JP2017511129A - 遺伝子操作された光活性化アニオンチャネルタンパク質及びその使用方法 - Google Patents

遺伝子操作された光活性化アニオンチャネルタンパク質及びその使用方法 Download PDF

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JP2017511129A
JP2017511129A JP2016559160A JP2016559160A JP2017511129A JP 2017511129 A JP2017511129 A JP 2017511129A JP 2016559160 A JP2016559160 A JP 2016559160A JP 2016559160 A JP2016559160 A JP 2016559160A JP 2017511129 A JP2017511129 A JP 2017511129A
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amino acid
seq
residue
acid sequence
polypeptide
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JP2017511129A5 (enExample
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カール エイ． ダイセロス
カール エイ． ダイセロス
スー ユァン リー
スー ユァン リー
チャル ラマクリシュナン
チャル ラマクリシュナン
アンドレ バーント
アンドレ バーント
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016559160A 2014-03-28 2015-03-27 遺伝子操作された光活性化アニオンチャネルタンパク質及びその使用方法 Ceased JP2017511129A (ja)

Applications Claiming Priority (3)

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US201461972182P 2014-03-28 2014-03-28
US61/972,182 2014-03-28
PCT/US2015/023087 WO2015148974A2 (en) 2014-03-28 2015-03-27 Engineered light-activated anion channel proteins and methods of use thereof

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JP2017511129A5 JP2017511129A5 (enExample) 2018-05-10

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US (3) US10052383B2 (enExample)
EP (2) EP3122761B1 (enExample)
JP (1) JP2017511129A (enExample)
CN (1) CN106459138A (enExample)
AU (1) AU2015237265A1 (enExample)
CA (1) CA2943367A1 (enExample)
ES (1) ES2725951T3 (enExample)
WO (1) WO2015148974A2 (enExample)

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US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US20070053996A1 (en) 2005-07-22 2007-03-08 Boyden Edward S Light-activated cation channel and uses thereof
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
SG189813A1 (en) 2008-04-23 2013-05-31 Univ Leland Stanford Junior Systems, methods and compositions for optical stimulation of target cells
EP2303405A4 (en) 2008-06-17 2017-12-27 The Board of Trustees of the Leland Stanford Junior University Apparatus and methods for controlling cellular development
US9101759B2 (en) 2008-07-08 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
CN103491770B (zh) 2010-11-05 2016-06-08 斯坦福大学托管董事会 稳定阶跃函数视蛋白及其使用方法
EP3486253A1 (en) 2010-11-05 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
EP3524676A1 (en) 2011-12-16 2019-08-14 The Board of Trustees of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
ES2628006T3 (es) 2012-02-21 2017-08-01 Circuit Therapeutics, Inc. Composiciones para el tratamiento de trastornos neurogénicos del suelo pélvico
WO2016209654A1 (en) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
WO2017015395A1 (en) 2015-07-21 2017-01-26 The Board Of Trustees Of The Leland Stanford Junior University Carbon fiber optrodes for magnetic resonance imaging compatible optogenetics
EP3349851A4 (en) * 2015-09-15 2019-04-24 The Board of Trustees of the Leland Stanford Junior University LIGHT-RESPONSIBLE POLYPEPTIDES AND METHOD OF USE THEREOF
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
JP2021502101A (ja) * 2017-11-10 2021-01-28 ハワード ヒューズ メディカル インスティチュート 修飾されたリガンド依存性イオンチャネルおよび使用の方法
CN108192896B (zh) * 2018-02-10 2021-05-07 中国烟草总公司郑州烟草研究院 一个烟草慢阴离子通道蛋白NtSLAH1及其应用
US11858969B2 (en) 2018-09-18 2024-01-02 California Institute Of Technology Engineered light-sensitive proteins
WO2020059675A1 (ja) * 2018-09-20 2020-03-26 国立大学法人岩手大学 改変チャネルロドプシン
CN111263086A (zh) * 2020-02-10 2020-06-09 江南大学 细胞融合的光电传感器的制作方法及其成像系统的工作方法
US11921271B2 (en) 2020-05-22 2024-03-05 The Board Of Trustees Of The Leland Stanford Junior Univeristy Multifocal macroscope for large field of view imaging of dynamic specimens

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CA2943367A1 (en) 2015-10-01
US20200030446A1 (en) 2020-01-30
US20170095556A1 (en) 2017-04-06
CN106459138A (zh) 2017-02-22
US20180344851A1 (en) 2018-12-06
US10052383B2 (en) 2018-08-21
WO2015148974A3 (en) 2015-12-23
AU2015237265A1 (en) 2016-10-13
US10478499B2 (en) 2019-11-19
ES2725951T3 (es) 2019-09-30
EP3122761A4 (en) 2017-12-06
EP3581580A1 (en) 2019-12-18
WO2015148974A2 (en) 2015-10-01
EP3122761A2 (en) 2017-02-01
EP3122761B1 (en) 2019-03-06

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