JP2017517761A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017517761A5 JP2017517761A5 JP2016563166A JP2016563166A JP2017517761A5 JP 2017517761 A5 JP2017517761 A5 JP 2017517761A5 JP 2016563166 A JP2016563166 A JP 2016563166A JP 2016563166 A JP2016563166 A JP 2016563166A JP 2017517761 A5 JP2017517761 A5 JP 2017517761A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- microscope apparatus
- light
- alignment parameters
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 27
- 238000001514 detection method Methods 0.000 claims 11
- 238000003384 imaging method Methods 0.000 claims 11
- 238000005259 measurement Methods 0.000 claims 5
- 230000003287 optical effect Effects 0.000 claims 4
- 238000005286 illumination Methods 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005350 fused silica glass Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005703P | 2014-05-30 | 2014-05-30 | |
| US62/005,703 | 2014-05-30 | ||
| PCT/US2015/032951 WO2015184124A1 (en) | 2014-05-30 | 2015-05-28 | Methods and devices for imaging large intact tissue samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017517761A JP2017517761A (ja) | 2017-06-29 |
| JP2017517761A5 true JP2017517761A5 (enExample) | 2018-07-05 |
Family
ID=54699794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563166A Pending JP2017517761A (ja) | 2014-05-30 | 2015-05-28 | 大きなインタクトな組織試料を撮像するための方法及び装置 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10746981B2 (enExample) |
| EP (1) | EP3149534A4 (enExample) |
| JP (1) | JP2017517761A (enExample) |
| KR (1) | KR20170013855A (enExample) |
| CN (1) | CN106164736A (enExample) |
| AU (1) | AU2015266894A1 (enExample) |
| CA (1) | CA2947898A1 (enExample) |
| WO (1) | WO2015184124A1 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2850509C (en) | 2011-10-14 | 2023-08-01 | President And Fellows Of Harvard College | Sequencing by structure assembly |
| WO2014163886A1 (en) | 2013-03-12 | 2014-10-09 | President And Fellows Of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| AU2013300171B2 (en) | 2012-08-09 | 2017-09-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for preparing biological specimens for microscopic analysis |
| US9404869B2 (en) * | 2012-10-09 | 2016-08-02 | Howard Hughes Medical Institute | Multiview light-sheet microscopy |
| CN111500680B (zh) | 2013-06-25 | 2024-04-16 | 普罗格诺西斯生物科学公司 | 检测样品中生物靶标的空间分布的方法和系统 |
| AU2015266894A1 (en) | 2014-05-30 | 2016-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging large intact tissue samples |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| EP4321627A3 (en) | 2015-04-10 | 2024-04-17 | 10x Genomics Sweden AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| WO2017062741A1 (en) * | 2015-10-08 | 2017-04-13 | The Regents Of The University Of Colorado, A Body Corporate | Remote focusing all-optical digital scanning light sheet microscopy for optically cleared tissue sections |
| WO2017139501A1 (en) | 2016-02-10 | 2017-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | Rna fixation and detection in clarity-based hydrogel tissue |
| LU93021B1 (de) * | 2016-04-08 | 2017-11-08 | Leica Microsystems | Verfahren und Mikroskop zum Untersuchen einer Probe |
| LU93022B1 (de) * | 2016-04-08 | 2017-11-08 | Leica Microsystems | Verfahren und Mikroskop zum Untersuchen einer Probe |
