AU2015256507B2 - Process for the preparation of opioid compounds - Google Patents

Process for the preparation of opioid compounds Download PDF

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Publication number
AU2015256507B2
AU2015256507B2 AU2015256507A AU2015256507A AU2015256507B2 AU 2015256507 B2 AU2015256507 B2 AU 2015256507B2 AU 2015256507 A AU2015256507 A AU 2015256507A AU 2015256507 A AU2015256507 A AU 2015256507A AU 2015256507 B2 AU2015256507 B2 AU 2015256507B2
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AU
Australia
Prior art keywords
formula
compound
range
amount
molar equivalents
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015256507A
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English (en)
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AU2015256507A1 (en
Inventor
Jessica Cardot
Wen-Chun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
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Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Publication of AU2015256507A1 publication Critical patent/AU2015256507A1/en
Application granted granted Critical
Publication of AU2015256507B2 publication Critical patent/AU2015256507B2/en
Assigned to NORAMCO, LLC reassignment NORAMCO, LLC Amend patent request/document other than specification (104) Assignors: NORAMCO, INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2015256507A 2014-05-05 2015-04-28 Process for the preparation of opioid compounds Ceased AU2015256507B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988508P 2014-05-05 2014-05-05
US61/988,508 2014-05-05
US14/689,610 2015-04-17
US14/689,610 US9701687B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027906 WO2015171353A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (2)

Publication Number Publication Date
AU2015256507A1 AU2015256507A1 (en) 2016-11-24
AU2015256507B2 true AU2015256507B2 (en) 2019-11-21

Family

ID=54354747

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015256507A Ceased AU2015256507B2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Country Status (7)

Country Link
US (1) US9701687B2 (enExample)
EP (1) EP3140307A2 (enExample)
JP (2) JP2017514845A (enExample)
CN (1) CN107074869A (enExample)
AU (1) AU2015256507B2 (enExample)
CA (1) CA2947022A1 (enExample)
WO (1) WO2015171353A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10287296B2 (en) * 2015-10-12 2019-05-14 Noramco, Inc. Process for the preparation of (S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
EP4686721A1 (en) 2024-08-01 2026-02-04 Siegfried AG Crystalline naloxone-dimethylformamide solvate, methods for its preparation and its use as a reagent in a method of making naloxone

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064351A2 (en) * 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs
WO2008137672A1 (en) * 2007-05-04 2008-11-13 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
US20100081819A1 (en) * 2008-09-30 2010-04-01 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
US20120283443A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and Intermediates in the Preparation of Morphine Analogs via N-Demethylation of N-Oxides Using Cyclodehydration Reagents
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CN101636160A (zh) * 2006-11-22 2010-01-27 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物的(r)-n-立体异构体
ES2356412T3 (es) * 2007-05-04 2011-04-07 Mallinckrodt Inc. Procedimiento mejorado para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados.
EP2221306B1 (en) 2007-11-20 2016-04-13 Nissan Chemical Industries, Ltd. Method for producing 2-azaadamantane
KR20110014974A (ko) * 2008-03-31 2011-02-14 썬 파마슈티컬 인더스트리스 리미티드 모르피난 유사체의 개선된 제조 방법
PL2344507T5 (pl) 2008-09-30 2021-10-11 SpecGx LLC Sposoby zwiększania wydajności hydrolizy grupy 3-O-metylowej i 17-N-nitrylowej w wytwarzaniu pochodnych alkaloidów opiatowych
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
ES2529057T3 (es) 2008-09-30 2015-02-16 Mallinckrodt Inc. Procedimientos para la hidrogenación de derivados de alcaloides opiáceos
US8293906B2 (en) 2008-09-30 2012-10-23 Mallinckrodt Llc Processes for the alkylation of norbuprenorphine with reduced impurity formation
WO2010096416A1 (en) 2009-02-17 2010-08-26 Mallinckrodt Inc. Process for the reductive alkylation of normorphinans
US8853401B2 (en) 2009-04-24 2014-10-07 Brock University Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
SMT201700177T1 (it) * 2010-11-05 2017-05-08 H Lundbeck As Procedimento per la fabbricazione di naltrexone
JP2015506952A (ja) 2012-02-03 2015-03-05 ブロック ユニバーシティ モルフィナンから誘導されたオキサゾリジンと有機金属試薬との反応によるモルフィンアナログの製造方法
WO2013164383A1 (en) * 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064351A2 (en) * 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs
WO2008137672A1 (en) * 2007-05-04 2008-11-13 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
US20100081819A1 (en) * 2008-09-30 2010-04-01 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
US20120283443A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and Intermediates in the Preparation of Morphine Analogs via N-Demethylation of N-Oxides Using Cyclodehydration Reagents
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine

Also Published As

Publication number Publication date
CA2947022A1 (en) 2015-11-12
US9701687B2 (en) 2017-07-11
US20150315204A1 (en) 2015-11-05
EP3140307A2 (en) 2017-03-15
AU2015256507A1 (en) 2016-11-24
JP2020203872A (ja) 2020-12-24
WO2015171353A2 (en) 2015-11-12
WO2015171353A3 (en) 2016-03-10
JP2017514845A (ja) 2017-06-08
CN107074869A (zh) 2017-08-18

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Legal Events

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HB Alteration of name in register

Owner name: NORAMCO, LLC

Free format text: FORMER NAME(S): NORAMCO, INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired