JP2017517761A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017517761A5 JP2017517761A5 JP2016563166A JP2016563166A JP2017517761A5 JP 2017517761 A5 JP2017517761 A5 JP 2017517761A5 JP 2016563166 A JP2016563166 A JP 2016563166A JP 2016563166 A JP2016563166 A JP 2016563166A JP 2017517761 A5 JP2017517761 A5 JP 2017517761A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- microscope apparatus
- light
- alignment parameters
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 27
- 238000001514 detection method Methods 0.000 claims 11
- 238000003384 imaging method Methods 0.000 claims 11
- 238000005259 measurement Methods 0.000 claims 5
- 230000003287 optical effect Effects 0.000 claims 4
- 238000005286 illumination Methods 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005350 fused silica glass Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005703P | 2014-05-30 | 2014-05-30 | |
| US62/005,703 | 2014-05-30 | ||
| PCT/US2015/032951 WO2015184124A1 (en) | 2014-05-30 | 2015-05-28 | Methods and devices for imaging large intact tissue samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017517761A JP2017517761A (ja) | 2017-06-29 |
| JP2017517761A5 true JP2017517761A5 (https=) | 2018-07-05 |
Family
ID=54699794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563166A Pending JP2017517761A (ja) | 2014-05-30 | 2015-05-28 | 大きなインタクトな組織試料を撮像するための方法及び装置 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10746981B2 (https=) |
| EP (1) | EP3149534A4 (https=) |
| JP (1) | JP2017517761A (https=) |
| KR (1) | KR20170013855A (https=) |
| CN (1) | CN106164736A (https=) |
| AU (1) | AU2015266894A1 (https=) |
| CA (1) | CA2947898A1 (https=) |
| WO (1) | WO2015184124A1 (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013055995A2 (en) | 2011-10-14 | 2013-04-18 | President And Fellows Of Harvard College | Sequencing by structure assembly |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| WO2014025392A1 (en) | 2012-08-09 | 2014-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for preparing biological specimens for microscopic analysis |
| US9404869B2 (en) * | 2012-10-09 | 2016-08-02 | Howard Hughes Medical Institute | Multiview light-sheet microscopy |
| EP3578666A1 (en) | 2013-03-12 | 2019-12-11 | President and Fellows of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
| EP3013983B1 (en) | 2013-06-25 | 2023-02-15 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
| JP2017517761A (ja) | 2014-05-30 | 2017-06-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 大きなインタクトな組織試料を撮像するための方法及び装置 |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| US10774374B2 (en) | 2015-04-10 | 2020-09-15 | Spatial Transcriptomics AB and Illumina, Inc. | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| WO2017062741A1 (en) * | 2015-10-08 | 2017-04-13 | The Regents Of The University Of Colorado, A Body Corporate | Remote focusing all-optical digital scanning light sheet microscopy for optically cleared tissue sections |
| US11254974B2 (en) | 2016-02-10 | 2022-02-22 | The Board Of Trustees Of The Leland Stanford Junior University | RNA fixation and detection in clarity-based hydrogel tissue |
| LU93021B1 (de) | 2016-04-08 | 2017-11-08 | Leica Microsystems | Verfahren und Mikroskop zum Untersuchen einer Probe |
| LU93022B1 (de) * | 2016-04-08 | 2017-11-08 | Leica Microsystems | Verfahren und Mikroskop zum Untersuchen einer Probe |
