JP2017513868A - 刺激の低減された化粧品組成物 - Google Patents
刺激の低減された化粧品組成物 Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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Abstract
Description
本発明の化粧品組成物は、哺乳類のケラチン性組織、特に、ヒトの皮膚に塗布してよい。化粧品組成物は、様々な形態をとり得る。例えば、形態の幾つかの非限定的な例としては、溶液、懸濁液、ローション、クリーム、ゲル、化粧水、スティック、ペンシル、スプレー、エアゾール、軟膏、クレンジング洗浄液及びクレンジング棒状固形物、シャンプー及びヘアコンディショナー、ペースト、フォーム、粉末、ムース、髭剃りクリーム、拭き取り剤、ストリップ、パッチ、電動パッチ、創傷被覆材及び粘着包帯、ヒドロゲル、皮膜形成製品、フェイシャル及びスキンマスク、化粧品(例えば、ファンデーション、アイライナー、アイシャドウ)等が挙げられる。
以下の式を有するバチルアルコール:
物質又は物質の組み合わせを塗布した際の皮膚における発赤及び腫脹は、プロスタグランジンE2(PGE2)メディエータ等の炎症性メディエータの産生増加に関連している。国際公開第93/17336号に更に詳細に記載されている通り、物質を塗布した際のインビトロにおけるケラチン産生細胞におけるPGE2の産生量を測定することにより、物質又は物質の組み合わせが、皮膚に塗布されたときに、皮膚刺激性を引き起こす可能性があるかどうかを推定することができる。
Claims (13)
- 第1のスキンケア活性物質及び皮膚美白剤を含む化粧品組成物の被刺激性(irritability)を低減する方法であって、
a)前記化粧品組成物をケラチン性組織に塗布したとき、前記化粧品組成物が少なくとも1人のヒト被験者において刺激を引き起こすことを確認する工程と、
b)ビサボロールのグリセロールエーテルに対する比2:1〜1:15で、ビサボロール及び脂肪族アルコールのグリセロールエーテルを前記化粧品組成物に添加して、前記刺激を軽減する工程と、を含む、方法。 - PGE2アッセイを用いて前記化粧品組成物の被刺激性を測定する工程を更に含む、請求項1に記載の化粧品組成物の被刺激性を低減する方法。
- 前記脂肪族アルコールのグリセロールエーテルが、12〜24の炭素鎖長を有する、請求項1又は2に記載の化粧品組成物の被刺激性を低減する方法。
- 前記脂肪族アルコールのグリセロールエーテルが、バチルアルコールである、請求項1〜3のいずれか一項に記載の化粧品組成物の被刺激性を低減する方法。
- 前記化粧品組成物が、前記組成物の0.2重量%以下のビサボロールを含む、請求項1〜4のいずれか一項に記載の化粧品組成物の被刺激性を低減する方法。
- ビサボロールのグリセロールエーテルに対する比が、1:1.5である、請求項1〜5のいずれか一項に記載の化粧品組成物の被刺激性を低減する方法。
- 前記スキンケア活性物質が、ビタミンB3又はその誘導体である、請求項1〜6のいずれか一項に記載の化粧品組成物の被刺激性を低減する方法。
- 前記スキンケア活性物質が、ナイアシンアミドである、請求項1〜7のいずれか一項に記載の化粧品組成物の被刺激性を低減する方法。
- 前記皮膚美白剤が、N−アシルアミノ酸である、請求項1〜8のいずれか一項に記載の化粧品組成物の被刺激性を低減する方法。
- 前記皮膚美白剤が、N−ウンデシレノイル−L−フェニルアラニンである、請求項1〜9のいずれか一項に記載の化粧品組成物の被刺激性を低減する方法。
- 被刺激性の低減された皮膚美白用の化粧品組成物であって、
a)安全かつ有効な量のスキンケア活性物質と;
b)安全かつ有効な量の皮膚美白剤と;
c)安全かつ有効な量のビサボロールと、
d)安全かつ有効な量のバチルアルコール、キミルアルコール、又はセラキルアルコールを含み、ビサボロールのバチルアルコール、キミルアルコール、又はセラキルアルコールに対する比が、2:1〜1:15である、化粧品組成物。 - 被刺激性の低減された皮膚美白用の化粧品組成物であって、
a)前記組成物の約0.0005重量%〜約11重量%のスキンケア活性物質と;
b)前記組成物の約0.0001重量%〜約5重量%の皮膚美白剤と;
c)前記組成物の約0.0001重量%〜約0.2重量%のビサボロールと、
d)前記組成物の約0.001%からのバチルアルコール、キミルアルコール、又はセラキルアルコールを含み、ビサボロールのバチルアルコール、キミルアルコール、又はセラキルアルコールに対する比が、2:1〜1:15である化粧品組成物。 - 前記スキンケア活性物質が、ビタミンB3化合物であり、前記皮膚美白剤が、N−アシルアミノ酸である、請求項11又は12に記載の化粧品組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461982883P | 2014-04-23 | 2014-04-23 | |
US61/982,883 | 2014-04-23 | ||
PCT/US2015/026737 WO2015164290A1 (en) | 2014-04-23 | 2015-04-21 | Cosmetic compositions having reduced irritation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017513868A true JP2017513868A (ja) | 2017-06-01 |
JP6416284B2 JP6416284B2 (ja) | 2018-10-31 |
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Application Number | Title | Priority Date | Filing Date |
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JP2016563406A Active JP6416284B2 (ja) | 2014-04-23 | 2015-04-21 | 刺激の低減された化粧品組成物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US9480634B2 (ja) |
EP (1) | EP3134062B1 (ja) |
JP (1) | JP6416284B2 (ja) |
KR (1) | KR101939453B1 (ja) |
CN (1) | CN106470665B (ja) |
CA (1) | CA2944157C (ja) |
WO (1) | WO2015164290A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3026108A1 (en) | 2016-06-10 | 2017-12-14 | Clarity Cosmetics Inc. | Non-comedogenic hair and scalp care formulations and method for use |
EP3609465A1 (en) | 2017-04-11 | 2020-02-19 | The Procter and Gamble Company | Cosmetic compositions |
WO2018220916A1 (ja) * | 2017-06-02 | 2018-12-06 | 味の素株式会社 | 外用組成物 |
JP7102687B2 (ja) * | 2017-06-02 | 2022-07-20 | 味の素株式会社 | 外用組成物 |
