JP2017517553A5 - - Google Patents
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- Publication number
- JP2017517553A5 JP2017517553A5 JP2016572657A JP2016572657A JP2017517553A5 JP 2017517553 A5 JP2017517553 A5 JP 2017517553A5 JP 2016572657 A JP2016572657 A JP 2016572657A JP 2016572657 A JP2016572657 A JP 2016572657A JP 2017517553 A5 JP2017517553 A5 JP 2017517553A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- pruritus
- dose
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003908 antipruritic agent Substances 0.000 claims description 26
- 208000003251 Pruritus Diseases 0.000 claims description 21
- 201000004624 Dermatitis Diseases 0.000 claims description 8
- 239000006186 oral dosage form Substances 0.000 claims description 6
- 206010060875 Uraemic pruritus Diseases 0.000 claims description 4
- 208000024780 Urticaria Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 230000008085 renal dysfunction Effects 0.000 claims description 3
- 206010063409 Acarodermatitis Diseases 0.000 claims description 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 206010012442 Dermatitis contact Diseases 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- 206010021531 Impetigo Diseases 0.000 claims description 2
- 208000006877 Insect Bites and Stings Diseases 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 201000009053 Neurodermatitis Diseases 0.000 claims description 2
- 206010037083 Prurigo Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 2
- 241000447727 Scabies Species 0.000 claims description 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 2
- 208000002474 Tinea Diseases 0.000 claims description 2
- 241000893966 Trichophyton verrucosum Species 0.000 claims description 2
- 206010000496 acne Diseases 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 208000010247 contact dermatitis Diseases 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 201000006370 kidney failure Diseases 0.000 claims description 2
- 208000019423 liver disease Diseases 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 239000002207 metabolite Substances 0.000 claims description 2
- 229960000805 nalbuphine Drugs 0.000 claims description 2
- 230000001272 neurogenic effect Effects 0.000 claims description 2
- 230000001575 pathological effect Effects 0.000 claims description 2
- 230000035935 pregnancy Effects 0.000 claims description 2
- 230000001107 psychogenic effect Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 208000005687 scabies Diseases 0.000 claims description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 2
- 210000002374 sebum Anatomy 0.000 claims description 2
- 208000017520 skin disease Diseases 0.000 claims description 2
- 206010040882 skin lesion Diseases 0.000 claims description 2
- 231100000444 skin lesion Toxicity 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 208000037911 visceral disease Diseases 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 230000007774 longterm Effects 0.000 claims 3
- 230000001139 anti-pruritic effect Effects 0.000 claims 2
- 235000013912 Ceratonia siliqua Nutrition 0.000 claims 1
- 240000008886 Ceratonia siliqua Species 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical group C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 21
- 238000013265 extended release Methods 0.000 description 3
- YZLZPSJXMWGIFH-BCXQGASESA-N nalbuphine hydrochloride Chemical group [H+].[Cl-].C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 YZLZPSJXMWGIFH-BCXQGASESA-N 0.000 description 2
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960001513 nalbuphine hydrochloride Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011936P | 2014-06-13 | 2014-06-13 | |
| US62/011,936 | 2014-06-13 | ||
| PCT/US2015/035650 WO2015192071A1 (en) | 2014-06-13 | 2015-06-12 | Methods for treating pruritus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017517553A JP2017517553A (ja) | 2017-06-29 |
| JP2017517553A5 true JP2017517553A5 (enExample) | 2018-06-28 |
Family
ID=54834447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572657A Pending JP2017517553A (ja) | 2014-06-13 | 2015-06-12 | 掻痒の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20150359789A1 (enExample) |
| EP (1) | EP3154546A4 (enExample) |
| JP (1) | JP2017517553A (enExample) |
| KR (1) | KR20170016983A (enExample) |
| CN (1) | CN106535897A (enExample) |
| AU (1) | AU2015274327A1 (enExample) |
| BR (1) | BR112016029236A2 (enExample) |
| CA (1) | CA2951420A1 (enExample) |
| IL (1) | IL249475A0 (enExample) |
| MX (1) | MX2016016404A (enExample) |
| RU (1) | RU2017101102A (enExample) |
| WO (1) | WO2015192071A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| WO2017120468A1 (en) * | 2016-01-06 | 2017-07-13 | Trevi Therapeutics, Inc. | Therapeutic use of nalbuphine without aquaretic effects |
| KR20180120756A (ko) * | 2016-03-21 | 2018-11-06 | 트레비 테라퓨틱스, 인코포레이티드 | 요독증성 소양증의 치료 |
| US20180125840A1 (en) * | 2016-10-25 | 2018-05-10 | Trevi Therapeutics, Inc. | Treatment of prurigo nodularis |
| AU2019243571A1 (en) * | 2018-03-29 | 2020-10-15 | Lumosa Therapeutics Co., Ltd. | Compositions and methods for treating pruritus |
| CN112672743A (zh) * | 2018-07-11 | 2021-04-16 | 特雷维治疗股份有限公司 | 肝病瘙痒症状的治疗 |
| IL280301B2 (en) * | 2018-07-23 | 2025-06-01 | Trevi Therapeutics Inc | Treatment of chronic cough, breathlessness and dyspnea |
| EP4087569A4 (en) | 2020-01-10 | 2024-01-24 | Trevi Therapeutics, Inc. | METHODS OF ADMINISTRATION OF NALBUPHINE |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8394812B2 (en) * | 2005-08-24 | 2013-03-12 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
| WO2007025005A2 (en) * | 2005-08-24 | 2007-03-01 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
| WO2008128892A1 (en) * | 2007-04-23 | 2008-10-30 | Symrise Gmbh & Co. Kg | Polyethylene glycol esters and cosmetic and/or dermatological preparations |
| US8987289B2 (en) * | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US8637538B1 (en) * | 2012-12-14 | 2014-01-28 | Trevi Therapeutics, Inc. | Methods for treatment of pruritis |
| US20140179727A1 (en) * | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| CN104981246A (zh) * | 2012-12-14 | 2015-10-14 | 特雷维治疗股份有限公司 | 治疗瘙痒的方法 |
-
2015
- 2015-06-12 KR KR1020177001115A patent/KR20170016983A/ko not_active Withdrawn
- 2015-06-12 JP JP2016572657A patent/JP2017517553A/ja active Pending
- 2015-06-12 CA CA2951420A patent/CA2951420A1/en not_active Abandoned
- 2015-06-12 EP EP15807379.1A patent/EP3154546A4/en not_active Withdrawn
- 2015-06-12 US US14/738,550 patent/US20150359789A1/en not_active Abandoned
- 2015-06-12 WO PCT/US2015/035650 patent/WO2015192071A1/en not_active Ceased
- 2015-06-12 BR BR112016029236A patent/BR112016029236A2/pt not_active Application Discontinuation
- 2015-06-12 MX MX2016016404A patent/MX2016016404A/es unknown
- 2015-06-12 AU AU2015274327A patent/AU2015274327A1/en not_active Abandoned
- 2015-06-12 RU RU2017101102A patent/RU2017101102A/ru not_active Application Discontinuation
- 2015-06-12 CN CN201580039250.9A patent/CN106535897A/zh active Pending
-
2016
- 2016-12-11 IL IL249475A patent/IL249475A0/en unknown
-
2018
- 2018-04-30 US US15/966,850 patent/US20190099416A1/en not_active Abandoned
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