JP6407303B2 - ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用 - Google Patents

ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用 Download PDF

Info

Publication number
JP6407303B2
JP6407303B2 JP2016562470A JP2016562470A JP6407303B2 JP 6407303 B2 JP6407303 B2 JP 6407303B2 JP 2016562470 A JP2016562470 A JP 2016562470A JP 2016562470 A JP2016562470 A JP 2016562470A JP 6407303 B2 JP6407303 B2 JP 6407303B2
Authority
JP
Japan
Prior art keywords
parp
compound
mice
tracer
imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016562470A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017505336A (ja
JP2017505336A5 (enExample
Inventor
ロバート・マック
ウェンホア・チュウ
ドン・ジョウ
ローレン・ミシェル
デルフィン・チェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Washington University in St Louis WUSTL
Original Assignee
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Washington University in St Louis WUSTL filed Critical Washington University in St Louis WUSTL
Publication of JP2017505336A publication Critical patent/JP2017505336A/ja
Publication of JP2017505336A5 publication Critical patent/JP2017505336A5/ja
Application granted granted Critical
Publication of JP6407303B2 publication Critical patent/JP6407303B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016562470A 2014-01-05 2015-01-05 ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用 Active JP6407303B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461923759P 2014-01-05 2014-01-05
US61/923,759 2014-01-05
PCT/US2015/010129 WO2015103526A1 (en) 2014-01-05 2015-01-05 Radiolabeled tracers for poly (adp-ribose) polymerase-1 (parp-1), methods and uses therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018173457A Division JP2019001820A (ja) 2014-01-05 2018-09-18 ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用

Publications (3)

Publication Number Publication Date
JP2017505336A JP2017505336A (ja) 2017-02-16
JP2017505336A5 JP2017505336A5 (enExample) 2018-02-08
JP6407303B2 true JP6407303B2 (ja) 2018-10-17

Family

ID=53494075

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016562470A Active JP6407303B2 (ja) 2014-01-05 2015-01-05 ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用
JP2018173457A Withdrawn JP2019001820A (ja) 2014-01-05 2018-09-18 ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018173457A Withdrawn JP2019001820A (ja) 2014-01-05 2018-09-18 ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用

Country Status (7)

Country Link
US (2) US9993570B2 (enExample)
EP (2) EP3089965B1 (enExample)
JP (2) JP6407303B2 (enExample)
CN (1) CN106458935B (enExample)
CA (1) CA2935857C (enExample)
ES (1) ES2700348T3 (enExample)
WO (1) WO2015103526A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI761476B (zh) 2017-03-27 2022-04-21 美商提薩羅有限公司 尼拉帕尼(niraparib)組合物
CN110997068B (zh) * 2017-05-24 2022-12-06 宾夕法尼亚大学董事会 用于成像和放射疗法的经放射标记的荧光parp抑制剂
WO2019067634A1 (en) * 2017-09-26 2019-04-04 Tesaro, Inc. Niraparib formulations
CN117180277A (zh) * 2023-08-04 2023-12-08 中国辐射防护研究院 一种核素标记的靶向探针及其制备方法和应用
CN117586270B (zh) * 2023-11-07 2025-09-23 北京脑重大疾病研究院 放射性2，7，9a-三氮杂苯并[cd]天青-6（7H）酮衍生物及其制备方法和应用
CN120247879A (zh) * 2024-01-02 2025-07-04 南京亘泰医药技术有限公司 一种parp1和ulk1双靶点抑制剂及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1331682A (zh) * 1998-11-03 2002-01-16 巴斯福股份公司 取代的2－苯基苯并咪唑类,其制备和用途
TR200102005T2 (tr) 1999-01-11 2001-12-21 Agouron Pharmaceuticals,Inc. Poli(adp-ribaz) polimerazların trisiklik inhibitörleri.
ECSP003637A (es) * 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
HU0301154D0 (en) * 2003-04-28 2003-07-28 Hideg Kalman Dr Pharmaceutical composition
GB0428012D0 (en) * 2004-12-22 2005-01-26 Hammersmith Imanet Ltd Radiolabelling methods
US8329686B2 (en) * 2006-08-29 2012-12-11 Washington University Isatin analogues and uses therefor
PT2061765E (pt) 2006-09-01 2015-02-06 Senhwa Biosciences Inc Moduladores de serina-treonina-proteína-quinase e de parp
US8506927B2 (en) * 2011-01-05 2013-08-13 Washington University Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging
BR112015004858A2 (pt) * 2012-09-05 2017-07-04 Bayer Cropscience Ag uso de 2-amidobenzimidazóis, 2-amidobenzoxazóis e 2-amidobenzotiazóis substituídos ou sais dos mesmos como substâncias ativas contra estresse abiótico em plantas

