic BMSCs Engineered by Baculovirus-Mediated MicroRNAs Sponge to Heal Osteoporotic Bone Defect
Knyazev et al. Safety of mesenchymal stem cells therapy in patients with inflammatory bowel diseases–5 year follow-up
Laner-Plamberger et al. Heparin for in vitro culture of human mesenchymal stem cells: to use or not to use?