| CN109415761B (zh) | 2016-04-25 | 2022-09-20 | 哈佛学院董事及会员团体 | 用于原位分子检测的杂交链反应方法 |
| WO2017205531A1 (en) | 2016-05-25 | 2017-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for visualization and quantification of fiber-like structures |
| US10495554B2 (en) | 2016-05-25 | 2019-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Method and system for imaging and analysis of a biological specimen |
| WO2017222453A1 (en) | 2016-06-21 | 2017-12-28 | Hauling Thomas | Nucleic acid sequencing |
| AU2017281533B2 (en) | 2016-06-24 | 2019-06-27 | Howard Hughes Medical Institute | Automated adjustment of light sheet geometry in a microscope |
| JP2018004777A (ja) | 2016-06-28 | 2018-01-11 | オリンパス株式会社 | 光シート顕微鏡、及び、光シート顕微鏡の制御方法 |
| DE102017116892B4 (de) | 2016-07-26 | 2022-01-05 | Leica Microsystems Cms Gmbh | Lichtquellenmodul zur Erzeugung einer Lichtblattebene, Mikroskop und Verfahren zur sequentiellen Untersuchung mehrerer Proben mittels eines Lichtblattebenenmikroskops |
| JP2018017970A (ja) | 2016-07-29 | 2018-02-01 | オリンパス株式会社 | 光シート顕微鏡、及び、光シート顕微鏡の制御方法 |
| CN107666546B (zh) * | 2016-07-29 | 2020-01-07 | 广州康昕瑞基因健康科技有限公司 | 图像拍摄对位方法和系统 |
| US10310248B2 (en) | 2016-08-18 | 2019-06-04 | Olympus Corporation | Microscope including a medium container containing an immersion medium in which a specimen container containing an immersion medium and a sample is immersed |
| CN107844789A (zh) * | 2016-09-20 | 2018-03-27 | 广州康昕瑞基因健康科技有限公司 | 图像拍摄方法和系统 |
| US10409052B2 (en) | 2016-09-28 | 2019-09-10 | University Of Washington | Inverted light-sheet microscope |
| US11506877B2 (en) | 2016-11-10 | 2022-11-22 | The Trustees Of Columbia University In The City Of New York | Imaging instrument having objective axis and light sheet or light beam projector axis intersecting at less than 90 degrees |
| WO2018148309A1 (en) * | 2017-02-08 | 2018-08-16 | The Regents Of The University Of California | Selective plane illumination in the conventional inverted microscope geometry by side illumination |
| US10768400B2 (en) | 2017-04-24 | 2020-09-08 | Igor Lyuboshenko | Varying an illumination path of a selective plane illumination microscopy |
| US12474561B2 (en) | 2017-04-24 | 2025-11-18 | Igor Lyuboshenko | Automatic correction of spherical aberration in selective plane illumination microscopy |
| US11156822B2 (en) * | 2017-04-24 | 2021-10-26 | Igor Lyuboshenko | Selective plane illumination microscopy with multiple illumination units scanning an object in sync with a digital camera rolling shutter |
| EP3619567B1 (en) * | 2017-05-04 | 2023-09-27 | Intelligent Imaging Innovations, Inc. | A method to keep the excitation light sheet in focus in selective plane illumination microscopy |
| JP7397673B2 (ja) * | 2017-06-23 | 2023-12-13 | ライカ マイクロシステムズ シーエムエス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 光シート顕微鏡機能ユニットを有する顕微鏡システム |
| CN111033238A (zh) * | 2017-06-27 | 2020-04-17 | 定量癌症诊断有限责任公司 | 定量的液体活检诊断系统与方法 |
| CN110892251B (zh) * | 2017-07-11 | 2023-09-15 | 浜松光子学株式会社 | 试样观察装置和试样观察方法 |
| US10347480B2 (en) * | 2017-09-25 | 2019-07-09 | Bruker Daltonik, Gmbh | Method for evaluating the quality of mass spectrometric imaging preparations and kit-of-parts therefor |
| US11597965B2 (en) | 2017-10-06 | 2023-03-07 | 10X Genomics, Inc. | RNA templated ligation |
