CA2947022A1 - Process for the preparation of opioid compounds - Google Patents

Process for the preparation of opioid compounds Download PDF

Info

Publication number
CA2947022A1
CA2947022A1 CA2947022A CA2947022A CA2947022A1 CA 2947022 A1 CA2947022 A1 CA 2947022A1 CA 2947022 A CA2947022 A CA 2947022A CA 2947022 A CA2947022 A CA 2947022A CA 2947022 A1 CA2947022 A1 CA 2947022A1
Authority
CA
Canada
Prior art keywords
compound
formula
amount
range
molar equivalents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2947022A
Other languages
English (en)
French (fr)
Inventor
Jessica Cardot
Wen-Chun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Publication of CA2947022A1 publication Critical patent/CA2947022A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2947022A 2014-05-05 2015-04-28 Process for the preparation of opioid compounds Abandoned CA2947022A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988508P 2014-05-05 2014-05-05
US61/988,508 2014-05-05
US14/689,610 2015-04-17
US14/689,610 US9701687B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027906 WO2015171353A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (1)

Publication Number Publication Date
CA2947022A1 true CA2947022A1 (en) 2015-11-12

Family

ID=54354747

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2947022A Abandoned CA2947022A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Country Status (7)

Country Link
US (1) US9701687B2 (enExample)
EP (1) EP3140307A2 (enExample)
JP (2) JP2017514845A (enExample)
CN (1) CN107074869A (enExample)
AU (1) AU2015256507B2 (enExample)
CA (1) CA2947022A1 (enExample)
WO (1) WO2015171353A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10287296B2 (en) * 2015-10-12 2019-05-14 Noramco, Inc. Process for the preparation of (S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
EP4686721A1 (en) 2024-08-01 2026-02-04 Siegfried AG Crystalline naloxone-dimethylformamide solvate, methods for its preparation and its use as a reagent in a method of making naloxone

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
WO2008064351A2 (en) 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs
CN101636160A (zh) * 2006-11-22 2010-01-27 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物的(r)-n-立体异构体
MX2008013842A (es) * 2007-05-04 2009-03-06 Mallinckrodt Inc Proceso mejorado para la preparacion de opiatos 6-alfa-hidroxi-n-alquilados.
ES2356412T3 (es) * 2007-05-04 2011-04-07 Mallinckrodt Inc. Procedimiento mejorado para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados.
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
EP2221306B1 (en) 2007-11-20 2016-04-13 Nissan Chemical Industries, Ltd. Method for producing 2-azaadamantane
KR20110014974A (ko) * 2008-03-31 2011-02-14 썬 파마슈티컬 인더스트리스 리미티드 모르피난 유사체의 개선된 제조 방법
EP2328900B1 (en) 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. PROCESS FOR MAKING MORPHINAN-6 alpha-OLS
PL2344507T5 (pl) 2008-09-30 2021-10-11 SpecGx LLC Sposoby zwiększania wydajności hydrolizy grupy 3-O-metylowej i 17-N-nitrylowej w wytwarzaniu pochodnych alkaloidów opiatowych
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
ES2529057T3 (es) 2008-09-30 2015-02-16 Mallinckrodt Inc. Procedimientos para la hidrogenación de derivados de alcaloides opiáceos
US8293906B2 (en) 2008-09-30 2012-10-23 Mallinckrodt Llc Processes for the alkylation of norbuprenorphine with reduced impurity formation
AU2009300379B2 (en) 2008-09-30 2015-04-02 SpecGx LLC Processes for the alkylation of secondary amine groups of morphinan derivatives
WO2010096416A1 (en) 2009-02-17 2010-08-26 Mallinckrodt Inc. Process for the reductive alkylation of normorphinans
US8853401B2 (en) 2009-04-24 2014-10-07 Brock University Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
SMT201700177T1 (it) * 2010-11-05 2017-05-08 H Lundbeck As Procedimento per la fabbricazione di naltrexone
EP3042908A1 (en) 2011-05-02 2016-07-13 Brock University Intermediates in the preparation of morphine analogs
EP2763996B1 (en) 2011-10-03 2018-07-25 Johnson Matthey PLC Process for preparing buprenorphine
JP2015506952A (ja) 2012-02-03 2015-03-05 ブロック ユニバーシティ モルフィナンから誘導されたオキサゾリジンと有機金属試薬との反応によるモルフィンアナログの製造方法
WO2013164383A1 (en) * 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone

Also Published As

Publication number Publication date
US9701687B2 (en) 2017-07-11
US20150315204A1 (en) 2015-11-05
EP3140307A2 (en) 2017-03-15
AU2015256507A1 (en) 2016-11-24
JP2020203872A (ja) 2020-12-24
WO2015171353A2 (en) 2015-11-12
WO2015171353A3 (en) 2016-03-10
JP2017514845A (ja) 2017-06-08
AU2015256507B2 (en) 2019-11-21
CN107074869A (zh) 2017-08-18

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211123

FZDE Discontinued

Effective date: 20211123