| CN109415761B (zh) | 2016-04-25 | 2022-09-20 | 哈佛学院董事及会员团体 | 用于原位分子检测的杂交链反应方法 |
| WO2017205531A1 (en) | 2016-05-25 | 2017-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for visualization and quantification of fiber-like structures |
| EP3252452A1 (en) | 2016-05-25 | 2017-12-06 | The Board of Trustees of the Leland Stanford Junior University | Method for imaging and analysis of a biological specimen |
| EP4050112A1 (en) | 2016-06-21 | 2022-08-31 | 10X Genomics, Inc. | Nucleic acid sequencing |
| AU2017281533B2 (en) | 2016-06-24 | 2019-06-27 | Howard Hughes Medical Institute | Automated adjustment of light sheet geometry in a microscope |
| JP2018004777A (ja) | 2016-06-28 | 2018-01-11 | オリンパス株式会社 | 光シート顕微鏡、及び、光シート顕微鏡の制御方法 |
| DE102017116892B4 (de) | 2016-07-26 | 2022-01-05 | Leica Microsystems Cms Gmbh | Lichtquellenmodul zur Erzeugung einer Lichtblattebene, Mikroskop und Verfahren zur sequentiellen Untersuchung mehrerer Proben mittels eines Lichtblattebenenmikroskops |
| CN107666546B (zh) * | 2016-07-29 | 2020-01-07 | 广州康昕瑞基因健康科技有限公司 | 图像拍摄对位方法和系统 |
| JP2018017970A (ja) | 2016-07-29 | 2018-02-01 | オリンパス株式会社 | 光シート顕微鏡、及び、光シート顕微鏡の制御方法 |
| US10310248B2 (en) | 2016-08-18 | 2019-06-04 | Olympus Corporation | Microscope including a medium container containing an immersion medium in which a specimen container containing an immersion medium and a sample is immersed |
| CN109923216B (zh) | 2016-08-31 | 2024-08-02 | 哈佛学院董事及会员团体 | 将生物分子的检测组合到使用荧光原位测序的单个试验的方法 |
| CN107844789A (zh) * | 2016-09-20 | 2018-03-27 | 广州康昕瑞基因健康科技有限公司 | 图像拍摄方法和系统 |
| US10409052B2 (en) | 2016-09-28 | 2019-09-10 | University Of Washington | Inverted light-sheet microscope |
| US11506877B2 (en) | 2016-11-10 | 2022-11-22 | The Trustees Of Columbia University In The City Of New York | Imaging instrument having objective axis and light sheet or light beam projector axis intersecting at less than 90 degrees |
| WO2018148309A1 (en) * | 2017-02-08 | 2018-08-16 | The Regents Of The University Of California | Selective plane illumination in the conventional inverted microscope geometry by side illumination |
| US11156822B2 (en) * | 2017-04-24 | 2021-10-26 | Igor Lyuboshenko | Selective plane illumination microscopy with multiple illumination units scanning an object in sync with a digital camera rolling shutter |
| US12474561B2 (en) | 2017-04-24 | 2025-11-18 | Igor Lyuboshenko | Automatic correction of spherical aberration in selective plane illumination microscopy |
| US10768400B2 (en) | 2017-04-24 | 2020-09-08 | Igor Lyuboshenko | Varying an illumination path of a selective plane illumination microscopy |
| EP3619567B1 (en) | 2017-05-04 | 2023-09-27 | Intelligent Imaging Innovations, Inc. | A method to keep the excitation light sheet in focus in selective plane illumination microscopy |
| CN110799878B (zh) * | 2017-06-23 | 2022-10-14 | 莱卡微系统Cms有限责任公司 | 具有光片显微的功能单元的显微系统 |
| CN110892251B (zh) * | 2017-07-11 | 2023-09-15 | 浜松光子学株式会社 | 试样观察装置和试样观察方法 |
| US10347480B2 (en) * | 2017-09-25 | 2019-07-09 | Bruker Daltonik, Gmbh | Method for evaluating the quality of mass spectrometric imaging preparations and kit-of-parts therefor |
| CA3078158A1 (en) | 2017-10-06 | 2019-04-11 | Cartana Ab | Rna templated ligation |
| JP7114272B2 (ja) * | 2018-02-28 | 2022-08-08 | 浜松ホトニクス株式会社 | ライトシート顕微鏡及び試料観察方法 |
