JP2017514845A - オピオイド化合物を調製するプロセス - Google Patents

オピオイド化合物を調製するプロセス Download PDF

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Publication number
JP2017514845A
JP2017514845A JP2016565665A JP2016565665A JP2017514845A JP 2017514845 A JP2017514845 A JP 2017514845A JP 2016565665 A JP2016565665 A JP 2016565665A JP 2016565665 A JP2016565665 A JP 2016565665A JP 2017514845 A JP2017514845 A JP 2017514845A
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compound
formula
molar equivalents
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Japanese (ja)
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JP2017514845A5 (enExample
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カルド・ジェシカ
ツァン・ウェン−チュン
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Noramco LLC
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Noramco LLC
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Publication of JP2017514845A publication Critical patent/JP2017514845A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016565665A 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス Pending JP2017514845A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988508P 2014-05-05 2014-05-05
US61/988,508 2014-05-05
US14/689,610 US9701687B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
US14/689,610 2015-04-17
PCT/US2015/027906 WO2015171353A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020036660A Division JP2020203872A (ja) 2014-05-05 2020-03-04 オピオイド化合物を調製するプロセス

Publications (2)

Publication Number Publication Date
JP2017514845A true JP2017514845A (ja) 2017-06-08
JP2017514845A5 JP2017514845A5 (enExample) 2018-06-14

Family

ID=54354747

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016565665A Pending JP2017514845A (ja) 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス
JP2020036660A Pending JP2020203872A (ja) 2014-05-05 2020-03-04 オピオイド化合物を調製するプロセス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020036660A Pending JP2020203872A (ja) 2014-05-05 2020-03-04 オピオイド化合物を調製するプロセス

Country Status (7)

Country Link
US (1) US9701687B2 (enExample)
EP (1) EP3140307A2 (enExample)
JP (2) JP2017514845A (enExample)
CN (1) CN107074869A (enExample)
AU (1) AU2015256507B2 (enExample)
CA (1) CA2947022A1 (enExample)
WO (1) WO2015171353A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3001689A1 (en) * 2015-10-12 2017-04-20 Noramco, Inc. Process for the preparation of (s)-2-((4r,4as,6r,7r,7ar,12bs)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol

Citations (11)

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JP2009534472A (ja) * 2007-05-04 2009-09-24 マリンクロッド・インコーポレイテッド ６−アルファ−ヒドロキシ−ｎ−アルキル化オピエート類の改良型製造方法
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
US20100081819A1 (en) * 2008-09-30 2010-04-01 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
JP2010510328A (ja) * 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体の（ｒ）−ｎ−立体異性体
JP2011516464A (ja) * 2008-03-31 2011-05-26 サン・ファーマシューティカル・インダストリーズ・リミテッド モルフィナン類似体の改良された調製方法
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
WO2012149633A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine
WO2013164383A1 (en) * 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone
JP2013541564A (ja) * 2010-11-05 2013-11-14 ハー・ルンドベック・アクチエゼルスカベット ナルトレキソンの製造方法

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US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CN101610770A (zh) * 2006-11-22 2009-12-23 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物
CN101541808A (zh) * 2007-05-04 2009-09-23 马林克罗特公司 制备6-α-羟基-N-烷基化的阿片的改进的方法
CN101861315B (zh) 2007-11-20 2013-01-16 日产化学工业株式会社 2-氮杂金刚烷类的制造方法
US8227608B2 (en) 2008-09-30 2012-07-24 Mallinckrodt Llc Processes for increasing the yield of opiate alkaloid derivatives
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
CA2738089C (en) 2008-09-30 2017-07-18 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
EP2342207B1 (en) 2008-09-30 2015-11-11 Mallinckrodt LLC Processes for the alkylation of norbuprenorphine with reduced impurity formation
EP2398808B1 (en) 2009-02-17 2013-11-20 Mallinckrodt LLC Process for the reductive alkylation of normorphinans
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
CA2863242A1 (en) 2012-02-03 2013-08-08 Tomas Hudlicky Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510328A (ja) * 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体の（ｒ）−ｎ−立体異性体
JP2009534472A (ja) * 2007-05-04 2009-09-24 マリンクロッド・インコーポレイテッド ６−アルファ−ヒドロキシ−ｎ−アルキル化オピエート類の改良型製造方法
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
JP2011516464A (ja) * 2008-03-31 2011-05-26 サン・ファーマシューティカル・インダストリーズ・リミテッド モルフィナン類似体の改良された調製方法
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
US20100081819A1 (en) * 2008-09-30 2010-04-01 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
JP2013541564A (ja) * 2010-11-05 2013-11-14 ハー・ルンドベック・アクチエゼルスカベット ナルトレキソンの製造方法
WO2012149633A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine
WO2013164383A1 (en) * 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MACHARA A; WERNER L; ENDOMA-ARIAS M A; ET AL: "IMPROVED SYNTHESIS OF BUPRENORPHINE FROM THEBAINE AND/OR ORIPAVINE VIA PALLADIUM-CATALYZED 以下備考", ADVANCED SYNTHESIS AND CATALYSIS, vol. VOL:354, NR:4, JPN5017003356, 23 February 2012 (2012-02-23), DE, pages 613 - 626, ISSN: 0004143805 *

Also Published As

Publication number Publication date
EP3140307A2 (en) 2017-03-15
US9701687B2 (en) 2017-07-11
US20150315204A1 (en) 2015-11-05
AU2015256507B2 (en) 2019-11-21
AU2015256507A1 (en) 2016-11-24
CA2947022A1 (en) 2015-11-12
WO2015171353A3 (en) 2016-03-10
JP2020203872A (ja) 2020-12-24
WO2015171353A2 (en) 2015-11-12
CN107074869A (zh) 2017-08-18

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