MX2016017381A - Nucleosidos sustituidos, nucleotidos y analogos de los mismos. - Google Patents
Nucleosidos sustituidos, nucleotidos y analogos de los mismos.Info
- Publication number
- MX2016017381A MX2016017381A MX2016017381A MX2016017381A MX2016017381A MX 2016017381 A MX2016017381 A MX 2016017381A MX 2016017381 A MX2016017381 A MX 2016017381A MX 2016017381 A MX2016017381 A MX 2016017381A MX 2016017381 A MX2016017381 A MX 2016017381A
- Authority
- MX
- Mexico
- Prior art keywords
- analogs
- nucleotides
- substituted nucleosides
- nucleosides
- nucleotide analogs
- Prior art date
Links
- 125000003729 nucleotide group Chemical group 0.000 title abstract 4
- 239000002777 nucleoside Substances 0.000 title abstract 3
- 125000003835 nucleoside group Chemical group 0.000 title abstract 3
- 239000002773 nucleotide Substances 0.000 title 1
- 241000711950 Filoviridae Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462016219P | 2014-06-24 | 2014-06-24 | |
| US201462034629P | 2014-08-07 | 2014-08-07 | |
| US201462061819P | 2014-10-09 | 2014-10-09 | |
| PCT/US2015/036958 WO2015200205A1 (en) | 2014-06-24 | 2015-06-22 | Substituted nucleosides, nucleotides and analogs thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016017381A true MX2016017381A (es) | 2017-08-14 |
Family
ID=54868667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016017381A MX2016017381A (es) | 2014-06-24 | 2015-06-22 | Nucleosidos sustituidos, nucleotidos y analogos de los mismos. |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9603863B2 (enExample) |
| EP (1) | EP3160475B1 (enExample) |
| JP (1) | JP6669675B2 (enExample) |
| CN (1) | CN106604734B (enExample) |
| AP (1) | AP2016009653A0 (enExample) |
| AU (1) | AU2015280234B2 (enExample) |
| CA (1) | CA2952959C (enExample) |
| EA (1) | EA201692537A1 (enExample) |
| IL (1) | IL249627A0 (enExample) |
| MA (1) | MA40031A (enExample) |
| MX (1) | MX2016017381A (enExample) |
| NZ (1) | NZ727582A (enExample) |
| PH (1) | PH12016502563A1 (enExample) |
| SG (1) | SG11201610597QA (enExample) |
| TN (1) | TN2016000566A1 (enExample) |
| TW (1) | TW201613613A (enExample) |
| WO (1) | WO2015200205A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2595980B1 (en) | 2010-07-22 | 2014-09-03 | Gilead Sciences, Inc. | Methods and compounds for treating paramyxoviridae virus infections |
| AU2012358804B2 (en) | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| CA3107640A1 (en) | 2011-12-22 | 2013-06-27 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof and their use in ameliorating or treating a disease or condition associated with viral infections |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| NZ631601A (en) | 2012-03-21 | 2016-06-24 | Alios Biopharma Inc | Solid forms of a thiophosphoramidate nucleotide prodrug |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US9598457B2 (en) | 2012-12-21 | 2017-03-21 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TW201532606A (zh) | 2013-04-05 | 2015-09-01 | Alios Biopharma Inc | 使用化合物之組合治療ｃ型肝炎病毒感染 |
| US9422322B2 (en) | 2013-06-26 | 2016-08-23 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| AU2014302711A1 (en) | 2013-06-26 | 2015-12-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| CN105829333A (zh) | 2013-10-11 | 2016-08-03 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
| MA40031A (fr) | 2014-06-24 | 2015-12-30 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| EA201692535A1 (ru) | 2014-06-24 | 2017-05-31 | Элиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| JP6671355B2 (ja) | 2014-09-26 | 2020-03-25 | リボサイエンス・エルエルシー | 呼吸器多核体ウイルスのｒｎａ複製の阻害剤としての４’‐ビニル置換ヌクレオシド誘導体 |
| EP3204020B1 (en) * | 2014-10-06 | 2023-01-18 | ImmunityBio, Inc. | Treating viral hemorrhagic fever with nk-92 cells |