Also Published As

Publication number Publication date
CN106458935B (zh) 2019-05-28
US9993570B2 (en) 2018-06-12
CA2935857C (en) 2020-12-15
EP3089965A1 (en) 2016-11-09
ES2700348T3 (es) 2019-02-15
CN106458935A (zh) 2017-02-22
JP2017505336A (ja) 2017-02-16
WO2015103526A1 (en) 2015-07-09
US20160339124A1 (en) 2016-11-24
EP3424909A1 (en) 2019-01-09
CA2935857A1 (en) 2015-07-09
JP2019001820A (ja) 2019-01-10
EP3089965A4 (en) 2017-06-21
US20180326100A1 (en) 2018-11-15
EP3089965B1 (en) 2018-08-29

Similar Documents

Publication Publication Date Title
Zhou et al. Synthesis,[18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography
JP2019001820A (ja) ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用
JP7622113B2 (ja) Ｐｓｍａ阻害剤を含有する１８ｆ標識トリアゾール
Zhou et al. Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer
EP3389727B1 (en) Radiolabelled mglur2/3 pet ligands
Harada et al. Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A
US20050107398A1 (en) Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors
Chen et al. Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping
US10561748B2 (en) Anthranilic acid derivatives
JP5085824B2 (ja) 低酸素の検出のために有用な化合物の製造
Thomae et al. Synthesis and preclinical evaluation of an 18F labeled PDE7 inhibitor for PET neuroimaging
JP2007505101A (ja) 放射性標識されたアニリノキナゾリン型化合物ならびに放射線画像化および放射線治療におけるその使用
US20190054197A1 (en) Radiolabeled macrocyclic egfr inhibitor
Class et al. Patent application title: Radiolabeled Tracers for Poly (ADP-RIBOSE) Polymerase-1 (PARP-1), Methods and Uses Therefor
HK1231057B (en) Radiolabeled tracers for poly (adp-ribose) polymerase-1 (parp-1), methods and uses therefor
HK1231057A1 (en) Radiolabeled tracers for poly (adp-ribose) polymerase-1 (parp-1), methods and uses therefor
Selivanova et al. Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging
US20170174632A1 (en) 4-oxo-1, 4-dihydroquinoline-3-carboxamide as selective ligand for cannabinoid receptor 2 for diagnosis and therapy
US20240174608A1 (en) Compounds for brain imaging
KR20040007425A (ko) 불안 및 공황 장애를 치료하기 위한 비펩티드 봄베신수용체 길항물질의 신규 용도
JP2019064986A (ja) Ｂｃｒ−Ａｂｌタンパク質イメージング用分子プローブ
Nurmaya Development of Radiolabeled Compounds Directed Against Platelet-Derived Growth Factor Receptor Beta (PDGFRβ) for Tumor Imaging
HK40009754A (en) 18f-labeled triazole containing psma inhibitors
WO2015194954A1 (en) 6,7-dioxyalkyltetrahydroisoquinoline compounds

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171222

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171222

TRDD Decision of grant or rejection written
A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180816

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180821

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180918

R150 Certificate of patent or registration of utility model

Ref document number: 6407303

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250