JP2017506238A5 - - Google Patents
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- Publication number
- JP2017506238A5 JP2017506238A5 JP2016552328A JP2016552328A JP2017506238A5 JP 2017506238 A5 JP2017506238 A5 JP 2017506238A5 JP 2016552328 A JP2016552328 A JP 2016552328A JP 2016552328 A JP2016552328 A JP 2016552328A JP 2017506238 A5 JP2017506238 A5 JP 2017506238A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- pylori
- compound
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 101710185027 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000590002 Helicobacter pylori Species 0.000 claims 2
- 241001138501 Salmonella enterica Species 0.000 claims 2
- 241000607762 Shigella flexneri Species 0.000 claims 2
- 241000607626 Vibrio cholerae Species 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229940037467 helicobacter pylori Drugs 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 101710111176 5'-methylthioadenosine nucleosidase Proteins 0.000 claims 1
- 101710081557 Aminodeoxyfutalosine nucleosidase Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102000001696 Mannosidases Human genes 0.000 claims 1
- 108010054377 Mannosidases Proteins 0.000 claims 1
- 208000008469 Peptic Ulcer Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 229960003022 amoxicillin Drugs 0.000 claims 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 229960000282 metronidazole Drugs 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims 1
- 229960002180 tetracycline Drugs 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461938755P | 2014-02-12 | 2014-02-12 | |
| US61/938,755 | 2014-02-12 | ||
| PCT/US2015/014778 WO2015123101A1 (en) | 2014-02-12 | 2015-02-06 | Treatment of h. pylori infections using mtan inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506238A JP2017506238A (ja) | 2017-03-02 |
| JP2017506238A5 true JP2017506238A5 (enExample) | 2018-02-22 |
| JP6512613B2 JP6512613B2 (ja) | 2019-05-15 |
Family
ID=53800544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552328A Active JP6512613B2 (ja) | 2014-02-12 | 2015-02-06 | Ｍｔａｎ阻害剤を使用するピロリ菌（ｈ．ｐｙｌｏｒｉ）感染の治療 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10118928B2 (enExample) |
| EP (1) | EP3104707B1 (enExample) |
| JP (1) | JP6512613B2 (enExample) |
| AU (1) | AU2015217416B2 (enExample) |
| BR (1) | BR112016019469B1 (enExample) |
| CA (1) | CA2974916C (enExample) |
| HK (1) | HK1232071A1 (enExample) |
| IL (1) | IL247218B (enExample) |
| NZ (1) | NZ724103A (enExample) |
| RU (1) | RU2663803C2 (enExample) |
| SG (2) | SG10201806381VA (enExample) |
| WO (1) | WO2015123101A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6063571B2 (ja) | 2012-08-07 | 2017-01-18 | アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド | ヘリコバクター・ピロリ感染の治療 |
| CN108794628A (zh) * | 2018-05-28 | 2018-11-13 | 广东工业大学 | 一种抗幽门螺杆菌的卵黄抗体制备方法及应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| US7098334B2 (en) | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| AU2003245442B2 (en) * | 2002-06-13 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase IV inhibitors for the treatment of bacterial infections |
| US7553839B2 (en) | 2002-08-21 | 2009-06-30 | Industrial Research Limited | 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| WO2007016291A2 (en) | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| ES2362805T3 (es) | 2006-09-07 | 2011-07-13 | Industrial Research Limited | Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas. |
| US8383636B2 (en) * | 2006-09-07 | 2013-02-26 | Industrial Research Limited | Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase |
| DK2114925T3 (da) | 2006-12-22 | 2012-05-29 | Ind Res Ltd | Azetidin-analoger af nucleosidase- og phosphorylase-inhibitorer |
| WO2008115531A1 (en) * | 2007-03-21 | 2008-09-25 | Novacea, Inc. | Prevention and treatment of infectious conditions with active vitamin d compounds or mimics thereof |
| WO2010033236A2 (en) * | 2008-09-22 | 2010-03-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| JP5861243B2 (ja) | 2009-07-17 | 2016-02-16 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤 |
| US9290501B2 (en) * | 2010-11-29 | 2016-03-22 | Albert Einstein College Of Medicine, Inc. | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
| JP6063571B2 (ja) | 2012-08-07 | 2017-01-18 | アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド | ヘリコバクター・ピロリ感染の治療 |
| US9522159B2 (en) | 2012-09-11 | 2016-12-20 | Albert Einstein College Of Medicine, Inc. | Treatment and prevention of P. aeruginosa infections using coformycin analogs |
| WO2014073989A1 (en) | 2012-11-12 | 2014-05-15 | Callaghan Innovation Research Limited | Salt and polymorphic forms of (3r,4s)-l-((4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(mtdia) |
-
2015
- 2015-02-06 EP EP15748925.3A patent/EP3104707B1/en active Active
- 2015-02-06 WO PCT/US2015/014778 patent/WO2015123101A1/en not_active Ceased
- 2015-02-06 RU RU2016136533A patent/RU2663803C2/ru active
- 2015-02-06 BR BR112016019469-1A patent/BR112016019469B1/pt active IP Right Grant
- 2015-02-06 SG SG10201806381VA patent/SG10201806381VA/en unknown
- 2015-02-06 JP JP2016552328A patent/JP6512613B2/ja active Active
- 2015-02-06 US US15/118,113 patent/US10118928B2/en active Active
- 2015-02-06 AU AU2015217416A patent/AU2015217416B2/en active Active
- 2015-02-06 NZ NZ724103A patent/NZ724103A/en unknown
- 2015-02-06 SG SG11201606595RA patent/SG11201606595RA/en unknown
- 2015-02-06 CA CA2974916A patent/CA2974916C/en active Active
- 2015-02-06 HK HK17105755.5A patent/HK1232071A1/zh unknown
-
2016
- 2016-08-10 IL IL247218A patent/IL247218B/en active IP Right Grant
-
2018
- 2018-09-20 US US16/136,314 patent/US10294233B2/en active Active
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