ES2700348T3 - Trazadores radioetiquetados para poli (ADP-ribosa) polimerasa-1 (PARP-1), métodos y usos para estos - Google Patents
Trazadores radioetiquetados para poli (ADP-ribosa) polimerasa-1 (PARP-1), métodos y usos para estos Download PDFInfo
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- ES2700348T3 ES2700348T3 ES15733272T ES15733272T ES2700348T3 ES 2700348 T3 ES2700348 T3 ES 2700348T3 ES 15733272 T ES15733272 T ES 15733272T ES 15733272 T ES15733272 T ES 15733272T ES 2700348 T3 ES2700348 T3 ES 2700348T3
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Classifications
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201461923759P | 2014-01-05 | 2014-01-05 | |
| PCT/US2015/010129 WO2015103526A1 (en) | 2014-01-05 | 2015-01-05 | Radiolabeled tracers for poly (adp-ribose) polymerase-1 (parp-1), methods and uses therefor |
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| ES2700348T3 true ES2700348T3 (es) | 2019-02-15 |
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| EP (2) | EP3424909A1 (enExample) |
| JP (2) | JP6407303B2 (enExample) |
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| ES (1) | ES2700348T3 (enExample) |
| WO (1) | WO2015103526A1 (enExample) |
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| CN110944638A (zh) | 2017-03-27 | 2020-03-31 | 特沙诺有限公司 | 尼拉帕尼组合物 |
| US11161865B2 (en) * | 2017-05-24 | 2021-11-02 | The Trustees Of The University Of Pennsylvania | Radiolabeled and fluorescent PARP inhibitors for imaging and radiotherapy |
| JP7269227B2 (ja) * | 2017-09-26 | 2023-05-08 | テサロ， インコーポレイテッド | ニラパリブ処方物 |
| CN117180277A (zh) * | 2023-08-04 | 2023-12-08 | 中国辐射防护研究院 | 一种核素标记的靶向探针及其制备方法和应用 |
| CN117586270B (zh) * | 2023-11-07 | 2025-09-23 | 北京脑重大疾病研究院 | 放射性2，7，9a-三氮杂苯并[cd]天青-6（7H）酮衍生物及其制备方法和应用 |
| CN120247879A (zh) * | 2024-01-02 | 2025-07-04 | 南京亘泰医药技术有限公司 | 一种parp1和ulk1双靶点抑制剂及其制备方法与应用 |
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| HUP0200312A3 (en) * | 1998-11-03 | 2002-12-28 | Basf Ag | Substituted 2-phenylbenzimidazoles, pharmaceutical compositions containing them, the production thereof and their use |
| CA2360003C (en) | 1999-01-11 | 2012-07-10 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
| ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| HU0301154D0 (en) * | 2003-04-28 | 2003-07-28 | Hideg Kalman Dr | Pharmaceutical composition |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| US8329686B2 (en) * | 2006-08-29 | 2012-12-11 | Washington University | Isatin analogues and uses therefor |
| ES2528316T3 (es) | 2006-09-01 | 2015-02-06 | Senhwa Biosciences, Inc. | Moduladores de la serina-treonina proteína quinasa y de PARP |
| US8506927B2 (en) * | 2011-01-05 | 2013-08-13 | Washington University | Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging |
| WO2014037340A1 (de) * | 2012-09-05 | 2014-03-13 | Bayer Cropscience Ag | Verwendung substituierter 2-amidobenzimidazole, 2-amidobenzoxazole und 2-amidobenzothiazole oder deren salze als wirkstoffe gegen abiotischen pflanzenstress |
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2015
- 2015-01-05 EP EP18190718.9A patent/EP3424909A1/en not_active Withdrawn
- 2015-01-05 EP EP15733272.7A patent/EP3089965B1/en active Active
- 2015-01-05 CN CN201580011735.7A patent/CN106458935B/zh active Active
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2018
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Also Published As
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| EP3089965A1 (en) | 2016-11-09 |
| CA2935857A1 (en) | 2015-07-09 |
| EP3089965A4 (en) | 2017-06-21 |
| US9993570B2 (en) | 2018-06-12 |
| JP6407303B2 (ja) | 2018-10-17 |
| CN106458935A (zh) | 2017-02-22 |
| EP3424909A1 (en) | 2019-01-09 |
| JP2019001820A (ja) | 2019-01-10 |
| JP2017505336A (ja) | 2017-02-16 |
| US20160339124A1 (en) | 2016-11-24 |
| EP3089965B1 (en) | 2018-08-29 |
| CA2935857C (en) | 2020-12-15 |
| WO2015103526A1 (en) | 2015-07-09 |
| US20180326100A1 (en) | 2018-11-15 |
| CN106458935B (zh) | 2019-05-28 |
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