| JP7114272B2 (ja) * | 2018-02-28 | 2022-08-08 | 浜松ホトニクス株式会社 | ライトシート顕微鏡及び試料観察方法 |
| JP7336573B2 (ja) * | 2018-02-28 | 2023-08-31 | 浜松ホトニクス株式会社 | ライトシート顕微鏡及び試料観察方法 |
| WO2019185993A1 (en) * | 2018-03-28 | 2019-10-03 | Engemma Oy | Extended focal plane imaging by using a gemstone manipulator |
| CN109143562B (zh) * | 2018-09-12 | 2020-12-15 | 苏州大学 | 一种基于变焦原理的可变光片照明系统 |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| KR102105489B1 (ko) * | 2018-12-31 | 2020-04-28 | (주)유아이엠디 | 골수 판독을 위한 현미경용 슬라이드 스캐닝 시스템 |
| SG11202111878RA (en) | 2019-05-31 | 2021-11-29 | 10X Genomics Inc | Method of detecting target nucleic acid molecules |
| GB201919032D0 (en) | 2019-12-20 | 2020-02-05 | Cartana Ab | Method of detecting an analyte |
| US12110548B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Bi-directional in situ analysis |
| GB202001902D0 (en) * | 2020-02-12 | 2020-03-25 | Univ Oslo | Microscope apparatus |
| WO2021167986A1 (en) | 2020-02-17 | 2021-08-26 | 10X Genomics, Inc. | In situ analysis of chromatin interaction |
| EP4484571A3 (en) | 2020-02-21 | 2025-03-19 | 10X Genomics, Inc. | Methods and compositions for integrated in situ spatial assay |
| CN111258045B (zh) * | 2020-02-25 | 2022-02-11 | 中国科学院苏州生物医学工程技术研究所 | 一种用于观测自由活动斑马鱼的高分辨光片显微成像系统 |
| US12188085B2 (en) | 2020-03-05 | 2025-01-07 | 10X Genomics, Inc. | Three-dimensional spatial transcriptomics with sequencing readout |
| US12209273B2 (en) | 2020-06-12 | 2025-01-28 | 10X Genomics, Inc. | Nucleic acid assays using click chemistry bioconjugation |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| US12297499B2 (en) | 2020-08-17 | 2025-05-13 | 10X Genomics, Inc. | Multicomponent nucleic acid probes for sample analysis |
| US12387522B2 (en) * | 2020-09-28 | 2025-08-12 | Vectech | Apparatus and method of mosquito identification |
| US12071667B2 (en) | 2020-11-04 | 2024-08-27 | 10X Genomics, Inc. | Sequence analysis using meta-stable nucleic acid molecules |
| US12060603B2 (en) | 2021-01-19 | 2024-08-13 | 10X Genomics, Inc. | Methods for internally controlled in situ assays using padlock probes |
| US12275984B2 (en) | 2021-03-02 | 2025-04-15 | 10X Genomics, Inc. | Sequential hybridization and quenching |
| CN113156350B (zh) * | 2021-03-25 | 2022-07-19 | 华南理工大学 | 无创光不透明微米级活体组织磁共振断层成像方法及系统 |
| US12443023B2 (en) | 2021-05-14 | 2025-10-14 | Igor Lyuboshenko | Light sheet microscope having streamlined field of view changes |
| EP4326900B1 (en) | 2021-07-30 | 2024-09-04 | 10X Genomics, Inc. | Methods and compositions for synchronizing reactions in situ |
| US12139751B2 (en) | 2021-07-30 | 2024-11-12 | 10X Genomics, Inc. | Circularizable probes for in situ analysis |
| US12460251B2 (en) | 2021-08-03 | 2025-11-04 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid molecules |
| US12391984B2 (en) | 2021-08-03 | 2025-08-19 | 10X Genomics, Inc. | Compositions and methods for rolling circle amplification |
| EP4446426A3 (en) | 2021-08-16 | 2024-11-13 | 10x Genomics, Inc. | Probes comprising a split barcode region and methods of use |
| WO2023049164A1 (en) * | 2021-09-22 | 2023-03-30 | Howard Hughes Medical Institute | Multiscale multiview light-sheet imaging |
| WO2023172915A1 (en) | 2022-03-08 | 2023-09-14 | 10X Genomics, Inc. | In situ code design methods for minimizing optical crowding |
