JP2017508454A5 - - Google Patents
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- Publication number
- JP2017508454A5 JP2017508454A5 JP2016552921A JP2016552921A JP2017508454A5 JP 2017508454 A5 JP2017508454 A5 JP 2017508454A5 JP 2016552921 A JP2016552921 A JP 2016552921A JP 2016552921 A JP2016552921 A JP 2016552921A JP 2017508454 A5 JP2017508454 A5 JP 2017508454A5
- Authority
- JP
- Japan
- Prior art keywords
- coli
- strain
- methods
- crm197
- reduced genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461947234P | 2014-03-03 | 2014-03-03 | |
| US61/947,234 | 2014-03-03 | ||
| PCT/US2015/018338 WO2015134402A1 (en) | 2014-03-03 | 2015-03-02 | Enhanced production of recombinant crm197 in e. coli |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019011493A Division JP6636661B2 (ja) | 2014-03-03 | 2019-01-25 | 大腸菌における組換えｃｒｍ１９７の産生強化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508454A JP2017508454A (ja) | 2017-03-30 |
| JP2017508454A5 true JP2017508454A5 (enExample) | 2018-01-11 |
| JP6473460B2 JP6473460B2 (ja) | 2019-02-20 |
Family
ID=54055763
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552921A Active JP6473460B2 (ja) | 2014-03-03 | 2015-03-02 | 大腸菌における組換えｃｒｍ１９７の産生強化 |
| JP2019011493A Active JP6636661B2 (ja) | 2014-03-03 | 2019-01-25 | 大腸菌における組換えｃｒｍ１９７の産生強化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019011493A Active JP6636661B2 (ja) | 2014-03-03 | 2019-01-25 | 大腸菌における組換えｃｒｍ１９７の産生強化 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10479820B2 (enExample) |
| EP (1) | EP3113800B1 (enExample) |
| JP (2) | JP6473460B2 (enExample) |
| KR (1) | KR102315246B1 (enExample) |
| CN (1) | CN106456769B (enExample) |
| AU (2) | AU2015225439B2 (enExample) |
| CA (1) | CA2940316C (enExample) |
| WO (1) | WO2015134402A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3068887B1 (en) * | 2013-11-14 | 2019-10-30 | Scarab Genomics LLC | Bacteria with improved metabolic capacity |
| CA2968491C (en) | 2014-11-20 | 2023-09-26 | Biological E Limited | Codon optimized polynucleotide for high level expression of crm197 |
| CA2981583C (en) * | 2015-04-02 | 2022-11-15 | Scarab Genomics, Llc | Continuous fermentation process for production of biological product using reduced genome escherichia coli |
| KR101908590B1 (ko) * | 2017-02-01 | 2018-10-16 | (주)포바이오코리아 | Crm197의 용해성 단백질 발현 및 정제 방법 |
| WO2018193475A2 (en) * | 2017-04-22 | 2018-10-25 | Biological E Limited | An improved method for high level production of crm |
| EP3444269A1 (en) | 2017-08-17 | 2019-02-20 | National Research Council of Canada | Systems and methods for the production of diphtheria toxin polypeptides |
| US20200331973A1 (en) * | 2017-09-01 | 2020-10-22 | Lorven Biologics Private Limited | Nucleic acid encoding crm197 and process for improved expression thereof |
| WO2019050872A1 (en) | 2017-09-05 | 2019-03-14 | Scarab Genomics, Llc | METHODS AND COMPOSITIONS FOR ENHANCED EXPRESSION OF RECOMBINANT PROTEINS |
| WO2019143911A1 (en) * | 2018-01-19 | 2019-07-25 | Obi Pharma, Inc. | Crm197 protein expression |
| WO2019178587A1 (en) * | 2018-03-16 | 2019-09-19 | Bio-Rad Laboratories, Inc. | Purification of target molecules |
