JP2017507155A5 - - Google Patents
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- JP2017507155A5 JP2017507155A5 JP2016555590A JP2016555590A JP2017507155A5 JP 2017507155 A5 JP2017507155 A5 JP 2017507155A5 JP 2016555590 A JP2016555590 A JP 2016555590A JP 2016555590 A JP2016555590 A JP 2016555590A JP 2017507155 A5 JP2017507155 A5 JP 2017507155A5
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- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutical composition
- ctla
- composition according
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 11
- 229940127084 other anti-cancer agent Drugs 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 5
- 238000009097 single-agent therapy Methods 0.000 claims 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 230000008595 infiltration Effects 0.000 claims 4
- 238000001764 infiltration Methods 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 229960000639 pazopanib Drugs 0.000 claims 4
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims 4
- 206010061818 Disease progression Diseases 0.000 claims 3
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 3
- 102100022338 Integrin alpha-M Human genes 0.000 claims 3
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 3
- 210000001185 bone marrow Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000005750 disease progression Effects 0.000 claims 3
- 210000000066 myeloid cell Anatomy 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 229960001796 sunitinib Drugs 0.000 claims 3
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 3
- 230000001988 toxicity Effects 0.000 claims 3
- 231100000419 toxicity Toxicity 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 229960005386 ipilimumab Drugs 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 102000043321 human CTLA4 Human genes 0.000 claims 1
- 102000048362 human PDCD1 Human genes 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461948428P | 2014-03-05 | 2014-03-05 | |
| US61/948,428 | 2014-03-05 | ||
| US201461977318P | 2014-04-09 | 2014-04-09 | |
| US61/977,318 | 2014-04-09 | ||
| US201461992729P | 2014-05-13 | 2014-05-13 | |
| US61/992,729 | 2014-05-13 | ||
| US201462005600P | 2014-05-30 | 2014-05-30 | |
| US62/005,600 | 2014-05-30 | ||
| PCT/US2015/018727 WO2015134605A1 (en) | 2014-03-05 | 2015-03-04 | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019152086A Division JP2020007331A (ja) | 2014-03-05 | 2019-08-22 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017507155A JP2017507155A (ja) | 2017-03-16 |
| JP2017507155A5 true JP2017507155A5 (OSRAM) | 2018-04-12 |
Family
ID=52686508
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555590A Pending JP2017507155A (ja) | 2014-03-05 | 2015-03-04 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2019152086A Pending JP2020007331A (ja) | 2014-03-05 | 2019-08-22 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2022007365A Pending JP2022058698A (ja) | 2014-03-05 | 2022-01-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2024163901A Pending JP2024178325A (ja) | 2014-03-05 | 2024-09-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019152086A Pending JP2020007331A (ja) | 2014-03-05 | 2019-08-22 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2022007365A Pending JP2022058698A (ja) | 2014-03-05 | 2022-01-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2024163901A Pending JP2024178325A (ja) | 2014-03-05 | 2024-09-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20170088626A1 (OSRAM) |
| EP (2) | EP3572430A3 (OSRAM) |
| JP (4) | JP2017507155A (OSRAM) |
| KR (3) | KR20160119867A (OSRAM) |
| CN (2) | CN106255510A (OSRAM) |
| WO (1) | WO2015134605A1 (OSRAM) |
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| RS54271B1 (sr) | 2005-07-01 | 2016-02-29 | E. R. Squibb & Sons, L.L.C. | Humana monoklonska antitela za ligand programirane smrti 1 (pd-l1) |
| WO2007113648A2 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| AU2007272330A1 (en) * | 2006-07-13 | 2008-01-17 | Zymogenetics, Inc. | Interleukin 21 and tyrosine kinase inhibitor combination therapy |
| CN104013956B (zh) * | 2007-01-25 | 2018-12-18 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| NZ582150A (en) | 2007-06-18 | 2012-08-31 | Msd Oss Bv | Antibodies to human programmed death receptor pd-1 |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| JP5945096B2 (ja) * | 2008-07-04 | 2016-07-05 | 小野薬品工業株式会社 | 抗ヒトｐｄ−１抗体の癌に対する治療効果を最適化するための判定マーカーの使用 |
| CN102203132A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂的组合物和使用方法 |
| HRP20170908T1 (hr) | 2008-12-09 | 2017-09-22 | F. Hoffmann - La Roche Ag | Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice |
| MX360254B (es) | 2011-03-10 | 2018-10-26 | Pfizer | Combinacion de terapias inmunomoduladoras local y sistemica para tratamiento mejorado del cancer. |
| CA2833636A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
| EP2734551B1 (en) | 2011-07-24 | 2018-01-10 | Cure Tech Ltd. | Variants of humanized immunomodulatory monoclonal antibodies |
| CA2873402C (en) | 2012-05-15 | 2023-10-24 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| CN103242448B (zh) * | 2013-05-27 | 2015-01-14 | 郑州大学 | 一种全人源化抗pd-1单克隆抗体及其制备方法和应用 |
| CN103536917B (zh) * | 2013-10-30 | 2015-03-11 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗肿瘤中的用途及相关的产品和方法 |
| CN118286440A (zh) * | 2014-02-04 | 2024-07-05 | 辉瑞大药厂 | 用于治疗癌症的pd-1拮抗剂和vegfr抑制剂的组合 |
-
2015
- 2015-03-04 KR KR1020167027017A patent/KR20160119867A/ko not_active Ceased
- 2015-03-04 KR KR1020227030567A patent/KR20220127940A/ko not_active Ceased
- 2015-03-04 EP EP19167467.0A patent/EP3572430A3/en active Pending
- 2015-03-04 US US15/122,827 patent/US20170088626A1/en not_active Abandoned
- 2015-03-04 CN CN201580023210.5A patent/CN106255510A/zh active Pending
- 2015-03-04 KR KR1020247031210A patent/KR20240144452A/ko active Pending
- 2015-03-04 JP JP2016555590A patent/JP2017507155A/ja active Pending
- 2015-03-04 EP EP15710681.6A patent/EP3114144A1/en not_active Withdrawn
- 2015-03-04 WO PCT/US2015/018727 patent/WO2015134605A1/en not_active Ceased
- 2015-03-04 CN CN202111631085.XA patent/CN114432440A/zh active Pending
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2019
- 2019-05-06 US US16/404,593 patent/US20190263923A1/en not_active Abandoned
- 2019-08-22 JP JP2019152086A patent/JP2020007331A/ja active Pending
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2022
- 2022-01-20 JP JP2022007365A patent/JP2022058698A/ja active Pending
- 2022-05-04 US US17/662,034 patent/US20220389110A1/en not_active Abandoned
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2024
- 2024-09-20 JP JP2024163901A patent/JP2024178325A/ja active Pending
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2025
- 2025-04-07 US US19/172,371 patent/US20250297028A1/en active Pending
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