CA2943367A1 - Engineered light-activated anion channel proteins and methods of use thereof - Google Patents

Engineered light-activated anion channel proteins and methods of use thereof Download PDF

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Publication number
CA2943367A1
CA2943367A1 CA2943367A CA2943367A CA2943367A1 CA 2943367 A1 CA2943367 A1 CA 2943367A1 CA 2943367 A CA2943367 A CA 2943367A CA 2943367 A CA2943367 A CA 2943367A CA 2943367 A1 CA2943367 A1 CA 2943367A1
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CA
Canada
Prior art keywords
amino acid
seq
acid sequence
residue
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2943367A
Other languages
English (en)
French (fr)
Inventor
Karl A. DEISSEROTH
Soo Yeun Lee
Charu RAMAKRISHNAN
Andre Berndt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of CA2943367A1 publication Critical patent/CA2943367A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
CA2943367A 2014-03-28 2015-03-27 Engineered light-activated anion channel proteins and methods of use thereof Abandoned CA2943367A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461972182P 2014-03-28 2014-03-28
US61/972,182 2014-03-28
PCT/US2015/023087 WO2015148974A2 (en) 2014-03-28 2015-03-27 Engineered light-activated anion channel proteins and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2943367A1 true CA2943367A1 (en) 2015-10-01

Family

ID=54196574

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2943367A Abandoned CA2943367A1 (en) 2014-03-28 2015-03-27 Engineered light-activated anion channel proteins and methods of use thereof

Country Status (8)

Country Link
US (3) US10052383B2 (enExample)
EP (2) EP3581580A1 (enExample)
JP (1) JP2017511129A (enExample)
CN (1) CN106459138A (enExample)
AU (1) AU2015237265A1 (enExample)
CA (1) CA2943367A1 (enExample)
ES (1) ES2725951T3 (enExample)
WO (1) WO2015148974A2 (enExample)

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WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
EP3486253A1 (en) 2010-11-05 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
US10568307B2 (en) 2010-11-05 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
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US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
EP3324833B1 (en) 2015-07-21 2021-03-17 The Board of Trustees of the Leland Stanford Junior University Carbon fiber optrodes for magnetic resonance imaging compatible optogenetics
US11801301B2 (en) 2015-09-15 2023-10-31 The Board Of Trustees Of The Leland Stanford Junior University Light-responsive polypeptides and methods of use thereof
IL311984A (en) 2016-07-07 2024-06-01 Hughes Howard Med Inst Modified ligand-gated ion channels and methods of use
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
CN111556751B (zh) * 2017-11-10 2024-07-12 霍华休斯医学研究院 经修饰的配体门控的离子通道及使用方法
CN108192896B (zh) * 2018-02-10 2021-05-07 中国烟草总公司郑州烟草研究院 一个烟草慢阴离子通道蛋白NtSLAH1及其应用
US11858969B2 (en) 2018-09-18 2024-01-02 California Institute Of Technology Engineered light-sensitive proteins
EP3854876A4 (en) * 2018-09-20 2022-11-30 National University Corporation, Iwate University MODIFIED CHANNEL RRHODOPSIN
CN111263086A (zh) * 2020-02-10 2020-06-09 江南大学 细胞融合的光电传感器的制作方法及其成像系统的工作方法
US11921271B2 (en) 2020-05-22 2024-03-05 The Board Of Trustees Of The Leland Stanford Junior Univeristy Multifocal macroscope for large field of view imaging of dynamic specimens
EP4334471A1 (en) 2021-05-07 2024-03-13 The Broad Institute Inc. Spatiotemporally resolved transcriptomics at subcellular resolution
WO2025189030A1 (en) 2024-03-07 2025-09-12 Stellaromics, Inc. Methods and systems for volumetric imaging

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Also Published As

Publication number Publication date
AU2015237265A1 (en) 2016-10-13
EP3581580A1 (en) 2019-12-18
US10478499B2 (en) 2019-11-19
JP2017511129A (ja) 2017-04-20
US20200030446A1 (en) 2020-01-30
EP3122761A4 (en) 2017-12-06
ES2725951T3 (es) 2019-09-30
US20180344851A1 (en) 2018-12-06
WO2015148974A3 (en) 2015-12-23
WO2015148974A2 (en) 2015-10-01
CN106459138A (zh) 2017-02-22
US10052383B2 (en) 2018-08-21
US20170095556A1 (en) 2017-04-06
EP3122761B1 (en) 2019-03-06
EP3122761A2 (en) 2017-02-01

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Legal Events

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Effective date: 20211123