| EP3212657A4 (en) | 2014-10-28 | 2018-04-11 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) * | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| SMT202100592T1 (it) | 2014-12-26 | 2021-11-12 | Univ Emory | Derivati antivirali della n4-idrossicitidina |
| MX2017011386A (es) | 2015-03-06 | 2018-04-26 | Atea Pharmaceuticals Inc | NUCLEÓTIDOS DE PURINA ß-D-2'-DEOXI-2'A-FLUORO-2'-ß-C-SUSTITUIDOS-2 - MODIFICADOS-N6- SUSTITUIDOS PARA EL TRATAMIENTO DEL VIRUS DE LA HEPATITIS C. |
| AU2016229147C1 (en) | 2015-03-11 | 2021-03-25 | Janssen Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| WO2017189978A1 (en) * | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| RS62943B1 (sr) | 2016-09-07 | 2022-03-31 | Atea Pharmaceuticals Inc | 2’-supstituisani-n6-supstituisani purinski nukleotidi za lečenje bolesti izazvanih rnk virusima |
| IL288737B (en) | 2017-02-01 | 2022-09-01 | Atea Pharmaceuticals Inc | Hemisulfate nucleotide salt for treatment of hepatitis c virus |
| WO2018204198A1 (en) | 2017-05-01 | 2018-11-08 | Gilead Sciences, Inc. | Crystalline forms of (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| US10675296B2 (en) | 2017-07-11 | 2020-06-09 | Gilead Sciences, Inc. | Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections |
| JP2020534361A (ja) | 2017-09-18 | 2020-11-26 | ヤンセン・バイオファーマ・インコーポレイテッド | 置換ヌクレオシド、ヌクレオチド、及びそのアナログ |
| ES2995458T3 (en) | 2017-12-07 | 2025-02-10 | Univ Emory | N4-hydroxycytidine derivative and anti-viral uses related thereto |
| CN119633010A (zh) * | 2018-03-07 | 2025-03-18 | 埃默里大学 | 含4′-卤素的核苷酸和核苷治疗组合物以及其相关用途 |
| TW202012001A (zh) | 2018-04-10 | 2020-04-01 | 美商亞堤製藥公司 | C型肝炎病毒(hcv)感染硬化之患者的治療 |
| JP2022525013A (ja) | 2019-03-06 | 2022-05-11 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッド | Ｈｉｖ療法において有用な化合物 |
| BR112021019465A8 (pt) * | 2019-04-02 | 2022-06-07 | Aligos Therapeutics Inc | Compostos que têm como alvo prmt5 |
| KR20220132608A (ko) | 2020-01-27 | 2022-09-30 | 길리애드 사이언시즈, 인코포레이티드 | SARS CoV-2 감염증을 치료하기 위한 방법 |
| AR121356A1 (es) * | 2020-02-18 | 2022-05-11 | Gilead Sciences Inc | Compuestos antivirales |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| TWI890963B (zh) | 2020-03-12 | 2025-07-21 | 美商基利科學股份有限公司 | 1'-氰基核苷之製備方法 |
| WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| PE20230386A1 (es) * | 2020-04-14 | 2023-03-06 | Janssen Pharmaceuticals Inc | Analogos del nucleosido biciclico y monociclico para el tratamiento de la hepatitis e |
| EP4157272B1 (en) | 2020-05-29 | 2025-07-02 | Gilead Sciences, Inc. | Remdesivir for the treatment of viral infections |
| IL299202A (en) | 2020-06-24 | 2023-02-01 | Gilead Sciences Inc | 1'-cyano nucleoside analogs and uses thereof |
| CA3188373A1 (en) | 2020-08-24 | 2022-03-03 | Scott E. Lazerwith | Phospholipid compounds and uses thereof |
| KR20250111239A (ko) | 2020-08-27 | 2025-07-22 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스 감염 치료를 위한 화합물 및 방법 |
| TW202344257A (zh) | 2020-10-16 | 2023-11-16 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| US11697666B2 (en) | 2021-04-16 | 2023-07-11 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| JP2024525164A (ja) | 2021-06-17 | 2024-07-10 | アテア ファーマシューティカルズ， インコーポレイテッド | 有利な抗ｈｃｖ併用療法 |
| CN113735929A (zh) * | 2021-07-21 | 2021-12-03 | 海化生命(厦门)科技有限公司 | 一种抗冠状病毒的化合物及其制备方法与应用 |
| US12116380B2 (en) | 2021-08-18 | 2024-10-15 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| US11541071B1 (en) | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
| CN116554249B (zh) * | 2022-01-28 | 2025-03-18 | 北京恩泰伟医药科技有限公司 | 抗病毒化合物及其用途 |
| KR20240154647A (ko) | 2022-03-02 | 2024-10-25 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
| TW202400134A (zh) | 2022-03-15 | 2024-01-01 | 美商羅米醫療公司 | 用於治療疾病之化合物及方法 |
| CN116535385B (zh) * | 2022-08-29 | 2025-03-11 | 苏州华一新能源科技股份有限公司 | 一种制备硫酸乙烯酯的方法 |
| CN116589510B (zh) * | 2023-04-20 | 2025-08-26 | 安徽大学 | 一种氟代苄基核糖中间体的制备方法与应用 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| CN1267446C (zh) | 2001-01-22 | 2006-08-02 | 默克公司 | 作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物 |
