EP3854876A4 - Modified channel rhodopsin - Google Patents
Modified channel rhodopsin Download PDFInfo
- Publication number
- EP3854876A4 EP3854876A4 EP19861516.3A EP19861516A EP3854876A4 EP 3854876 A4 EP3854876 A4 EP 3854876A4 EP 19861516 A EP19861516 A EP 19861516A EP 3854876 A4 EP3854876 A4 EP 3854876A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- modified channel
- channel rhodopsin
- rhodopsin
- modified
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018176671 | 2018-09-20 | ||
PCT/JP2019/036252 WO2020059675A1 (en) | 2018-09-20 | 2019-09-15 | Modified channel rhodopsin |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3854876A1 EP3854876A1 (en) | 2021-07-28 |
EP3854876A4 true EP3854876A4 (en) | 2022-11-30 |
Family
ID=69887070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19861516.3A Pending EP3854876A4 (en) | 2018-09-20 | 2019-09-15 | Modified channel rhodopsin |
Country Status (4)
Country | Link |
---|---|
US (1) | US20210347831A1 (en) |
EP (1) | EP3854876A4 (en) |
JP (1) | JPWO2020059675A1 (en) |
WO (1) | WO2020059675A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230331790A1 (en) * | 2020-03-24 | 2023-10-19 | National University Corporation, Iwate University | Modified channelrhodopsin |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2465931A1 (en) * | 2009-08-10 | 2012-06-20 | Tohoku University | Light-receiving channel rhodopsin having improved expression efficiency |
US20150232528A1 (en) * | 2014-02-18 | 2015-08-20 | Board Of Regents Of The University Of Texas System | High-efficiency, sodium -specific, blue-shifted channelrhodopsins |
WO2015148974A2 (en) * | 2014-03-28 | 2015-10-01 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered light-activated anion channel proteins and methods of use thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5322067B1 (en) | 1967-12-08 | 1978-07-06 |
-
2019
- 2019-09-15 JP JP2020548485A patent/JPWO2020059675A1/en active Pending
- 2019-09-15 WO PCT/JP2019/036252 patent/WO2020059675A1/en active Search and Examination
- 2019-09-15 EP EP19861516.3A patent/EP3854876A4/en active Pending
- 2019-09-15 US US17/277,468 patent/US20210347831A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2465931A1 (en) * | 2009-08-10 | 2012-06-20 | Tohoku University | Light-receiving channel rhodopsin having improved expression efficiency |
US20150232528A1 (en) * | 2014-02-18 | 2015-08-20 | Board Of Regents Of The University Of Texas System | High-efficiency, sodium -specific, blue-shifted channelrhodopsins |
WO2015148974A2 (en) * | 2014-03-28 | 2015-10-01 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered light-activated anion channel proteins and methods of use thereof |
Non-Patent Citations (7)
Title |
---|
ERBGUTH KAREN ET AL: "Bimodal Activation of Different Neuron Classes with the Spectrally Red-Shifted Channelrhodopsin Chimera C1V1 in Caenorhabditis elegans", PLOS ONE, vol. 7, no. 10, 3 October 2012 (2012-10-03), pages e46827/1 - 9, XP009171856, ISSN: 1932-6203, [retrieved on 20121003], DOI: 10.1371/JOURNAL.PONE.0046827 * |
HEGEMANN PETER ET AL: "Channelrhodopsin engineering and exploration of new optogenetic tools", NATURE METHODS, vol. 8, no. 1, 1 January 2011 (2011-01-01), New York, pages 39 - 42, XP055914434, ISSN: 1548-7091, Retrieved from the Internet <URL:https://www.nature.com/articles/nmeth.f.327.pdf> DOI: 10.1038/nmeth.f.327 * |
HONGXIA WANG ET AL: "Molecular Determinants Differentiating Photocurrent Properties of Two Channelrhodopsins from Chlamydomonas", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 284, no. 9, 27 February 2009 (2009-02-27), pages 5685 - 5696, XP008151880, ISSN: 0021-9258, [retrieved on 20081222], DOI: 10.1074/JBC.M807632200 * |
JOHN Y LIN ET AL: "Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics", BIOPHYSICAL JOURNAL, ELSEVIER, AMSTERDAM, NL, vol. 96, no. 5, 1 March 2009 (2009-03-01), pages 1803 - 1814, XP008151895, ISSN: 0006-3495, [retrieved on 20090303], DOI: 10.1016/J.BPJ.2008.11.034 * |
JOHN Y LIN ET AL: "ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation", NATURE NEUROSCIENCE, vol. f16, no. 10, 1 January 2013 (2013-01-01), New York, pages 1499 - 1508, XP055226552, ISSN: 1097-6256, DOI: 10.1038/nn.3502 * |
M. PRIGGE ET AL: "Color-tuned Channelrhodopsins for Multiwavelength Optogenetics", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 38, 27 July 2012 (2012-07-27), US, pages 31804 - 31812, XP055075027, ISSN: 0021-9258, DOI: 10.1074/jbc.M112.391185 * |
See also references of WO2020059675A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20210347831A1 (en) | 2021-11-11 |
EP3854876A1 (en) | 2021-07-28 |
WO2020059675A1 (en) | 2020-03-26 |
JPWO2020059675A1 (en) | 2021-09-16 |
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Legal Events
Date | Code | Title | Description |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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17P | Request for examination filed |
Effective date: 20210419 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/85 20060101ALI20220614BHEP Ipc: C12N 15/31 20060101ALI20220614BHEP Ipc: C12N 5/10 20060101ALI20220614BHEP Ipc: C07K 19/00 20060101ALI20220614BHEP Ipc: C07K 14/405 20060101ALI20220614BHEP Ipc: A61P 27/02 20060101ALI20220614BHEP Ipc: A61K 48/00 20060101ALI20220614BHEP Ipc: A61K 38/02 20060101ALI20220614BHEP Ipc: A61K 35/76 20150101ALI20220614BHEP Ipc: C12N 15/62 20060101AFI20220614BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20221028 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/85 20060101ALI20221024BHEP Ipc: C12N 15/31 20060101ALI20221024BHEP Ipc: C12N 5/10 20060101ALI20221024BHEP Ipc: C07K 19/00 20060101ALI20221024BHEP Ipc: C07K 14/405 20060101ALI20221024BHEP Ipc: A61P 27/02 20060101ALI20221024BHEP Ipc: A61K 48/00 20060101ALI20221024BHEP Ipc: A61K 38/02 20060101ALI20221024BHEP Ipc: A61K 35/76 20150101ALI20221024BHEP Ipc: C12N 15/62 20060101AFI20221024BHEP |
|
P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230524 |