HK1243714A1 - 製備取代的核苷類似物的方法 - Google Patents
製備取代的核苷類似物的方法Info
- Publication number
- HK1243714A1 HK1243714A1 HK18103109.2A HK18103109A HK1243714A1 HK 1243714 A1 HK1243714 A1 HK 1243714A1 HK 18103109 A HK18103109 A HK 18103109A HK 1243714 A1 HK1243714 A1 HK 1243714A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- nucleoside analogs
- substituted nucleoside
- preparing substituted
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462069770P | 2014-10-28 | 2014-10-28 | |
PCT/US2015/057405 WO2016069489A1 (en) | 2014-10-28 | 2015-10-26 | Methods of preparing substituted nucleoside analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1243714A1 true HK1243714A1 (zh) | 2018-07-20 |
Family
ID=55791453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103109.2A HK1243714A1 (zh) | 2014-10-28 | 2018-03-05 | 製備取代的核苷類似物的方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US9908914B2 (zh) |
EP (1) | EP3212657A4 (zh) |
KR (1) | KR20170073649A (zh) |
CN (1) | CN107108681B (zh) |
HK (1) | HK1243714A1 (zh) |
TW (1) | TWI671310B (zh) |
WO (1) | WO2016069489A1 (zh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
CN104321333A (zh) | 2012-03-21 | 2015-01-28 | 沃泰克斯药物股份有限公司 | 硫代氨基磷酸酯核苷酸前药的固体形式 |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
EP3421482A1 (en) | 2012-12-21 | 2019-01-02 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
AU2013361193B2 (en) | 2012-12-21 | 2018-05-24 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9504705B2 (en) | 2013-04-05 | 2016-11-29 | Alios Biopharma, Inc. | Hepatitis C viral infection treatment using a combination of compounds |
TW201542578A (zh) | 2013-06-26 | 2015-11-16 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
DK3013843T3 (en) | 2013-06-26 | 2018-09-03 | Alios Biopharma Inc | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF |
TW201524990A (zh) | 2013-10-11 | 2015-07-01 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
EP3160475B1 (en) | 2014-06-24 | 2024-01-03 | Janssen Pharmaceuticals, Inc. | Substituted nucleosides and nucleotides to treat filoviridae infections |
SG11201610259SA (en) * | 2014-06-24 | 2017-01-27 | Alios Biopharma Inc | Methods of preparing substituted nucleotide analogs |
DK3160476T3 (da) | 2014-06-24 | 2020-12-21 | Janssen Biopharma Inc | Substituerede nukleosider, nukleotider og analoger dertil til anvendelse til behandling af virusinfektioner |
WO2016069489A1 (en) * | 2014-10-28 | 2016-05-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
EA036776B1 (ru) | 2015-03-11 | 2020-12-21 | Янссен Байофарма, Инк. | Соединения азапиридона и способы их применения |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110079783A (ko) | 2003-02-19 | 2011-07-07 | 예일 유니버시티 | 항-바이러스 뉴클레오시드 유사체 및 바이러스 감염, 특히 에이치아이브이 감염의 치료방법 |
AU2010226466A1 (en) | 2009-03-20 | 2011-10-20 | Alios Biopharma, Inc. | Substituted nucleoside and nucleotide analogs |
KR101701510B1 (ko) | 2010-07-09 | 2017-02-01 | 엘지이노텍 주식회사 | 발광소자 |
CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
WO2012040126A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
CA2810928A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
CA2819041A1 (en) | 2010-12-22 | 2012-06-28 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
CN104203253A (zh) * | 2012-03-21 | 2014-12-10 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
CN104321333A (zh) | 2012-03-21 | 2015-01-28 | 沃泰克斯药物股份有限公司 | 硫代氨基磷酸酯核苷酸前药的固体形式 |
WO2013142159A1 (en) | 2012-03-21 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US8846896B2 (en) | 2012-03-21 | 2014-09-30 | Alios Biopharma, Inc. | Methods of preparing substituted nucleotide analogs |
WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
AU2013361193B2 (en) | 2012-12-21 | 2018-05-24 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
EP3421482A1 (en) | 2012-12-21 | 2019-01-02 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
US20140309413A1 (en) | 2013-03-11 | 2014-10-16 | Vertex Pharmaceuticals Incorporated | Methods of stereoselective synthesis of substituted nucleoside analogs |
US9504705B2 (en) | 2013-04-05 | 2016-11-29 | Alios Biopharma, Inc. | Hepatitis C viral infection treatment using a combination of compounds |
TW201542578A (zh) | 2013-06-26 | 2015-11-16 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
DK3013843T3 (en) | 2013-06-26 | 2018-09-03 | Alios Biopharma Inc | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF |
TW201524990A (zh) | 2013-10-11 | 2015-07-01 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
EP3160475B1 (en) | 2014-06-24 | 2024-01-03 | Janssen Pharmaceuticals, Inc. | Substituted nucleosides and nucleotides to treat filoviridae infections |
SG11201610259SA (en) | 2014-06-24 | 2017-01-27 | Alios Biopharma Inc | Methods of preparing substituted nucleotide analogs |
DK3160476T3 (da) | 2014-06-24 | 2020-12-21 | Janssen Biopharma Inc | Substituerede nukleosider, nukleotider og analoger dertil til anvendelse til behandling af virusinfektioner |
BR112017001162A2 (pt) | 2014-07-22 | 2017-11-14 | Alios Biopharma Inc | métodos para tratar paramixovírus |
SG10201901010PA (en) | 2014-08-05 | 2019-03-28 | Alios Biopharma Inc | Combination therapy for treating a paramyxovirus |
WO2016069489A1 (en) | 2014-10-28 | 2016-05-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
TW201811339A (zh) | 2016-08-12 | 2018-04-01 | 美商艾洛斯生物製藥公司 | 經取代之核苷、核苷酸及其類似物 |
US20180117042A1 (en) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Methods for treating respiratory syncytial virus infection |
-
2015
- 2015-10-26 WO PCT/US2015/057405 patent/WO2016069489A1/en active Application Filing
- 2015-10-26 EP EP15855437.8A patent/EP3212657A4/en not_active Withdrawn
- 2015-10-26 US US14/923,283 patent/US9908914B2/en active Active
- 2015-10-26 CN CN201580059053.3A patent/CN107108681B/zh not_active Expired - Fee Related
- 2015-10-26 KR KR1020177013721A patent/KR20170073649A/ko not_active Application Discontinuation
- 2015-10-28 TW TW104135489A patent/TWI671310B/zh not_active IP Right Cessation
-
2018
- 2018-02-26 US US15/905,526 patent/US10519185B2/en not_active Expired - Fee Related
- 2018-03-05 HK HK18103109.2A patent/HK1243714A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20160115190A1 (en) | 2016-04-28 |
TWI671310B (zh) | 2019-09-11 |
CN107108681B (zh) | 2021-04-06 |
EP3212657A4 (en) | 2018-04-11 |
KR20170073649A (ko) | 2017-06-28 |
TW201625657A (zh) | 2016-07-16 |
US10519185B2 (en) | 2019-12-31 |
EP3212657A1 (en) | 2017-09-06 |
CN107108681A (zh) | 2017-08-29 |
US20180186825A1 (en) | 2018-07-05 |
WO2016069489A1 (en) | 2016-05-06 |
US9908914B2 (en) | 2018-03-06 |
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