| EP4249889B1 (en) | 2022-03-23 | 2024-11-27 | Nebulum Technologies Co., Ltd. | Methods for analyzing biopsies and biological samples |
| WO2023192616A1 (en) | 2022-04-01 | 2023-10-05 | 10X Genomics, Inc. | Compositions and methods for targeted masking of autofluorescence |
| JP2025516589A (ja) | 2022-05-11 | 2025-05-30 | 10エックス ジェノミクス インコーポレイテッド | インサイチュー配列決定のための組成物及び方法 |
| WO2023245190A1 (en) | 2022-06-17 | 2023-12-21 | 10X Genomics, Inc. | Catalytic de-crosslinking of samples for in situ analysis |
| US20240053618A1 (en) * | 2022-08-15 | 2024-02-15 | Martineau & Associates | Container system for monitoring and imaging aquatic organisms |
| WO2024040060A1 (en) | 2022-08-16 | 2024-02-22 | 10X Genomics, Inc. | Ap50 polymerases and uses thereof |
| EP4343404A1 (en) * | 2022-09-20 | 2024-03-27 | Leica Microsystems CMS GmbH | Controller for an imaging system, system and corresponding method |
| US12319956B2 (en) | 2023-07-31 | 2025-06-03 | 10X Genomics, Inc. | Methods and systems for targeted RNA cleavage and target RNA-primed rolling circle amplification |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3129158A (en) | 1961-01-24 | 1964-04-14 | Raymond Samuel | Process for gel electrophoresis |
| US3208929A (en) | 1962-09-11 | 1965-09-28 | Robert H Raymond | Apparatus for gel electrophoresis |
| US3346479A (en) | 1964-04-09 | 1967-10-10 | Scientific Industries | Preparative separation by a combination of gel separation and electrophoresis |
| US3375187A (en) | 1965-05-13 | 1968-03-26 | Buchler Instr Inc | Apparatus for temperature controlled preparative and analytical electrophoresis |
| US3576727A (en) | 1968-05-23 | 1971-04-27 | Bruce Lee Evatt | Gel electrophoresis process |
| US3563880A (en) | 1968-08-28 | 1971-02-16 | Arthur W Anderson | Gel electrophoresis unit |
| SE328135B (enExample) | 1968-09-19 | 1970-09-07 | Lkb Produkter Ab | |
| US3616454A (en) | 1969-03-13 | 1971-10-26 | Univ New York | Method of and apparatus for electrophoretic separation in a gel column |
| US3674678A (en) | 1970-10-28 | 1972-07-04 | Millipore Corp | Electrophoretic apparatus |
| US3865712A (en) | 1972-04-13 | 1975-02-11 | Lkb Produkter Ab | Electrode arrangement for an electrophoretical separation performed in a gel plate |
| US3989613A (en) | 1973-05-16 | 1976-11-02 | The Dow Chemical Company | Continuous balanced flow fixed boundary electrophoresis |
| US4088561A (en) | 1977-06-27 | 1978-05-09 | The United States Of America As Represented By The United States Department Of Energy | Apparatus for electrophoresis separation |
| US4151065A (en) | 1978-01-30 | 1979-04-24 | The Regents Of The University Of California | Horizontal slab gel electrophoresis |
| US4292161A (en) | 1979-01-03 | 1981-09-29 | Hoefer Scientific Instruments | Vertical gel slab electrophoresis apparatus |
| FR2496889A1 (fr) | 1980-12-22 | 1982-06-25 | Hours Michel | Cuve de migration et de reaction utilisable pour des analyses par electrophorese |
| US4339327A (en) | 1981-04-23 | 1982-07-13 | Tyler Jonathan M | Miniature slab gel electrophoresis system |
| US4375401A (en) | 1981-05-20 | 1983-03-01 | Nicholas Catsimpoolas | Electrophoresis system |
