JP2017505336A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017505336A5 JP2017505336A5 JP2016562470A JP2016562470A JP2017505336A5 JP 2017505336 A5 JP2017505336 A5 JP 2017505336A5 JP 2016562470 A JP2016562470 A JP 2016562470A JP 2016562470 A JP2016562470 A JP 2016562470A JP 2017505336 A5 JP2017505336 A5 JP 2017505336A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- tracer
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 13
- 238000003384 imaging method Methods 0.000 claims 3
- 239000000700 radioactive tracer Substances 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010064218 Poly (ADP-Ribose) Polymerase-1 Proteins 0.000 claims 1
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923759P | 2014-01-05 | 2014-01-05 | |
| US61/923,759 | 2014-01-05 | ||
| PCT/US2015/010129 WO2015103526A1 (en) | 2014-01-05 | 2015-01-05 | Radiolabeled tracers for poly (adp-ribose) polymerase-1 (parp-1), methods and uses therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018173457A Division JP2019001820A (ja) | 2014-01-05 | 2018-09-18 | ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505336A JP2017505336A (ja) | 2017-02-16 |
| JP2017505336A5 true JP2017505336A5 (enExample) | 2018-02-08 |
| JP6407303B2 JP6407303B2 (ja) | 2018-10-17 |
Family
ID=53494075
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562470A Active JP6407303B2 (ja) | 2014-01-05 | 2015-01-05 | ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用 |
| JP2018173457A Withdrawn JP2019001820A (ja) | 2014-01-05 | 2018-09-18 | ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018173457A Withdrawn JP2019001820A (ja) | 2014-01-05 | 2018-09-18 | ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9993570B2 (enExample) |
| EP (2) | EP3089965B1 (enExample) |
| JP (2) | JP6407303B2 (enExample) |
| CN (1) | CN106458935B (enExample) |
| CA (1) | CA2935857C (enExample) |
| ES (1) | ES2700348T3 (enExample) |
| WO (1) | WO2015103526A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201992177A1 (ru) | 2017-03-27 | 2020-02-25 | Тесаро, Инк. | Композиции на основе нирапариба |
| ES3062817T3 (en) * | 2017-05-24 | 2026-04-14 | Univ Pennsylvania | Radiolabeled and fluorescent parp inhibitors for imaging and radiotherapy |
| AU2018341479B2 (en) * | 2017-09-26 | 2022-02-17 | Tesaro, Inc. | Niraparib formulations |
| CN117180277A (zh) * | 2023-08-04 | 2023-12-08 | 中国辐射防护研究院 | 一种核素标记的靶向探针及其制备方法和应用 |
| CN117586270B (zh) * | 2023-11-07 | 2025-09-23 | 北京脑重大疾病研究院 | 放射性2，7，9a-三氮杂苯并[cd]天青-6（7H）酮衍生物及其制备方法和应用 |
| CN120247879A (zh) * | 2024-01-02 | 2025-07-04 | 南京亘泰医药技术有限公司 | 一种parp1和ulk1双靶点抑制剂及其制备方法与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1391457B1 (de) * | 1998-11-03 | 2013-12-25 | AbbVie Deutschland GmbH & Co KG | Substituierte 2-Phenylbenzimidazole und deren Verwendung als PARP Inhibitoren |
| EE05006B1 (et) | 1999-01-11 | 2008-04-15 | Agouron Pharmaceuticals, Inc. | Polü(ADP-riboos)polümeraaside tritsüklilised inhibiitorid ja neid sisaldavad farmatseutilised kompositsioonid |
| ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| HU0301154D0 (en) * | 2003-04-28 | 2003-07-28 | Hideg Kalman Dr | Pharmaceutical composition |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| US8329686B2 (en) * | 2006-08-29 | 2012-12-11 | Washington University | Isatin analogues and uses therefor |
| US7956064B2 (en) | 2006-09-01 | 2011-06-07 | Cylene Pharmaceuticals, Inc. | Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators |
| US8506927B2 (en) * | 2011-01-05 | 2013-08-13 | Washington University | Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging |
| CN104780764A (zh) | 2012-09-05 | 2015-07-15 | 拜尔农作物科学股份公司 | 取代的2-酰氨基苯并咪唑、2-酰氨基苯并噁唑和2-酰氨基苯并噻唑或其盐作为活性物质对抗非生物植物胁迫的用途 |
-
2015
- 2015-01-05 CA CA2935857A patent/CA2935857C/en active Active
- 2015-01-05 EP EP15733272.7A patent/EP3089965B1/en active Active
- 2015-01-05 WO PCT/US2015/010129 patent/WO2015103526A1/en not_active Ceased
- 2015-01-05 CN CN201580011735.7A patent/CN106458935B/zh active Active
- 2015-01-05 ES ES15733272T patent/ES2700348T3/es active Active
- 2015-01-05 EP EP18190718.9A patent/EP3424909A1/en not_active Withdrawn
- 2015-01-05 JP JP2016562470A patent/JP6407303B2/ja active Active
-
2016
- 2016-07-05 US US15/201,765 patent/US9993570B2/en active Active
-
2018
- 2018-05-14 US US15/978,374 patent/US20180326100A1/en not_active Abandoned
- 2018-09-18 JP JP2018173457A patent/JP2019001820A/ja not_active Withdrawn