| JP7336573B2 (ja) * | 2018-02-28 | 2023-08-31 | 浜松ホトニクス株式会社 | ライトシート顕微鏡及び試料観察方法 |
| WO2019185993A1 (en) * | 2018-03-28 | 2019-10-03 | Engemma Oy | Extended focal plane imaging by using a gemstone manipulator |
| CN109143562B (zh) * | 2018-09-12 | 2020-12-15 | 苏州大学 | 一种基于变焦原理的可变光片照明系统 |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| KR102105489B1 (ko) * | 2018-12-31 | 2020-04-28 | (주)유아이엠디 | 골수 판독을 위한 현미경용 슬라이드 스캐닝 시스템 |
| WO2020240025A1 (en) | 2019-05-31 | 2020-12-03 | Cartana Ab | Method of detecting target nucleic acid molecules |
| GB201919032D0 (en) | 2019-12-20 | 2020-02-05 | Cartana Ab | Method of detecting an analyte |
| WO2021155063A1 (en) | 2020-01-29 | 2021-08-05 | Readcoor, Llc | Compositions and methods for analyte detection |
| US12110548B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Bi-directional in situ analysis |
| GB202001902D0 (en) * | 2020-02-12 | 2020-03-25 | Univ Oslo | Microscope apparatus |
| EP4107284A1 (en) | 2020-02-17 | 2022-12-28 | 10X Genomics, Inc. | In situ analysis of chromatin interaction |
| EP4484571A3 (en) | 2020-02-21 | 2025-03-19 | 10X Genomics, Inc. | Methods and compositions for integrated in situ spatial assay |
| CN111258045B (zh) * | 2020-02-25 | 2022-02-11 | 中国科学院苏州生物医学工程技术研究所 | 一种用于观测自由活动斑马鱼的高分辨光片显微成像系统 |
| US12188085B2 (en) | 2020-03-05 | 2025-01-07 | 10X Genomics, Inc. | Three-dimensional spatial transcriptomics with sequencing readout |
| US12209273B2 (en) | 2020-06-12 | 2025-01-28 | 10X Genomics, Inc. | Nucleic acid assays using click chemistry bioconjugation |
| US12297499B2 (en) | 2020-08-17 | 2025-05-13 | 10X Genomics, Inc. | Multicomponent nucleic acid probes for sample analysis |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| US12387522B2 (en) * | 2020-09-28 | 2025-08-12 | Vectech | Apparatus and method of mosquito identification |
| US12071667B2 (en) | 2020-11-04 | 2024-08-27 | 10X Genomics, Inc. | Sequence analysis using meta-stable nucleic acid molecules |
| EP4012046A1 (en) | 2020-12-11 | 2022-06-15 | 10X Genomics, Inc. | Methods and compositions for multimodal in situ analysis |
| US12060603B2 (en) | 2021-01-19 | 2024-08-13 | 10X Genomics, Inc. | Methods for internally controlled in situ assays using padlock probes |
| US12275984B2 (en) | 2021-03-02 | 2025-04-15 | 10X Genomics, Inc. | Sequential hybridization and quenching |
| CN113156350B (zh) * | 2021-03-25 | 2022-07-19 | 华南理工大学 | 无创光不透明微米级活体组织磁共振断层成像方法及系统 |
| US12443023B2 (en) | 2021-05-14 | 2025-10-14 | Igor Lyuboshenko | Light sheet microscope having streamlined field of view changes |
| US12139751B2 (en) | 2021-07-30 | 2024-11-12 | 10X Genomics, Inc. | Circularizable probes for in situ analysis |
| CA3224093A1 (en) | 2021-07-30 | 2023-02-02 | Jorge Ivan Hernandez Neuta | Methods and compositions for synchronizing reactions in situ |
| US12391984B2 (en) | 2021-08-03 | 2025-08-19 | 10X Genomics, Inc. | Compositions and methods for rolling circle amplification |
| US12460251B2 (en) | 2021-08-03 | 2025-11-04 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid molecules |
| US12529096B2 (en) | 2021-08-03 | 2026-01-20 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid structures |
| EP4381095A1 (en) | 2021-08-03 | 2024-06-12 | 10X Genomics, Inc. | Nucleic acid concatemers and methods for stabilizing and/or compacting the same |
| US12435364B2 (en) | 2021-08-16 | 2025-10-07 | 10X Genomics, Inc. | Probes comprising a split barcode region and methods of use |
| US20240427129A1 (en) * | 2021-09-22 | 2024-12-26 | Howard Hughes Medical Institute | Multiscale multiview light-sheet imaging |
| EP4733410A2 (en) | 2022-01-21 | 2026-04-29 | 10X Genomics, Inc. | Multiple readout signals for analyzing a sample |
| EP4490737A1 (en) | 2022-03-08 | 2025-01-15 | 10X Genomics, Inc. | In situ code design methods for minimizing optical crowding |
| EP4249889B1 (en) | 2022-03-23 | 2024-11-27 | Nebulum Technologies Co., Ltd. | Methods for analyzing biopsies and biological samples |
| AU2023243205A1 (en) | 2022-04-01 | 2024-09-19 | 10X Genomics, Inc. | Compositions and methods for targeted masking of autofluorescence |
| EP4519453A1 (en) | 2022-05-06 | 2025-03-12 | 10X Genomics, Inc. | Methods and compositions for in situ analysis of v(d)j sequences |
| CN119213143A (zh) | 2022-05-11 | 2024-12-27 | 10X基因组学有限公司 | 用于原位测序的组合物和方法 |
| WO2023245190A1 (en) | 2022-06-17 | 2023-12-21 | 10X Genomics, Inc. | Catalytic de-crosslinking of samples for in situ analysis |
| US12578584B2 (en) * | 2022-08-15 | 2026-03-17 | Martineau & Associates | Container system for monitoring and imaging aquatic organisms |
| WO2024040060A1 (en) | 2022-08-16 | 2024-02-22 | 10X Genomics, Inc. | Ap50 polymerases and uses thereof |
| EP4343404A1 (en) * | 2022-09-20 | 2024-03-27 | Leica Microsystems CMS GmbH | Controller for an imaging system, system and corresponding method |
| WO2025029831A1 (en) | 2023-07-31 | 2025-02-06 | 10X Genomics, Inc. | Methods and systems for targeted rna cleavage and target rna-primed rolling circle amplification |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3129158A (en) | 1961-01-24 | 1964-04-14 | Raymond Samuel | Process for gel electrophoresis |
| US3208929A (en) | 1962-09-11 | 1965-09-28 | Robert H Raymond | Apparatus for gel electrophoresis |
| US3346479A (en) | 1964-04-09 | 1967-10-10 | Scientific Industries | Preparative separation by a combination of gel separation and electrophoresis |
| US3375187A (en) | 1965-05-13 | 1968-03-26 | Buchler Instr Inc | Apparatus for temperature controlled preparative and analytical electrophoresis |
| US3576727A (en) | 1968-05-23 | 1971-04-27 | Bruce Lee Evatt | Gel electrophoresis process |
| US3563880A (en) | 1968-08-28 | 1971-02-16 | Arthur W Anderson | Gel electrophoresis unit |
| SE328135B (https=) | 1968-09-19 | 1970-09-07 | Lkb Produkter Ab | |
| US3616454A (en) | 1969-03-13 | 1971-10-26 | Univ New York | Method of and apparatus for electrophoretic separation in a gel column |
| US3674678A (en) | 1970-10-28 | 1972-07-04 | Millipore Corp | Electrophoretic apparatus |
| US3865712A (en) | 1972-04-13 | 1975-02-11 | Lkb Produkter Ab | Electrode arrangement for an electrophoretical separation performed in a gel plate |
| US3989613A (en) | 1973-05-16 | 1976-11-02 | The Dow Chemical Company | Continuous balanced flow fixed boundary electrophoresis |
| US4088561A (en) | 1977-06-27 | 1978-05-09 | The United States Of America As Represented By The United States Department Of Energy | Apparatus for electrophoresis separation |
| US4151065A (en) | 1978-01-30 | 1979-04-24 | The Regents Of The University Of California | Horizontal slab gel electrophoresis |
| US4292161A (en) | 1979-01-03 | 1981-09-29 | Hoefer Scientific Instruments | Vertical gel slab electrophoresis apparatus |
| FR2496889A1 (fr) | 1980-12-22 | 1982-06-25 | Hours Michel | Cuve de migration et de reaction utilisable pour des analyses par electrophorese |
| US4339327A (en) | 1981-04-23 | 1982-07-13 | Tyler Jonathan M | Miniature slab gel electrophoresis system |
| US4375401A (en) | 1981-05-20 | 1983-03-01 | Nicholas Catsimpoolas | Electrophoresis system |
| EP0101859B1 (de) | 1982-07-23 | 1987-10-14 | Matthias Hediger | Einrichtung für präparative Gelelektrophorese, insbesondere zur Gemischtrennung an einer einen Gradienten enthaltenden Polyacrylamid-Gelsäure |
| US4588491A (en) | 1984-02-27 | 1986-05-13 | International Biotechnologies, Inc. | Horizontal gel electrophoresis device |
| US4685025A (en) | 1985-03-14 | 1987-08-04 | Raychem Corporation | Conductive polymer circuit protection devices having improved electrodes |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| US5475429A (en) * | 1991-07-25 | 1995-12-12 | Olympus Optical Co., Ltd. | In-focus sensing device for sensing an in-focus condition using a ratio of frequency components at different positions |
| JP3236033B2 (ja) * | 1991-07-25 | 2001-12-04 | オリンパス光学工業株式会社 | 合焦点検出装置 |
| WO1999036559A1 (en) | 1998-01-13 | 1999-07-22 | Julien Jean Pierre | Viral vectors expressing self-polymerizing neuronal intermediate filaments and their use |
| US6722395B2 (en) | 1998-01-13 | 2004-04-20 | James W. Overbeck | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays |
| WO2000017355A2 (en) | 1998-09-18 | 2000-03-30 | Incyte Pharmaceuticals, Inc. | Human cytoskeleton associated proteins |
| US6232092B1 (en) | 1998-10-02 | 2001-05-15 | Rogers Imaging Corporation | Method for preparing biological specimens for visual analysis |
| US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
| US6409774B1 (en) | 1999-06-11 | 2002-06-25 | Resolution Sciences Corporation | Electrophoresis-assisted staining of materials |
| EP2363828A1 (en) * | 2000-10-24 | 2011-09-07 | Cyntellect, Inc. | Device for selectively targeting cells within a three-dimensional specimen |
| US6472216B1 (en) | 2001-07-24 | 2002-10-29 | Ann-Shyn Chiang | Aqueous tissue clearing solution |
| DK1438976T3 (da) | 2001-09-28 | 2008-04-28 | Biopharma Dev Ltd | Polyfunktionel biokompatibel hydrogel og fremgangsmåde til fremstilling deraf |
| DE10209609A1 (de) | 2002-03-05 | 2003-10-02 | Europ Lab Molekularbiolog | Verfahren und Vorrichtung zur Parallelanalyse von Bio-Molekülen |
| AU2003238162A1 (en) | 2002-06-28 | 2004-01-19 | Cardio Inc | Decellularized tissue |
| AU2003284875A1 (en) | 2002-10-17 | 2004-05-04 | Vacanti, Joseph P. | Biological scaffolding material |
| JP3746771B2 (ja) * | 2003-05-23 | 2006-02-15 | 株式会社日立製作所 | サンプルトランスファ装置 |
| US7713923B2 (en) | 2003-06-25 | 2010-05-11 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| US8226715B2 (en) | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
| US7326571B2 (en) | 2003-07-17 | 2008-02-05 | Boston Scientific Scimed, Inc. | Decellularized bone marrow extracellular matrix |
| US7660620B2 (en) | 2003-09-29 | 2010-02-09 | Medtronic, Inc. | Timing techniques for magnetic resonance imaging |
| US7955788B2 (en) | 2003-10-30 | 2011-06-07 | Medtronic, Inc. | Bioprosthetic tissue preparation with synthetic hydrogels |
| WO2005062938A2 (en) | 2003-12-23 | 2005-07-14 | The Regents Of The University Of California | Chemical agents and methods for optical clearing of skin and mucous membranes to improve light-based diagnostics and therapeutics |
| GB0414825D0 (en) | 2004-07-02 | 2004-08-04 | Biostatus Ltd | Gel formulations and uses thereof |
| WO2007030012A2 (en) | 2005-09-05 | 2007-03-15 | Stichting Voor De Technische Wetenscahappen | Extracellular matrix imaging |
| US8163565B2 (en) | 2005-12-08 | 2012-04-24 | Cytyc Corporation | Light curing fixative |
| DE102007018862A1 (de) * | 2007-04-18 | 2008-10-23 | Carl Zeiss Microimaging Gmbh | Objektivwechseleinrichtung für Mikroskope |
| EP2187985B1 (en) | 2007-08-14 | 2016-09-28 | Smith & Nephew PLC | Scaffolds |
| DE102007045897A1 (de) | 2007-09-26 | 2009-04-09 | Carl Zeiss Microimaging Gmbh | Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe |
| WO2010014244A2 (en) * | 2008-07-30 | 2010-02-04 | The Regents Of The University Of California, San Francisco | Multidirectional selective plane illumination microscopy |
| US20100055733A1 (en) | 2008-09-04 | 2010-03-04 | Lutolf Matthias P | Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels |
| WO2010030358A1 (en) | 2008-09-12 | 2010-03-18 | Quickmbed, Inc. | Scaffold for tissue sample orientation |
| AU2010229858A1 (en) * | 2009-03-25 | 2011-09-22 | Los Alamos National Security, Llc | Fiber optical assembly for fluorescence spectrometry |
| DE102009044983A1 (de) * | 2009-09-24 | 2011-03-31 | Carl Zeiss Microimaging Gmbh | Mikroskop |
| US8852614B2 (en) | 2010-03-12 | 2014-10-07 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogels with network defects enhanced by nanoparticle incorporation |
| US20130045503A1 (en) | 2010-03-12 | 2013-02-21 | Riken | Clearing reagent for biological material, and use thereof |
| US8867803B2 (en) | 2010-04-20 | 2014-10-21 | Eric J. Seibel | Optical projection tomography microscopy (OPTM) for large specimen sizes |
| US8927624B2 (en) | 2010-05-14 | 2015-01-06 | Fujifilm Imaging Colorants Limited | Dispersion, process for preparing a dispersion and ink jet printing ink |
| TWI425201B (zh) | 2010-10-01 | 2014-02-01 | Nat Univ Tsing Hua | 觀察厚組織三維結構之方法 |
| DE102010060121C5 (de) | 2010-10-22 | 2023-09-28 | Leica Microsystems Cms Gmbh | SPIM-Mikroskop mit sequenziellem Lightsheet |
| US20140030192A1 (en) | 2011-01-28 | 2014-01-30 | Karl A. Deisseroth | Functional Targeted Brain Endoskeletonization |
| CN103492852B (zh) | 2011-04-28 | 2016-08-17 | 独立行政法人理化学研究所 | 生物材料的透明化方法、及其利用 |
| WO2012161143A1 (ja) | 2011-05-20 | 2012-11-29 | 独立行政法人理化学研究所 | 生物材料用透明化試薬、及びその利用 |
| WO2013016712A2 (en) | 2011-07-27 | 2013-01-31 | The Rockefeller University | Methods for fixing and detecting rna |
| JP5967528B2 (ja) | 2012-06-22 | 2016-08-10 | 国立研究開発法人理化学研究所 | 生物材料を透明化する方法および生物材料用透明化処理キット |
| DE102012211462A1 (de) * | 2012-07-03 | 2014-01-23 | Carl Zeiss Microscopy Gmbh | Verfahren zur Vorbereitung und Durchführung der Aufnahme von Bildstapeln einer Probe aus verschiedenen Orientierungswinkeln |
| WO2014025392A1 (en) * | 2012-08-09 | 2014-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for preparing biological specimens for microscopic analysis |
| US20140092376A1 (en) * | 2012-10-01 | 2014-04-03 | Momentive Performance Materials, Inc. | Container and method for in-line analysis of protein compositions |
| US9404869B2 (en) * | 2012-10-09 | 2016-08-02 | Howard Hughes Medical Institute | Multiview light-sheet microscopy |
| DE102012020240A1 (de) | 2012-10-12 | 2014-04-17 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur SPIM Mikroskopie |
| CA2907493A1 (en) | 2013-04-30 | 2014-11-13 | California Institute Of Technology | Multiplex labeling of molecules by sequential hybridization barcoding |
| JP6433901B2 (ja) | 2013-08-14 | 2018-12-05 | 国立研究開発法人理化学研究所 | 光透過性に優れた生物材料を調製するための組成物およびその利用 |
| DE102013216934A1 (de) | 2013-08-26 | 2015-02-26 | Leica Microsystems Cms Gmbh | Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe |
| JP2016538569A (ja) | 2013-09-20 | 2016-12-08 | カリフォルニア インスティチュート オブ テクノロジー | 無傷全組織の表現型分類のための方法 |
| CN103513411B (zh) | 2013-09-27 | 2016-02-03 | 香港应用科技研究院有限公司 | 荧光显微镜中聚焦的装置和方法 |
| JP2017517761A (ja) | 2014-05-30 | 2017-06-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 大きなインタクトな組織試料を撮像するための方法及び装置 |
| WO2016023009A1 (en) | 2014-08-07 | 2016-02-11 | Wake Forest University Health Sciences | Compositions and methods for clearing a biological sample |
| US20160131560A1 (en) | 2014-11-07 | 2016-05-12 | California Institute Of Technology | Methods for phenotyping of intact bones by tissue clearing and staining |
| WO2016117614A1 (ja) | 2015-01-20 | 2016-07-28 | 国立研究開発法人理化学研究所 | 生物材料用透明化試薬、システム及びその利用 |
| EP3273218A4 (en) | 2015-03-18 | 2018-12-26 | Riken | Method for observing biological material and clearing method |
| KR20180091024A (ko) | 2015-12-02 | 2018-08-14 | 클리어라이트 다이어그노스틱스 엘엘씨 | 암의 검출 및 모니터링을 위해 종양 조직 시료를 준비하고 분석하는 방법 |
-
2015
- 2015-05-28 JP JP2016563166A patent/JP2017517761A/ja active Pending
- 2015-05-28 CN CN201580009141.2A patent/CN106164736A/zh active Pending
- 2015-05-28 CA CA2947898A patent/CA2947898A1/en not_active Abandoned
- 2015-05-28 WO PCT/US2015/032951 patent/WO2015184124A1/en not_active Ceased
- 2015-05-28 US US15/120,716 patent/US10746981B2/en not_active Expired - Fee Related
- 2015-05-28 EP EP15799907.9A patent/EP3149534A4/en not_active Withdrawn
- 2015-05-28 KR KR1020167024311A patent/KR20170013855A/ko not_active Withdrawn
- 2015-05-28 AU AU2015266894A patent/AU2015266894A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017517761A5 (https=) | ||
| CN110389021B (zh) | 透镜图像产生系统及屈光能力和厚度确定与缺陷检测方法 | |
| TWI738808B (zh) | 用於量測穿通孔之幾何參數的方法及系統 | |
| CN105157625A (zh) | 一种基于变焦成像透镜的光纤端面显微干涉测量系统 | |
| JP2014515471A5 (https=) | ||
| WO2009078617A3 (en) | Surface shape measuring system and surface shape measuring method using the same | |
| JP2010169496A5 (https=) | ||
| CN108646396B (zh) | 自动对焦显微镜系统 | |
| JP2017522603A (ja) | 試料を顕微鏡検査する方法及び装置 | |
| CN108007381A (zh) | 光学元件激光诱导损伤三维形貌在线测量装置和测量方法 | |
| JP2012502316A5 (https=) | ||
| RU2013124820A (ru) | Микроскоп, устройство получения изображения и система получения изображения | |
| JP6387381B2 (ja) | オートフォーカスシステム、方法及び画像検査装置 | |
| TW200834048A (en) | Surface form measuring apparatus and stress measuring apparatus and surface form measuring method and stress measuring method | |
| KR101356706B1 (ko) | 광량 변조와 스캐닝 시스템 기반의 구조 조명 현미경 | |
| CN102175690A (zh) | 一种红外玻璃内部宏观缺陷检测装置 | |
| US20180139366A1 (en) | System and method for light sheet microscope and clearing for tracing | |
| JP6886464B2 (ja) | 試料媒質の波長依存性屈折率を決定するための光学顕微鏡及び方法 | |
| KR101830785B1 (ko) | 3차원 형상 측정장치 | |
| JP2018533014A5 (https=) | ||
| JP2019500607A5 (https=) | ||
| KR20150021346A (ko) | 3차원 형상 측정기 | |
| JP2016148569A (ja) | 画像測定方法、及び画像測定装置 | |
| KR102010136B1 (ko) | 다중모드 영상의 획득이 가능한 영상 획득 시스템 | |
| JP2015163844A5 (https=) |