| KR102048456B1 (ko) | 2018-03-28 | 2019-11-25 | 강원대학교 산학협력단 | 재조합 대장균을 이용한 rCRM197 생산방법 |
| CN109402035A (zh) * | 2018-11-06 | 2019-03-01 | 华中农业大学 | 一种肠外致病性大肠杆菌重组菌株及其应用 |
| KR102099342B1 (ko) * | 2019-09-03 | 2020-04-10 | 주식회사 제노포커스 | Crm197 단백질 발현 방법 |
| NL2023863B1 (en) * | 2019-09-20 | 2021-05-25 | Univ Griffith | Protein particles and uses thereof |
| KR102142255B1 (ko) * | 2019-12-05 | 2020-08-07 | 주식회사 제노포커스 | Crm197 단백질 발현 방법 |
| BE1029146B1 (fr) * | 2021-02-26 | 2022-09-26 | Xpress Biologics | Procede de purification d'une proteine d'interet |
| BE1029145B1 (fr) | 2021-02-26 | 2022-09-27 | Curavac Europe | Methode de production d'une forme periplasmique de la proteine crm197 |
| CN115850524A (zh) * | 2022-12-29 | 2023-03-28 | 北京吉诺卫生物科技有限公司 | 一种生产白喉毒素无毒突变蛋白的方法及其使用的特异dna分子 |
| CN119552230B (zh) * | 2024-12-12 | 2026-03-13 | 中国人民解放军军事科学院军事医学研究院 | 一种脂肪酸化修饰的白喉毒素抗原及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6989265B2 (en) | 2002-01-23 | 2006-01-24 | Wisconsin Alumni Research Foundation | Bacteria with reduced genome |
| US7300776B2 (en) * | 2004-04-26 | 2007-11-27 | Ajinomoto Co., Inc. | L-amino acid-producing bacterium and a method for producing L-amino acid |
| CA2626900C (en) * | 2005-08-20 | 2013-07-23 | Scarab Genomics, Llc | Reduced genome e. coli |
| JP2009165355A (ja) * | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法 |
| JP5506149B2 (ja) * | 2007-11-22 | 2014-05-28 | 住友化学株式会社 | 昆虫由来のコリンアセチルトランスフェラーゼ活性に関わる有害生物の生理状態に変化を与える薬剤 |
| EP2254994B1 (en) * | 2008-02-22 | 2015-05-20 | Scarab Genomics, LLC | Compositions and methods for amino acid biosynthesis |
| DE102008063900A1 (de) * | 2008-12-19 | 2010-06-24 | Wacker Chemie Ag | Verfahren zur fermentativen Herstellung von heterologen Proteinen mittels Escherichia coli |
| IT1398927B1 (it) * | 2009-06-25 | 2013-03-28 | Consorzio Interuniversitario Per Lo Sviluppo Dei Sistemi A Grande Interfase Csgi | Espressione batterica di un gene artificiale per la produzione di crm197 e derivati. |
| GB0917647D0 (en) * | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| US8546125B2 (en) * | 2011-02-21 | 2013-10-01 | Tianjin Greenbio Material Co., Ltd. | Recombinant hosts and methods for manufacturing polyhydroxyalkanoate |
| US20160251609A1 (en) * | 2011-10-20 | 2016-09-01 | Scarab Genomics, Llc | Reduced Genome Bacteria With Improved Genetic Stability |
| EP2768943B1 (en) * | 2011-10-20 | 2017-06-21 | Scarab Genomics LLC | Reduced genome bacteria with improved genetic stability |
-
2015
- 2015-03-02 JP JP2016552921A patent/JP6473460B2/ja active Active
- 2015-03-02 EP EP15758620.7A patent/EP3113800B1/en active Active
- 2015-03-02 AU AU2015225439A patent/AU2015225439B2/en active Active
- 2015-03-02 CA CA2940316A patent/CA2940316C/en active Active
- 2015-03-02 CN CN201580011743.1A patent/CN106456769B/zh active Active
- 2015-03-02 US US15/122,891 patent/US10479820B2/en active Active
- 2015-03-02 WO PCT/US2015/018338 patent/WO2015134402A1/en not_active Ceased
- 2015-03-02 KR KR1020167026716A patent/KR102315246B1/ko active Active
-
2019
- 2019-01-25 JP JP2019011493A patent/JP6636661B2/ja active Active
-
2021
- 2021-03-17 AU AU2021201686A patent/AU2021201686A1/en not_active Abandoned
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