| WO2002069903A2 (en) | 2001-03-06 | 2002-09-12 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| US20040138170A1 (en) | 2002-03-06 | 2004-07-15 | Montgomery John A. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| EA200600540A1 (ru) | 2003-09-05 | 2006-08-25 | Анадис Фармасьютикалз, Инк. | Введение лигандов tlr7 и их пролекарств для лечения инфекции вируса гепатита с |
| WO2006033709A2 (en) | 2004-07-29 | 2006-03-30 | Metabasis Therapeutics, Inc. | Novel nucleoside derivatives |
| US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| US20090176732A1 (en) | 2007-12-21 | 2009-07-09 | Alios Biopharma Inc. | Protected nucleotide analogs |
| US8475804B2 (en) * | 2009-02-20 | 2013-07-02 | U.S. Army Medical Research And Material Command | Compositions and methods for treatment of filovirus-mediated diseases |
| US20100249068A1 (en) * | 2009-03-20 | 2010-09-30 | Alios Biopharma, Inc. | Substituted nucleoside and nucleotide analogs |
| WO2010108135A1 (en) * | 2009-03-20 | 2010-09-23 | Alios Biopharma, Inc. | Protected nucleotide analogs |
| WO2012040126A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| NZ607996A (en) | 2010-09-22 | 2014-07-25 | Alios Biopharma Inc | Substituted nucleotide analogs |
| US8877731B2 (en) | 2010-09-22 | 2014-11-04 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| US8772474B2 (en) | 2010-12-22 | 2014-07-08 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
| UA111761C2 (uk) | 2011-12-20 | 2016-06-10 | Рібосаєнс Ллс | 2',4'-дифтор-2'-метилзаміщені нуклеозидні похідні як інгібітори реплікації phk вірусу гепатиту c |
| CA3107640A1 (en) | 2011-12-22 | 2013-06-27 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof and their use in ameliorating or treating a disease or condition associated with viral infections |
| AU2012358804B2 (en) | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| NZ631601A (en) | 2012-03-21 | 2016-06-24 | Alios Biopharma Inc | Solid forms of a thiophosphoramidate nucleotide prodrug |
| WO2013142159A1 (en) | 2012-03-21 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| PL2827875T3 (pl) | 2012-03-21 | 2019-07-31 | Janssen Biopharma, Inc. | Podstawione nukleozydy, nukleotydy i ich analogi |
| HK1203513A1 (en) | 2012-03-21 | 2015-10-30 | 艾丽奥斯生物制药有限公司 | Methods of preparing substituted nucleotide analogs |
| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| US9598457B2 (en) | 2012-12-21 | 2017-03-21 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
| US20140309413A1 (en) | 2013-03-11 | 2014-10-16 | Vertex Pharmaceuticals Incorporated | Methods of stereoselective synthesis of substituted nucleoside analogs |
| TW201532606A (zh) | 2013-04-05 | 2015-09-01 | Alios Biopharma Inc | 使用化合物之組合治療ｃ型肝炎病毒感染 |
| AU2014302711A1 (en) | 2013-06-26 | 2015-12-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9422322B2 (en) | 2013-06-26 | 2016-08-23 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3043803B1 (en) * | 2013-09-11 | 2022-04-27 | Emory University | Nucleotide and nucleoside compositions and their uses |
| CN105829333A (zh) | 2013-10-11 | 2016-08-03 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
| MA40031A (fr) | 2014-06-24 | 2015-12-30 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| AU2015280245A1 (en) | 2014-06-24 | 2017-01-05 | Alios Biopharma, Inc. | Methods of preparing substituted nucleotide analogs |
| EA201692535A1 (ru) | 2014-06-24 | 2017-05-31 | Элиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| US20160022724A1 (en) | 2014-07-22 | 2016-01-28 | Alios Biopharma, Inc. | Methods for treating paramyxoviruses |
| AU2015301334A1 (en) | 2014-08-05 | 2017-02-23 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| EP3212657A4 (en) | 2014-10-28 | 2018-04-11 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA45925A (fr) | 2016-08-12 | 2019-06-19 | Janssen Biopharma Inc | Nucléosides et nucléotides substitués et leurs analogues |