CN115645294A (zh) * | 2022-09-30 | 2023-01-31 | 露乐健康科技股份有限公司 | 鲨肝醇在制备治疗女性哺乳乳头不适的产品中的用途及治疗女性哺乳乳头不适的产品 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1993017336A1 (en) * | 1992-02-19 | 1993-09-02 | The Procter & Gamble Company | In vitro model for eye and skin irritation testing |
JPH083034A (ja) * | 1994-06-14 | 1996-01-09 | Beiersdorf Ag | グリセロールアルキルエーテル類の内容物を有する活性化合物組み合わせ、並びに上記活性化合物組み合わせを含んでいる化粧品および皮膚科学調合物 |
JPH10279417A (ja) * | 1997-04-01 | 1998-10-20 | Shiseido Co Ltd | 皮膚外用剤 |
JPH1160463A (ja) * | 1997-08-19 | 1999-03-02 | Shigeo Serizawa | 化粧料 |
WO2013158824A2 (en) * | 2012-04-19 | 2013-10-24 | The Procter & Gamble Company | Cosmetic compositions |
Family Cites Families (10)
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US3755560A (en) | 1971-06-30 | 1973-08-28 | Dow Chemical Co | Nongreasy cosmetic lotions |
US4421769A (en) | 1981-09-29 | 1983-12-20 | The Procter & Gamble Company | Skin conditioning composition |
DE19538555A1 (de) * | 1995-10-17 | 1997-04-24 | Beiersdorf Ag | Gegen Akne und entzündete Comedonen wirksame Wirkstoffkombinationen |
US7270805B1 (en) * | 2006-03-30 | 2007-09-18 | Conopco, Inc. | Skin lightening agents, compositions and methods |
CN101578086A (zh) * | 2007-01-16 | 2009-11-11 | 宝洁公司 | 化妆品组合物 |
KR100823533B1 (ko) * | 2007-02-27 | 2008-04-30 | 바이오스펙트럼 주식회사 | 알파 비사볼올을 유효성분으로 포함하는 피부 상태 개선용조성물 |
US8031366B2 (en) | 2007-07-31 | 2011-10-04 | Canon Kabushiki Kaisha | Control apparatus, controlling method, program and recording medium |
JP5689026B2 (ja) * | 2010-06-17 | 2015-03-25 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
JP5570442B2 (ja) | 2011-01-24 | 2014-08-13 | 株式会社シャネル化粧品技術開発研究所 | 水中油型乳化組成物及びその製造方法 |
KR101830599B1 (ko) * | 2013-05-01 | 2018-02-22 | 더 프록터 앤드 갬블 캄파니 | 멜라닌 합성을 억제하기 위한 화장 조성물 및 방법 |
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- 2015-04-21 CA CA2944157A patent/CA2944157C/en active Active
- 2015-04-21 KR KR1020167029050A patent/KR101939453B1/ko active IP Right Grant
- 2015-04-21 JP JP2016563406A patent/JP6416284B2/ja active Active
- 2015-04-21 CN CN201580023121.0A patent/CN106470665B/zh active Active
- 2015-04-21 WO PCT/US2015/026737 patent/WO2015164290A1/en active Application Filing
- 2015-04-21 EP EP15720530.3A patent/EP3134062B1/en active Active
- 2015-04-23 US US14/694,128 patent/US9480634B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993017336A1 (en) * | 1992-02-19 | 1993-09-02 | The Procter & Gamble Company | In vitro model for eye and skin irritation testing |
JPH083034A (ja) * | 1994-06-14 | 1996-01-09 | Beiersdorf Ag | グリセロールアルキルエーテル類の内容物を有する活性化合物組み合わせ、並びに上記活性化合物組み合わせを含んでいる化粧品および皮膚科学調合物 |
JPH10279417A (ja) * | 1997-04-01 | 1998-10-20 | Shiseido Co Ltd | 皮膚外用剤 |
JPH1160463A (ja) * | 1997-08-19 | 1999-03-02 | Shigeo Serizawa | 化粧料 |
WO2013158824A2 (en) * | 2012-04-19 | 2013-10-24 | The Procter & Gamble Company | Cosmetic compositions |
Also Published As
Publication number | Publication date |
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WO2015164290A1 (en) | 2015-10-29 |
KR20160129088A (ko) | 2016-11-08 |
CA2944157C (en) | 2020-01-07 |
CN106470665A (zh) | 2017-03-01 |
CA2944157A1 (en) | 2015-10-29 |
JP6416284B2 (ja) | 2018-10-31 |
EP3134062B1 (en) | 2019-09-04 |
US9480634B2 (en) | 2016-11-01 |
EP3134062A1 (en) | 2017-03-01 |
US20150305994A1 (en) | 2015-10-29 |
CN106470665B (zh) | 2019-12-24 |
KR101939453B1 (ko) | 2019-01-16 |
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