JP2017519780A5 - - Google Patents
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- JP2017519780A5 JP2017519780A5 JP2016575325A JP2016575325A JP2017519780A5 JP 2017519780 A5 JP2017519780 A5 JP 2017519780A5 JP 2016575325 A JP2016575325 A JP 2016575325A JP 2016575325 A JP2016575325 A JP 2016575325A JP 2017519780 A5 JP2017519780 A5 JP 2017519780A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- unsubstituted
- hydrogen
- interferon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HWPZZUQOWRWFDB-UHFFFAOYSA-N CN(C=CC(N)=N1)C1=O Chemical compound CN(C=CC(N)=N1)C1=O HWPZZUQOWRWFDB-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462016219P | 2014-06-24 | 2014-06-24 | |
| US62/016,219 | 2014-06-24 | ||
| US201462034629P | 2014-08-07 | 2014-08-07 | |
| US62/034,629 | 2014-08-07 | ||
| US201462061819P | 2014-10-09 | 2014-10-09 | |
| US62/061,819 | 2014-10-09 | ||
| PCT/US2015/036958 WO2015200205A1 (en) | 2014-06-24 | 2015-06-22 | Substituted nucleosides, nucleotides and analogs thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519780A JP2017519780A (ja) | 2017-07-20 |
| JP2017519780A5 true JP2017519780A5 (enExample) | 2018-09-13 |
| JP6669675B2 JP6669675B2 (ja) | 2020-03-18 |
Family
ID=54868667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575325A Expired - Fee Related JP6669675B2 (ja) | 2014-06-24 | 2015-06-22 | 置換ヌクレオシド、ヌクレオチドおよびその類似体 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9603863B2 (enExample) |
| EP (1) | EP3160475B1 (enExample) |
| JP (1) | JP6669675B2 (enExample) |
| CN (1) | CN106604734B (enExample) |
| AP (1) | AP2016009653A0 (enExample) |
| AU (1) | AU2015280234B2 (enExample) |
| CA (1) | CA2952959C (enExample) |
| EA (1) | EA201692537A1 (enExample) |
| IL (1) | IL249627A0 (enExample) |
| MA (1) | MA40031A (enExample) |
| MX (1) | MX2016017381A (enExample) |
| NZ (1) | NZ727582A (enExample) |
| PH (1) | PH12016502563A1 (enExample) |
| SG (1) | SG11201610597QA (enExample) |
| TN (1) | TN2016000566A1 (enExample) |
| TW (1) | TW201613613A (enExample) |
| WO (1) | WO2015200205A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013500035A1 (en) | 2010-07-22 | 2013-03-11 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
| SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US8980865B2 (en) | 2011-12-22 | 2015-03-17 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| CN110684067A (zh) | 2012-12-21 | 2020-01-14 | 艾丽奥斯生物制药有限公司 | 取代的核苷和核苷酸 |
| WO2014100498A1 (en) | 2012-12-21 | 2014-06-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2014165704A1 (en) | 2013-04-05 | 2014-10-09 | Vertex Pharmaceuticals, Inc. | Hepatitis c viral infection treatment using a combination of compounds |
| US9815864B2 (en) | 2013-06-26 | 2017-11-14 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3424938B1 (en) | 2013-06-26 | 2020-07-22 | Janssen BioPharma, Inc. | 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof |
| AU2014331863C1 (en) | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| CN117379452A (zh) | 2014-06-24 | 2024-01-12 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸和其类似物 |
| AU2015280234B2 (en) | 2014-06-24 | 2021-04-01 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| MX381291B (es) | 2014-09-26 | 2025-03-12 | Riboscience Llc | Derivados de nucleósidos sustituidos con 4'-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial. |
| EP3204020B1 (en) * | 2014-10-06 | 2023-01-18 | ImmunityBio, Inc. | Treating viral hemorrhagic fever with nk-92 cells |
| US9908914B2 (en) | 2014-10-28 | 2018-03-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| SG10202105371YA (en) | 2014-12-26 | 2021-07-29 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| GEAP202215528A (en) | 2015-03-06 | 2022-11-10 | Atea Pharmaceuticals Inc | B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT |
| MX383931B (es) | 2015-03-11 | 2025-03-14 | Janssen Biopharma Inc | Compuestos de aza-piridona y usos de estos. |
| EA201892448A1 (ru) * | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| BR112019004297A2 (pt) | 2016-09-07 | 2019-05-28 | Atea Pharmaceuticals Inc | método, uso de uma quantidade eficaz de um composto, composto, e, composição farmacêutica. |
| SG11201906163TA (en) | 2017-02-01 | 2019-08-27 | Atea Pharmaceuticals Inc | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus |
| ES2938859T3 (es) | 2017-05-01 | 2023-04-17 | Gilead Sciences Inc | Una forma cristalina de (S)-2-etilbutilo 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato |
| WO2019014247A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS |
| US11149049B2 (en) | 2017-09-18 | 2021-10-19 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| FI3706762T3 (fi) | 2017-12-07 | 2024-12-13 | Univ Emory | N4-hydroksisytidiini ja johdannaisia sekä niihin liittyviä virusten vastaisia käyttötapoja |
| US20210308168A1 (en) * | 2018-03-07 | 2021-10-07 | Emory University | 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| EP3773753A4 (en) | 2018-04-10 | 2021-12-22 | ATEA Pharmaceuticals, Inc. | TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS |
| EA202192433A1 (ru) | 2019-03-06 | 2021-12-28 | Глэксосмитклайн Интеллекчуал Проперти (№2) Лимитед | Соединения, полезные в терапии вич |
| CN114072407A (zh) * | 2019-04-02 | 2022-02-18 | 阿里戈斯治疗公司 | 靶向prmt5的化合物 |
| CN118662520A (zh) | 2020-01-27 | 2024-09-20 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| EP4106876B1 (en) * | 2020-02-18 | 2025-09-17 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| US11613553B2 (en) | 2020-03-12 | 2023-03-28 | Gilead Sciences, Inc. | Methods of preparing 1′-cyano nucleosides |
| AR121620A1 (es) | 2020-03-20 | 2022-06-22 | Gilead Sciences Inc | Profármacos de nucleósidos 4-c-sustituidos-2-halo-2-deoxiadenosina y métodos de preparación y uso de los mismos |
| EP4132651B1 (en) | 2020-04-06 | 2026-03-18 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| US20230310481A1 (en) * | 2020-04-14 | 2023-10-05 | Janssen Pharmaceuticals, Inc. | Bi- and monocyclic nucleoside analogs for treatment of hepatitis e |
| ES3041698T3 (en) | 2020-05-29 | 2025-11-13 | Gilead Sciences Inc | Remdesivir for the treatment of viral infections |
| EP4172160A2 (en) | 2020-06-24 | 2023-05-03 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
| EP4200301B1 (en) | 2020-08-24 | 2025-02-26 | Gilead Sciences, Inc. | Phospholipid compounds and uses thereof |
| HUE067491T2 (hu) | 2020-08-27 | 2024-10-28 | Gilead Sciences Inc | Vegyületek és eljárások vírusfertõzések kezelésére |
| TWI811812B (zh) | 2020-10-16 | 2023-08-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| KR102923359B1 (ko) | 2021-04-16 | 2026-02-05 | 길리애드 사이언시즈, 인코포레이티드 | 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법 |
| JP2024525164A (ja) | 2021-06-17 | 2024-07-10 | アテア ファーマシューティカルズ， インコーポレイテッド | 有利な抗ｈｃｖ併用療法 |
| CN113735929A (zh) * | 2021-07-21 | 2021-12-03 | 海化生命(厦门)科技有限公司 | 一种抗冠状病毒的化合物及其制备方法与应用 |
| EP4387977A1 (en) | 2021-08-18 | 2024-06-26 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| US11541071B1 (en) | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
| CN116554249B (zh) * | 2022-01-28 | 2025-03-18 | 北京恩泰伟医药科技有限公司 | 抗病毒化合物及其用途 |
| AU2023227794A1 (en) | 2022-03-02 | 2024-10-17 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| JP2025509635A (ja) | 2022-03-15 | 2025-04-11 | ローム・セラピューティクス・インコーポレイテッド | 疾患を治療するための化合物及び方法 |
| CN116947947A (zh) * | 2022-04-20 | 2023-10-27 | 中国科学院上海药物研究所 | 抗病毒核苷类似物及其药物组合物和用途 |
| CN116535385B (zh) * | 2022-08-29 | 2025-03-11 | 苏州华一新能源科技股份有限公司 | 一种制备硫酸乙烯酯的方法 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| CN116589510B (zh) * | 2023-04-20 | 2025-08-26 | 安徽大学 | 一种氟代苄基核糖中间体的制备方法与应用 |
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| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| DZ3487A1 (fr) | 2001-01-22 | 2002-07-25 | Merck Sharp & Dohme | Derives de nucleoside comme inhibiteurs de l'arn polymerase virale d'arn-dependant |
| WO2002069903A2 (en) * | 2001-03-06 | 2002-09-12 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| US20040138170A1 (en) | 2002-03-06 | 2004-07-15 | Montgomery John A. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
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| JP2008508319A (ja) * | 2004-07-29 | 2008-03-21 | メタバシス・セラピューティクス・インコーポレイテッド | 新規ヌクレオシド誘導体 |
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| EA025341B1 (ru) | 2010-09-22 | 2016-12-30 | Алиос Биофарма, Инк. | Замещенные аналоги нуклеотидов |
| AU2011305652B2 (en) | 2010-09-22 | 2016-10-20 | Janssen Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
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| EA024297B1 (ru) | 2011-12-20 | 2016-09-30 | Рибосайенс Ллк | 2',4'-дифтор-2'-метилзамещенные нуклеозидные производные в качестве ингибиторов репликации рнк вируса гепатита с |
| US8980865B2 (en) | 2011-12-22 | 2015-03-17 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| CN104203253A (zh) | 2012-03-21 | 2014-12-10 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
| EP2828278A4 (en) | 2012-03-21 | 2015-12-09 | Alios Biopharma Inc | PROCESSES FOR PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS |
| WO2013142159A1 (en) | 2012-03-21 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| HK1203356A1 (en) | 2012-03-22 | 2015-10-30 | 艾丽奥斯生物制药有限公司 | Pharmaceutical combinations comprising a thionucleotide analog |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| WO2014100498A1 (en) | 2012-12-21 | 2014-06-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| CN110684067A (zh) | 2012-12-21 | 2020-01-14 | 艾丽奥斯生物制药有限公司 | 取代的核苷和核苷酸 |
| WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
| WO2014164533A1 (en) | 2013-03-11 | 2014-10-09 | Vertex Pharmaceuticals Incorporated | Methods of stereoselective synthesis of substituted nucleoside analogs |
| WO2014165704A1 (en) | 2013-04-05 | 2014-10-09 | Vertex Pharmaceuticals, Inc. | Hepatitis c viral infection treatment using a combination of compounds |
| EP3424938B1 (en) | 2013-06-26 | 2020-07-22 | Janssen BioPharma, Inc. | 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof |
| US9815864B2 (en) | 2013-06-26 | 2017-11-14 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3043803B1 (en) * | 2013-09-11 | 2022-04-27 | Emory University | Nucleotide and nucleoside compositions and their uses |
| AU2014331863C1 (en) | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EA201692473A1 (ru) | 2014-06-24 | 2017-03-31 | Элиос Биофарма, Инк. | Способы получения замещенных нуклеотидных аналогов |
| CN117379452A (zh) | 2014-06-24 | 2024-01-12 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸和其类似物 |
| AU2015280234B2 (en) | 2014-06-24 | 2021-04-01 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| CA2955604A1 (en) | 2014-07-22 | 2016-01-28 | Alios Biopharma, Inc. | Methods for treating paramyxoviruses |
| EP3177299A4 (en) | 2014-08-05 | 2018-04-04 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| US9908914B2 (en) | 2014-10-28 | 2018-03-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA45925A (fr) | 2016-08-12 | 2019-06-19 | Janssen Biopharma Inc | Nucléosides et nucléotides substitués et leurs analogues |
| US20180117042A1 (en) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Methods for treating respiratory syncytial virus infection |
| US11149049B2 (en) | 2017-09-18 | 2021-10-19 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
-
2015
- 2015-06-22 AU AU2015280234A patent/AU2015280234B2/en not_active Ceased
- 2015-06-22 JP JP2016575325A patent/JP6669675B2/ja not_active Expired - Fee Related
- 2015-06-22 NZ NZ727582A patent/NZ727582A/en not_active IP Right Cessation
- 2015-06-22 CN CN201580045400.7A patent/CN106604734B/zh active Active
- 2015-06-22 MX MX2016017381A patent/MX2016017381A/es unknown
- 2015-06-22 SG SG11201610597QA patent/SG11201610597QA/en unknown
- 2015-06-22 WO PCT/US2015/036958 patent/WO2015200205A1/en not_active Ceased
- 2015-06-22 MA MA040031A patent/MA40031A/fr unknown
- 2015-06-22 EP EP15810951.2A patent/EP3160475B1/en active Active
- 2015-06-22 CA CA2952959A patent/CA2952959C/en active Active
- 2015-06-22 TN TN2016000566A patent/TN2016000566A1/en unknown
- 2015-06-22 EA EA201692537A patent/EA201692537A1/ru unknown
- 2015-06-22 US US14/746,138 patent/US9603863B2/en active Active
- 2015-06-22 AP AP2016009653A patent/AP2016009653A0/en unknown
- 2015-06-24 TW TW104120407A patent/TW201613613A/zh unknown
-
2016
- 2016-12-18 IL IL249627A patent/IL249627A0/en unknown
- 2016-12-21 PH PH12016502563A patent/PH12016502563A1/en unknown
-
2017
- 2017-02-08 US US15/427,964 patent/US10052342B2/en active Active
-
2018
- 2018-08-20 US US16/105,859 patent/US10780105B2/en active Active
-
2020
- 2020-08-24 US US17/001,512 patent/US11590155B2/en active Active
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