CN107074869A - 制备阿片类化合物的方法 - Google Patents

制备阿片类化合物的方法 Download PDF

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Publication number
CN107074869A
CN107074869A CN201580035275.1A CN201580035275A CN107074869A CN 107074869 A CN107074869 A CN 107074869A CN 201580035275 A CN201580035275 A CN 201580035275A CN 107074869 A CN107074869 A CN 107074869A
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China
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formula
compound
amount
molar equivalents
present
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CN201580035275.1A
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English (en)
Chinese (zh)
Inventor
J.卡多
W-C.张
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Noramco LLC
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Noramco LLC
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Publication of CN107074869A publication Critical patent/CN107074869A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580035275.1A 2014-05-05 2015-04-28 制备阿片类化合物的方法 Pending CN107074869A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988508P 2014-05-05 2014-05-05
US61/988508 2014-05-05
US14/689,610 US9701687B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
US14/689610 2015-04-17
PCT/US2015/027906 WO2015171353A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (1)

Publication Number Publication Date
CN107074869A true CN107074869A (zh) 2017-08-18

Family

ID=54354747

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580035275.1A Pending CN107074869A (zh) 2014-05-05 2015-04-28 制备阿片类化合物的方法

Country Status (7)

Country Link
US (1) US9701687B2 (enExample)
EP (1) EP3140307A2 (enExample)
JP (2) JP2017514845A (enExample)
CN (1) CN107074869A (enExample)
AU (1) AU2015256507B2 (enExample)
CA (1) CA2947022A1 (enExample)
WO (1) WO2015171353A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3001689A1 (en) * 2015-10-12 2017-04-20 Noramco, Inc. Process for the preparation of (s)-2-((4r,4as,6r,7r,7ar,12bs)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol

Citations (7)

* Cited by examiner, † Cited by third party
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CN101541808A (zh) * 2007-05-04 2009-09-23 马林克罗特公司 制备6-α-羟基-N-烷基化的阿片的改进的方法
CN101636160A (zh) * 2006-11-22 2010-01-27 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物的(r)-n-立体异构体
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
CN102227433A (zh) * 2008-09-30 2011-10-26 马林克罗特公司 烷基化吗啡喃衍生物的仲胺基团的方法
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine
CN103596962A (zh) * 2011-05-02 2014-02-19 布鲁克大学 通过使用环化脱水试剂的n-氧化物的n-脱甲基化制备吗啡类似物的方法和中间体

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US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2670136A1 (en) 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. 7,8-saturated-4,5-epoxy-morphinanium analogs
DE602008004245D1 (de) 2007-05-04 2011-02-10 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten
CN101861315B (zh) 2007-11-20 2013-01-16 日产化学工业株式会社 2-氮杂金刚烷类的制造方法
US8546572B2 (en) * 2008-03-31 2013-10-01 Sun Pharmaceutical Industries Limited Process for the preparation of morphinane analogues
US8227608B2 (en) 2008-09-30 2012-07-24 Mallinckrodt Llc Processes for increasing the yield of opiate alkaloid derivatives
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
CA2738089C (en) 2008-09-30 2017-07-18 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
EP2342207B1 (en) 2008-09-30 2015-11-11 Mallinckrodt LLC Processes for the alkylation of norbuprenorphine with reduced impurity formation
EP2398808B1 (en) 2009-02-17 2013-11-20 Mallinckrodt LLC Process for the reductive alkylation of normorphinans
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
EA022266B1 (ru) * 2010-11-05 2015-11-30 Х. Лундбекк А/С Способ получения налтрексона
CA2863242A1 (en) 2012-02-03 2013-08-08 Tomas Hudlicky Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
US20140155608A1 (en) * 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101636160A (zh) * 2006-11-22 2010-01-27 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物的(r)-n-立体异构体
CN101541808A (zh) * 2007-05-04 2009-09-23 马林克罗特公司 制备6-α-羟基-N-烷基化的阿片的改进的方法
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
CN102227433A (zh) * 2008-09-30 2011-10-26 马林克罗特公司 烷基化吗啡喃衍生物的仲胺基团的方法
CN103596962A (zh) * 2011-05-02 2014-02-19 布鲁克大学 通过使用环化脱水试剂的n-氧化物的n-脱甲基化制备吗啡类似物的方法和中间体
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine

Non-Patent Citations (2)

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Title
ALES MACHARA ET AL.: "Improved Synthesis of Buprenorphine from Thebaine and/or Oripavine via Palladium-Catalyzed N-Demethylation/Acylation and/or Concomitant O-Demethylation", 《ADV. SYNTH. CATAL.》 *
章思规 等: "《精细有机化工制备手册》", 30 April 1994, 科学技术文献出版社 *

Also Published As

Publication number Publication date
EP3140307A2 (en) 2017-03-15
US9701687B2 (en) 2017-07-11
US20150315204A1 (en) 2015-11-05
AU2015256507B2 (en) 2019-11-21
AU2015256507A1 (en) 2016-11-24
CA2947022A1 (en) 2015-11-12
WO2015171353A3 (en) 2016-03-10
JP2020203872A (ja) 2020-12-24
WO2015171353A2 (en) 2015-11-12
JP2017514845A (ja) 2017-06-08

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