CN106459138A - 工程化的光激活阴离子通道蛋白及其使用方法 - Google Patents

工程化的光激活阴离子通道蛋白及其使用方法 Download PDF

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Publication number
CN106459138A
CN106459138A CN201580028022.1A CN201580028022A CN106459138A CN 106459138 A CN106459138 A CN 106459138A CN 201580028022 A CN201580028022 A CN 201580028022A CN 106459138 A CN106459138 A CN 106459138A
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China
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amino acid
seq
acid sequence
residue
polypeptide
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CN201580028022.1A
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English (en)
Chinese (zh)
Inventor
K·A·戴瑟罗斯
S·Y·李
C·拉马卡利施南
A·伯恩特
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201580028022.1A 2014-03-28 2015-03-27 工程化的光激活阴离子通道蛋白及其使用方法 Pending CN106459138A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461972182P 2014-03-28 2014-03-28
US61/972,182 2014-03-28
PCT/US2015/023087 WO2015148974A2 (en) 2014-03-28 2015-03-27 Engineered light-activated anion channel proteins and methods of use thereof

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Publication Number Publication Date
CN106459138A true CN106459138A (zh) 2017-02-22

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CN201580028022.1A Pending CN106459138A (zh) 2014-03-28 2015-03-27 工程化的光激活阴离子通道蛋白及其使用方法

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US (3) US10052383B2 (enExample)
EP (2) EP3581580A1 (enExample)
JP (1) JP2017511129A (enExample)
CN (1) CN106459138A (enExample)
AU (1) AU2015237265A1 (enExample)
CA (1) CA2943367A1 (enExample)
ES (1) ES2725951T3 (enExample)
WO (1) WO2015148974A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108192896A (zh) * 2018-02-10 2018-06-22 中国烟草总公司郑州烟草研究院 一个烟草慢阴离子通道蛋白NtSLAH1及其应用
CN111263086A (zh) * 2020-02-10 2020-06-09 江南大学 细胞融合的光电传感器的制作方法及其成像系统的工作方法
CN111556751A (zh) * 2017-11-10 2020-08-18 霍华休斯医学研究院 经修饰的配体门控的离子通道及使用方法

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US8398692B2 (en) 2007-01-10 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
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US11921271B2 (en) 2020-05-22 2024-03-05 The Board Of Trustees Of The Leland Stanford Junior Univeristy Multifocal macroscope for large field of view imaging of dynamic specimens

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111556751A (zh) * 2017-11-10 2020-08-18 霍华休斯医学研究院 经修饰的配体门控的离子通道及使用方法
CN111556751B (zh) * 2017-11-10 2024-07-12 霍华休斯医学研究院 经修饰的配体门控的离子通道及使用方法
US12247064B2 (en) 2017-11-10 2025-03-11 Howard Hughes Medical Institute Modified ligand-gated ion channels and methods of use
CN108192896A (zh) * 2018-02-10 2018-06-22 中国烟草总公司郑州烟草研究院 一个烟草慢阴离子通道蛋白NtSLAH1及其应用
CN108192896B (zh) * 2018-02-10 2021-05-07 中国烟草总公司郑州烟草研究院 一个烟草慢阴离子通道蛋白NtSLAH1及其应用
CN111263086A (zh) * 2020-02-10 2020-06-09 江南大学 细胞融合的光电传感器的制作方法及其成像系统的工作方法

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US20200030446A1 (en) 2020-01-30
EP3581580A1 (en) 2019-12-18
US20180344851A1 (en) 2018-12-06
US10478499B2 (en) 2019-11-19
ES2725951T3 (es) 2019-09-30
CA2943367A1 (en) 2015-10-01
EP3122761A4 (en) 2017-12-06
US20170095556A1 (en) 2017-04-06
US10052383B2 (en) 2018-08-21
EP3122761A2 (en) 2017-02-01
AU2015237265A1 (en) 2016-10-13
WO2015148974A2 (en) 2015-10-01
JP2017511129A (ja) 2017-04-20
WO2015148974A3 (en) 2015-12-23
EP3122761B1 (en) 2019-03-06

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Application publication date: 20170222