| WO2018081449A1 (en) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Methods for treating respiratory syncytial virus infection |
| JP2020534361A (ja) | 2017-09-18 | 2020-11-26 | ヤンセン・バイオファーマ・インコーポレイテッド | 置換ヌクレオシド、ヌクレオチド、及びそのアナログ |
-
2015
- 2015-06-22 MA MA040031A patent/MA40031A/fr unknown
- 2015-06-22 JP JP2016575325A patent/JP6669675B2/ja not_active Expired - Fee Related
- 2015-06-22 MX MX2016017381A patent/MX2016017381A/es unknown
- 2015-06-22 TN TN2016000566A patent/TN2016000566A1/en unknown
- 2015-06-22 AP AP2016009653A patent/AP2016009653A0/en unknown
- 2015-06-22 WO PCT/US2015/036958 patent/WO2015200205A1/en not_active Ceased
- 2015-06-22 EA EA201692537A patent/EA201692537A1/ru unknown
- 2015-06-22 NZ NZ727582A patent/NZ727582A/en not_active IP Right Cessation
- 2015-06-22 SG SG11201610597QA patent/SG11201610597QA/en unknown
- 2015-06-22 EP EP15810951.2A patent/EP3160475B1/en active Active
- 2015-06-22 CA CA2952959A patent/CA2952959C/en active Active
- 2015-06-22 AU AU2015280234A patent/AU2015280234B2/en not_active Ceased
- 2015-06-22 CN CN201580045400.7A patent/CN106604734B/zh active Active
- 2015-06-22 US US14/746,138 patent/US9603863B2/en active Active
- 2015-06-24 TW TW104120407A patent/TW201613613A/zh unknown
-
2016
- 2016-12-18 IL IL249627A patent/IL249627A0/en unknown
- 2016-12-21 PH PH12016502563A patent/PH12016502563A1/en unknown
-
2017
- 2017-02-08 US US15/427,964 patent/US10052342B2/en active Active
-
2018
- 2018-08-20 US US16/105,859 patent/US10780105B2/en active Active
-
2020
- 2020-08-24 US US17/001,512 patent/US11590155B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA201692537A1 (ru) | 2017-05-31 |
| SG11201610597QA (en) | 2017-01-27 |
| AU2015280234B2 (en) | 2021-04-01 |
| NZ727582A (en) | 2018-06-29 |
| US9603863B2 (en) | 2017-03-28 |
| WO2015200205A1 (en) | 2015-12-30 |
| MA40031A (fr) | 2015-12-30 |
| US20210106604A1 (en) | 2021-04-15 |
| CA2952959A1 (en) | 2015-12-30 |
| EP3160475A1 (en) | 2017-05-03 |
| EP3160475A4 (en) | 2018-02-21 |
| US11590155B2 (en) | 2023-02-28 |
| AU2015280234A1 (en) | 2017-01-12 |
| CN106604734B (zh) | 2021-08-13 |
| TW201613613A (en) | 2016-04-16 |
| CN106604734A (zh) | 2017-04-26 |
| JP6669675B2 (ja) | 2020-03-18 |
| PH12016502563A1 (en) | 2017-04-17 |
| EP3160475C0 (en) | 2024-01-03 |
| US20190054108A1 (en) | 2019-02-21 |
| IL249627A0 (en) | 2017-02-28 |
| US20170143751A1 (en) | 2017-05-25 |
| TN2016000566A1 (en) | 2018-04-04 |
| CA2952959C (en) | 2023-03-07 |
| US20150366887A1 (en) | 2015-12-24 |
| AP2016009653A0 (en) | 2016-12-31 |
| EP3160475B1 (en) | 2024-01-03 |
| US10052342B2 (en) | 2018-08-21 |
| US10780105B2 (en) | 2020-09-22 |
| JP2017519780A (ja) | 2017-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12016502563A1 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| PH12016502564A1 (en) | Substituted nucleosides, nucleosides and analogs thereof | |
| MX2017008183A (es) | Nucleosidos sustituidos, nucleotidos y analogos de estos. | |
| MX2017008184A (es) | Nucleosidos sustituidos, nucleotidos y analogos de estos. | |
| PH12016500660A1 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| PH12015501423A1 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| PH12020551055A1 (en) | Methods for treating filoviridae virus infections | |
| WO2018031818A3 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| PH12015502799A1 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| PH12016502555A1 (en) | Methods of preparing substituted nucleotide analogs | |
| HK1243714A1 (zh) | 制备取代的核苷类似物的方法 | |
| HK1216535A1 (zh) | 取代的核苷、核苷酸及其類似物 | |
| HK1224229A1 (zh) | 取代的核苷，核苷酸及其类似物 | |
| LT3265102T (lt) | Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui |