CA2947022A1 - Process for the preparation of opioid compounds - Google Patents

Process for the preparation of opioid compounds Download PDF

Info

Publication number
CA2947022A1
CA2947022A1 CA2947022A CA2947022A CA2947022A1 CA 2947022 A1 CA2947022 A1 CA 2947022A1 CA 2947022 A CA2947022 A CA 2947022A CA 2947022 A CA2947022 A CA 2947022A CA 2947022 A1 CA2947022 A1 CA 2947022A1
Authority
CA
Canada
Prior art keywords
compound
formula
amount
range
molar equivalents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2947022A
Other languages
English (en)
French (fr)
Inventor
Jessica Cardot
Wen-Chun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Publication of CA2947022A1 publication Critical patent/CA2947022A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2947022A 2014-05-05 2015-04-28 Process for the preparation of opioid compounds Abandoned CA2947022A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988508P 2014-05-05 2014-05-05
US61/988,508 2014-05-05
US14/689,610 2015-04-17
US14/689,610 US9701687B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027906 WO2015171353A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (1)

Publication Number Publication Date
CA2947022A1 true CA2947022A1 (en) 2015-11-12

Family

ID=54354747

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2947022A Abandoned CA2947022A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Country Status (7)

Country Link
US (1) US9701687B2 (enExample)
EP (1) EP3140307A2 (enExample)
JP (2) JP2017514845A (enExample)
CN (1) CN107074869A (enExample)
AU (1) AU2015256507B2 (enExample)
CA (1) CA2947022A1 (enExample)
WO (1) WO2015171353A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3001689A1 (en) * 2015-10-12 2017-04-20 Noramco, Inc. Process for the preparation of (s)-2-((4r,4as,6r,7r,7ar,12bs)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
EP4686721A1 (en) 2024-08-01 2026-02-04 Siegfried AG Crystalline naloxone-dimethylformamide solvate, methods for its preparation and its use as a reagent in a method of making naloxone

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
JP2010510328A (ja) * 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体の（ｒ）−ｎ−立体異性体
CN101636160A (zh) * 2006-11-22 2010-01-27 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物的(r)-n-立体异构体
ATE493416T1 (de) 2007-05-04 2011-01-15 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten
ES2356412T3 (es) * 2007-05-04 2011-04-07 Mallinckrodt Inc. Procedimiento mejorado para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados.
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
EP2221306B1 (en) 2007-11-20 2016-04-13 Nissan Chemical Industries, Ltd. Method for producing 2-azaadamantane
AU2009233315B2 (en) * 2008-03-31 2013-08-29 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
WO2010017573A1 (en) 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
WO2010039214A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for increasing the yield of the hydrolysis of the 3-0-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives
US8293906B2 (en) 2008-09-30 2012-10-23 Mallinckrodt Llc Processes for the alkylation of norbuprenorphine with reduced impurity formation
ES2566559T3 (es) 2008-09-30 2016-04-13 Mallinckrodt Llc Procesos para la alquilación de grupos amino secundarios de derivados de morfinano
US8273887B2 (en) 2008-09-30 2012-09-25 Mallinckrodt Llc Processes for synthesis of opiate alkaloid derivatives
PL2342208T3 (pl) 2008-09-30 2014-11-28 SpecGx LLC Proces zawracania do ponownego wykorzystania w celu zwiększania wydajności reakcji grignarda w wytwarzaniu pochodnych alkaloidów opiatowych
US8431701B2 (en) 2009-02-17 2013-04-30 Mallinckrodt Llc Process for the reductive alkylation of normorphinans
JP5824448B2 (ja) 2009-04-24 2015-11-25 ブロック ユニバーシティ モルフィナンおよびモルフィノン化合物の調製法
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
DK2635586T3 (en) * 2010-11-05 2017-03-27 H Lundbeck As PROCEDURE FOR THE PREPARATION OF NALTREXON
CN103596962B (zh) * 2011-05-02 2017-02-15 布鲁克大学 通过使用环化脱水试剂的n‑氧化物的n‑脱甲基化制备吗啡类似物的方法和中间体
HUE040284T2 (hu) 2011-10-03 2019-02-28 Johnson Matthey Plc Eljárás buprenorfin elõállítására
EP2809674A4 (en) 2012-02-03 2015-09-02 Univ Brock METHOD FOR THE PRODUCTION OF MORPHINE ANALOGUE BY REACTION OF ORGANOMETALLIC REAGENTS WITH AN OXAZOLIDINE DERIVED FROM MORPHINANESE
WO2013164383A1 (en) * 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone

Also Published As

Publication number Publication date
EP3140307A2 (en) 2017-03-15
US9701687B2 (en) 2017-07-11
US20150315204A1 (en) 2015-11-05
AU2015256507B2 (en) 2019-11-21
CN107074869A (zh) 2017-08-18
WO2015171353A2 (en) 2015-11-12
AU2015256507A1 (en) 2016-11-24
JP2017514845A (ja) 2017-06-08
WO2015171353A3 (en) 2016-03-10
JP2020203872A (ja) 2020-12-24

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211123

FZDE Discontinued

Effective date: 20211123