| DE3374082D1 (en) | 1982-07-23 | 1987-11-19 | Matthias Hediger | Apparatus for preparative gel electrophoresis, in particular for separating mixtures on a gradient gel polyacryl amide column |
| US4588491A (en) | 1984-02-27 | 1986-05-13 | International Biotechnologies, Inc. | Horizontal gel electrophoresis device |
| US4685025A (en) | 1985-03-14 | 1987-08-04 | Raychem Corporation | Conductive polymer circuit protection devices having improved electrodes |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| US5475429A (en) * | 1991-07-25 | 1995-12-12 | Olympus Optical Co., Ltd. | In-focus sensing device for sensing an in-focus condition using a ratio of frequency components at different positions |
| JP3236033B2 (ja) * | 1991-07-25 | 2001-12-04 | オリンパス光学工業株式会社 | 合焦点検出装置 |
| US6722395B2 (en) | 1998-01-13 | 2004-04-20 | James W. Overbeck | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays |
| AU2144899A (en) | 1998-01-13 | 1999-08-02 | Claude Gravel | Viral vectors expressing self-polymerizing neuronal intermediate filaments and their use |
| WO2000017355A2 (en) | 1998-09-18 | 2000-03-30 | Incyte Pharmaceuticals, Inc. | Human cytoskeleton associated proteins |
| US6232092B1 (en) | 1998-10-02 | 2001-05-15 | Rogers Imaging Corporation | Method for preparing biological specimens for visual analysis |
| US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
| US6409774B1 (en) | 1999-06-11 | 2002-06-25 | Resolution Sciences Corporation | Electrophoresis-assisted staining of materials |
| AU3289202A (en) * | 2000-10-24 | 2002-05-21 | Oncosis Llp | Method and device for selectively targeting cells within a three -dimensional specimen |
| US6472216B1 (en) | 2001-07-24 | 2002-10-29 | Ann-Shyn Chiang | Aqueous tissue clearing solution |
| RU2205034C1 (ru) | 2001-09-28 | 2003-05-27 | Биофарма Девелопмент Лтд. | Полифункциональный биосовместимый гидрогель и способ его получения |
| DE10209609A1 (de) | 2002-03-05 | 2003-10-02 | Europ Lab Molekularbiolog | Verfahren und Vorrichtung zur Parallelanalyse von Bio-Molekülen |
| EP1649879A3 (en) | 2002-06-28 | 2006-05-03 | Cardio, Inc. | Decellularized tissue |
| US7319035B2 (en) | 2002-10-17 | 2008-01-15 | Vbi Technologies, L.L.C. | Biological scaffolding material |
| JP3746771B2 (ja) * | 2003-05-23 | 2006-02-15 | 株式会社日立製作所 | サンプルトランスファ装置 |
| US7713923B2 (en) | 2003-06-25 | 2010-05-11 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| US8226715B2 (en) | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
| US7326571B2 (en) | 2003-07-17 | 2008-02-05 | Boston Scientific Scimed, Inc. | Decellularized bone marrow extracellular matrix |
| US7660620B2 (en) | 2003-09-29 | 2010-02-09 | Medtronic, Inc. | Timing techniques for magnetic resonance imaging |
| US7955788B2 (en) | 2003-10-30 | 2011-06-07 | Medtronic, Inc. | Bioprosthetic tissue preparation with synthetic hydrogels |
| WO2005062938A2 (en) | 2003-12-23 | 2005-07-14 | The Regents Of The University Of California | Chemical agents and methods for optical clearing of skin and mucous membranes to improve light-based diagnostics and therapeutics |
| GB0414825D0 (en) | 2004-07-02 | 2004-08-04 | Biostatus Ltd | Gel formulations and uses thereof |
| WO2007030012A2 (en) | 2005-09-05 | 2007-03-15 | Stichting Voor De Technische Wetenscahappen | Extracellular matrix imaging |
| US8163565B2 (en) | 2005-12-08 | 2012-04-24 | Cytyc Corporation | Light curing fixative |
| DE102007018862A1 (de) * | 2007-04-18 | 2008-10-23 | Carl Zeiss Microimaging Gmbh | Objektivwechseleinrichtung für Mikroskope |
| EP2187985B1 (en) | 2007-08-14 | 2016-09-28 | Smith & Nephew PLC | Scaffolds |
| DE102007045897A1 (de) * | 2007-09-26 | 2009-04-09 | Carl Zeiss Microimaging Gmbh | Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe |
| WO2010014244A2 (en) * | 2008-07-30 | 2010-02-04 | The Regents Of The University Of California, San Francisco | Multidirectional selective plane illumination microscopy |
| US20100055733A1 (en) | 2008-09-04 | 2010-03-04 | Lutolf Matthias P | Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels |
| WO2010030358A1 (en) | 2008-09-12 | 2010-03-18 | Quickmbed, Inc. | Scaffold for tissue sample orientation |
| WO2010111508A1 (en) * | 2009-03-25 | 2010-09-30 | Los Alamos National Security, Llc | Fiber optical assembly for fluorescence spectrometry |
| DE102009044983A1 (de) * | 2009-09-24 | 2011-03-31 | Carl Zeiss Microimaging Gmbh | Mikroskop |
| US20130045503A1 (en) | 2010-03-12 | 2013-02-21 | Riken | Clearing reagent for biological material, and use thereof |
| US8852614B2 (en) | 2010-03-12 | 2014-10-07 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogels with network defects enhanced by nanoparticle incorporation |
| US8867803B2 (en) | 2010-04-20 | 2014-10-21 | Eric J. Seibel | Optical projection tomography microscopy (OPTM) for large specimen sizes |
| US8927624B2 (en) | 2010-05-14 | 2015-01-06 | Fujifilm Imaging Colorants Limited | Dispersion, process for preparing a dispersion and ink jet printing ink |
| TWI425201B (zh) | 2010-10-01 | 2014-02-01 | Nat Univ Tsing Hua | 觀察厚組織三維結構之方法 |
| DE102010060121C5 (de) * | 2010-10-22 | 2023-09-28 | Leica Microsystems Cms Gmbh | SPIM-Mikroskop mit sequenziellem Lightsheet |
| US20140030192A1 (en) | 2011-01-28 | 2014-01-30 | Karl A. Deisseroth | Functional Targeted Brain Endoskeletonization |
| WO2012147965A1 (ja) | 2011-04-28 | 2012-11-01 | 独立行政法人理化学研究所 | 生物材料を透明化する方法、及びその利用 |
| US10444124B2 (en) | 2011-05-20 | 2019-10-15 | Riken | Clarifying reagent for biological materials and use thereof |
| WO2013016712A2 (en) | 2011-07-27 | 2013-01-31 | The Rockefeller University | Methods for fixing and detecting rna |
| JP5967528B2 (ja) | 2012-06-22 | 2016-08-10 | 国立研究開発法人理化学研究所 | 生物材料を透明化する方法および生物材料用透明化処理キット |
| DE102012211462A1 (de) * | 2012-07-03 | 2014-01-23 | Carl Zeiss Microscopy Gmbh | Verfahren zur Vorbereitung und Durchführung der Aufnahme von Bildstapeln einer Probe aus verschiedenen Orientierungswinkeln |
| AU2013300171B2 (en) | 2012-08-09 | 2017-09-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for preparing biological specimens for microscopic analysis |
| US20140092376A1 (en) * | 2012-10-01 | 2014-04-03 | Momentive Performance Materials, Inc. | Container and method for in-line analysis of protein compositions |
| US9404869B2 (en) * | 2012-10-09 | 2016-08-02 | Howard Hughes Medical Institute | Multiview light-sheet microscopy |
| DE102012020240A1 (de) * | 2012-10-12 | 2014-04-17 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zur SPIM Mikroskopie |
| JP6605452B2 (ja) | 2013-04-30 | 2019-11-13 | カリフォルニア インスティチュート オブ テクノロジー | 逐次ハイブリダイゼーションバーコーディングによる分子の多重標識化 |
| EP3035026A4 (en) | 2013-08-14 | 2017-04-26 | Riken | Composition for preparing biomaterial with excellent light-transmitting property, and use thereof |
| DE102013216934A1 (de) | 2013-08-26 | 2015-02-26 | Leica Microsystems Cms Gmbh | Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe |
| CA2924478A1 (en) | 2013-09-20 | 2015-03-26 | California Institute Of Technology | Methods for phenotyping of intact whole tissues |
| CN103513411B (zh) * | 2013-09-27 | 2016-02-03 | 香港应用科技研究院有限公司 | 荧光显微镜中聚焦的装置和方法 |
| AU2015266894A1 (en) | 2014-05-30 | 2016-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging large intact tissue samples |
| WO2016023009A1 (en) | 2014-08-07 | 2016-02-11 | Wake Forest University Health Sciences | Compositions and methods for clearing a biological sample |
| US20160131560A1 (en) | 2014-11-07 | 2016-05-12 | California Institute Of Technology | Methods for phenotyping of intact bones by tissue clearing and staining |
| US20170370810A1 (en) | 2015-01-20 | 2017-12-28 | Riken | Biological-specimen transparentizing agent, system, and use therefor |
| JP6781421B2 (ja) | 2015-03-18 | 2020-11-04 | 国立研究開発法人理化学研究所 | 生物材料の観察方法および透明化方法 |
| AU2016364917A1 (en) | 2015-12-02 | 2018-06-21 | Clearlight Diagnostics Llc | Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers |
-
2015
- 2015-05-28 AU AU2015266894A patent/AU2015266894A1/en not_active Abandoned
- 2015-05-28 CA CA2947898A patent/CA2947898A1/en not_active Abandoned
- 2015-05-28 US US15/120,716 patent/US10746981B2/en not_active Expired - Fee Related
- 2015-05-28 KR KR1020167024311A patent/KR20170013855A/ko not_active Withdrawn
- 2015-05-28 JP JP2016563166A patent/JP2017517761A/ja active Pending
- 2015-05-28 WO PCT/US2015/032951 patent/WO2015184124A1/en not_active Ceased
- 2015-05-28 EP EP15799907.9A patent/EP3149534A4/en not_active Withdrawn
- 2015-05-28 CN CN201580009141.2A patent/CN106164736A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017517761A5 (enExample) | ||
| CN110389021B (zh) | 透镜图像产生系统及屈光能力和厚度确定与缺陷检测方法 | |
| CN105157625A (zh) | 一种基于变焦成像透镜的光纤端面显微干涉测量系统 | |
| JP2014515471A5 (enExample) | ||
| WO2009078617A3 (en) | Surface shape measuring system and surface shape measuring method using the same | |
| JP2010169496A5 (enExample) | ||
| CN104062233A (zh) | 精密表面缺陷散射三维显微成像装置 | |
| CN108646396B (zh) | 自动对焦显微镜系统 | |
| JP2017522603A (ja) | 試料を顕微鏡検査する方法及び装置 | |
| CN108007381A (zh) | 光学元件激光诱导损伤三维形貌在线测量装置和测量方法 | |
| TWI764801B (zh) | 用於量測穿通孔之幾何參數的方法及系統 | |
| TW200834048A (en) | Surface form measuring apparatus and stress measuring apparatus and surface form measuring method and stress measuring method | |
| RU2013124820A (ru) | Микроскоп, устройство получения изображения и система получения изображения | |
| KR101356706B1 (ko) | 광량 변조와 스캐닝 시스템 기반의 구조 조명 현미경 | |
| CN102175690A (zh) | 一种红外玻璃内部宏观缺陷检测装置 | |
| JP6387381B2 (ja) | オートフォーカスシステム、方法及び画像検査装置 | |
| KR101830785B1 (ko) | 3차원 형상 측정장치 | |
| JP2018533014A5 (enExample) | ||
| JP2019500607A5 (enExample) | ||
| KR101239409B1 (ko) | 2d 형상 정보와 3d 형상 정보의 동시 획득이 가능하며 레이저와 백색광을 광원으로 한 위상천이기반 형상측정장치 및 형상측정방법 | |
| CN108291870A (zh) | 用于确定样本介质的波长相关折射率的光显微镜和方法 | |
| JP2016148569A (ja) | 画像測定方法、及び画像測定装置 | |
| CN103852166B (zh) | 一种宽视场光谱成像系统辅助装调装置及方法 | |
| KR102010136B1 (ko) | 다중모드 영상의 획득이 가능한 영상 획득 시스템 | |
| JP2015163844A5 (enExample) |